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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxyisophthalic acid
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Accession:CHEBI:19643 term browser browse the term
Definition:A hydroxybenzoic acid that is isophthalic acid in which the hydrogen at position 2 is substituted by a hydroxy group.
Synonyms:exact_synonym: 2-hydroxybenzene-1,3-dicarboxylic acid
 related_synonym: 2-Hydroxy-1,3-benzenedicarboxylic acid;   Formula=C8H6O5;   InChI=1S/C8H6O5/c9-6-4(7(10)11)2-1-3-5(6)8(12)13/h1-3,9H,(H,10,11)(H,12,13);   InChIKey=WVDGHGISNBRCAO-UHFFFAOYSA-N;   SMILES=OC(=O)c1cccc(C(O)=O)c1O
 alt_id: CHEBI:34290
 xref: CAS:606-19-9;   KEGG:C14097;   Reaxys:2102863;   UM-BBD_compID:c0729



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Di-n-hexyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO di-n-hexyl phthalate results in decreased expression of ACADL mRNA CTD PMID:33043605 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO di-n-hexyl phthalate results in decreased expression of ACADM mRNA CTD PMID:33043605 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO di-n-hexyl phthalate results in decreased expression of ACSL1 mRNA CTD PMID:33043605 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression EXP di-n-hexyl phthalate results in decreased expression of ALDH2 mRNA CTD PMID:33983380 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Ar androgen receptor multiple interactions ISO di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:15840436 PMID:28571686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO di-n-hexyl phthalate results in increased expression of BAX mRNA CTD PMID:33043605 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO di-n-hexyl phthalate results in decreased expression of BCL2 mRNA CTD PMID:33043605 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression ISO di-n-hexyl phthalate results in increased expression of CASP3 mRNA CTD PMID:33043605 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression ISO di-n-hexyl phthalate results in increased expression of CASP8 mRNA CTD PMID:33043605 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cela3b chymotrypsin like elastase 3B increases expression EXP di-n-hexyl phthalate results in increased expression of ELA3B mRNA CTD PMID:33983380 NCBI chr 5:149,628,773...149,636,937
Ensembl chr 5:149,628,773...149,636,937
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO di-n-hexyl phthalate results in decreased expression of CPT1B mRNA CTD PMID:33043605 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP11A1 protein CTD PMID:22112501 PMID:23754470 PMID:26934186 PMID:33983380 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11B1 mRNA CTD PMID:22112501 PMID:33983380 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11B2 mRNA CTD PMID:33983380 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP17A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP17A1 protein CTD PMID:22112501 PMID:23754470 PMID:26934186 PMID:33983380 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP46A1 mRNA CTD PMID:33983380 NCBI chr 6:127,243,315...127,274,765
Ensembl chr 6:127,243,315...127,274,760
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP51 mRNA CTD PMID:33983380 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP di-n-hexyl phthalate results in decreased expression of DHCR7 mRNA CTD PMID:33983380 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dhh desert hedgehog signaling molecule increases expression EXP di-n-hexyl phthalate results in increased expression of DHH mRNA; di-n-hexyl phthalate results in increased expression of DHH protein CTD PMID:32693021 NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression EXP di-n-hexyl phthalate results in decreased expression of EBP mRNA CTD PMID:33983380 NCBI chr  X:14,299,427...14,305,826
Ensembl chr  X:14,299,448...14,305,826
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression ISO di-n-hexyl phthalate results in decreased expression of ELOVL5 mRNA CTD PMID:33043605 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases expression
multiple interactions
ISO
EXP
di-n-hexyl phthalate analog binds to ESR1 protein
di-n-hexyl phthalate results in increased expression of ESR1 mRNA
di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein]
CTD PMID:15464722 PMID:15840436 PMID:22112501 PMID:28571686 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO di-n-hexyl phthalate binds to and results in decreased activity of ESR2 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
di-n-hexyl phthalate analog binds to ESR2 protein
CTD PMID:15464722 PMID:15840436 PMID:28571686 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO di-n-hexyl phthalate results in decreased expression of FADS2 mRNA CTD PMID:33043605 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fasn fatty acid synthase decreases expression ISO di-n-hexyl phthalate results in decreased expression of FASN mRNA CTD PMID:33043605 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression EXP di-n-hexyl phthalate results in decreased expression of FDPS mRNA CTD PMID:33983380 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of GSK3B protein CTD PMID:32693021 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP di-n-hexyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:26934186 PMID:33983380 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HMGCS1 mRNA CTD PMID:26934186 PMID:33983380 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD11B1 protein CTD PMID:32693021 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression EXP di-n-hexyl phthalate results in increased expression of HSD17B3 mRNA CTD PMID:26934186 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD3B1 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B1 protein CTD PMID:26934186 PMID:32693021 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD3B3 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B3 protein CTD PMID:32693021 PMID:33983380 NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033
