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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl
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Accession:CHEBI:193138 term browser browse the term
Definition:A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 4, 4', and 5 and a methoxy groups at positions 3 and 3'. It is isolated from Dendrobium ellipsophyllum and sensitizes lung cancer cells to anoikis.
Synonyms:exact_synonym: 5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-3-methoxybenzene-1,2-diol
 related_synonym: 3',5-dimethoxybibenzyl-3,4,4'-triol;   Formula=C16H18O5;   InChI=1S/C16H18O5/c1-20-14-8-10(5-6-12(14)17)3-4-11-7-13(18)16(19)15(9-11)21-2/h5-9,17-19H,3-4H2,1-2H3;   InChIKey=DAQVNMKZMKBKOF-UHFFFAOYSA-N;   SMILES=COC1=CC(CCC2=CC(OC)=C(O)C(O)=C2)=CC=C1O;   TDB
 xref: PMID:21812336;   PMID:24692728;   PMID:26109451;   PMID:29488156;   PMID:33562174;   PMID:34349823;   PMID:35679136;   PMID:36094346


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4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 decreases activity ISO TDB decreases activity of RAC1 protein in lung cancer cells RGD PMID:26109451 RGD:155791640 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
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  CHEBI ontology 19909
    role 19880
      application 19720
        pharmaceutical 19558
          drug 19558
            antineoplastic agent 17846
              4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl 1
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  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic aromatic compound 19395
                                  phenols 18705
                                    benzenediols 9174
                                      catechols 3444
                                        4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl 1
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