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ONTOLOGY REPORT - ANNOTATIONS


Term:4-hydroperoxycyclophosphamide
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Accession:CHEBI:196991 term browser browse the term
Definition:A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties.
Synonyms:exact_synonym: 2-[bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-yl hydroperoxide
 related_synonym: 2-(Bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine;   2-(bis(2-chloroethyl)amino)tetrahydro-2-oxideo-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide;   4-Hydroperoxycyclofosfamide;   4-OOH Cyclophosphamide;   Formula=C7H15Cl2N2O4P;   InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(13)10-7(15-12)1-6-14-16/h7,12H,1-6H2,(H,10,13);   InChIKey=VPAWVRUHMJVRHU-UHFFFAOYSA-N;   Perfosfamide (unspecified);   SMILES=OOC1CCOP(=O)(N1)N(CCCl)CCCl
 xref: Beilstein:531579 "Beilstein";   CAS:39800-16-3 "ChemIDplus"
 xref_mesh: MESH:C011272
 xref: PMID:8024619 "Europe PMC";   Patent:NL7208895;   Patent:US3808297;   Reaxys:531579 "Reaxys"


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4-hydroperoxycyclophosphamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6480464
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:6480464
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 JBrowse link 5 61,382,351 61,387,359 RGD:6480464
G Aldh2 aldehyde dehydrogenase 2 family member JBrowse link 12 40,466,418 40,498,813 RGD:6480464
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 JBrowse link 10 47,490,168 47,499,855 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6480464
G Bmpr1b bone morphogenetic protein receptor type 1B JBrowse link 2 247,392,195 247,662,026 RGD:6480464
G C1d C1D nuclear receptor corepressor JBrowse link 14 100,415,645 100,427,878 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:6480464
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6480464
G Epha6 Eph receptor A6 JBrowse link 11 41,867,607 42,843,800 RGD:6480464
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:6480464
G Gjc1 gap junction protein, gamma 1 JBrowse link 10 90,781,408 90,912,440 RGD:6480464
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:6480464
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hoxa11 homeobox A11 JBrowse link 4 82,296,888 82,301,419 RGD:6480464
G Hoxa13 homeo box A13 RGD:6480464
G Hoxd10 homeo box D10 JBrowse link 3 61,614,133 61,617,342 RGD:6480464
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6480464
G Kl Klotho JBrowse link 12 942,974 987,206 RGD:6480464
G Lig3 DNA ligase 3 JBrowse link 10 70,134,734 70,158,051 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Mpg N-methylpurine-DNA glycosylase JBrowse link 10 15,661,768 15,667,995 RGD:6480464
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:6480464
G Myo1b myosin Ib JBrowse link 9 54,706,005 54,766,054 RGD:6480464
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:6480464
G Ndn necdin, MAGE family member JBrowse link 1 122,981,755 122,983,354 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Pea15 proliferation and apoptosis adaptor protein 15 JBrowse link 13 90,579,844 90,589,466 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Pms1 PMS1 homolog 1, mismatch repair system component JBrowse link 9 53,120,656 53,206,520 RGD:6480464
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:6480464
G Polb DNA polymerase beta JBrowse link 16 74,237,001 74,260,272 RGD:6480464
G Pold1 DNA polymerase delta 1, catalytic subunit JBrowse link 1 100,538,066 100,554,105 RGD:6480464
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:6480464
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:6480464
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6480464
G Sdf4 stromal cell derived factor 4 JBrowse link 5 173,425,922 173,444,478 RGD:6480464
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:6480464
G Slc30a4 solute carrier family 30 member 4 JBrowse link 3 114,805,919 114,828,154 RGD:6480464
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:6480464
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:6480464
G Tcf12 transcription factor 12 JBrowse link 8 78,343,634 78,657,738 RGD:6480464
G Terc telomerase RNA component JBrowse link 2 116,432,723 116,433,110 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trim27 tripartite motif-containing 27 JBrowse link 17 45,613,863 45,626,212 RGD:6480464
G Ttf1 transcription termination factor 1 JBrowse link 3 7,635,630 7,660,153 RGD:6480464
G Ubb ubiquitin B JBrowse link 10 48,880,231 48,881,896 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:6480464
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:6480464
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:6480464
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          metabolite 19106
            4-hydroperoxycyclophosphamide 74
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      chalcogen 19233
                        oxygen atom 19188
                          oxygen molecular entity 19188
                            hydroxides 18965
                              oxoacid 18076
                                pnictogen oxoacid 8534
                                  phosphorus oxoacid 8429
                                    phosphoric acids 7314
                                      phosphoric acid 7314
                                        phosphoramide 968
                                          phosphorodiamide 949
                                            4-hydroperoxycyclophosphamide 74
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.