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G |
A2m |
alpha-2-macroglobulin |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein] |
CTD |
PMID:15618353 |
|
NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity multiple interactions |
ISO |
Apigenin results in decreased activity of ABCC1 protein [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]] |
CTD |
PMID:11306701 PMID:12485947 PMID:15670588 |
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NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Rotenone results in increased activity of ACHE protein] |
CTD |
PMID:28389404 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACSL4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACSL4 protein] |
CTD |
PMID:35500696 |
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NCBI chr X:110,739,633...110,803,416
Ensembl chr X:105,942,799...106,006,427
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G |
Afg3l2 |
AFG3 like matrix AAA peptidase subunit 2 |
increases expression |
ISO |
Apigenin results in increased expression of AFG3L2 mRNA |
CTD |
PMID:22359648 |
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NCBI chr18:63,224,163...63,269,000
Ensembl chr18:60,954,268...60,999,110
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
Apigenin binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Apigenin binds to and results in increased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] Apigenin binds to and results in decreased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] |
CTD |
PMID:14644660 PMID:17869316 PMID:20450880 PMID:29584932 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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G |
Aip |
aryl-hydrocarbon receptor-interacting protein |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] |
CTD |
PMID:20450880 |
|
NCBI chr 1:210,837,473...210,848,691
Ensembl chr 1:201,407,288...201,419,122
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases expression |
ISO |
[Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein Apigenin results in decreased expression of AKT1 protein |
CTD |
PMID:15947208 PMID:19885610 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO EXP |
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 mRNA] |
CTD |
PMID:24070738 PMID:30107153 |
|
NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Apigenin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] |
CTD |
PMID:33049310 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgap29 |
Rho GTPase activating protein 29 |
increases expression |
ISO |
Apigenin results in increased expression of ARHGAP29 mRNA |
CTD |
PMID:22359648 |
|
NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:210,071,199...210,132,028
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] |
CTD |
PMID:20450880 |
|
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein] |
CTD |
PMID:20493918 |
|
NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
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G |
Atg7 |
autophagy related 7 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] |
CTD |
PMID:29247770 |
|
NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593
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G |
B3galt5 |
Beta-1,3-galactosyltransferase 5 |
increases expression |
ISO |
Apigenin results in increased expression of B3GALT5 protein |
CTD |
PMID:22906706 |
|
NCBI chr11:49,053,959...49,100,398
Ensembl chr11:35,585,220...35,630,917
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression multiple interactions |
EXP ISO |
Apigenin results in decreased expression of BAX protein (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of BAX protein; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of BAX protein]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]] [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX protein |
CTD |
PMID:24070738 PMID:24144774 PMID:25557508 PMID:30107153 PMID:30152906 PMID:31930969 PMID:35373622 More...
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions decreases response to substance |
ISO EXP |
Apigenin results in decreased expression of BCL2 protein (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]] [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in decreased expression of BCL2 mRNA; [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein BCL2 protein results in decreased susceptibility to Apigenin |
CTD |
PMID:15486995 PMID:24070738 PMID:25557508 PMID:29247770 PMID:30107153 PMID:30152906 PMID:31930969 PMID:35373622 More...
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
EXP |
Apigenin results in decreased expression of BCL2L1 protein Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 protein] |
CTD |
PMID:24144774 PMID:30152906 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA] |
CTD |
PMID:28389404 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
Apigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]; Fluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein] |
CTD |
PMID:28025107 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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G |
Bid |
BH3 interacting domain death agonist |
increases expression |
EXP |
Apigenin results in increased expression of BID protein |
CTD |
PMID:24144774 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein |
CTD |
PMID:29247770 |
|
NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases cleavage multiple interactions |
ISO |
Apigenin results in increased cleavage of BIRC3 protein [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein |
CTD |
PMID:15486995 PMID:29247770 |
|
NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802
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G |
Bnip3l |
BCL2 interacting protein 3 like |
increases expression |
ISO |
Apigenin results in increased expression of BNIP3L mRNA |
CTD |
PMID:22359648 |
|
NCBI chr15:45,350,081...45,373,213
Ensembl chr15:41,174,594...41,197,803
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form] |
CTD |
PMID:29960001 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein] |
CTD |
PMID:20493918 |
|
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases cleavage |
ISO EXP |
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein] Apigenin results in increased activity of CASP3 protein Apigenin results in increased cleavage of CASP3 protein (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP3 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of CASP3 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP3 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP3 protein] Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]; Apigenin inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP3 protein] |
CTD |
PMID:15486995 PMID:17132221 PMID:19397994 PMID:19647729 PMID:19885610 PMID:20493918 PMID:24070738 PMID:24144774 PMID:24148603 PMID:25557508 PMID:28025107 PMID:29247770 PMID:30107153 PMID:30152906 PMID:31930969 PMID:33845614 PMID:35373622 More...
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases cleavage increases activity |
ISO |
Apigenin results in increased cleavage of CASP7 protein Apigenin results in increased activity of CASP7 protein |
CTD |
PMID:15486995 PMID:19647729 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases cleavage multiple interactions increases activity |
ISO EXP |
Apigenin results in increased cleavage of CASP8 protein [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein Apigenin results in increased activity of CASP8 protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein] |
CTD |
PMID:15486995 PMID:24144774 PMID:29247770 PMID:30152906 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage increases activity multiple interactions |
ISO EXP |
Apigenin results in increased cleavage of CASP9 protein Apigenin results in increased activity of CASP9 protein Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP9 protein] (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP9 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP9 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP9 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form] [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in increased expression of CASP9 mRNA; [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in increased expression of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein |
CTD |
PMID:15486995 PMID:19397994 PMID:24070738 PMID:25557508 PMID:28025107 PMID:29247770 PMID:30107153 PMID:30152906 PMID:31930969 More...
