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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydroartemisinin
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Accession:CHEBI:207229 term browser browse the term
Definition:A sesquiterpenoid compound which is used as a drug for treatment of malaria.
Synonyms:exact_synonym: (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-ol
 related_synonym: 1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol(Dihydroartemisinin);   Formula=C15H24O5;   InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1;   InChIKey=BJDCWCLMFKKGEE-HVDUHBCDSA-N;   SMILES=[H][C@@]12CC[C@@]3(C)OO[C@]11[C@]([H])(OC(O)[C@H](C)[C@]1([H])CC[C@H]2C)O3
 xref: Beilstein:4185848
 xref_mesh: MESH:C039060
 xref: PMID:10893313;   PMID:3669021



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dihydroartemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Actg1 actin, gamma 1 affects binding ISO artenimol analog binds to ACTG1 protein CTD PMID:26340163 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Aim2 absent in melanoma 2 multiple interactions
affects response to substance
increases expression
ISO AIM2 protein affects the reaction [artenimol results in increased expression of DFNA5 protein alternative form]; AIM2 protein affects the reaction [artenimol results in increased expression of DFNA5 protein]; AIM2 protein affects the reaction [artenimol results in increased expression of HMGB1 protein]; AIM2 protein affects the reaction [artenimol results in increased secretion of IL18 protein]; AIM2 protein affects the reaction [artenimol results in increased secretion of IL1B protein]
AIM2 protein affects the susceptibility to artenimol
artenimol results in increased expression of AIM2 mRNA; artenimol results in increased expression of AIM2 protein
CTD PMID:33689708 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
JBrowse link
G Alb albumin affects binding ISO artenimol analog binds to ALB protein CTD PMID:26340163 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 affects binding ISO artenimol analog binds to ALDH7A1 protein CTD PMID:26340163 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Anxa2 annexin A2 affects binding ISO artenimol analog binds to ANXA2 protein CTD PMID:26340163 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects binding ISO artenimol analog binds to ATP5F1A protein CTD PMID:26340163 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5mg ATP synthase membrane subunit g affects binding ISO artenimol analog binds to ATP5MG protein CTD PMID:26340163 NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP affects binding ISO artenimol analog binds to ATP5PO protein CTD PMID:26340163 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
multiple interactions
ISO artenimol results in increased cleavage of CASP3 protein
artenimol results in increased expression of CASP3 mRNA
artenimol results in increased expression of and results in increased cleavage of CASP3 protein
CTD PMID:21547369 PMID:33689708 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cast calpastatin affects binding ISO artenimol analog binds to CAST protein modified form CTD PMID:26340163 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cat catalase increases expression ISO artenimol results in increased expression of CAT protein CTD PMID:20361947 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 affects binding ISO artenimol analog binds to CCT3 protein modified form CTD PMID:26340163 NCBI chr 2:173,765,792...173,790,353
Ensembl chr 2:173,765,698...173,790,757
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO artenimol results in increased expression of CDKN1A mRNA CTD PMID:21547369 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cfl1 cofilin 1 affects binding ISO artenimol analog binds to CFL1 protein CTD PMID:26340163 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Clic1 chloride intracellular channel 1 affects binding ISO artenimol analog binds to CLIC1 protein modified form CTD PMID:26340163 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP
[artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; artenimol inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; artenimol inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]
CTD
RGD
PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 affects binding ISO artenimol analog binds to CSRP1 protein CTD PMID:26340163 NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO artenimol results in decreased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO artenimol results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO artenimol results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO artenimol results in increased expression of DDIT3 mRNA CTD PMID:21547369 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects binding ISO artenimol analog binds to DPYSL2 protein modified form CTD PMID:26340163 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Dsp desmoplakin affects binding ISO artenimol analog binds to DSP protein CTD PMID:26340163 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects binding ISO artenimol analog binds to EEF1A1 protein modified form CTD PMID:26340163 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Egr1 early growth response 1 increases expression ISO artenimol results in increased expression of EGR1 mRNA CTD PMID:21547369 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eno1 enolase 1 affects binding