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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:superoxide
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Accession:CHEBI:18421 term browser browse the term
Definition:An oxygen radical that has formula O2.
Synonyms:exact_synonym: dioxidanidyl
 related_synonym: Formula=O2;   Hyperoxid;   InChI=1S/HO2/c1-2/h1H/p-1;   InChIKey=OUUQCZGPVNCOIJ-UHFFFAOYSA-M;   O2;   SMILES=[O][O-];   Superoxide anion;   dioxide(1-);   hyperoxide;   superoxide radical;   superoxide radical anion;   superoxyde
 alt_id: CHEBI:15143;   CHEBI:26839;   CHEBI:7710
 xref: CAS:11062-77-4;   Gmelin:487;   KEGG:C00704
 xref_mesh: MESH:D013481


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superoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides] CTD PMID:17272743 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Aco1 aconitase 1 decreases activity
multiple interactions
ISO Superoxides results in decreased activity of ACO1 protein
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein
CTD PMID:28542246 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity
EXP [[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron CTD PMID:16162655 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Ada adenosine deaminase multiple interactions ISO ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Agt angiotensinogen multiple interactions
increases abundance
ISO
EXP
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]
CTD PMID:12606818, PMID:16531806, PMID:16864745, PMID:17272743, PMID:17391658, PMID:18250367, PMID:18768397, PMID:20881940, PMID:22753205, PMID:24363997 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides CTD PMID:19442656, PMID:21910479 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions ISO [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides CTD PMID:21910479 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Alb albumin increases chemical synthesis
multiple interactions
ISO ALB protein modified form results in increased chemical synthesis of Superoxides
Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]
CTD PMID:25421967 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions ISO [ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides CTD PMID:29031482 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Apoe apolipoprotein E increases chemical synthesis
increases abundance
multiple interactions
ISO APOE gene mutant form results in increased chemical synthesis of Superoxides
APOE gene mutant form results in increased abundance of Superoxides
imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides]
CTD PMID:11397713, PMID:12871831 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases chemical synthesis
ISO 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; Resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides] CTD PMID:16212921, PMID:22886847 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions ISO Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein] CTD PMID:16928829 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arf6 ADP-ribosylation factor 6 multiple interactions ISO 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10931844 NCBI chr 6:91,697,109...91,698,257
Ensembl chr 6:91,697,109...91,698,255
JBrowse link
G Arrb2 arrestin, beta 2 affects abundance ISO ARRB2 protein affects the abundance of Superoxides CTD PMID:16210646 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:22753205 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941
JBrowse link
G Atp7a ATPase copper transporting alpha increases abundance
multiple interactions
ISO ATP7A mutant form results in increased abundance of Superoxides
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
CTD PMID:18768397, PMID:23884884 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G C5 complement C5 multiple interactions
increases abundance
ISO 8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein] CTD PMID:19268487 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase affects abundance
multiple interactions
ISO CBS protein affects the abundance of Superoxides
SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]
CTD PMID:23024785 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Superoxides results in increased expression of CCL2 mRNA
1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA]
CTD PMID:8856246, PMID:19158351 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd38 CD38 molecule affects localization
multiple interactions
ISO Superoxides affects the localization of CD38 protein
tempol inhibits the reaction [Superoxides affects the localization of CD38 protein]
CTD PMID:23940720 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Crp C-reactive protein multiple interactions EXP CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:9767445 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases abundance
ISO
EXP
CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]
CYBA protein results in increased abundance of Superoxides
CTD PMID:10720412, PMID:14871555, PMID:20523355 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]
IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]
CTD PMID:16354686, PMID:17275678, PMID:20116427, PMID:21647593 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance ISO CYP1A1 protein results in increased abundance of Superoxides CTD PMID:20634294 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
increases chemical synthesis
ISO [DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]
DCXR protein results in increased chemical synthesis of Superoxides
CTD PMID:28595002 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases abundance
increases expression
multiple interactions
ISO DDIT3 protein results in increased abundance of Superoxides
Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein
CTD PMID:16400006 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance
EXP
ISO
[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]
CTD PMID:20977430, PMID:23940720 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A affects abundance EXP EDNRA protein affects the abundance of Superoxides CTD PMID:12600921 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ep300 E1A binding protein p300 decreases abundance ISO EP300 protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] CTD PMID:25490417 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
decreases abundance
increases abundance
ISO 3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 protein results in decreased abundance of Superoxides
CTD PMID:25440059 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides] CTD PMID:18354059, PMID:23000059 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
increases abundance
ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] CTD PMID:27385396 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:16572112 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA] CTD PMID:9067545 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO
EXP
SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
CTD PMID:11050244 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein CTD PMID:16400006 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gch1 GTP cyclohydrolase 1 affects abundance ISO GCH1 protein affects the abundance of Superoxides CTD PMID:21963838 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases abundance
increases abundance
ISO
EXP
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
HMOX1 protein results in decreased abundance of Superoxides
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
CTD PMID:15821039, PMID:16959961, PMID:18073186, PMID:18178725, PMID:18334666, PMID:19323979 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase increases abundance
multiple interactions
ISO HRAS protein mutant form results in increased abundance of Superoxides
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein
CTD PMID:11313892 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
decreases abundance
ISO [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein
HSPB1 protein results in decreased abundance of Superoxides
CTD PMID:14975446, PMID:19193722 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Ier3 immediate early response 3 affects chemical synthesis ISO IER3 protein affects the chemical synthesis of Superoxides CTD PMID:20713914 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Igf1 insulin-like growth factor 1 decreases abundance ISO IGF1 protein results in decreased abundance of Superoxides CTD PMID:22843358 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