JBrowse link
G Il1b interleukin 1 beta increases expression ISO di-n-hexyl phthalate results in increased expression of IL1B mRNA CTD PMID:33043605 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP di-n-hexyl phthalate results in decreased expression of INHA mRNA CTD PMID:22112501 PMID:33983380 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of INSIG1 mRNA CTD PMID:33983380 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insl3 insulin-like 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of INSL3 mRNA CTD PMID:22112501 PMID:33983380 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression EXP di-n-hexyl phthalate results in decreased expression of LDLR mRNA CTD PMID:33983380 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP di-n-hexyl phthalate results in increased expression of LHB protein CTD PMID:32693021 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP di-n-hexyl phthalate results in decreased expression of LHCGR mRNA; di-n-hexyl phthalate results in decreased expression of LHCGR protein CTD PMID:32693021 PMID:33983380 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of MAPK1 protein CTD PMID:32693021 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of MAPK3 protein CTD PMID:32693021 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression EXP di-n-hexyl phthalate results in decreased expression of MVD mRNA CTD PMID:33983380 NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of NR0B1 mRNA CTD PMID:33983380 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects binding
increases activity
ISO di-n-hexyl phthalate binds to NR1I3 protein
di-n-hexyl phthalate results in increased activity of NR1I3 protein
CTD PMID:25938866 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases expression EXP di-n-hexyl phthalate results in decreased expression of NSDHL mRNA CTD PMID:33983380 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO di-n-hexyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO di-n-hexyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO di-n-hexyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP di-n-hexyl phthalate results in decreased expression of PPARGC1A protein CTD PMID:32693021 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G RGD1564999 similar to isopentenyl-diphosphate delta isomerase 2 decreases expression EXP di-n-hexyl phthalate results in decreased expression of RGD1564999 mRNA CTD PMID:33983380 NCBI chr17:61,518,138...61,535,484
Ensembl chr17:61,519,390...61,531,603
JBrowse link
G Rhox10 reproductive homeobox 10 decreases expression EXP di-n-hexyl phthalate results in decreased expression of RHOX10 mRNA CTD PMID:22112501 NCBI chr  X:116,850,460...116,854,898
Ensembl chr  X:116,850,460...116,854,941
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO di-n-hexyl phthalate binds to RXRA protein CTD PMID:23843199 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO di-n-hexyl phthalate binds to RXRB protein CTD PMID:23843199 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO di-n-hexyl phthalate binds to RXRG protein CTD PMID:23843199 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of SCARB1 mRNA CTD PMID:22112501 PMID:23754470 PMID:26934186 PMID:33983380 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of SIRT1 protein CTD PMID:32693021 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP di-n-hexyl phthalate results in decreased expression of STAR mRNA CTD PMID:22112501 PMID:23754470 PMID:26934186 PMID:33983380 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of TGFB1 mRNA CTD PMID:22112501 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression EXP di-n-hexyl phthalate results in decreased expression of TM7SF2 mRNA CTD PMID:33983380 NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
JBrowse link
G Tnf tumor necrosis factor increases expression ISO di-n-hexyl phthalate results in increased expression of TNF mRNA CTD PMID:33043605 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Wnt7a Wnt family member 7A decreases expression EXP di-n-hexyl phthalate results in decreased expression of WNT7A mRNA CTD PMID:22112501 PMID:33983380 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        antimicrobial agent 17793
          antimicrobial food preservative 11909
            benzoic acid 4328
              hydroxybenzoic acid 3734
                2-hydroxyisophthalic acid 62
                  4-[(1-naphthalenylamino)-oxomethyl]benzene-1,3-dicarboxylic acid 0
                  5-Carboxyvanillic acid 0
                  5-[(1,3-dimethyl-2,4-dioxo-6-quinazolinyl)sulfonylamino]benzene-1,3-dicarboxylic acid 0
                  5-[3-[[[[3-(dimethylamino)phenyl]-oxomethyl]hydrazinylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzene-1,3-dicarboxylic acid 0
                  Chlorthal 0
                  Di-n-hexyl phthalate 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        aromatic carboxylic acid 11788
                                          benzoic acids 11763
                                            benzoic acid 4328
                                              hydroxybenzoic acid 3734
                                                2-hydroxyisophthalic acid 62
                                                  4-[(1-naphthalenylamino)-oxomethyl]benzene-1,3-dicarboxylic acid 0
                                                  5-Carboxyvanillic acid 0
                                                  5-[(1,3-dimethyl-2,4-dioxo-6-quinazolinyl)sulfonylamino]benzene-1,3-dicarboxylic acid 0
                                                  5-[3-[[[[3-(dimethylamino)phenyl]-oxomethyl]hydrazinylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzene-1,3-dicarboxylic acid 0
                                                  Chlorthal 0
                                                  Di-n-hexyl phthalate 62
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