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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,10-methylenetetrahydrofolic acid
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Accession:CHEBI:20502 term browser browse the term
Definition:A methylenetetrahydrofolic acid that has formula C20H23N7O6.
Synonyms:exact_synonym: N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid
 related_synonym: Formula=C20H23N7O6;   InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1;   InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N;   SMILES=Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 xref: Beilstein:72305
 xref_mesh: MESH:C013123
 cyclic_relationship: is_conjugate_acid_of CHEBI:12071


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5,10-methylenetetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase increases metabolic processing
increases reduction		 ISO MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid
MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid		 CTD PMID:7647779 PMID:16187112 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          nitrogen atom 18962
            nitrogen molecular entity 18934
              amide 17755
                aromatic amide 8430
                  arenecarboxamide 8245
                    benzamides 8250
                      5,10-methylenetetrahydrofolic acid 1
                        (6R)-5,10-methylenetetrahydrofolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        amino acid 15943
                                          alpha-amino acid 13846
                                            L-alpha-amino acid 12846
                                              glutamine family amino acid 10312
                                                L-glutamic acid 10257
                                                  L-glutamic acid derivative 9397
                                                    folic acids 9397
                                                      tetrahydrofolic acid 68
                                                        methylenetetrahydrofolic acid 1
                                                          5,10-methylenetetrahydrofolic acid 1
                                                            (6R)-5,10-methylenetetrahydrofolic acid + 0
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