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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7,8-Diacetoxy-4-methylcoumarin
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Accession:CHEBI:193139 term browser browse the term
Definition:This compound is 4-methyl coumarin with two acetoxy groups in the benzoid ring at positions ortho to each other, has been shown to have very strong antioxidant and radical scavenging properties.
Synonyms:exact_synonym: (8-acetyloxy-4-methyl-2-oxochromen-7-yl) acetate
 related_synonym: DAMC;   NSC688794;   Oprea1_472625
 xref: CAS:68454-15-9
 xref_mesh: MESH:C114369
 xref: PMID:19061872;   PMID:23059821


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7,8-Diacetoxy-4-methylcoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of BCL2L1 protein CTD PMID:19061872 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Calr calreticulin increases activity
multiple interactions		 ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CALR protein
7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein]		 CTD PMID:20188080 PMID:24103856 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp3 caspase 3 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP3 protein CTD PMID:19061872 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP9 protein CTD PMID:19061872 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 7,8-diacetoxy-4-methylcoumarin affects the localization of CYCS protein CTD PMID:19061872 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein] CTD PMID:24103856 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS2 CTD PMID:24103856 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS3 CTD PMID:24103856 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of PTGS2 protein CTD PMID:19061872 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO DAMTC decreases expression of RAC1 protein in non-small cell lung cancer cells RGD PMID:23059821 RGD:155791641 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TP53 protein CTD PMID:19061872 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 increases activity
increases expression		 ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of TXN protein
7,8-diacetoxy-4-methylcoumarin results in increased expression of TXN mRNA		 CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of TXNIP mRNA CTD PMID:24103856 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TXNRD1 mRNA CTD PMID:24103856 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA mRNA; 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    chemical entity 19816
      atom 19816
        nonmetal atom 19749
          carbon atom 19698
            organic molecular entity 19698
              7,8-Diacetoxy-4-methylcoumarin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            7,8-Diacetoxy-4-methylcoumarin 17
paths to the root