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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cobamamide
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Accession:CHEBI:18408 term browser browse the term
Definition:A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.
Synonyms:exact_synonym: Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide
 related_synonym: (5,6-Dimethylbenzimidazolyl)cobamide coenzyme;   5'-Deoxy-5'-adenosyl vitamin B12;   5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide;   5'-Deoxy-5'-adenosylcobalamin;   5'-deoxyadenosyl vitamin B12;   5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide;   5'-deoxyadenosylcobalamin;   5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide;   5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide;   AdoCbl;   Calomide;   Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide;   Cobalamin coenzyme;   Coenzyme B12;   DBC coenzyme;   DMBC coenzyme;   Deoxyadenosylcobalamin;   Dibencozide;   Formula=C72H100CoN18O17P;   Funacomide;   InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1;   InChIKey=ZIHHMGTYZOSFRC-OUCXYWSSSA-L;   SMILES=[H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]4[C@@H](CO)O[C@@H]([C@@H]4O)n4c[n+](c5cc(C)c(C)cc45)[Co-3]456(C[C@H]7O[C@H]([C@H](O)[C@@H]7O)n7cnc8c(N)ncnc78)N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O;   Vitamin B12 coenzyme;   adenosylcob(III)alamin;   adenosylcobalamin;   alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme;   cobamamid;   cobamamida;   cobamamidum;   cobamide coenzyme;   coenzyme B-12
 alt_id: CHEBI:13739;   CHEBI:23340;   CHEBI:3797
 xref: Beilstein:4122932;   CAS:13870-90-1;   DrugBank:DB11191;   Gmelin:439994;   HMDB:HMDB0002086;   KEGG:C00194
 xref_mesh: MESH:C000913
 xref: MetaCyc:ADENOSYLCOBALAMIN;   PDBeChem:B1Z;   PMID:11792214;   PMID:12093296;   PMID:17011224;   Reaxys:4122932;   Wikipedia:Cobamamide


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cobamamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          cofactor 15551
            cobamamide 1
              adenosylcobalamin 5'-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  organonitrogen heterocyclic compound 17523
                                    polypyrrole 610
                                      tetrapyrrole 498
                                        cyclic tetrapyrrole 369
                                          metallotetrapyrrole 337
                                            cobalt corrinoid 39
                                              cobalt-corrinoid hexaamide 39
                                                cobamides 39
                                                  cobalamins 39
                                                    cobamamide 1
                                                      adenosylcobalamin 5'-phosphate 0
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