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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,3-dichloropropan-2-ol
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Accession:CHEBI:18917 term browser browse the term
Definition:A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose.
Synonyms:related_synonym: 1,3-DCP;   1,3-Dichloro-2-propanol;   1,3-dichloro-1,3-dideoxyglycerol;   1,3-dichloro-2-hydroxypropane;   1,3-dichlorohydrin;   1,3-dichloroisopropanol;   1,3-dichloroisopropyl alcohol;   2-chloro-1-(chloromethyl)ethanol;   Formula=C3H6Cl2O;   HOCH(CH2Cl)2;   InChI=1S/C3H6Cl2O/c4-1-3(6)2-5/h3,6H,1-2H2;   InChIKey=DEWLEGDTCGBNGU-UHFFFAOYSA-N;   SMILES=OC(CCl)CCl;   alpha,gamma-dichlorohydrin;   alpha-dichlorohydrin;   glycerol 1,3-dichlorohydrin;   sym-dichloroisopropyl alcohol;   sym-glycerol dichlorohydrin
 alt_id: CHEBI:34059
 xref: CAS:96-23-1;   KEGG:C14399
 xref_mesh: MESH:C033489
 xref: PMID:12110283;   PMID:17524555;   PMID:19047007;   PMID:19731046;   PMID:20113855;   Patent:RU2263656;   Reaxys:1732063;   UM-BBD_compID:c0018


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1,3-dichloropropan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of ACACA protein] CTD PMID:30092300 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of ACSL4 protein
[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein]; ferrostatin-1 inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein]		 CTD PMID:35870111 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of AKT1 protein] CTD PMID:33581215 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of BAX protein]		 CTD PMID:29248572 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of BCL2 protein] CTD PMID:29248572 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 multiple interactions
decreases expression		 ISO BMAL1 protein inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of and results in decreased localization of PNPLA2 protein]; BMAL1 protein inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of PPARA protein]
1,3-dichloro-2-propanol results in decreased expression of BMAL1 protein		 CTD PMID:36805544 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions		 EXP
ISO		 1,3-dichloro-2-propanol results in increased expression of CASP3 protein
1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein]		 CTD PMID:26143167 PMID:29248572 PMID:34269859 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity EXP 1,3-dichloro-2-propanol results in decreased activity of CAT protein CTD PMID:26143167 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccna2 cyclin A2 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of CCNA2 mRNA CTD PMID:34269859 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of CCNB1 mRNA CTD PMID:34269859 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of CCNE1 mRNA CTD PMID:34269859 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd36 CD36 molecule increases expression ISO 1,3-dichloro-2-propanol results in increased expression of CD36 protein CTD PMID:24333398 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Clock clock circadian regulator decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of CLOCK protein CTD PMID:36805544 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of CNOT2 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CNOT2 protein]		 CTD PMID:30092300 NCBI chr 7:52,130,445...52,222,338
Ensembl chr 7:52,130,441...52,223,575 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased phosphorylation of CREB1 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of CREB1 protein]		 CTD PMID:30092300 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctsd cathepsin D decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of CTSD protein CTD PMID:33581215 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CYCS protein] CTD PMID:29248572 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of CYP11A1 mRNA CTD PMID:24518350 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of FASN protein
1,3-dichloro-2-propanol results in increased expression of FASN mRNA; 1,3-dichloro-2-propanol results in increased expression of FASN protein
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein]		 CTD PMID:24333398 PMID:29305303 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased expression of FTH1 protein
[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of FTH1 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of FTH1 protein]		 CTD PMID:35870111 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GCLC mRNA CTD PMID:26143167 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GCLM mRNA CTD PMID:26143167 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 ISO epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of GPT protein] CTD PMID:30092300 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased expression of GPX4 protein
[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]		 CTD PMID:35870111 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP 1,3-dichloro-2-propanol results in decreased activity of GSR protein CTD PMID:26143167 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GSTP1 mRNA; 1,3-dichloro-2-propanol results in increased expression of GSTP1 protein CTD PMID:34269859 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA; 1,3-dichloro-2-propanol results in increased expression of HMGCR protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]		 CTD PMID:24333398 PMID:29305303 PMID:30092300 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
decreases expression		 EXP
ISO		 1,3-dichloro-2-propanol results in increased expression of HMOX1 mRNA
[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]		 CTD PMID:26143167 PMID:35870111 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of IL1B protein CTD PMID:29248572 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of IL6 protein CTD PMID:29248572 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of LAMP1 protein CTD PMID:33581215 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases secretion		 EXP Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased secretion of LDHA protein]; GSK872 inhibits the reaction [1,3-dichloro-2-propanol results in increased secretion of LDHA protein]; RIPK3 protein promotes the reaction [1,3-dichloro-2-propanol results in increased secretion of LDHA protein] CTD PMID:36000575 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of MAP1LC3A protein CTD PMID:36000575 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of MAP1LC3B protein CTD PMID:36000575 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions		 EXP
