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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:19363 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups.
Synonyms:exact_synonym: 2,5-bis(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione
 related_synonym: 2,5,-bis(ethyleneimine)-1,4-benzoquinone;   2,5,-bisethylene-imine-1,4-benzoquinone;   2,5-Bisaethyleniminobenzochinon-1,4;   2,5-bis(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione;   2,5-bis(1-aziridinyl)-p-benzoquinone;   2,5-bis(1-aziridynyl)benzoquinone;   2,5-bis(aziridino)-1,4-benzoquinone;   2,5-bis(aziridino)benzoquinone;   2,5-bis(ethyleneimino)-1,4-benzoquinone;   2,5-bis-ethyleniminobenzoquinone;   2,5-bisethyleneiminebenzoquinone;   2,5-di(ethyleneimino)-1,4-benzoquinone;   2,5-diaziridinyl-1,4-benzoquinone;   3,6-diaziridinyl-1,4-benzoquinone;   DZQ;   Formula=C10H10N2O2;   InChI=1S/C10H10N2O2/c13-9-6-8(12-3-4-12)10(14)5-7(9)11-1-2-11/h5-6H,1-4H2;   InChIKey=RCWJMKCTHJPXJV-UHFFFAOYSA-N;   SMILES=O=C1C=C(N2CC2)C(=O)C=C1N1CC1;   TW 13;   ethylenimine quinone
 xref: Beilstein:169182;   CAS:526-62-5
 xref_mesh: MESH:C009970
 xref: PMID:10373575;   PMID:10978162;   PMID:11211879;   PMID:13415397;   PMID:17094478;   PMID:1751490;   PMID:8137269;   PMID:8461296;   PMID:9690517;   Reaxys:169182

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2,5-bis(aziridin-1-yl)-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein
CTD PMID:8943236 PMID:9343371 PMID:9586815 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        aetiopathogenetic role 19006
          genotoxin 17042
            mutagen 16861
              2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      ketone 16216
                                        cyclic ketone 13930
                                          quinone 8386
                                            benzoquinones 722
                                              1,4-benzoquinones 718
                                                2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
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