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ONTOLOGY REPORT - ANNOTATIONS


Term:dihydroartemisinin
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Accession:CHEBI:207229 term browser browse the term
Definition:A sesquiterpenoid compound which is used as a drug for treatment of malaria.
Synonyms:exact_synonym: (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-ol
 related_synonym: 1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol(Dihydroartemisinin);   Formula=C15H24O5;   InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1;   InChIKey=BJDCWCLMFKKGEE-HVDUHBCDSA-N;   SMILES=[H][C@@]12CC[C@@]3(C)OO[C@]11[C@]([H])(OC(O)[C@H](C)[C@]1([H])CC[C@H]2C)O3
 xref: Beilstein:4185848 "Beilstein"
 xref_mesh: MESH:C039060
 xref: PMID:10893313 "ChEMBL";   PMID:3669021 "ChEMBL"


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dihydroartemisinin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actg1 actin, gamma 1 JBrowse link 10 109,518,429 109,521,288 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 JBrowse link 18 51,619,007 51,651,267 RGD:6480464
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:6480464
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6480464
G Atp5mg ATP synthase membrane subunit g JBrowse link 8 49,220,441 49,227,273 RGD:6480464
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cct3 chaperonin containing TCP1 subunit 3 JBrowse link 2 187,669,051 187,693,610 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:6480464
G Clic1 chloride intracellular channel 1 JBrowse link 20 5,040,314 5,049,166 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Csrp1 cysteine and glycine-rich protein 1 JBrowse link 13 52,553,843 52,575,054 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Dpysl2 dihydropyrimidinase-like 2 JBrowse link 15 43,475,640 43,581,725 RGD:6480464
G Dsp desmoplakin JBrowse link 17 27,286,811 27,334,453 RGD:6480464
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 JBrowse link 8 85,838,594 85,841,816 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:6480464
G Fto FTO, alpha-ketoglutarate dependent dioxygenase JBrowse link 19 16,774,549 17,115,098 RGD:6480464
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:6480464
G Gpi glucose-6-phosphate isomerase JBrowse link 1 90,063,411 90,091,287 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:6480464
G Hnrnpd heterogeneous nuclear ribonucleoprotein D JBrowse link 14 11,256,163 11,274,684 RGD:6480464
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:6480464
G Hp1bp3 heterochromatin protein 1, binding protein 3 JBrowse link 5 156,581,732 156,609,059 RGD:6480464
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6480464
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Khsrp KH-type splicing regulatory protein JBrowse link 9 10,013,795 10,023,670 RGD:6480464
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6480464
G Ldhb lactate dehydrogenase B JBrowse link 4 176,701,980 176,719,999 RGD:6480464
G Lgals1 galectin 1 JBrowse link 7 120,153,184 120,156,290 RGD:6480464
G Map4 microtubule-associated protein 4 JBrowse link 8 118,013,584 118,159,934 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mdh1 malate dehydrogenase 1 JBrowse link 14 106,378,349 106,393,642 RGD:6480464
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Npepps aminopeptidase puromycin sensitive JBrowse link 10 85,140,368 85,222,861 RGD:6480464
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:6480464
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6480464
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppia peptidylprolyl isomerase A JBrowse link 14 86,673,775 86,677,443 RGD:6480464
G Prdx1 peroxiredoxin 1 JBrowse link 5 135,536,413 135,551,986 RGD:6480464
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rpl10 ribosomal protein L10 JBrowse link X 156,438,251 156,440,461 RGD:6480464
G Rpl14 ribosomal protein L14 JBrowse link 8 129,240,528 129,243,400 RGD:6480464
G Rpl18 ribosomal protein L18 JBrowse link 1 101,700,910 101,703,551 RGD:6480464
G Rpl23a ribosomal protein L23a JBrowse link 10 65,441,295 65,443,981 RGD:6480464
G Rpl35 ribosomal protein L35 JBrowse link 3 23,294,813 23,297,774 RGD:6480464
G Rpl4 ribosomal protein L4 JBrowse link 8 69,121,682 69,126,805 RGD:6480464
G Rps13 ribosomal protein S13 JBrowse link 1 185,328,902 185,331,332 RGD:6480464
G Rps17 ribosomal protein S17 JBrowse link 1 143,167,329 143,169,915 RGD:6480464
G Rps18 ribosomal protein S18 JBrowse link 20 5,441,875 5,445,553 RGD:6480464
G Rps19 ribosomal protein S19 JBrowse link 1 81,750,873 81,756,629 RGD:6480464
G Rps28 ribosomal protein S28 JBrowse link 7 18,682,071 18,683,440 RGD:6480464
G Rps5 ribosomal protein S5 JBrowse link 1 65,660,470 65,664,767 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Rps8 ribosomal protein S8 JBrowse link 5 136,020,941 136,023,511 RGD:6480464
G Rps9 ribosomal protein S9 JBrowse link 1 64,086,625 64,090,023 RGD:6480464
G Sf1 splicing factor 1 JBrowse link 1 221,735,512 221,749,216 RGD:6480464
G Sfpq splicing factor proline and glutamine rich JBrowse link 5 145,079,803 145,088,517 RGD:6480464
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide JBrowse link 1 80,057,140 80,059,990 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Srp14 signal recognition particle 14 JBrowse link 3 110,245,936 110,249,627 RGD:6480464
G Srsf4 serine and arginine rich splicing factor 4 JBrowse link 5 150,032,999 150,060,769 RGD:6480464
G Tagln transgelin JBrowse link 8 50,222,895 50,228,369 RGD:6480464
G Tagln2 transgelin 2 JBrowse link 13 90,807,196 90,814,119 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpi1 triosephosphate isomerase 1 JBrowse link 4 157,328,375 157,331,905 RGD:6480464
G Tpm1 tropomyosin 1 JBrowse link 8 72,814,737 72,841,496 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Zyx zyxin JBrowse link 4 71,740,188 71,749,386 RGD:6480464

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  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          antimicrobial drug 6008
            antiprotozoal drug 3670
              antiplasmodial drug 2486
                antimalarial 2448
                  dihydroartemisinin 98
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  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  terpene 9228
                                    sesquiterpene 2364
                                      sesquiterpenoid 2364
                                        dihydroartemisinin 98
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.