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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:6-Acetylmorphine
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Accession:CHEBI:2168 term browser browse the term
Definition:A morphinane alkaloid that has formula C19H21NO4.
Synonyms:related_synonym: 6-O-Monoacetylmorphine;   Formula=C19H21NO4;   InChI=1S/C19H21NO4/c1-10(21)23-15-6-4-12-13-9-11-3-5-14(22)17-16(11)19(12,18(15)24-17)7-8-20(13)2/h3-6,12-13,15,18,22H,7-9H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1;   InChIKey=JJGYGPZNTOPXGV-SSTWWWIQSA-N;   SMILES=CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4OC(C)=O)ccc5O
 xref: CAS:2784-73-8;   KEGG:C11781
 xref_mesh: MESH:C026979


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6-Acetylmorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases chemical synthesis
increases degradation
multiple interactions		 ISO ACHE protein results in increased chemical synthesis of 6-O-monoacetylmorphine
ACHE protein results in increased degradation of 6-O-monoacetylmorphine
[ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine; [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine		 CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases degradation
increases chemical synthesis		 ISO [BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine; [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine
BCHE protein results in increased chemical synthesis of 6-O-monoacetylmorphine		 CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Ces1d carboxylesterase 1D affects binding
increases chemical synthesis
multiple interactions		 ISO 6-O-monoacetylmorphine binds to CES1 protein
CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine
Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]		 CTD PMID:8930175 PMID:9311626 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis
increases chemical synthesis
multiple interactions		 ISO CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine
CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine]		 CTD PMID:8930175 PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            alkaloid 7816
              isoquinoline alkaloid 1194
                morphinane alkaloid 697
                  6-Acetylmorphine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      p-block molecular entity 19779
                        carbon group molecular entity 19728
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organonitrogen compound 18804
                                alkaloid 7816
                                  isoquinoline alkaloid 1194
                                    morphinane alkaloid 697
                                      6-Acetylmorphine 4
paths to the root