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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydroartemisinin
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Accession:CHEBI:207229 term browser browse the term
Definition:A sesquiterpenoid compound which is used as a drug for treatment of malaria.
Synonyms:exact_synonym: (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-ol
 related_synonym: 1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol(Dihydroartemisinin);   Formula=C15H24O5;   InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1;   InChIKey=BJDCWCLMFKKGEE-HVDUHBCDSA-N;   SMILES=[H][C@@]12CC[C@@]3(C)OO[C@]11[C@]([H])(OC(O)[C@H](C)[C@]1([H])CC[C@H]2C)O3
 xref: Beilstein:4185848
 xref_mesh: MESH:C039060
 xref: PMID:10893313;   PMID:3669021


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dihydroartemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Actg1 actin, gamma 1 affects binding ISO dihydroartemisinin analog binds to ACTG1 protein CTD PMID:26340163 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Alb albumin affects binding ISO dihydroartemisinin analog binds to ALB protein CTD PMID:26340163 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 affects binding ISO dihydroartemisinin analog binds to ALDH7A1 protein CTD PMID:26340163 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
G Anxa2 annexin A2 affects binding ISO dihydroartemisinin analog binds to ANXA2 protein CTD PMID:26340163 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects binding ISO dihydroartemisinin analog binds to ATP5F1A protein CTD PMID:26340163 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5mg ATP synthase membrane subunit g affects binding ISO dihydroartemisinin analog binds to ATP5MG protein CTD PMID:26340163 NCBI chr 8:49,220,441...49,227,273
Ensembl chr 8:49,220,443...49,227,273
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP affects binding ISO dihydroartemisinin analog binds to ATP5PO protein CTD PMID:26340163 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Casp3 caspase 3 increases cleavage ISO dihydroartemisinin results in increased cleavage of CASP3 protein CTD PMID:21547369 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cast calpastatin affects binding ISO dihydroartemisinin analog binds to CAST protein modified form CTD PMID:26340163 NCBI chr 2:1,452,111...1,561,669
Ensembl chr 2:1,452,116...1,561,464
JBrowse link
G Cat catalase increases expression ISO dihydroartemisinin results in increased expression of CAT protein CTD PMID:20361947 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 affects binding ISO dihydroartemisinin analog binds to CCT3 protein modified form CTD PMID:26340163 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dihydroartemisinin results in increased expression of CDKN1A mRNA CTD PMID:21547369 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cfl1 cofilin 1 affects binding ISO dihydroartemisinin analog binds to CFL1 protein CTD PMID:26340163 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Clic1 chloride intracellular channel 1 affects binding ISO dihydroartemisinin analog binds to CLIC1 protein modified form CTD PMID:26340163 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP
[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; dihydroartemisinin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; dihydroartemisinin inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]
CTD PMID:27939985, PMID:27939985 RGD:15036816 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 affects binding ISO dihydroartemisinin analog binds to CSRP1 protein CTD PMID:26340163 NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO dihydroartemisinin results in decreased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO dihydroartemisinin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO dihydroartemisinin results in increased expression of DDIT3 mRNA CTD PMID:21547369 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects binding ISO dihydroartemisinin analog binds to DPYSL2 protein modified form CTD PMID:26340163 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dsp desmoplakin affects binding ISO dihydroartemisinin analog binds to DSP protein CTD PMID:26340163 NCBI chr17:27,286,811...27,334,453
Ensembl chr17:27,286,796...27,334,379
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects binding ISO dihydroartemisinin analog binds to EEF1A1 protein modified form CTD PMID:26340163 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Egr1 early growth response 1 increases expression ISO dihydroartemisinin results in increased expression of EGR1 mRNA CTD PMID:21547369 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eno1 enolase 1 affects binding ISO dihydroartemisinin analog binds to ENO1 protein CTD PMID:26340163 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN protein]; dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of FASN protein] CTD PMID:27939985 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine] RGD PMID:27939985 RGD:15036816 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Flna filamin A affects binding ISO dihydroartemisinin analog binds to FLNA protein CTD PMID:26340163 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase affects binding ISO dihydroartemisinin analog binds to FTO protein CTD PMID:26340163 NCBI chr19:16,774,549...17,115,098
