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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1H-pyrrole
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Accession:CHEBI:19203 term browser browse the term
Definition:A tautomer of pyrrole that has the double bonds at positions 2 and 4.
Synonyms:related_synonym: 1-aza-2,4-cyclopentadiene;   Formula=C4H5N;   InChI=1S/C4H5N/c1-2-4-5-3-1/h1-5H;   InChIKey=KAESVJOAVNADME-UHFFFAOYSA-N;   Pyrrol;   SMILES=c1cc[nH]c1;   divinyleneimine;   divinylenimine;   imidole;   monopyrrole;   pyrrole
 xref: Beilstein:1159;   CAS:109-97-7;   Gmelin:1705;   PMID:1556177;   PMID:2917974
 cyclic_relationship: is_tautomer_of CHEBI:35557;   is_tautomer_of CHEBI:35558


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maleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 multiple interactions EXP maleimide analog binds to and results in increased activity of TP53 protein mutant form CTD PMID:15998635 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 affects activity
multiple interactions
EXP Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ALB albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions
increases glutathionylation
EXP Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:57,646,426...57,803,822
Ensembl chr18:57,646,426...57,803,315
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHAT choline O-acetyltransferase decreases activity ISO Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G DUSP23 dual specificity phosphatase 23 multiple interactions EXP Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:159,780,962...159,782,543
Ensembl chr 1:159,780,932...159,782,543
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G GAD1 glutamate decarboxylase 1 decreases activity EXP Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GAD2 glutamate decarboxylase 2 decreases activity EXP Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
JBrowse link
G HOXB13 homeobox B13 increases response to substance EXP HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr17:48,724,763...48,728,750
Ensembl chr17:48,724,763...48,728,750
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr16:67,431,121...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MT3 metallothionein 3 increases alkylation EXP Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G PAH phenylalanine hydroxylase multiple interactions ISO Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G SENP1 SUMO specific peptidase 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr12:48,042,893...48,106,308
Ensembl chr12:48,042,897...48,106,079
JBrowse link
G SENP6 SUMO specific peptidase 6 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 6:75,601,864...75,718,281
Ensembl chr 6:75,601,509...75,718,281
JBrowse link
G SLC12A5 solute carrier family 12 member 5 increases activity
multiple interactions
EXP Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr20:46,021,686...46,060,150
Ensembl chr20:46,021,690...46,060,150
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO
EXP
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SUMO2 small ubiquitin like modifier 2 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr17:75,165,586...75,182,959
Ensembl chr17:75,165,586...75,182,959
JBrowse link
G TF transferrin decreases uptake ISO Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VDAC1 voltage dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr 5:133,971,871...134,070,987
Ensembl chr 5:133,971,871...134,004,975
JBrowse link
Ro 31-8220 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
EXP Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]
Ro 31-8220 results in decreased expression of ABCA1 mRNA
CTD PMID:15037193 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein] CTD PMID:22001173 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
EXP
ISO
Ro 31-8220 results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:17561261 PMID:18054255 PMID:22001173 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP Ro 31-8220 results in increased activity of CASP8 protein CTD PMID:18054255 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions ISO Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein] CTD PMID:22001173 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CD38 CD38 molecule multiple interactions EXP Ro 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA] CTD PMID:21393419 NCBI chr 4:15,778,328...15,853,232
Ensembl chr 4:15,778,275...15,853,232
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]
Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]
CTD PMID:15522277 PMID:16280361 PMID:22138297 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Ro 31-8220 inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA] CTD PMID:17000667 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DPP3 dipeptidyl peptidase 3 multiple interactions EXP Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr11:66,480,434...66,509,657
Ensembl chr11:66,480,013...66,509,657
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein] CTD PMID:12169099 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGF epidermal growth factor multiple interactions ISO Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 PMID:16877402 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G FCER1A Fc fragment of IgE receptor Ia multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr 1:159,283,575...159,308,202
Ensembl chr 1:159,289,714...159,308,224
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Ro 31-8220 results in decreased expression of FOS mRNA
CTD PMID:11353138 PMID:11568973 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions EXP Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GRP gastrin releasing peptide multiple interactions EXP Ro 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:59,219,188...59,230,771
Ensembl chr18:59,220,158...59,230,774
