Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,3-dichloropropan-2-ol
go back to main search page
Accession:CHEBI:18917 term browser browse the term
Definition:A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose.
Synonyms:related_synonym: 1,3-DCP;   1,3-Dichloro-2-propanol;   1,3-dichloro-1,3-dideoxyglycerol;   1,3-dichloro-2-hydroxypropane;   1,3-dichlorohydrin;   1,3-dichloroisopropanol;   1,3-dichloroisopropyl alcohol;   2-chloro-1-(chloromethyl)ethanol;   Formula=C3H6Cl2O;   HOCH(CH2Cl)2;   InChI=1S/C3H6Cl2O/c4-1-3(6)2-5/h3,6H,1-2H2;   InChIKey=DEWLEGDTCGBNGU-UHFFFAOYSA-N;   SMILES=OC(CCl)CCl;   alpha,gamma-dichlorohydrin;   alpha-dichlorohydrin;   glycerol 1,3-dichlorohydrin;   sym-dichloroisopropyl alcohol;   sym-glycerol dichlorohydrin
 alt_id: CHEBI:34059
 xref: CAS:96-23-1;   KEGG:C14399
 xref_mesh: MESH:C033489
 xref: PMID:12110283;   PMID:17524555;   PMID:19047007;   PMID:19731046;   PMID:20113855;   Patent:RU2263656;   Reaxys:1732063;   UM-BBD_compID:c0018



show annotations for term's descendants           Sort by:
 
1,3-dichloropropan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases phosphorylation
ISO epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of ACACA protein] CTD PMID:30092300 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of AKT1 protein] CTD PMID:33581215 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of BAX protein]
CTD PMID:29248572 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of BCL2 protein] CTD PMID:29248572 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased expression of CASP3 protein
1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein]
CTD PMID:26143167 PMID:29248572 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity EXP 1,3-dichloro-2-propanol results in decreased activity of CAT protein CTD PMID:26143167 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd36 CD36 molecule increases expression ISO 1,3-dichloro-2-propanol results in increased expression of CD36 protein CTD PMID:24333398 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of CNOT2 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CNOT2 protein]
CTD PMID:30092300 NCBI chr 7:52,130,444...52,222,338
Ensembl chr 7:52,130,441...52,223,575
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO 1,3-dichloro-2-propanol results in decreased phosphorylation of CREB1 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of CREB1 protein]
CTD PMID:30092300 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Ctsd cathepsin D decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of CTSD protein CTD PMID:33581215 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CYCS protein] CTD PMID:29248572 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of CYP11A1 mRNA CTD PMID:24518350 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of FASN protein
1,3-dichloro-2-propanol results in increased expression of FASN mRNA; 1,3-dichloro-2-propanol results in increased expression of FASN protein
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein]
CTD PMID:24333398 PMID:29305303 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GCLC mRNA CTD PMID:26143167 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GCLM mRNA CTD PMID:26143167 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of GPT protein] CTD PMID:30092300 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP 1,3-dichloro-2-propanol results in decreased activity of GSR protein CTD PMID:26143167 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA; 1,3-dichloro-2-propanol results in increased expression of HMGCR protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
CTD PMID:24333398 PMID:29305303 PMID:30092300 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of HMOX1 mRNA CTD PMID:26143167 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of IL1B protein CTD PMID:29248572 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of IL6 protein CTD PMID:29248572 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of LAMP1 protein CTD PMID:33581215 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK1 protein
1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein]
CTD PMID:26143167 PMID:29248572 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK3 protein]
CTD PMID:26143167 PMID:29248572 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein]
CTD PMID:26143167 PMID:29248572 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein]
CTD PMID:26143167 PMID:29248572 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MTOR protein]
CTD PMID:33581215 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of NFE2L2 protein CTD PMID:26143167 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of NOS2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of NOS2 protein]
CTD PMID:29248572 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of NQO1 mRNA CTD PMID:26143167 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of PARP1 protein] CTD PMID:29248572 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of PPARA protein CTD PMID:24333398 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein] CTD PMID:29248572 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA; 1,3-dichloro-2-propanol results in increased expression of SREBF1 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]
CTD PMID:24333398 PMID:29305303 PMID:30092300 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression
ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]
1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA; 1,3-dichloro-2-propanol results in increased expression of SREBF2 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]
CTD PMID:29305303 PMID:30092300 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of STAR mRNA; 1,3-dichloro-2-propanol results in decreased expression of STAR protein CTD PMID:24518350 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stk11 serine/threonine kinase 11 decreases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in decreased expression of STK11 protein
epigallocatechin gallate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of STK11 protein]
CTD PMID:30092300 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of TNF protein CTD PMID:29248572 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        reagent 17476
          cross-linking reagent 7405
            1,3-dichloropropan-2-ol 38
              1,3-dichloroacetone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      chalcogen 19471
                        oxygen atom 19447
                          oxygen molecular entity 19447
                            hydroxides 19175
                              organic hydroxy compound 18666
                                alcohol 15089
                                  secondary alcohol 7313
                                    1,3-dichloropropan-2-ol 38
                                      1,3-dichloroacetone 0
paths to the root