Ensembl chr19:16,772,744...17,115,113
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects binding ISO dihydroartemisinin analog binds to G6PD protein CTD PMID:26340163 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO dihydroartemisinin results in increased expression of GADD45A mRNA CTD PMID:21547369 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects binding ISO dihydroartemisinin analog binds to GAPDH protein CTD PMID:26340163 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gpi glucose-6-phosphate isomerase affects binding ISO dihydroartemisinin analog binds to GPI protein CTD PMID:26340163 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO dihydroartemisinin inhibits the reaction [Ethanol results in increased activity of GPT protein]; dihydroartemisinin promotes the reaction [NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NR1H4 protein promotes the reaction [dihydroartemisinin inhibits the reaction [Ethanol results in increased activity of GPT protein]] CTD PMID:27939985 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO dihydroartemisinin results in increased expression of HMOX1 mRNA CTD PMID:21547369 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 affects binding ISO dihydroartemisinin analog binds to HNRNPA2B1 protein CTD PMID:26340163 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects binding ISO dihydroartemisinin analog binds to HNRNPD protein CTD PMID:26340163 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K affects binding ISO dihydroartemisinin analog binds to HNRNPK protein CTD PMID:26340163 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 affects binding ISO dihydroartemisinin analog binds to HP1BP3 protein CTD PMID:26340163 NCBI chr 5:156,581,732...156,609,059
Ensembl chr 5:156,581,732...156,609,059
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects binding ISO dihydroartemisinin analog binds to HSPA8 protein CTD PMID:26340163 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects binding ISO dihydroartemisinin analog binds to IQGAP1 protein modified form CTD PMID:26340163 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of and results in increased phosphorylation of JUN protein] CTD PMID:20152819 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects binding ISO dihydroartemisinin analog binds to KEAP1 protein CTD PMID:26340163 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Khsrp KH-type splicing regulatory protein affects binding ISO dihydroartemisinin analog binds to KHSRP protein CTD PMID:26340163 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
JBrowse link
G Ldha lactate dehydrogenase A affects binding ISO dihydroartemisinin analog binds to LDHA protein CTD PMID:26340163 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B affects binding ISO dihydroartemisinin analog binds to LDHB protein modified form CTD PMID:26340163 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Lgals1 galectin 1 affects binding ISO dihydroartemisinin analog binds to LGALS1 protein CTD PMID:26340163 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Map4 microtubule-associated protein 4 affects binding ISO dihydroartemisinin analog binds to MAP4 protein modified form CTD PMID:26340163 NCBI chr 8:118,013,584...118,159,934
Ensembl chr 8:118,013,612...118,159,933
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK1 protein] CTD PMID:20152819, PMID:31976328 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:20152819, PMID:31976328 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdh1 malate dehydrogenase 1 affects binding ISO dihydroartemisinin analog binds to MDH1 protein CTD PMID:26340163 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]; dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 protein] CTD PMID:20152819 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA] CTD PMID:20152819 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein] CTD PMID:20152819 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO dihydroartemisinin results in decreased expression of MYC protein CTD PMID:26036281 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO dihydroartemisinin analog affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of NF-kB protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver]
