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Term:4-methylumbelliferone beta-D-glucuronide
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Accession:CHEBI:1904 term browser browse the term
Definition:A beta-D-glucosiduronic acid having a 4-methylumbelliferyl substituent at the anomeric position. A hyaluronan synthesis inhibitor, it is anti-tumourigenic for various malignant tumours.
Synonyms:exact_synonym: 4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid
 related_synonym: 4-MUG;   4-Methylumbelliferone glucuronide;   4-Methylumbelliferyl beta-glucuronide;   4-Methylumbelliferyl glucuronide;   Formula=C16H16O9;   InChI=1S/C16H16O9/c1-6-4-10(17)24-9-5-7(2-3-8(6)9)23-16-13(20)11(18)12(19)14(25-16)15(21)22/h2-5,11-14,16,18-20H,1H3,(H,21,22)/t11-,12-,13+,14-,16+/m0/s1;   InChIKey=ARQXEQLMMNGFDU-JHZZJYKESA-N;   SMILES=O([C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(=O)O)C2=CC3=C(C(=CC(O3)=O)C)C=C2
 xref: CAS:6160-80-1;   KEGG:C11584
 xref_mesh: MESH:C034888
 xref: PMID:21401602;   PMID:21512263;   PMID:27218304;   PMID:27833847;   PMID:28054956;   PMID:28116598;   PMID:28479734;   PMID:29846918;   PMID:30914479;   Reaxys:53625
 cyclic_relationship: is_conjugate_acid_of CHEBI:144582

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4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:6480464
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:6480464
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6480464
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 JBrowse link 14 22,597,103 22,619,968 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      biological role 19726
        inhibitor 18175
          hyaluronan synthesis inhibitor 6
            4-methylumbelliferone beta-D-glucuronide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic molecule 19472
                              organic cyclic compound 19236
                                organic heterocyclic compound 18361
                                  oxacycle 17134
                                    benzopyran 9494
                                      1-benzopyran 9190
                                        chromenes 925
                                          chromenone 843
                                            coumarins 563
                                              hydroxycoumarin 300
                                                umbelliferone 79
                                                  4-methylumbelliferone 24
                                                    4-methylumbelliferone beta-D-glucuronide 6
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.