ISO artenimol analog binds to ENO1 protein CTD PMID:26340163 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN protein]; artenimol inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; artenimol inhibits the reaction [Ethanol results in increased expression of FASN protein] CTD PMID:27939985 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine] RGD PMID:27939985 RGD:15036816 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Flna filamin A affects binding ISO artenimol analog binds to FLNA protein CTD PMID:26340163 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase affects binding ISO artenimol analog binds to FTO protein CTD PMID:26340163 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects binding ISO artenimol analog binds to G6PD protein CTD PMID:26340163 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO artenimol results in increased expression of GADD45A mRNA CTD PMID:21547369 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects binding ISO artenimol analog binds to GAPDH protein CTD PMID:26340163 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gpi glucose-6-phosphate isomerase affects binding ISO artenimol analog binds to GPI protein CTD PMID:26340163 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO artenimol inhibits the reaction [Ethanol results in increased activity of GPT protein]; artenimol promotes the reaction [NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NR1H4 protein promotes the reaction [artenimol inhibits the reaction [Ethanol results in increased activity of GPT protein]] CTD PMID:27939985 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsdme gasdermin E affects response to substance
increases expression
multiple interactions
ISO DFNA5 protein affects the susceptibility to artenimol
artenimol results in increased expression of DFNA5 mRNA; artenimol results in increased expression of DFNA5 protein; artenimol results in increased expression of DFNA5 protein alternative form
AIM2 protein affects the reaction [artenimol results in increased expression of DFNA5 protein alternative form]; AIM2 protein affects the reaction [artenimol results in increased expression of DFNA5 protein]; DFNA5 protein affects the reaction [artenimol results in increased expression of HMGB1 protein]; DFNA5 protein affects the reaction [artenimol results in increased secretion of IL18 protein]; DFNA5 protein affects the reaction [artenimol results in increased secretion of IL1B protein]
CTD PMID:33689708 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
JBrowse link
G Gypa glycophorin A affects expression ISO artenimol affects the expression of GYPA protein CTD PMID:20688127 NCBI chr19:27,450,311...27,465,940 JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions
ISO artenimol results in increased expression of HMGB1 mRNA; artenimol results in increased expression of HMGB1 protein
AIM2 protein affects the reaction [artenimol results in increased expression of HMGB1 protein]; DFNA5 protein affects the reaction [artenimol results in increased expression of HMGB1 protein]
CTD PMID:33689708 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO artenimol results in increased expression of HMOX1 mRNA CTD PMID:21547369 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 affects binding ISO artenimol analog binds to HNRNPA2B1 protein CTD PMID:26340163 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects binding ISO artenimol analog binds to HNRNPD protein CTD PMID:26340163 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K affects binding ISO artenimol analog binds to HNRNPK protein CTD PMID:26340163 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 affects binding ISO artenimol analog binds to HP1BP3 protein CTD PMID:26340163 NCBI chr 5:150,435,781...150,463,004
Ensembl chr 5:150,433,740...150,463,000
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects binding ISO artenimol analog binds to HSPA8 protein CTD PMID:26340163 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
increases secretion
ISO AIM2 protein affects the reaction [artenimol results in increased secretion of IL18 protein]; DFNA5 protein affects the reaction [artenimol results in increased secretion of IL18 protein]
artenimol results in increased expression of IL18 mRNA; artenimol results in increased expression of IL18 protein
CTD PMID:33689708 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression
ISO artenimol results in increased secretion of IL1B protein
AIM2 protein affects the reaction [artenimol results in increased secretion of IL1B protein]; DFNA5 protein affects the reaction [artenimol results in increased secretion of IL1B protein]
artenimol results in increased expression of IL1B mRNA; artenimol results in increased expression of IL1B protein
CTD PMID:33689708 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects binding ISO artenimol analog binds to IQGAP1 protein modified form CTD PMID:26340163 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of and results in increased phosphorylation of JUN protein] CTD PMID:20152819 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects binding ISO artenimol analog binds to KEAP1 protein CTD PMID:26340163 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Khsrp KH-type splicing regulatory protein affects binding ISO artenimol analog binds to KHSRP protein CTD PMID:26340163 NCBI chr 9:1,862,555...1,872,301
Ensembl chr 9:1,862,899...1,872,451
JBrowse link