ISO		 1,3-dichloro-2-propanol results in increased phosphorylation of MAPK1 protein
1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:26143167 PMID:29248572 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation		 EXP
ISO		 1,3-dichloro-2-propanol results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:26143167 PMID:29248572 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP
ISO		 1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein]		 CTD PMID:26143167 PMID:29248572 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 EXP
ISO		 1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein]		 CTD PMID:26143167 PMID:29248572 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of MKI67 protein CTD PMID:34269859 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression
multiple interactions		 EXP
ISO		 1,3-dichloro-2-propanol results in increased expression of MLKL protein
1,3-dichloro-2-propanol results in increased expression of and results in increased phosphorylation of MLKL protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of MLKL protein]; GSK872 inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of MLKL protein]; RIPK3 protein promotes the reaction [1,3-dichloro-2-propanol results in increased expression of MLKL protein]		 CTD PMID:36000575 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MTOR protein]		 CTD PMID:33581215 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
decreases expression
multiple interactions
affects binding		 EXP
ISO		 1,3-dichloro-2-propanol results in increased expression of NFE2L2 protein
1,3-dichloro-2-propanol results in decreased expression of NFE2L2 protein
Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of NFE2L2 protein]
1,3-dichloro-2-propanol binds to NFE2L2 protein		 CTD PMID:26143167 PMID:35870111 PMID:36000575 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of NOS2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of NOS2 protein]		 CTD PMID:29248572 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of NQO1 mRNA CTD PMID:26143167 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of NR1D1 protein CTD PMID:36805544 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of PARP1 protein] CTD PMID:29248572 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of PINK1 protein CTD PMID:36000575 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO 1,3-dichloro-2-propanol results in decreased expression of and results in decreased localization of PNPLA2 protein; BMAL1 protein inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of and results in decreased localization of PNPLA2 protein]; pirinixic acid inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of and results in decreased localization of PNPLA2 protein] CTD PMID:36805544 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased expression of PPARA protein
BMAL1 protein inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of PPARA protein]; pirinixic acid inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of PPARA protein]		 CTD PMID:24333398 PMID:36805544 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of PARK protein CTD PMID:36000575 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein] CTD PMID:29248572 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions
increases expression		 ISO
EXP		 1,3-dichloro-2-propanol results in increased expression of and results in increased phosphorylation of RIPK3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein]; GSK872 inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein]; RIPK3 protein promotes the reaction [1,3-dichloro-2-propanol results in increased expression of MLKL protein]; RIPK3 protein promotes the reaction [1,3-dichloro-2-propanol results in increased secretion of LDHA protein]		 CTD PMID:36000575 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein
[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein]		 CTD PMID:35870111 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein
[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein]		 CTD PMID:35870111 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of SQSTM1 protein CTD PMID:36000575 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA; 1,3-dichloro-2-propanol results in increased expression of SREBF1 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]		 CTD PMID:24333398 PMID:29305303 PMID:30092300 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression		 ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]
1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA; 1,3-dichloro-2-propanol results in increased expression of SREBF2 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]		 CTD PMID:29305303 PMID:30092300 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of STAR mRNA; 1,3-dichloro-2-propanol results in decreased expression of STAR protein CTD PMID:24518350 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stk11 serine/threonine kinase 11 decreases expression
multiple interactions		 ISO 1,3-dichloro-2-propanol results in decreased expression of STK11 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of STK11 protein]		 CTD PMID:30092300 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of TNF protein CTD PMID:29248572 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        reagent 18051
          cross-linking reagent 7557
            1,3-dichloropropan-2-ol 60
              1,3-dichloroacetone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              organic hydroxy compound 18951
                                alcohol 15716
                                  secondary alcohol 7756
                                    1,3-dichloropropan-2-ol 60
                                      1,3-dichloroacetone 0
paths to the root