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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxyisophthalic acid
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Accession:CHEBI:19643 term browser browse the term
Definition:A benzenedicarboxylic acid that is isophthalic acid in which the hydrogen at position 2 is substituted by a hydroxy group.
Synonyms:exact_synonym: 2-hydroxybenzene-1,3-dicarboxylic acid
 related_synonym: 2-Hydroxy-1,3-benzenedicarboxylic acid;   Formula=C8H6O5;   InChI=1S/C8H6O5/c9-6-4(7(10)11)2-1-3-5(6)8(12)13/h1-3,9H,(H,10,11)(H,12,13);   InChIKey=WVDGHGISNBRCAO-UHFFFAOYSA-N;   SMILES=OC(=O)c1cccc(C(O)=O)c1O
 alt_id: CHEBI:34290
 xref: CAS:606-19-9;   KEGG:C14097;   Reaxys:2102863;   UM-BBD_compID:c0729


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Di-n-hexyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:15840436, PMID:28571686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP11A1 protein CTD PMID:22112501, PMID:23754470, PMID:26934186 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11B1 mRNA CTD PMID:22112501 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP17A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP17A1 protein CTD PMID:22112501, PMID:23754470, PMID:26934186 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Dhh desert hedgehog signaling molecule increases expression EXP di-n-hexyl phthalate results in increased expression of DHH mRNA; di-n-hexyl phthalate results in increased expression of DHH protein CTD PMID:32693021 NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases expression
multiple interactions
ISO
EXP
di-n-hexyl phthalate analog binds to ESR1 protein
di-n-hexyl phthalate results in increased expression of ESR1 mRNA
di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein]
CTD PMID:15464722, PMID:15840436, PMID:22112501, PMID:28571686 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO di-n-hexyl phthalate binds to and results in decreased activity of ESR2 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
di-n-hexyl phthalate analog binds to ESR2 protein
CTD PMID:15464722, PMID:15840436, PMID:28571686 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of GSK3B protein CTD PMID:32693021 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP di-n-hexyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:26934186 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HMGCS1 mRNA CTD PMID:26934186 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD11B1 protein CTD PMID:32693021 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression EXP di-n-hexyl phthalate results in increased expression of HSD17B3 mRNA CTD PMID:26934186 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD3B1 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B1 protein CTD PMID:26934186, PMID:32693021
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD3B3 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B3 protein CTD PMID:32693021 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP di-n-hexyl phthalate results in decreased expression of INHA mRNA CTD PMID:22112501 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Insl3 insulin-like 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of INSL3 mRNA CTD PMID:22112501 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP di-n-hexyl phthalate results in increased expression of LHB protein CTD PMID:32693021 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP di-n-hexyl phthalate results in decreased expression of LHCGR mRNA; di-n-hexyl phthalate results in decreased expression of LHCGR protein CTD PMID:32693021 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of MAPK1 protein CTD PMID:32693021 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of MAPK3 protein CTD PMID:32693021 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects binding
increases activity
ISO di-n-hexyl phthalate binds to NR1I3 protein
di-n-hexyl phthalate results in increased activity of NR1I3 protein
CTD PMID:25938866, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO di-n-hexyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO di-n-hexyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO di-n-hexyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP di-n-hexyl phthalate results in decreased expression of PPARGC1A protein CTD PMID:32693021 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rhox10 reproductive homeobox 10 decreases expression EXP di-n-hexyl phthalate results in decreased expression of RHOX10 mRNA CTD PMID:22112501 NCBI chr  X:124,207,017...124,211,455
Ensembl chr  X:124,207,017...124,211,455
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO di-n-hexyl phthalate binds to RXRA protein CTD PMID:23843199 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO di-n-hexyl phthalate binds to RXRB protein CTD PMID:23843199 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO di-n-hexyl phthalate binds to RXRG protein CTD PMID:23843199 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of SCARB1 mRNA CTD PMID:22112501, PMID:23754470, PMID:26934186 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of SIRT1 protein CTD PMID:32693021 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP di-n-hexyl phthalate results in decreased expression of STAR mRNA CTD PMID:22112501, PMID:23754470, PMID:26934186 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of TGFB1 mRNA CTD PMID:22112501 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Wnt7a Wnt family member 7A decreases expression EXP di-n-hexyl phthalate results in decreased expression of WNT7A mRNA CTD PMID:22112501 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          antimicrobial food preservative 11695
            benzoic acid 3841
              hydroxybenzoic acid 3231
                2-hydroxyisophthalic acid 34
                  4-[(1-naphthalenylamino)-oxomethyl]benzene-1,3-dicarboxylic acid 0
                  5-Carboxyvanillic acid 0
                  5-[(1,3-dimethyl-2,4-dioxo-6-quinazolinyl)sulfonylamino]benzene-1,3-dicarboxylic acid 0
                  5-[3-[[[[3-(dimethylamino)phenyl]-oxomethyl]hydrazinylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzene-1,3-dicarboxylic acid 0
                  Di-n-hexyl phthalate 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        aromatic carboxylic acid 10901
                                          benzoic acids 10870
                                            benzoic acid 3841
                                              hydroxybenzoic acid 3231
                                                2-hydroxyisophthalic acid 34
                                                  4-[(1-naphthalenylamino)-oxomethyl]benzene-1,3-dicarboxylic acid 0
                                                  5-Carboxyvanillic acid 0
                                                  5-[(1,3-dimethyl-2,4-dioxo-6-quinazolinyl)sulfonylamino]benzene-1,3-dicarboxylic acid 0
                                                  5-[3-[[[[3-(dimethylamino)phenyl]-oxomethyl]hydrazinylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzene-1,3-dicarboxylic acid 0
                                                  Di-n-hexyl phthalate 34
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.