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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mevalonolactone
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Accession:CHEBI:194429 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)-mevalonolactone and (S)-mevalonolactone.
Synonyms:exact_synonym: rac-4-hydroxy-4-methyltetrahydro-2H-pyran-2-one
 related_synonym: (4RS)-4-hydroxy-4-methyloxan-2-one;   (4RS)-4-hydroxy-4-methyltetrahydro-2H-pyran-2-one;   DL-mevalonic acid delta-lactone;   DL-mevalonic acid lactone;   DL-mevalonolactone;   Formula=C6H10O3;   R,S-mevalonolactone;   RS-mevalonolactone;   mevalolactone;   mevalonic acid delta-lactone;   mevalonic acid lactone;   mevalonic lactone;   rac-mevalonolactone;   racemic mevalonolactone
 xref: CAS:674-26-0;   HMDB:HMDB0006024;   KNApSAcK:C00062661;   LINCS:LSM-6380
 xref_mesh: MESH:C015367
 xref: PMID:11522061;   PMID:12481687;   PMID:36745799;   PMID:9208099


show annotations for term's descendants           Sort by:
mevalonolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO mevalonolactone results in decreased activity of HMGCR protein CTD PMID:3042028 PMID:12477733 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Ptgir prostaglandin I2 receptor affects binding ISO mevalonolactone binds to PTGIR protein CTD PMID:11895442 NCBI chr 1:86,707,690...86,710,073
Ensembl chr 1:86,707,503...86,711,874 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases farnesylation ISO mevalonolactone results in increased farnesylation of RAP2A protein CTD PMID:8424780 NCBI chr15:104,003,744...104,004,234 JBrowse link
G Rap2b RAP2B, member of RAS oncogene family increases prenylation ISO mevalonolactone results in increased prenylation of RAP2B protein CTD PMID:8424780 NCBI chr 2:147,749,387...147,749,938
Ensembl chr 2:147,748,791...147,755,549 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    chemical entity 20839
      chemical substance 14568
        mixture 13884
          racemate 12274
            mevalonolactone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbon oxoacid 19142
                                    carboxylic acid 19139
                                      monocarboxylic acid 18291
                                        fatty acid 16980
                                          saturated fatty acid 16678
                                            straight-chain saturated fatty acid 16191
                                              valeric acid 14566
                                                3,5-dihydroxy-3-methylpentanoic acid 116
                                                  (R)-mevalonic acid 116
                                                    mevalonic acid 116
                                                      mevalonolactone 4
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