CTD PMID:20152819, PMID:27939985 RGD:15036816 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Npepps aminopeptidase puromycin sensitive affects binding ISO dihydroartemisinin analog binds to NPEPPS protein modified form CTD PMID:26340163 NCBI chr10:85,140,368...85,222,861
Ensembl chr10:85,140,370...85,222,861
JBrowse link
G Npm1 nucleophosmin 1 affects binding ISO dihydroartemisinin analog binds to NPM1 protein CTD PMID:26340163 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine] RGD PMID:27939985 RGD:15036816 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
ISO
EXP
[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN protein]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; dihydroartemisinin inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; dihydroartemisinin inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; dihydroartemisinin promotes the reaction [NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NR1H4 protein promotes the reaction [dihydroartemisinin inhibits the reaction [Ethanol results in increased activity of GPT protein]]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]
dihydroartemisinin results in increased expression of NR1H4 protein
CTD PMID:27939985, PMID:27939985 RGD:15036816 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pfn1 profilin 1 affects binding ISO dihydroartemisinin analog binds to PFN1 protein CTD PMID:26340163 NCBI chr10:57,273,003...57,275,708
Ensembl chr10:57,273,005...57,275,708
JBrowse link
G Pgk1 phosphoglycerate kinase 1 affects binding ISO dihydroartemisinin analog binds to PGK1 protein CTD PMID:26340163 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pkm pyruvate kinase M1/2 affects binding ISO dihydroartemisinin analog binds to PKM protein CTD PMID:26340163 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO dihydroartemisinin results in increased expression of PMAIP1 mRNA; dihydroartemisinin results in increased expression of PMAIP1 protein CTD PMID:21547369 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP
[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; dihydroartemisinin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; dihydroartemisinin inhibits the reaction [Ethanol results in decreased expression of PPARA protein]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]
CTD PMID:27939985, PMID:27939985 RGD:15036816 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppia peptidylprolyl isomerase A affects binding ISO dihydroartemisinin analog binds to PPIA protein CTD PMID:26340163 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Prdx1 peroxiredoxin 1 affects binding ISO dihydroartemisinin analog binds to PRDX1 protein CTD PMID:26340163 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein] CTD PMID:20152819 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of and results in increased phosphorylation of RELA protein]; dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of RELA protein] CTD PMID:20152819, PMID:31976328 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpl10 ribosomal protein L10 affects binding ISO dihydroartemisinin analog binds to RPL10 protein CTD PMID:26340163 NCBI chr  X:156,438,251...156,440,461
Ensembl chr  X:156,438,251...156,440,461
JBrowse link
G Rpl14 ribosomal protein L14 affects binding ISO dihydroartemisinin analog binds to RPL14 protein modified form CTD PMID:26340163 NCBI chr 8:129,240,528...129,243,400
Ensembl chr 8:129,240,528...129,243,402
JBrowse link
G Rpl18 ribosomal protein L18 affects binding ISO dihydroartemisinin analog binds to RPL18 protein CTD PMID:26340163 NCBI chr 1:101,700,910...101,703,551
Ensembl chr 1:101,701,975...101,703,550
JBrowse link
G Rpl23a ribosomal protein L23a affects binding ISO dihydroartemisinin analog binds to RPL23A protein CTD PMID:26340163 NCBI chr10:65,441,295...65,443,981
Ensembl chr10:65,441,295...65,443,981
JBrowse link
G Rpl35 ribosomal protein L35 affects binding ISO dihydroartemisinin analog binds to RPL35 protein CTD PMID:26340163 NCBI chr 3:23,294,813...23,297,774
Ensembl chr 3:23,294,814...23,297,774
JBrowse link
G Rpl4 ribosomal protein L4 affects binding ISO dihydroartemisinin analog binds to RPL4 protein CTD PMID:26340163 NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805
JBrowse link
G Rps13 ribosomal protein S13 affects binding ISO dihydroartemisinin analog binds to RPS13 protein CTD PMID:26340163 NCBI chr 1:185,328,902...185,331,332
Ensembl chr 3:4,341,249...4,341,771
JBrowse link
G Rps17 ribosomal protein S17 affects binding ISO dihydroartemisinin analog binds to RPS17 protein CTD PMID:26340163 NCBI chr 1:143,167,329...143,169,915
Ensembl chr 1:143,167,362...143,169,657
JBrowse link
G Rps18 ribosomal protein S18 affects binding ISO dihydroartemisinin analog binds to RPS18 protein CTD PMID:26340163 NCBI chr20:5,441,875...5,445,553
Ensembl chr20:5,441,876...5,445,553
JBrowse link
