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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:18399 term browser browse the term
Definition:An isoquinoline alkaloid that has formula C18H19NO3.
Synonyms:exact_synonym: 3-methoxy-17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-6-one
 related_synonym: (5alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-one;   Formula=C18H19NO3;   InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-12,17H,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1;   InChIKey=XYYVYLMBEZUESM-CMKMFDCUSA-N;   SMILES=[H][C@]12C=CC(=O)[C@@H]3Oc4c(OC)ccc5C[C@H]1N(C)CC[C@@]23c45
 alt_id: CHEBI:14007;   CHEBI:2248;   CHEBI:23349
 xref: CAS:467-13-0;   KEGG:C06171;   KNApSAcK:C00027603
 xref_mesh: MESH:C046414
 cyclic_relationship: is_conjugate_base_of CHEBI:58473

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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 6-codeinone results in increased expression of BAX protein CTD PMID:12894543 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-codeinone results in decreased expression of BCL2 protein CTD PMID:12894543 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO 6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein
CTD PMID:12606908 PMID:12894543 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO 6-codeinone results in increased activity of CASP9 protein CTD PMID:12894543 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 6-codeinone affects the localization of CYCS protein CTD PMID:12894543 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        xenobiotic 18387
          morphine 463
            codeinone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    main group molecular entity 19653
                      s-block molecular entity 19418
                        hydrogen molecular entity 19411
                          hydrides 18751
                            inorganic hydride 17451
                              pnictogen hydride 17426
                                nitrogen hydride 17271
                                  azane 17007
                                    ammonia 17006
                                      organic amino compound 17005
                                        tertiary amino compound 8650
                                          morphine 463
                                            codeinone 5
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