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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5alpha-pregnane
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Accession:CHEBI:20656 term browser browse the term
Definition:A pregnane that has formula C21H36.
Synonyms:related_synonym: Formula=C21H36;   InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3/t15-,16+,17-,18-,19-,20-,21+/m0/s1;   InChIKey=JWMFYGXQPXQEEM-GCOKGBOCSA-N;   SMILES=[H][C@]1(CC)CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CCCC[C@]4(C)[C@@]3([H])CC[C@]12C;   allopregnane
 xref: Beilstein:2502007;   CAS:641-85-0


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21-dehydrocortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 21-dehydrocortisol CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
5alpha-pregnane-3,20-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 affects reduction ISO AKR1C4 protein affects the reduction of 5-alpha-Dihydroprogesterone CTD PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 affects reduction
increases reduction
ISO AKR1C2 protein affects the reduction of 5-alpha-Dihydroprogesterone
AKR1C2 protein results in increased reduction of 5-alpha-Dihydroprogesterone
CTD PMID:11995921, PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone CTD PMID:25463305 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases chemical synthesis
multiple interactions
ISO AKR1D1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
AKR1D1 protein alternative form results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
[AKR1D1 protein alternative form results in increased reduction of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
CTD PMID:18624455, PMID:30928400 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO 3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA] CTD PMID:19931389 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases hydroxylation ISO CYP17A1 protein results in increased hydroxylation of 5-alpha-Dihydroprogesterone CTD PMID:14522586 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Egr2 early growth response 2 increases expression EXP 5-alpha-Dihydroprogesterone results in increased expression of EGR2 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of EGR2 protein CTD PMID:17478888 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO 5-alpha-Dihydroprogesterone results in increased expression of ESR1 mRNA CTD PMID:17683929 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP 5-alpha-Dihydroprogesterone results in decreased expression of GSK3B protein CTD PMID:17443805 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
increases phosphorylation
EXP 5-alpha-Dihydroprogesterone results in decreased expression of MAPT protein
5-alpha-Dihydroprogesterone results in increased phosphorylation of MAPT protein
CTD PMID:17443805 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects activity
multiple interactions
ISO 5-alpha-Dihydroprogesterone affects the activity of NR1I2 protein
5-alpha-Dihydroprogesterone binds to and results in increased activity of NR1I2 protein
NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride]; NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide]
CTD PMID:15846226, PMID:16054614, PMID:17159084, PMID:21291553 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 5-alpha-Dihydroprogesterone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Sox10 SRY-box transcription factor 10 increases expression EXP 5-alpha-Dihydroprogesterone results in increased expression of SOX10 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of SOX10 protein CTD PMID:17478888 NCBI chr 7:120,393,238...120,403,523
Ensembl chr 7:120,393,254...120,403,523
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions
increases chemical synthesis
ISO [SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
SRD5A1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
CTD PMID:23183084, PMID:25463305 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          carbon atom 19563
            organic molecular entity 19563
              lipid 16977
                steroid 12788
                  C21-steroid 3903
                    5alpha-pregnane 15
                      11,21-dioxoprogesterone 0
                      21-dehydrocortisol 1
                      21-dehydrocortisone 0
                      3-hydroxy-5alpha-pregnan-20-one + 0
                      5alpha-pregan-20beta-ol-3-one 0
                      5alpha-pregnane-3,20-dione 14
                      hookerianamide H 0
                      hookerianamide I 0
                      hookerianamide J 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic polycyclic compound 16384
                                  steroid 12788
                                    steroid fundamental parent 12403
                                      pregnane 6716
                                        5alpha-pregnane 15
                                          11,21-dioxoprogesterone 0
                                          21-dehydrocortisol 1
                                          21-dehydrocortisone 0
                                          3-hydroxy-5alpha-pregnan-20-one + 0
                                          5alpha-pregan-20beta-ol-3-one 0
                                          5alpha-pregnane-3,20-dione 14
                                          hookerianamide H 0
                                          hookerianamide I 0
                                          hookerianamide J 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.