Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl
go back to main search page
Accession:CHEBI:193138 term browser browse the term
Definition:A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 4, 4', and 5 and a methoxy groups at positions 3 and 3'. It is isolated from Dendrobium ellipsophyllum and sensitizes lung cancer cells to anoikis.
Synonyms:exact_synonym: 5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-3-methoxybenzene-1,2-diol
 related_synonym: 3',5-dimethoxybibenzyl-3,4,4'-triol;   Formula=C16H18O5;   InChI=1S/C16H18O5/c1-20-14-8-10(5-6-12(14)17)3-4-11-7-13(18)16(19)15(9-11)21-2/h5-9,17-19H,3-4H2,1-2H3;   InChIKey=DAQVNMKZMKBKOF-UHFFFAOYSA-N;   SMILES=COC1=CC(CCC2=CC(OC)=C(O)C(O)=C2)=CC=C1O;   TDB
 xref: PMID:21812336;   PMID:24692728;   PMID:26109451;   PMID:29488156;   PMID:33562174;   PMID:34349823;   PMID:35679136;   PMID:36094346



show annotations for term's descendants           Sort by:
4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 decreases activity ISO TDB decreases activity of RAC1 protein in lung cancer cells RGD PMID:26109451 RGD:155791640 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      application 19652
        pharmaceutical 19462
          drug 19493
            antineoplastic agent 17761
              4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    p-block element atom 19780
                      carbon group element atom 19728
                        carbon atom 19725
                          organic molecular entity 19725
                            organic molecule 19678
                              organic cyclic compound 19491
                                organic aromatic compound 19331
                                  phenols 18634
                                    benzenediols 9130
                                      catechols 3377
                                        4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl 1
paths to the root