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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefotaxime
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Accession:CHEBI:204928 term browser browse the term
Definition:A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.
Synonyms:exact_synonym: 3-(acetoxymethyl)-7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   (6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   (6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Cephotaxime;   Formula=C16H17N5O7S2;   InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1;   InChIKey=GPRBEKHLDVQUJE-QSWIMTSFSA-N;   SMILES=[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O;   cefotaxima;   cefotaximum
 alt_id: CHEBI:112504;   CHEBI:3497;   CHEBI:41475
 xref: Beilstein:1096643;   CAS:63527-52-6;   DrugBank:DB00493;   Drug_Central:546;   KEGG:C06885;   KEGG:D07647
 xref_mesh: MESH:D002439
 xref: PDBeChem:CE3;   PMID:10866367;   PMID:11034276;   PMID:11061623;   PMID:11677129;   PMID:12833570;   PMID:1384868;   PMID:14512220;   PMID:1502708;   PMID:15164972;   PMID:15361989;   PMID:15969234;   PMID:1635063;   PMID:17006042;   PMID:17386217;   PMID:18611527;   PMID:19741292;   PMID:21425867;   PMID:24038683;   PMID:24211456;   PMID:29017833;   PMID:9131470;   Patent:DE2556736;   Patent:DE2702501;   Patent:US4098888;   Patent:US4152432;   Reaxys:1096643;   Wikipedia:Cefotaxime
 cyclic_relationship: is_conjugate_acid_of CHEBI:53670


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cefotaxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Cefotaxime results in increased expression of BAX protein CTD PMID:15012731 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Cefotaxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Cefotaxime results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Cefotaxime affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cefotaxime results in increased expression of TP53 protein CTD PMID:15012731 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            antibacterial drug 3162
              cefotaxime 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          cefotaxime 5
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