G Ldha lactate dehydrogenase A affects binding ISO artenimol analog binds to LDHA protein CTD PMID:26340163 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldhb lactate dehydrogenase B affects binding ISO artenimol analog binds to LDHB protein modified form CTD PMID:26340163 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Lgals1 galectin 1 affects binding ISO artenimol analog binds to LGALS1 protein CTD PMID:26340163 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Map4 microtubule-associated protein 4 affects binding ISO artenimol analog binds to MAP4 protein modified form CTD PMID:26340163 NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; artenimol inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK1 protein] CTD PMID:20152819 PMID:31976328 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; artenimol inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:20152819 PMID:31976328 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdh1 malate dehydrogenase 1 affects binding ISO artenimol analog binds to MDH1 protein CTD PMID:26340163 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 protein] CTD PMID:20152819 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA] CTD PMID:20152819 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein] CTD PMID:20152819 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO artenimol results in decreased expression of MYC protein CTD PMID:26036281 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO artenimol analog affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of NF-kB protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver]
CTD
RGD
PMID:20152819 PMID:27939985 RGD:15036816 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Npepps aminopeptidase puromycin sensitive affects binding ISO artenimol analog binds to NPEPPS protein modified form CTD PMID:26340163 NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
JBrowse link
G Npm1 nucleophosmin 1 affects binding ISO artenimol analog binds to NPM1 protein CTD PMID:26340163 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine] RGD PMID:27939985 RGD:15036816 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
ISO
EXP
[artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; artenimol inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; artenimol inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; artenimol promotes the reaction [NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NR1H4 protein promotes the reaction [artenimol inhibits the reaction [Ethanol results in increased activity of GPT protein]]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]
artenimol results in increased expression of NR1H4 protein
CTD
RGD
PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Pfn1 profilin 1 affects binding ISO artenimol analog binds to PFN1 protein CTD PMID:26340163 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pgk1 phosphoglycerate kinase 1 affects binding ISO artenimol analog binds to PGK1 protein CTD PMID:26340163 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Pkm pyruvate kinase M1/2 affects binding ISO artenimol analog binds to PKM protein CTD PMID:26340163 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO artenimol results in increased expression of PMAIP1 mRNA; artenimol results in increased expression of PMAIP1 protein CTD PMID:21547369 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP
[artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; artenimol inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; artenimol inhibits the reaction [Ethanol results in decreased expression of PPARA protein]
Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]
CTD
RGD
PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppia peptidylprolyl isomerase A affects binding ISO artenimol analog binds to PPIA protein CTD PMID:26340163 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Prdx1 peroxiredoxin 1 affects binding ISO artenimol analog binds to PRDX1 protein CTD PMID:26340163 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein] CTD PMID:20152819 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO artenimol inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of and results in increased phosphorylation of RELA protein]; artenimol inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of RELA protein] CTD PMID:20152819 PMID:31976328 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rpl10 ribosomal protein L10 affects binding ISO artenimol analog binds to RPL10 protein CTD PMID:26340163 NCBI chr  X:152,054,547...152,056,757
Ensembl chr  X:152,054,452...152,056,761
JBrowse link
G Rpl14 ribosomal protein L14 affects binding ISO artenimol analog binds to RPL14 protein modified form CTD PMID:26340163 NCBI chr 8:120,286,035...120,288,912
Ensembl chr 8:120,284,645...120,289,064
JBrowse link
G Rpl18 ribosomal protein L18 affects binding ISO artenimol analog binds to RPL18 protein CTD PMID:26340163 NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452
JBrowse link
G Rpl23a ribosomal protein L23a affects binding ISO artenimol analog binds to RPL23A protein CTD PMID:26340163 NCBI chr10:63,076,660...63,079,346
Ensembl chr10:63,076,066...63,079,346
JBrowse link
G Rpl35 ribosomal protein L35 affects binding ISO artenimol analog binds to RPL35 protein CTD PMID:26340163 NCBI chr 3:22,753,255...22,756,217
Ensembl chr 3:22,753,253...22,756,243
JBrowse link