ISO diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides] CTD PMID:16354686, PMID:21211511 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein CTD PMID:16400006 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein CTD PMID:16400006 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein]
Superoxides results in increased expression of JUN mRNA
SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
CTD PMID:9067545, PMID:16572112 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kat2a lysine acetyltransferase 2A decreases abundance ISO KAT2A protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr10:88,611,586...88,619,558
Ensembl chr10:88,611,586...88,619,537
JBrowse link
G Kat2b lysine acetyltransferase 2B decreases abundance ISO KAT2B protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kdr kinase insert domain receptor increases phosphorylation ISO Superoxides results in increased phosphorylation of KDR protein CTD PMID:19571580 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lep leptin multiple interactions
increases abundance
ISO acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]
[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides
CTD PMID:11342529, PMID:16380530 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions
increases abundance
ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Superoxides results in increased phosphorylation of MAPK1 protein
CTD PMID:16572112, PMID:19268487 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Superoxides results in increased phosphorylation of MAPK3 protein
CTD PMID:16572112, PMID:19268487 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides CTD PMID:26867495 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to Superoxides CTD PMID:12383939 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides CTD PMID:11919077 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
affects chemical synthesis
decreases abundance
increases abundance
ISO
EXP
7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein]
NOS3 protein affects the chemical synthesis of Superoxides
NOS3 protein results in decreased abundance of Superoxides
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]
[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
CTD PMID:10625313, PMID:17272743, PMID:18714161, PMID:19011239, PMID:19696404, PMID:20977430, PMID:21300668, PMID:25490417 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
increases abundance
EXP
ISO
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]
CTD PMID:23824088, PMID:23940720, PMID:24912985, PMID:27816504 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox3 NADPH oxidase 3 multiple interactions ISO [resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides CTD PMID:20675566 NCBI chr 1:44,550,994...44,615,760
Ensembl chr 1:44,550,994...44,615,760
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides] CTD PMID:26535918 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides] CTD PMID:21300143 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 affects abundance ISO PDHA1 protein affects the abundance of Superoxides CTD PMID:21846590 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
G Pink1 PTEN induced kinase 1 affects abundance ISO PINK1 protein affects the abundance of Superoxides CTD PMID:21421046 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases chemical synthesis
multiple interactions
ISO POLG gene mutant form results in increased chemical synthesis of Superoxides
Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]
CTD PMID:30038268 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Pomc proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Superoxides CTD PMID:16620303 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Superoxides results in increased expression of PON2 protein CTD PMID:15544923 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]
CTD PMID:21215309 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein] CTD PMID:10718345 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides CTD PMID:21544240 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Selenoh selenoprotein H decreases abundance ISO SELENOH protein results in decreased abundance of Superoxides CTD PMID:17389926 NCBI chr 3:72,070,342...72,071,909
Ensembl chr 3:72,070,390...72,071,895
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein CTD PMID:11681624 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] CTD PMID:18424637 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions ISO SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides] CTD PMID:20600837 NCBI chr  X:135,470,855...135,509,223
Ensembl chr  X:135,470,915...135,509,221
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides] CTD PMID:23024785 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Sod1 superoxide dismutase 1 increases abundance
decreases abundance
multiple interactions
decreases chemical synthesis
ISO SOD1 protein results in increased abundance of Superoxides
SOD1 protein results in decreased abundance of Superoxides
[tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
SOD1 protein results in decreased chemical synthesis of Superoxides
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]
CTD PMID:11756504, PMID:12489993, PMID:15364863, PMID:15829915, PMID:17391658, PMID:18480265, PMID:21443684, PMID:21900685, PMID:24363997, PMID:28542246 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases metabolic processing
affects metabolic processing
decreases abundance
multiple interactions
increases expression
affects abundance
affects chemical synthesis
ISO
EXP
SOD2 protein results in increased metabolism of Superoxides
SOD2 protein polymorphism affects the metabolism of Superoxides
SOD2 protein results in decreased abundance of Superoxides
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
Superoxides results in increased expression of SOD2 protein
[Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
[SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides]
SOD2 protein affects the chemical synthesis of Superoxides
CTD PMID:1850207, PMID:9067545, PMID:11050244, PMID:16179351, PMID:17150972, PMID:17901229, PMID:18594523, PMID:19193722, PMID:19265433, PMID:20304815, PMID:20638473, PMID:26108578, PMID:28495429, PMID:32243540 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:16864745, PMID:23884884 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases secretion
increases abundance
EXP
ISO
Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA]
Superoxides results in increased secretion of TGFB1 protein
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]
TGFB1 protein results in increased abundance of Superoxides
CTD PMID:12606818, PMID:16572112, PMID:19268487 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects abundance
decreases abundance
increases abundance
ISO [HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
TNF protein affects the abundance of Superoxides
TNF gene mutant form results in decreased abundance of Superoxides
TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides]
CTD PMID:1850207, PMID:11121130, PMID:11313892, PMID:15450858, PMID:19478208, PMID:19608869, PMID:21211511 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] CTD PMID:11050244 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
decreases abundance
EXP
ISO
[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA
UCP2 protein results in decreased abundance of Superoxides
CTD PMID:10860543, PMID:25440059 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 multiple interactions
increases abundance
ISO 2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides] CTD PMID:23940720 NCBI chr 3:5,811,504...5,976,311
Ensembl chr 3:5,811,504...5,976,244
JBrowse link
G Vdr vitamin D receptor decreases abundance ISO VDR protein results in decreased abundance of Superoxides CTD PMID:25201890 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases chemical synthesis
ISO [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] CTD PMID:19268487, PMID:19555678 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        elemental molecular entity 16230
          elemental oxygen 4402
            diatomic oxygen 3544
              superoxide 94
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            elemental oxygen 4402
                              diatomic oxygen 3544
                                superoxide 94
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.