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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:193597 term browser browse the term
Definition:A qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals.
Synonyms:exact_synonym: 1-{4-[(7Sa)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl}prop-2-en-1-one
 related_synonym: (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one;   1-[4-[(7S)-6-chloro-8-fluoro-7-[(1S)-2-fluoro-6-hydroxyphenyl]-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one;   Formula=C21H17ClF2N4O2;   InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2;   InChIKey=ZRPZPNYZFSJUPA-UHFFFAOYSA-N;   SMILES=OC1=CC=CC(F)=C1C1=C(F)C2=NC=NC(N3CCN(CC3)C(=O)C=C)=C2C=C1Cl
 xref_mesh: MESH:C000629713
 xref: PDBeChem:91S;   PMID:35158284;   PMID:35281897;   PMID:36099883

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ARS-1620 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ARS-1620 results in decreased phosphorylation of AKT1 protein CTD PMID:31332011 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects binding ISO ARS-1620 binds to KRAS protein mutant form CTD PMID:31666701 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO ARS-1620 results in decreased phosphorylation of MAPK1 protein CTD PMID:31332011 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ARS-1620 results in decreased phosphorylation of MAPK3 protein CTD PMID:31332011 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link

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  CHEBI ontology 19911
    role 19887
      biological role 19885
        inhibitor 18944
          ARS-1620 4
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  CHEBI ontology 19911
    subatomic particle 19909
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                        carbon atom 19799
                          organic molecular entity 19799
                            organic molecule 19753
                              organic cyclic compound 19558
                                organic heterocyclic compound 18901
                                  organic heteropolycyclic compound 18324
                                    organic heterobicyclic compound 17260
                                      quinazolines 536
                                        ARS-1620 4
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