Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7,8-diacetoxy-4-methylcoumarin
go back to main search page
Accession:CHEBI:193139 term browser browse the term
Definition:A coumarin substituted by a methyl group at position 4 and by acetyloxy groups at positions 7 and 8. It exhibits strong antioxidant and radical scavenging properties.
Synonyms:exact_synonym: 4-methyl-2-oxo-2H-chromene-7,8-diyl diacetate
 related_synonym: (8-acetyloxy-4-methyl-2-oxochromen-7-yl) acetate;   4-methyl-2-oxo-2H-1-benzopyran-7,8-diyl diacetate;   7,8-dihydroxy-4-methylcoumarin diacetate;   DAMC;   DAMTC;   Formula=C14H12O6;   InChI=1S/C14H12O6/c1-7-6-12(17)20-13-10(7)4-5-11(18-8(2)15)14(13)19-9(3)16/h4-6H,1-3H3;   InChIKey=BENRIKOGQFXSRY-UHFFFAOYSA-N;   SMILES=CC(=O)OC1=C(OC(C)=O)C2=C(C=C1)C(C)=CC(=O)O2
 xref: CAS:68454-15-9
 xref_mesh: MESH:C114369
 xref: PMID:10218830;   PMID:10530959;   PMID:10968282;   PMID:11969347;   PMID:19061872;   PMID:23059821;   PMID:24103856;   PMID:25547104;   PMID:27849061;   PMID:28406076;   PMID:31186684;   PMID:31575959;   PMID:35968883;   PMID:9681149;   PMID:9839019



show annotations for term's descendants           Sort by:
7,8-diacetoxy-4-methylcoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of BCL2L1 protein CTD PMID:19061872 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Calr calreticulin increases activity
multiple interactions
ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CALR protein
7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein]
CTD PMID:20188080 PMID:24103856 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp3 caspase 3 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP3 protein CTD PMID:19061872 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP9 protein CTD PMID:19061872 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 7,8-diacetoxy-4-methylcoumarin affects the localization of CYCS protein CTD PMID:19061872 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein] CTD PMID:24103856 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS2 CTD PMID:24103856 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS3 CTD PMID:24103856 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of PTGS2 protein CTD PMID:19061872 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO DAMTC decreases expression of RAC1 protein in non-small cell lung cancer cells RGD PMID:23059821 RGD:155791641 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TP53 protein CTD PMID:19061872 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txn1 thioredoxin 1 increases activity
increases expression
ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of TXN protein
7,8-diacetoxy-4-methylcoumarin results in increased expression of TXN mRNA
CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of TXNIP mRNA CTD PMID:24103856 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TXNRD1 mRNA CTD PMID:24103856 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA mRNA; 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      chemical role 19462
        antioxidant 16162
          radical scavenger 6683
            7,8-diacetoxy-4-methylcoumarin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            organic molecule 19692
                              organic cyclic compound 19503
                                organic heterocyclic compound 18875
                                  oxacycle 17892
                                    benzopyran 11975
                                      1-benzopyran 11728
                                        chromenes 4431
                                          chromenone 4375
                                            coumarins 4148
                                              hydroxycoumarin 357
                                                7,8-dihydroxy-4-methyl-1-benzopyran-2-one 17
                                                  7,8-diacetoxy-4-methylcoumarin 17
paths to the root