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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Cirsimarin
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Accession:CHEBI:192417 term browser browse the term
Synonyms:exact_synonym: 5-hydroxy-6,7-dimethoxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one
 related_synonym: Formula=C23H24O11;   InChI=1S/C23H24O11/c1-30-15-8-14-17(19(27)22(15)31-2)12(25)7-13(33-14)10-3-5-11(6-4-10)32-23-21(29)20(28)18(26)16(9-24)34-23/h3-8,16,18,20-21,23-24,26-29H,9H2,1-2H3/t16-,18-,20+,21-,23-/m1/s1;   InChIKey=RETJLKUBHXTIGH-FZFRBNDOSA-N;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=C(C=C2)C=3OC=4C(C(=O)C3)=C(O)C(OC)=C(OC)C4)CO
 xref: CAS:13020-19-4;   Chemspider:140227
 xref_mesh: MESH:C107783


show annotations for term's descendants           Sort by:
Cirsimarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO cirsimarin results in decreased expression of BAX mRNA CTD PMID:35710092 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cirsimarin results in decreased expression of BCL2L1 mRNA CTD PMID:35710092 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO cirsimarin results in decreased expression of BIRC5 mRNA CTD PMID:35710092 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp9 caspase 9 decreases expression ISO cirsimarin results in decreased expression of CASP9 mRNA CTD PMID:35710092 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cirsimarin results in decreased expression of CCNA2 mRNA CTD PMID:35710092 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO cirsimarin results in decreased expression of CCND1 mRNA CTD PMID:35710092 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO cirsimarin results in decreased expression of CCR5 mRNA CTD PMID:35710092 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO cirsimarin results in decreased expression of CDH1 mRNA CTD PMID:35710092 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO cirsimarin results in decreased expression of CDK2 mRNA CTD PMID:35710092 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO cirsimarin results in decreased expression of CDK4 mRNA CTD PMID:35710092 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 mRNA] CTD PMID:30053449 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:30053449 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:30053449 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein] CTD PMID:30053449 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein] CTD PMID:30053449 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression ISO cirsimarin results in decreased expression of MMP11 mRNA CTD PMID:35710092 NCBI chr20:12,730,284...12,739,067
Ensembl chr20:12,730,277...12,739,290 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO cirsimarin results in decreased expression of MMP9 mRNA CTD PMID:35710092 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:30053449 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:30053449 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:30053449 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:30053449 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
cirsimarin results in decreased expression of TNF mRNA 		CTD PMID:30053449 PMID:35710092 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO cirsimarin results in decreased expression of TP53 mRNA CTD PMID:35710092 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          oxygen atom 20457
            oxygen molecular entity 20457
              flavonoids 12082
                Cirsimarin 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbohydrates and carbohydrate derivatives 15487
                                    carbohydrate 15487
                                      carbohydrate derivative 14459
                                        glycosyl compound 13167
                                          glycoside 11941
                                            Cirsimarin 23
paths to the root