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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5,10-methylenetetrahydrofolic acid
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Accession:CHEBI:20502 term browser browse the term
Definition:A methylenetetrahydrofolic acid that has formula C20H23N7O6.
Synonyms:exact_synonym: N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid
 related_synonym: Formula=C20H23N7O6;   InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1;   InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N;   SMILES=Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 xref: Beilstein:72305
 xref_mesh: MESH:C013123
 cyclic_relationship: is_conjugate_acid_of CHEBI:12071

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5,10-methylenetetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase increases metabolic processing
increases reduction
ISO MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid
MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid
CTD PMID:7647779 PMID:16187112 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18774
            nitrogen molecular entity 18774
              amide 17590
                aromatic amide 7463
                  arenecarboxamide 7271
                    benzamides 7271
                      5,10-methylenetetrahydrofolic acid 1
                        (6R)-5,10-methylenetetrahydrofolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        amino acid 14892
                                          alpha-amino acid 12874
                                            L-alpha-amino acid 11589
                                              glutamine family amino acid 10278
                                                L-glutamic acid 10223
                                                  L-glutamic acid derivative 9382
                                                    folic acids 9382
                                                      tetrahydrofolic acid 66
                                                        methylenetetrahydrofolic acid 1
                                                          5,10-methylenetetrahydrofolic acid 1
                                                            (6R)-5,10-methylenetetrahydrofolic acid + 0
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