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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefoxitin
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Accession:CHEBI:209807 term browser browse the term
Definition:A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.
Synonyms:exact_synonym: (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   3-[(carbamoyloxy)methyl]-7alpha-methoxy-7beta-[(thiophen-2-yl)acetamido]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CFX;   Cephoxitin;   Formula=C16H17N3O7S2;   InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1;   InChIKey=WZOZEZRFJCJXNZ-ZBFHGGJFSA-N;   Rephoxitin;   SMILES=[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)Cc1cccs1)OC)C(O)=O;   cefoxitina;   cefoxitine;   cefoxitinum;   ceftoxitin
 alt_id: CHEBI:3500;   CHEBI:41436;   CHEBI:471714;   CHEBI:658070
 xref: Beilstein:4216947;   CAS:35607-66-0;   DrugBank:DB01331;   Drug_Central:550;   HMDB:HMDB0015426;   KEGG:C06887;   KEGG:D02345;   LINCS:LSM-5786
 xref_mesh: MESH:D002440
 xref: PDBeChem:CFX;   PMID:12569987;   PMID:17043131;   PMID:17178800;   PMID:17220412;   PMID:17353248;   PMID:17387156;   PMID:17923492;   PMID:18056283;   PMID:18070972;   PMID:2083978;   PMID:29017833;   PMID:8360877;   Patent:DE2129675;   Patent:DE2203653;   Patent:US4297488;   Reaxys:4216947;   Wikipedia:Cefoxitin
 cyclic_relationship: is_conjugate_acid_of CHEBI:53655



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cefoxitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of IFNG mRNA] CTD PMID:37269894 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of IKBKB mRNA] CTD PMID:37269894 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of IL10 mRNA] CTD PMID:37269894 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of IL1B mRNA] CTD PMID:37269894 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of IL6 mRNA] CTD PMID:37269894 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of MYD88 mRNA] CTD PMID:37269894 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of RELA mRNA] CTD PMID:37269894 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects expression ISO Cefoxitin affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,261,656...3,265,548 JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Cefoxitin affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,763,033...4,772,141
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of TGFB1 mRNA] CTD PMID:37269894 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of TLR2 mRNA] CTD PMID:37269894 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of TNF mRNA] CTD PMID:37269894 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of TRAF6 mRNA] CTD PMID:37269894 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          antibacterial agent 16665
            antibacterial drug 7535
              cefoxitin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              lactam 8438
                                                beta-lactam 855
                                                  beta-lactam antibiotic 840
                                                    cephem 569
                                                      cephalosporin 568
                                                        cefoxitin 13
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