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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,3-dichloropropan-2-ol
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Accession:CHEBI:18917 term browser browse the term
Definition:A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose.
Synonyms:related_synonym: 1,3-DCP;   1,3-Dichloro-2-propanol;   1,3-dichloro-1,3-dideoxyglycerol;   1,3-dichloro-2-hydroxypropane;   1,3-dichlorohydrin;   1,3-dichloroisopropanol;   1,3-dichloroisopropyl alcohol;   2-chloro-1-(chloromethyl)ethanol;   Formula=C3H6Cl2O;   HOCH(CH2Cl)2;   InChI=1S/C3H6Cl2O/c4-1-3(6)2-5/h3,6H,1-2H2;   InChIKey=DEWLEGDTCGBNGU-UHFFFAOYSA-N;   SMILES=OC(CCl)CCl;   alpha,gamma-dichlorohydrin;   alpha-dichlorohydrin;   glycerol 1,3-dichlorohydrin;   sym-dichloroisopropyl alcohol;   sym-glycerol dichlorohydrin
 alt_id: CHEBI:34059
 xref: CAS:96-23-1;   KEGG:C14399
 xref_mesh: MESH:C033489
 xref: PMID:12110283;   PMID:17524555;   PMID:19047007;   PMID:19731046;   PMID:20113855;   Patent:RU2263656;   Reaxys:1732063;   UM-BBD_compID:c0018


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1,3-dichloropropan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of BAX protein]
CTD PMID:29248572 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of BCL2 protein] CTD PMID:29248572 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased expression of CASP3 protein
1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein]
CTD PMID:26143167, PMID:29248572 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity EXP 1,3-dichloro-2-propanol results in decreased activity of CAT protein CTD PMID:26143167 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd36 CD36 molecule increases expression ISO 1,3-dichloro-2-propanol results in increased expression of CD36 protein CTD PMID:24333398 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CYCS protein] CTD PMID:29248572 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of CYP11A1 mRNA CTD PMID:24518350 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of FASN protein
1,3-dichloro-2-propanol results in increased expression of FASN mRNA; 1,3-dichloro-2-propanol results in increased expression of FASN protein
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein]
CTD PMID:24333398, PMID:29305303 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GCLC mRNA CTD PMID:26143167 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP 1,3-dichloro-2-propanol results in increased expression of GCLM mRNA CTD PMID:26143167 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP 1,3-dichloro-2-propanol results in decreased activity of GSR protein CTD PMID:26143167 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of HMGCR protein
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA; 1,3-dichloro-2-propanol results in increased expression of HMGCR protein
CTD PMID:24333398, PMID:29305303 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of HMOX1 mRNA CTD PMID:26143167 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of IL1B protein CTD PMID:29248572 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of IL6 protein CTD PMID:29248572 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK1 protein
1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein]
CTD PMID:26143167, PMID:29248572 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK3 protein]
CTD PMID:26143167, PMID:29248572 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein]
CTD PMID:26143167, PMID:29248572 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
EXP
ISO
1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein]
CTD PMID:26143167, PMID:29248572 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of NFE2L2 protein CTD PMID:26143167 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of NOS2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of NOS2 protein]
CTD PMID:29248572 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 1,3-dichloro-2-propanol results in increased expression of NQO1 mRNA CTD PMID:26143167 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of PARP1 protein] CTD PMID:29248572 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO 1,3-dichloro-2-propanol results in decreased expression of PPARA protein CTD PMID:24333398 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein] CTD PMID:29248572 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO 1,3-dichloro-2-propanol results in increased expression of SREBF1 protein
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]
1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA; 1,3-dichloro-2-propanol results in increased expression of SREBF1 protein
CTD PMID:24333398, PMID:29305303 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression
ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]
1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA; 1,3-dichloro-2-propanol results in increased expression of SREBF2 protein
CTD PMID:29305303 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP 1,3-dichloro-2-propanol results in decreased expression of STAR mRNA; 1,3-dichloro-2-propanol results in decreased expression of STAR protein CTD PMID:24518350 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 1,3-dichloro-2-propanol results in increased secretion of TNF protein CTD PMID:29248572 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        reagent 17167
          cross-linking reagent 7366
            1,3-dichloropropan-2-ol 29
              1,3-dichloroacetone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              organic hydroxy compound 18630
                                alcohol 14984
                                  secondary alcohol 7197
                                    1,3-dichloropropan-2-ol 29
                                      1,3-dichloroacetone 0
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