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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxycyclophosphamide
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Accession:CHEBI:1864 term browser browse the term
Definition:A phosphorodiamide that consists of 2-amino-1,3,2-oxazaphosphinan-4-ol 2-oxide having two 2-chloroethyl groups attached to the exocyclic nitrogen.
Synonyms:exact_synonym: 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-ol 2-oxide
 related_synonym: Formula=C7H15Cl2N2O3P;   InChI=1S/C7H15Cl2N2O3P/c8-2-4-11(5-3-9)15(13)10-7(12)1-6-14-15/h7,12H,1-6H2,(H,10,13);   InChIKey=RANONBLIHMVXAJ-UHFFFAOYSA-N;   SMILES=OC1CCOP(=O)(N1)N(CCCl)CCCl;   Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
 xref: CAS:40277-05-2;   KEGG:C07643
 xref_mesh: MESH:C012358
 xref: Reaxys:526395;   Wikipedia:4-Hydroxycyclophosphamide


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4-hydroxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Cd40 CD40 molecule multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:71,165,378...71,169,078
Ensembl chr  X:71,162,585...71,169,865
JBrowse link
G Klk15 kallikrein-related peptidase 15 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 1:99,393,283...99,401,339
Ensembl chr 1:99,398,248...99,401,126
Ensembl chr 1:99,398,248...99,401,126
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA CTD PMID:25833159 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            4-hydroxycyclophosphamide 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoramide 1006
                                          phosphorodiamide 975
                                            4-hydroxycyclophosphamide 9
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