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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cobamamide
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Accession:CHEBI:18408 term browser browse the term
Definition:A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.
Synonyms:exact_synonym: Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide
 related_synonym: (5,6-dimethylbenzimidazolyl)cobamide coenzyme;   5'-Deoxy-5'-adenosyl vitamin B12;   5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide;   5'-Deoxy-5'-adenosylcobalamin;   5'-deoxyadenosyl vitamin B12;   5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide;   5'-deoxyadenosylcobalamin;   5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide;   5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide;   Adenosylcob(III)alamin;   AdoCbl;   Calomide;   Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide;   Cobalamin coenzyme;   Coenzyme B12;   DBC coenzyme;   DMBC coenzyme;   Deoxyadenosylcobalamin;   Dibencozide;   Formula=C72H100CoN18O17P;   Funacomide;   InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1;   InChIKey=ZIHHMGTYZOSFRC-OUCXYWSSSA-L;   SMILES=[H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]4[C@@H](CO)O[C@@H]([C@@H]4O)n4c[n+](c5cc(C)c(C)cc45)[Co-3]456(C[C@H]7O[C@H]([C@H](O)[C@@H]7O)n7cnc8c(N)ncnc78)N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O;   Vitamin B12 coenzyme;   adenosylcobalamin;   alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme;   cobamamid;   cobamamida;   cobamamidum;   cobamide coenzyme;   coenzyme B-12
 alt_id: CHEBI:13739;   CHEBI:23340;   CHEBI:3797
 xref: CAS:13870-90-1;   DrugBank:DB11191;   Gmelin:439994;   HMDB:HMDB0002086;   KEGG:C00194
 xref_mesh: MESH:C000913
 xref: MetaCyc:ADENOSYLCOBALAMIN;   PDBeChem:B1Z;   PMID:11792214;   PMID:12093296;   PMID:17011224;   Reaxys:4122932;   Wikipedia:Cobamamide


show annotations for term's descendants           Sort by:
cobamamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          cofactor 16571
            cobamamide 1
              adenosylcobalamin 5'-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            organic molecule 19692
                              organic cyclic compound 19482
                                organic heterocyclic compound 18872
                                  organonitrogen heterocyclic compound 18150
                                    polypyrrole 698
                                      tetrapyrrole 585
                                        cyclic tetrapyrrole 456
                                          metallotetrapyrrole 421
                                            cobalt corrinoid 111
                                              cobalt-corrinoid hexaamide 111
                                                cobamides 111
                                                  cobalamins 111
                                                    cobamamide 1
                                                      adenosylcobalamin 5'-phosphate 0
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