6-O-methylguanine - Ontology Report - Rat Genome Database

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	6-O-methylguanine	go back to main search page
Accession:	CHEBI:20689	browse the term
Definition:	A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
Synonyms:	exact_synonym:	6-methoxy-7H-purin-2-amine
	related_synonym:	2-Amino-6-methoxypurine; 6-Methoxy-1H-purine-2-amine; 6-Methoxyguanine; Formula=C6H7N5O; InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11); InChIKey=BXJHWYVXLGLDMZ-UHFFFAOYSA-N; SMILES=COc1nc(N)nc2nc[nH]c12
	xref:	CAS:20535-83-5
	xref_mesh:	MESH:C008449
	xref:	PMID:1474583; PMID:15239064; PMID:22185597; PMID:2271591; Reaxys:5334996; Wikipedia:6-O-Methylguanine

show annotations for term's descendants Sort by:

Rat (13) Mouse (13) Human (13) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) All
Genes (13)

6-O-methylguanine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptotic peptidase activating factor 1

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of APAF1 mRNA

NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192

G

Bcl-2 binding component 3

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BBC3 mRNA

NCBI chr 1:78,261,491...78,267,802

G

BH3 interacting domain death agonist

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BID mRNA

NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203

G

BTG anti-proliferation factor 2

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BTG2 mRNA

NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982

G

cyclin A2

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNA2 protein

NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214

G

cyclin B1

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNB1 protein

NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A mRNA; [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A protein

NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864

G

polo-like kinase 2

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PLK2 mRNA

NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PMAIP1 mRNA

NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102

G

RB transcriptional corepressor 1

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of RB1 protein modified form

NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342

G

stratifin

multiple interactions

[O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of SFN mRNA

NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633

G

tumor protein p53

multiple interactions

[O(6)-benzylguanine results in increased susceptibility to O-(6)-methylguanine] which results in increased expression of TP53 mRNA mutant form

NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449

G

WRN RecQ like helicase

decreases response to substance

WRN protein results in decreased susceptibility to O-(6)-methylguanine

NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19770
role	19720
biological role	19720
aetiopathogenetic role	18973
genotoxin	17324
mutagen	17202
6-O-methylguanine	13
Path 2
Term	Annotations
CHEBI ontology	19770
subatomic particle	19768
composite particle	19768
hadron	19768
baryon	19768
nucleon	19768
atomic nucleus	19768
atom	19768
main group element atom	19662
p-block element atom	19662
carbon group element atom	19580
carbon atom	19571
organic molecular entity	19571
organic molecule	19504
organic cyclic compound	19331
organic heterocyclic compound	18519
organic heteropolycyclic compound	17978
organic heterobicyclic compound	16778
imidazopyrimidine	5583
purines	5581
aminopurine	4416
2-aminopurines	4027
guanine	3991
methylguanine	16
6-O-methylguanine	13

paths to the root