Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:LY 379268
go back to main search page
Accession:CHEBI:192545 term browser browse the term
Definition:An organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.
Synonyms:exact_synonym: (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
 related_synonym: Formula=C7H9NO5;   InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1;   InChIKey=YASVRZWVUGJELU-MDASVERJSA-N;   LY-379,268;   LY379268;   SMILES=[H][C@@]12OC[C@@](N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O
 xref: CAS:191471-52-0
 xref_mesh: MESH:C118218
 xref: PMID:10090786;   PMID:21139059;   PMID:21477044;   PMID:22659409;   PMID:22820300;   PMID:23593498;   PMID:23624743;   PMID:23769742;   PMID:23827202;   PMID:23948211;   PMID:23953655;   PMID:24631484;   PMID:24859609;   PMID:25063582;   PMID:25158962;   PMID:26044619;   PMID:26149611;   PMID:26241341;   PMID:26317098;   PMID:26861891;   PMID:26955838;   PMID:27394931;   PMID:29462112;   PMID:29562588;   PMID:29858599;   PMID:30909243;   PMID:31306647;   PMID:31536785;   PMID:31580222;   PMID:31705165;   PMID:33763176;   PMID:34330748;   PMID:34416343;   PMID:35772967;   Wikipedia:LY-379\,268

show annotations for term's descendants           Sort by:
LY 379268 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP LY 379268 inhibits the reaction [bisphenol A results in decreased expression of NR3C1 mRNA] CTD PMID:25812946 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        pharmacological role 19031
          agonist 18571
            metabotropic glutamate receptor agonist 3
              LY 379268 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        amino acid 15540
                                          amino dicarboxylic acid 51
                                            LY 379268 1
paths to the root