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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SB 290157
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Accession:CHEBI:197424 term browser browse the term
Definition:Antagonist of C3aR
Synonyms:exact_synonym: N(2)-[(2,2-diphenylethoxy)acetyl]-L-arginine trifluoroacetate
 related_synonym: Formula=C22H28N4O4.C2HF3O2;   InChI=1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1;   InChIKey=ZJRMPPVJAQWGEG-FYZYNONXSA-N;   N(2)-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt;   N2-[2-(2,2-diphenylethoxy)acetyl]-L-arginine, 2,2,2-trifluoroacetate;   SB 290157 trifluoroacetate salt;   SB290157;   SB290157 trifluoroacetate;   SMILES=OC(=O)C(F)(F)F.NC(=N)NCCCC(NC(=O)COCC(C1=CC=CC=C1)C1=CC=CC=C1)C(O)=O
 xref: CAS:1140525-25-2
 xref_mesh: MESH:C431907
 xref: PMID:11342658;   PMID:15944244;   PMID:16154494;   PMID:20051658;   PMID:33073351;   PMID:33551801


show annotations for term's descendants           Sort by:
SB 290157 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3ar1 complement C3a receptor 1 multiple interactions
decreases activity		 ISO SB 290157 inhibits the reaction [Trichloroethylene results in increased expression of C3AR1 protein]
SB 290157 results in decreased activity of C3AR1 protein		 CTD PMID:24974766 PMID:32898628 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in decreased expression of CDH1 protein] CTD PMID:32898628 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of CDH2 protein] CTD PMID:32898628 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO SB 290157 inhibits the reaction [Trichloroethylene results in increased expression of IL4 protein] CTD PMID:24974766 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased secretion of IL6 protein] CTD PMID:37084829 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of MMP9 mRNA]; SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of MMP9 protein] CTD PMID:37084829 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of RELA mRNA]; SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of RELA protein] CTD PMID:37084829 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Vim vimentin multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of VIM protein] CTD PMID:32898628 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          carbon atom 19802
            organic molecular entity 19775
              SB 290157 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            SB 290157 8
paths to the root