Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lobaplatin
go back to main search page
Accession:CHEBI:192744 term browser browse the term
Definition:A 1:1 diastereomeric mixture comprising of R,R,S and S,S,S configuration of platinum(II) complexes with 1,2-bis(aminomethyl)cyclobutane as the carrier ligand and lactate as the leaving group. It is a third-generation platinum anticancer drug approved in China for the treatment of chronic myelogenous leukaemia, inoperable metastatic breast cancer and small cell lung cancer.
Synonyms:related_synonym: 1,2-diamino-methylcyclobutane platinum(II) lactate;   D-19466;   D19466;   [2-hydroxypropanoato(2-)-O1,O2][1,2-cyclobutanedimethanamine-N,N']platinum(II);   lobaplatine;   lobaplatino;   lobaplatinum
 xref: CAS:135558-11-1;   DrugBank:DB13049;   PMCID:PMC7750111;   PMID:14584968;   PMID:2229133;   PMID:25516654;   PMID:31876741;   PMID:32413426;   PMID:32582992;   PMID:32636676;   PMID:33262658;   PMID:33469307;   PMID:33613708;   PMID:33791202;   PMID:34282830;   PMID:34306603;   PMID:34430592;   PMID:34589419;   PMID:34666646;   PMID:34746003;   PMID:34837558;   PMID:34853650;   PMID:35025294;   PMID:35164703;   PMID:35211587;   PMID:35575667;   PMID:35648285;   PMID:35652401;   PMID:35719323;   PMID:35722417;   PMID:35769355;   PMID:35794989;   PMID:36119883;   PMID:36186198;   PMID:36221355;   PMID:36247269;   PMID:36330235;   PMID:36626436;   PMID:36714400;   PMID:36727741;   PMID:36741012;   Wikipedia:Lobaplatin


show annotations for term's descendants           Sort by:
lobaplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 increases degradation ISO Lobaplatin increases degradation of BIRC2 protein in human nasopharyngeal carcinoma cells RGD PMID:32413426 RGD:155226873 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases degradation ISO Lobaplatin increases degradation of BIRC3 protein in human nasopharyngeal carcinoma cells RGD PMID:32413426 RGD:155226873 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        reagent 18447
          cross-linking reagent 7589
            lobaplatin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic ion 11559
                              organic anion 6933
                                carboxylic acid anion 2620
                                  monocarboxylic acid anion 1741
                                    fatty acid anion 203
                                      short-chain fatty acid anion 203
                                        fatty acid anion 3:0 91
                                          propionate 91
                                            lactate 67
                                              (S)-lactate 2
                                                (R,R,S)-lobaplatin 2
                                                  lobaplatin 2
paths to the root