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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:19363 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups.
Synonyms:exact_synonym: 2,5-bis(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione
 related_synonym: 2,5,-bis(ethyleneimine)-1,4-benzoquinone;   2,5,-bisethylene-imine-1,4-benzoquinone;   2,5-Bisaethyleniminobenzochinon-1,4;   2,5-bis(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione;   2,5-bis(1-aziridinyl)-p-benzoquinone;   2,5-bis(1-aziridynyl)benzoquinone;   2,5-bis(aziridino)-1,4-benzoquinone;   2,5-bis(aziridino)benzoquinone;   2,5-bis(ethyleneimino)-1,4-benzoquinone;   2,5-bis-ethyleniminobenzoquinone;   2,5-bisethyleneiminebenzoquinone;   2,5-di(ethyleneimino)-1,4-benzoquinone;   2,5-diaziridinyl-1,4-benzoquinone;   3,6-diaziridinyl-1,4-benzoquinone;   DZQ;   Formula=C10H10N2O2;   InChI=1S/C10H10N2O2/c13-9-6-8(12-3-4-12)10(14)5-7(9)11-1-2-11/h5-6H,1-4H2;   InChIKey=RCWJMKCTHJPXJV-UHFFFAOYSA-N;   SMILES=O=C1C=C(N2CC2)C(=O)C=C1N1CC1;   TW 13;   ethylenimine quinone
 xref: Beilstein:169182;   CAS:526-62-5
 xref_mesh: MESH:C009970
 xref: PMID:10373575;   PMID:10978162;   PMID:11211879;   PMID:13415397;   PMID:17094478;   PMID:1751490;   PMID:8137269;   PMID:8461296;   PMID:9690517;   Reaxys:169182

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2,5-bis(aziridin-1-yl)-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein
CTD PMID:8943236 PMID:9343371 PMID:9586815 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        aetiopathogenetic role 19027
          genotoxin 17464
            mutagen 17366
              2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      ketone 16957
                                        cyclic ketone 15522
                                          quinone 8385
                                            benzoquinones 740
                                              1,4-benzoquinones 736
                                                2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
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