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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5,10-methylenetetrahydrofolic acid
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Accession:CHEBI:20502 term browser browse the term
Definition:A methylenetetrahydrofolic acid that has formula C20H23N7O6.
Synonyms:exact_synonym: N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid
 related_synonym: Formula=C20H23N7O6;   InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1;   InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N;   SMILES=Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 xref: Beilstein:72305
 xref_mesh: MESH:C013123
 cyclic_relationship: is_conjugate_acid_of CHEBI:12071

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5,10-methylenetetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase increases metabolic processing
increases reduction
ISO MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid
MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid
CTD PMID:7647779, PMID:16187112 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          nitrogen atom 18542
            nitrogen molecular entity 18542
              amide 17389
                aromatic amide 6677
                  arenecarboxamide 6508
                    benzamides 6508
                      5,10-methylenetetrahydrofolic acid 1
                        (6R)-5,10-methylenetetrahydrofolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        amino acid 14072
                                          alpha-amino acid 11539
                                            L-alpha-amino acid 11374
                                              glutamine family amino acid 10243
                                                L-glutamic acid 10190
                                                  L-glutamic acid derivative 9354
                                                    folic acids 9354
                                                      tetrahydrofolic acid 66
                                                        methylenetetrahydrofolic acid 1
                                                          5,10-methylenetetrahydrofolic acid 1
                                                            (6R)-5,10-methylenetetrahydrofolic acid + 0
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