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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5alpha-pregnane
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Accession:CHEBI:20656 term browser browse the term
Definition:A pregnane that has formula C21H36.
Synonyms:related_synonym: Formula=C21H36;   InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3/t15-,16+,17-,18-,19-,20-,21+/m0/s1;   InChIKey=JWMFYGXQPXQEEM-GCOKGBOCSA-N;   SMILES=[H][C@]1(CC)CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CCCC[C@]4(C)[C@@]3([H])CC[C@]12C;   allopregnane
 xref: Beilstein:2502007;   CAS:641-85-0



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5alpha-pregnane-3,20-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 affects reduction
increases reduction
ISO AKR1C1 protein affects the reduction of 5-alpha-Dihydroprogesterone
AKR1C1 protein results in increased reduction of 5-alpha-Dihydroprogesterone
CTD PMID:11995921 PMID:12604236 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 affects reduction
increases reduction
ISO AKR1C2 protein affects the reduction of 5-alpha-Dihydroprogesterone
AKR1C2 protein results in increased reduction of 5-alpha-Dihydroprogesterone
CTD PMID:11995921 PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone CTD PMID:25463305 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases chemical synthesis
multiple interactions
ISO AKR1D1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
[AKR1D1 protein alternative form results in increased reduction of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
AKR1D1 protein alternative form results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
CTD PMID:18624455 PMID:30928400 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO 3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA] CTD PMID:19931389 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases hydroxylation ISO CYP17A1 protein results in increased hydroxylation of 5-alpha-Dihydroprogesterone CTD PMID:14522586 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Egr2 early growth response 2 increases expression EXP 5-alpha-Dihydroprogesterone results in increased expression of EGR2 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of EGR2 protein CTD PMID:17478888 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO 5-alpha-Dihydroprogesterone results in increased expression of ESR1 mRNA CTD PMID:17683929 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP 5-alpha-Dihydroprogesterone results in decreased expression of GSK3B protein CTD PMID:17443805 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
increases phosphorylation
EXP 5-alpha-Dihydroprogesterone results in decreased expression of MAPT protein
5-alpha-Dihydroprogesterone results in increased phosphorylation of MAPT protein
CTD PMID:17443805 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects activity
multiple interactions
ISO 5-alpha-Dihydroprogesterone affects the activity of NR1I2 protein
NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride]; NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide]
5-alpha-Dihydroprogesterone binds to and results in increased activity of NR1I2 protein
CTD PMID:15846226 PMID:16054614 PMID:17159084 PMID:21291553 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 5-alpha-Dihydroprogesterone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Sox10 SRY-box transcription factor 10 increases expression EXP 5-alpha-Dihydroprogesterone results in increased expression of SOX10 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of SOX10 protein CTD PMID:17478888 NCBI chr 7:110,725,274...110,735,544
Ensembl chr 7:110,725,274...110,735,544
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions
increases chemical synthesis
ISO [SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
SRD5A1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
CTD PMID:23183084 PMID:25463305 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    chemical entity 19738
      atom 19738
        nonmetal atom 19678
          carbon atom 19627
            organic molecular entity 19627
              lipid 17797
                steroid 14369
                  C21-steroid 3994
                    5alpha-pregnane 14
                      11,21-dioxoprogesterone 0
                      21-dehydrocortisol 0
                      21-dehydrocortisone 0
                      3-hydroxy-5alpha-pregnan-20-one + 0
                      5alpha-dihydrodeoxycorticosterone 0
                      5alpha-pregan-20beta-ol-3-one 0
                      5alpha-pregnane-3,20-dione 14
                      hookerianamide H 0
                      hookerianamide I 0
                      hookerianamide J 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic polycyclic compound 17178
                                  steroid 14369
                                    steroid fundamental parent 14132
                                      pregnane 6822
                                        5alpha-pregnane 14
                                          11,21-dioxoprogesterone 0
                                          21-dehydrocortisol 0
                                          21-dehydrocortisone 0
                                          3-hydroxy-5alpha-pregnan-20-one + 0
                                          5alpha-dihydrodeoxycorticosterone 0
                                          5alpha-pregan-20beta-ol-3-one 0
                                          5alpha-pregnane-3,20-dione 14
                                          hookerianamide H 0
                                          hookerianamide I 0
                                          hookerianamide J 0
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