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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6-O-methylguanine
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Accession:CHEBI:20689 term browser browse the term
Definition:A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
Synonyms:exact_synonym: 6-methoxy-7H-purin-2-amine
 related_synonym: 2-Amino-6-methoxypurine;   6-Methoxy-1H-purine-2-amine;   6-Methoxyguanine;   Formula=C6H7N5O;   InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11);   InChIKey=BXJHWYVXLGLDMZ-UHFFFAOYSA-N;   SMILES=COc1nc(N)nc2nc[nH]c12
 xref: CAS:20535-83-5
 xref_mesh: MESH:C008449
 xref: PMID:1474583;   PMID:15239064;   PMID:22185597;   PMID:2271591;   Reaxys:5334996;   Wikipedia:6-O-Methylguanine


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6-O-methylguanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of APAF1 mRNA CTD PMID:29666243 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BBC3 mRNA CTD PMID:29666243 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BID mRNA CTD PMID:29666243 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BTG2 mRNA CTD PMID:29666243 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNA2 protein CTD PMID:29666243 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNB1 protein CTD PMID:29666243 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A mRNA; [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A protein CTD PMID:29666243 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Plk2 polo-like kinase 2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PLK2 mRNA CTD PMID:29666243 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PMAIP1 mRNA CTD PMID:29666243 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of RB1 protein modified form CTD PMID:29666243 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Sfn stratifin multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of SFN mRNA CTD PMID:29666243 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [O(6)-benzylguanine results in increased susceptibility to O-(6)-methylguanine] which results in increased expression of TP53 mRNA mutant form CTD PMID:29666243 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wrn WRN RecQ like helicase decreases response to substance ISO WRN protein results in decreased susceptibility to O-(6)-methylguanine CTD PMID:29616805 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375
JBrowse link

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  CHEBI ontology 19770
    role 19720
      biological role 19720
        aetiopathogenetic role 18973
          genotoxin 17324
            mutagen 17202
              6-O-methylguanine 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterobicyclic compound 16778
                                      imidazopyrimidine 5583
                                        purines 5581
                                          aminopurine 4416
                                            2-aminopurines 4027
                                              guanine 3991
                                                methylguanine 16
                                                  6-O-methylguanine 13
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