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases activity EXP Ro 31-8220 results in decreased activity of GSK3B protein CTD PMID:10998351 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18048804 PMID:18357586 PMID:26275128 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HRH1 histamine receptor H1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] CTD PMID:18360087 NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
JBrowse link
G IL11 interleukin 11 multiple interactions EXP Ro 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10712238 PMID:11854442 PMID:18054255 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA] CTD PMID:16818790 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Ro 31-8220 results in decreased expression of JUN mRNA
Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:11353138 PMID:11568973 PMID:12169099 PMID:19002563 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] CTD PMID:11756236 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK9 protein] CTD PMID:11756236 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MAPT microtubule associated protein tau multiple interactions EXP Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein] CTD PMID:12605413 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MT1X metallothionein 1X decreases expression
multiple interactions
ISO Ro 31-8220 results in decreased expression of MT1 mRNA
Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
CTD PMID:11551972 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein] CTD PMID:32416088 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NTS neurotensin increases activity
multiple interactions
EXP Ro 31-8220 results in increased activity of NTS protein
Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]
CTD PMID:18313772 NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992
JBrowse link
G PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A multiple interactions ISO Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr19:38,251,237...38,256,374
Ensembl chr19:38,251,237...38,256,532
JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein] CTD PMID:32416088 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PRKCG protein kinase C gamma multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr19:53,882,197...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link
G PRKCI protein kinase C iota decreases activity ISO Ro 31-8220 results in decreased activity of PRKCI protein CTD PMID:14511371 NCBI chr 3:170,222,424...170,305,981
Ensembl chr 3:170,222,424...170,305,977
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Ro 31-8220 inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]
Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]
CTD PMID:11854442 PMID:19576865 PMID:32416088 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RHOA ras homolog family member A multiple interactions ISO Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form] CTD PMID:18986333 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998
JBrowse link
G RNF187 ring finger protein 187 multiple interactions
decreases stability
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ro 31-8220 results in decreased stability of RNF187 protein] CTD PMID:25851810 NCBI chr 1:228,487,382...228,496,188
Ensembl chr 1:228,487,382...228,496,188
JBrowse link
G RPS6KA5 ribosomal protein S6 kinase A5 decreases activity ISO Ro 31-8220 results in decreased activity of RPS6KA5 protein CTD PMID:15522277 NCBI chr14:90,847,861...91,060,641
Ensembl chr14:90,847,861...91,060,641
JBrowse link
G SCARB1 scavenger receptor class B member 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA] CTD PMID:15037193 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SFTPB surfactant protein B multiple interactions ISO Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein] CTD PMID:11704537 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SFTPC surfactant protein C multiple interactions ISO Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein] CTD PMID:11704537 NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions EXP Ro 31-8220 inhibits the reaction [decitabine results in increased expression of TNFSF10 protein] CTD PMID:17283156 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO Ro 31-8220 results in decreased expression of VEGFA mRNA CTD PMID:12590138 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24839
    role 24759
      application 23907
        refrigerant 19276
          ammonia 18832
            organic amino compound 18832
              amine 7965
                secondary amine 1707
                  1H-pyrrole 78
                    1H-pyrrolediyl group + 0
                    maleimide + 78
Path 2
Term Annotations click to browse term
  CHEBI ontology 24839
    subatomic particle 24800
      composite particle 24800
        hadron 24800
          baryon 24800
            nucleon 24800
              atomic nucleus 24800
                atom 24800
                  main group element atom 24668
                    main group molecular entity 24668
                      s-block molecular entity 23987
                        hydrogen molecular entity 23827
                          hydrides 22066
                            inorganic hydride 19441
                              pnictogen hydride 19418
                                nitrogen hydride 19142
                                  azane 18833
                                    ammonia 18832
                                      organic amino compound 18832
                                        amine 7965
                                          secondary amine 1707
                                            1H-pyrrole 78
                                              1H-pyrrolediyl group + 0
                                              maleimide + 78
paths to the root