G Rpl4 ribosomal protein L4 affects binding ISO artenimol analog binds to RPL4 protein CTD PMID:26340163 NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306
JBrowse link
G Rps13 ribosomal protein S13 affects binding ISO artenimol analog binds to RPS13 protein CTD PMID:26340163 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
JBrowse link
G Rps17 ribosomal protein S17 affects binding ISO artenimol analog binds to RPS17 protein CTD PMID:26340163 NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:135,295,919...135,298,535
JBrowse link
G Rps18 ribosomal protein S18 affects binding ISO artenimol analog binds to RPS18 protein CTD PMID:26340163 NCBI chr20:4,931,427...4,935,538 JBrowse link
G Rps19 ribosomal protein S19 affects binding ISO artenimol analog binds to RPS19 protein CTD PMID:26340163 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
JBrowse link
G Rps28 ribosomal protein S28 affects binding ISO artenimol analog binds to RPS28 protein CTD PMID:26340163 NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170
JBrowse link
G Rps5 ribosomal protein S5 affects binding ISO artenimol analog binds to RPS5 protein modified form CTD PMID:26340163 NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073
JBrowse link
G Rps6 ribosomal protein S6 affects binding ISO artenimol analog binds to RPS6 protein CTD PMID:26340163 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps8 ribosomal protein S8 affects binding ISO artenimol analog binds to RPS8 protein CTD PMID:26340163 NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268
JBrowse link
G Rps9 ribosomal protein S9 affects binding ISO artenimol analog binds to RPS9 protein CTD PMID:26340163
G Sf1 splicing factor 1 affects binding ISO artenimol analog binds to SF1 protein CTD PMID:26340163 NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330
JBrowse link
G Sfpq splicing factor proline and glutamine rich affects binding ISO artenimol analog binds to SFPQ protein CTD PMID:26340163 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide affects binding ISO artenimol analog binds to SNRPD2 protein CTD PMID:26340163 NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO artenimol results in increased expression of SOD1 protein CTD PMID:20361947 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO artenimol results in increased expression of SOD2 protein CTD PMID:20361947 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
[artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; artenimol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; artenimol inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]
Dihydroartemisinin inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]
CTD
RGD
PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srp14 signal recognition particle 14 affects binding ISO artenimol analog binds to SRP14 protein CTD PMID:26340163 NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 affects binding ISO artenimol analog binds to SRSF4 protein CTD PMID:26340163 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229
JBrowse link
G Tagln transgelin affects binding ISO artenimol analog binds to TAGLN protein CTD PMID:26340163 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tagln2 transgelin 2 affects binding ISO artenimol analog binds to TAGLN2 protein CTD PMID:26340163 NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dihydroartemisinin inhibits the reaction [ethanol increases expression of Tnf protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions
ISO artenimol results in increased phosphorylation of TP53 protein
artenimol inhibits the reaction [TP53 protein mutant form results in increased export of Doxorubicin]; artenimol inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK1 protein]; artenimol inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of MAPK3 protein]; artenimol inhibits the reaction [TP53 protein mutant form results in increased phosphorylation of RELA protein]
CTD PMID:21547369 PMID:31976328 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects binding ISO artenimol analog binds to TPI1 protein CTD PMID:26340163 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpm1 tropomyosin 1 affects binding ISO artenimol analog binds to TPM1 protein CTD PMID:26340163 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
G Tuba1a tubulin, alpha 1A affects binding ISO artenimol analog binds to TUBA1A protein CTD PMID:26340163 NCBI chr 7:130,113,214...130,116,880 JBrowse link
G Vim vimentin affects binding ISO artenimol analog binds to VIM protein modified form CTD PMID:26340163 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zyx zyxin affects binding ISO artenimol analog binds to ZYX protein CTD PMID:26340163 NCBI chr 4:71,236,767...71,246,553
Ensembl chr 4:71,237,451...71,246,553
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        antimicrobial agent 17469
          antimicrobial drug 8725
            antiprotozoal drug 7019
              antiplasmodial drug 2656
                antimalarial 2626
                  dihydroartemisinin 114
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            organic hydride 18346
                              organic fundamental parent 18346
                                hydrocarbon 18057
                                  terpene 12723
                                    sesquiterpene 2768
                                      sesquiterpenoid 2768
                                        dihydroartemisinin 114
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