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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GYS32661
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Accession:CHEBI:197341 term browser browse the term
Definition:A member of the class of quinolines that is quinoline substituted by (5-{4-[(morpholin-4-yl)methyl]-1H-imidazol-1-yl}pentyl)sulfanediyl and trifluoromethyl groups at positions 4 and 7, respectively. It is a Rac inhibitor that inhibits both Rac1 and Rac1b.
Synonyms:exact_synonym: 4-({5-[4-(morpholin-4-ylmethyl)-1H-imidazol-1-yl]pentyl}sulfanyl)-7-(trifluoromethyl)quinoline
 related_synonym: 4-((1-(5-((7-(trifluoromethyl)quinolin-4-yl)thio)pentyl)-1H-imidazol-4-yl)methyl)morpholine;   Formula=C23H27F3N4OS;   GYS 32661;   InChI=1S/C23H27F3N4OS/c24-23(25,26)18-4-5-20-21(14-18)27-7-6-22(20)32-13-3-1-2-8-30-16-19(28-17-30)15-29-9-11-31-12-10-29/h4-7,14,16-17H,1-3,8-13,15H2;   InChIKey=UEZJAHLAEKXBTP-UHFFFAOYSA-N;   SMILES=FC(F)(F)C1=CC2=NC=CC(SCCCCCN3C=NC(CN4CCOCC4)=C3)=C2C=C1
 xref: CAS:2589092-11-3;   PMID:30926638;   PMID:35740379;   PMID:35853497;   PMID:37664052


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GYS32661 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 decreases expression ISO GYS32661 decreases expression of RAC1 and RAC1b proteins in colorectal carcinoma cells RGD PMID:30926638 RGD:155230818 NCBI chr12:16,150,411...16,170,864 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        inhibitor 18949
          Rac1 inhibitor 1
            GYS32661 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  heteroarene 17174
                                    monocyclic heteroarene 15021
                                      azole 14518
                                        diazole 10781
                                          imidazoles 10231
                                            GYS32661 1
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