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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mevalonolactone
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Accession:CHEBI:194429 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)-mevalonolactone and (S)-mevalonolactone.
Synonyms:exact_synonym: rac-4-hydroxy-4-methyltetrahydro-2H-pyran-2-one
 related_synonym: (4RS)-4-hydroxy-4-methyloxan-2-one;   (4RS)-4-hydroxy-4-methyltetrahydro-2H-pyran-2-one;   DL-mevalonic acid delta-lactone;   DL-mevalonic acid lactone;   DL-mevalonolactone;   Formula=C6H10O3;   R,S-mevalonolactone;   RS-mevalonolactone;   mevalolactone;   mevalonic acid delta-lactone;   mevalonic acid lactone;   mevalonic lactone;   rac-mevalonolactone;   racemic mevalonolactone
 xref: CAS:674-26-0;   HMDB:HMDB0006024;   KNApSAcK:C00062661;   LINCS:LSM-6380
 xref_mesh: MESH:C015367
 xref: PMID:11522061;   PMID:12481687;   PMID:36745799;   PMID:9208099


show annotations for term's descendants           Sort by:
mevalonolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO mevalonolactone results in decreased activity of HMGCR protein CTD PMID:3042028 PMID:12477733 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Ptgir prostaglandin I2 receptor affects binding ISO mevalonolactone binds to PTGIR protein CTD PMID:11895442 NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases farnesylation ISO mevalonolactone results in increased farnesylation of RAP2A protein CTD PMID:8424780 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family increases prenylation ISO mevalonolactone results in increased prenylation of RAP2B protein CTD PMID:8424780 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      chemical substance 14414
        mixture 13733
          racemate 12111
            mevalonolactone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      monocarboxylic acid 18028
                                        fatty acid 16848
                                          saturated fatty acid 16571
                                            straight-chain saturated fatty acid 16105
                                              valeric acid 14530
                                                3,5-dihydroxy-3-methylpentanoic acid 116
                                                  (R)-mevalonic acid 116
                                                    mevalonic acid 116
                                                      mevalonolactone 4
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