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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,10-methylenetetrahydrofolic acid
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Accession:CHEBI:20502 term browser browse the term
Definition:A methylenetetrahydrofolic acid that has formula C20H23N7O6.
Synonyms:exact_synonym: N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid
 related_synonym: Formula=C20H23N7O6;   InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1;   InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N;   SMILES=Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 xref: Beilstein:72305
 xref_mesh: MESH:C013123
 cyclic_relationship: is_conjugate_acid_of CHEBI:12071


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5,10-methylenetetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase increases metabolic processing
increases reduction 		ISO MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid
MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid 		CTD PMID:7647779 PMID:16187112 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              amide 18213
                aromatic amide 8516
                  arenecarboxamide 8285
                    benzamides 8285
                      5,10-methylenetetrahydrofolic acid 1
                        (6R)-5,10-methylenetetrahydrofolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          alpha-amino acid 14255
                                            L-alpha-amino acid 12393
                                              glutamine family amino acid 10355
                                                L-glutamic acid 10288
                                                  L-glutamic acid derivative 9440
                                                    folic acids 9440
                                                      tetrahydrofolic acid 69
                                                        methylenetetrahydrofolic acid 1
                                                          5,10-methylenetetrahydrofolic acid 1
                                                            (6R)-5,10-methylenetetrahydrofolic acid + 0
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