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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefoxitin
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Accession:CHEBI:209807 term browser browse the term
Definition:A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.
Synonyms:exact_synonym: (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   3-[(carbamoyloxy)methyl]-7alpha-methoxy-7beta-[(thiophen-2-yl)acetamido]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CFX;   Cephoxitin;   Formula=C16H17N3O7S2;   InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1;   InChIKey=WZOZEZRFJCJXNZ-ZBFHGGJFSA-N;   Rephoxitin;   SMILES=[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)Cc1cccs1)OC)C(O)=O;   cefoxitina;   cefoxitine;   cefoxitinum;   ceftoxitin
 alt_id: CHEBI:3500;   CHEBI:41436;   CHEBI:471714;   CHEBI:658070
 xref: Beilstein:4216947;   CAS:35607-66-0;   DrugBank:DB01331;   Drug_Central:550;   HMDB:HMDB0015426;   KEGG:C06887;   KEGG:D02345;   LINCS:LSM-5786
 xref_mesh: MESH:D002440
 xref: PDBeChem:CFX;   PMID:12569987;   PMID:17043131;   PMID:17178800;   PMID:17220412;   PMID:17353248;   PMID:17387156;   PMID:17923492;   PMID:18056283;   PMID:18070972;   PMID:2083978;   PMID:29017833;   PMID:8360877;   Patent:DE2129675;   Patent:DE2203653;   Patent:US4297488;   Reaxys:4216947;   Wikipedia:Cefoxitin
 cyclic_relationship: is_conjugate_acid_of CHEBI:53655

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cefoxitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO Cefoxitin affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Cefoxitin affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            antibacterial drug 3162
              cefoxitin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          cefoxitin 2
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