G Rps19 ribosomal protein S19 affects binding ISO dihydroartemisinin analog binds to RPS19 protein CTD PMID:26340163 NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627
JBrowse link
G Rps28 ribosomal protein S28 affects binding ISO dihydroartemisinin analog binds to RPS28 protein CTD PMID:26340163 NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440
JBrowse link
G Rps5 ribosomal protein S5 affects binding ISO dihydroartemisinin analog binds to RPS5 protein modified form CTD PMID:26340163 NCBI chr 1:65,660,470...65,664,767
Ensembl chr 1:65,660,470...65,664,767
JBrowse link
G Rps6 ribosomal protein S6 affects binding ISO dihydroartemisinin analog binds to RPS6 protein CTD PMID:26340163 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps8 ribosomal protein S8 affects binding ISO dihydroartemisinin analog binds to RPS8 protein CTD PMID:26340163 NCBI chr 5:136,020,941...136,023,511
Ensembl chr 5:136,020,941...136,023,511
JBrowse link
G Rps9 ribosomal protein S9 affects binding ISO dihydroartemisinin analog binds to RPS9 protein CTD PMID:26340163 NCBI chr 1:64,086,625...64,090,023
Ensembl chr 1:64,018,125...64,090,021
JBrowse link
G Sf1 splicing factor 1 affects binding ISO dihydroartemisinin analog binds to SF1 protein CTD PMID:26340163 NCBI chr 1:221,735,512...221,749,216
Ensembl chr 1:221,735,517...221,749,086
JBrowse link
G Sfpq splicing factor proline and glutamine rich affects binding ISO dihydroartemisinin analog binds to SFPQ protein CTD PMID:26340163 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide affects binding ISO dihydroartemisinin analog binds to SNRPD2 protein CTD PMID:26340163 NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO dihydroartemisinin results in increased expression of SOD1 protein CTD PMID:20361947 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO dihydroartemisinin results in increased expression of SOD2 protein CTD PMID:20361947 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
[dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]
Dihydroartemisinin inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]
CTD PMID:27939985, PMID:27939985 RGD:15036816 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srp14 signal recognition particle 14 affects binding ISO dihydroartemisinin analog binds to SRP14 protein CTD PMID:26340163 NCBI chr 3:110,245,936...110,249,627
Ensembl chr 3:110,245,936...110,249,627
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 affects binding ISO dihydroartemisinin analog binds to SRSF4 protein CTD PMID:26340163 NCBI chr 5:150,032,999...150,060,769
Ensembl chr 5:150,032,999...150,060,765
JBrowse link
G Tagln transgelin affects binding ISO dihydroartemisinin analog binds to TAGLN protein CTD PMID:26340163 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tagln2 transgelin 2 affects binding ISO dihydroartemisinin analog binds to TAGLN2 protein CTD PMID:26340163 NCBI chr13:90,807,196...90,814,119
Ensembl chr13:90,807,199...90,814,119
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Tnf protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions
ISO dihydroartemisinin results in increased phosphorylation of TP53 protein
dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased export of Doxorubicin]; dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK1 protein]; dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK3 protein]; dihydroartemisinin inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of RELA protein]
CTD PMID:21547369, PMID:31976328 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects binding ISO dihydroartemisinin analog binds to TPI1 protein CTD PMID:26340163 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Tpm1 tropomyosin 1 affects binding ISO dihydroartemisinin analog binds to TPM1 protein CTD PMID:26340163 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228
JBrowse link
G Tuba1a tubulin, alpha 1A affects binding ISO dihydroartemisinin analog binds to TUBA1A protein CTD PMID:26340163 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Vim vimentin affects binding ISO dihydroartemisinin analog binds to VIM protein modified form CTD PMID:26340163 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Zyx zyxin affects binding ISO dihydroartemisinin analog binds to ZYX protein CTD PMID:26340163 NCBI chr 4:71,740,188...71,749,386
Ensembl chr 4:71,740,532...71,749,386
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antimicrobial drug 6206
            antiprotozoal drug 3817
              antiplasmodial drug 2614
                antimalarial 2584
                  dihydroartemisinin 107
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  terpene 9594
                                    sesquiterpene 2692
                                      sesquiterpenoid 2692
                                        dihydroartemisinin 107
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.