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Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression multiple interactions increases activity increases expression decreases response to substance |
ISO EXP |
Apigenin results in decreased expression of CAT mRNA Apigenin inhibits the reaction [Methotrexate results in decreased activity of CAT protein] Apigenin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Apigenin inhibits the reaction [Rotenone results in decreased activity of CAT protein] Apigenin results in increased activity of CAT protein Apigenin results in increased expression of CAT mRNA CAT protein results in decreased susceptibility to Apigenin |
CTD |
PMID:21756884 PMID:22359648 PMID:28389404 PMID:30152906 PMID:33845614 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] |
CTD |
PMID:24134915 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G |
Ccn5 |
cellular communication network factor 5 |
increases expression multiple interactions |
ISO |
Apigenin results in increased expression of CCN5 mRNA ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA] |
CTD |
PMID:23384675 |
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NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:152,491,220...152,502,636
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Apigenin results in decreased expression of CCNB1 mRNA; Apigenin results in decreased expression of CCNB1 protein |
CTD |
PMID:19397994 PMID:26961604 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] |
CTD |
PMID:16601352 |
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NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534
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G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
Apigenin results in decreased expression of CDC25C protein |
CTD |
PMID:26961604 |
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NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions decreases expression |
ISO |
Apigenin results in increased phosphorylation of and results in decreased activity of CDK1 protein Apigenin results in decreased expression of CDK1 protein |
CTD |
PMID:11322924 PMID:26872304 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkal1 |
CDK5 regulatory subunit associated protein 1-like 1 |
increases expression |
ISO |
Apigenin results in increased expression of CDKAL1 mRNA |
CTD |
PMID:22359648 |
|
NCBI chr17:34,927,221...35,479,827
Ensembl chr17:34,718,687...35,407,524
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO EXP |
Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein]; TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein] Apigenin results in increased expression of CDKN1A mRNA Apigenin results in increased expression of CDKN1A mRNA; Apigenin results in increased expression of CDKN1A protein |
CTD |
PMID:11790449 PMID:16023288 PMID:19397994 PMID:26872304 PMID:31201582 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
increases expression |
ISO |
Apigenin results in increased expression of CDKN2C mRNA |
CTD |
PMID:18331776 |
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NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:124,411,124...124,416,278
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
decreases expression |
ISO |
Apigenin results in decreased expression of CEBPB mRNA |
CTD |
PMID:18359623 |
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NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces1d |
carboxylesterase 1D |
decreases activity |
EXP |
Apigenin results in decreased activity of CES1 protein |
CTD |
PMID:37353134 |
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NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity affects localization |
ISO |
Apigenin results in increased activity of CFTR protein; Apigenin results in increased activity of CFTR protein mutant form Apigenin affects the localization of CFTR protein mutant form |
CTD |
PMID:15191910 PMID:15277574 |
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NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein] |
CTD |
PMID:25935278 |
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NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CKM protein] |
CTD |
PMID:25557508 |
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NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720
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G |
Clca1 |
chloride channel accessory 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of CLCA1 mRNA |
CTD |
PMID:22359648 |
|
NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:233,938,677...233,964,369
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G |
Cox17 |
cytochrome c oxidase copper chaperone COX17 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 protein] |
CTD |
PMID:30107153 |
|
NCBI chr11:75,906,245...75,912,036
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Methotrexate results in increased expression of CRP protein] |
CTD |
PMID:33845614 |
|
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Bleomycin results in increased expression of CSF2 mRNA] |
CTD |
PMID:32554301 |
|
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
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G |
Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Methotrexate results in increased expression of CSF3 protein] |
CTD |
PMID:33845614 |
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NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Bleomycin results in increased expression of CXCL1 mRNA] |
CTD |
PMID:32554301 |
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NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression multiple interactions |
ISO |
Apigenin results in increased expression of CXCL12 mRNA ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA] |
CTD |
PMID:23384675 PMID:28396216 |
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NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Bleomycin results in increased expression of CXCL1 mRNA] |
CTD |
PMID:32554301 |
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NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
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G |
Cycs |
cytochrome c, somatic |
affects localization multiple interactions |
ISO EXP |
Apigenin affects the localization of CYCS protein (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein] [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] affects the localization of CYCS protein |
CTD |
PMID:15486995 PMID:24070738 PMID:30152906 PMID:31930969 |
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NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
EXP |
Apigenin results in decreased expression of CYP11A1 mRNA |
CTD |
PMID:31201582 |
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NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
decreases expression |
ISO |
Apigenin results in decreased expression of CYP11B1 mRNA |
CTD |
PMID:22172629 |
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NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] |
CTD |
PMID:23370353 |
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NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity decreases expression |
ISO |
Apigenin results in decreased activity of CYP19A1 protein Apigenin results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:10403137 PMID:15319488 PMID:16023337 PMID:16965912 |
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NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases expression |
ISO |
Apigenin binds to and results in decreased activity of CYP1A1 protein; Apigenin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Apigenin results in decreased activity of CYP1A1 protein Apigenin results in increased expression of CYP1A1 mRNA Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Apigenin promotes the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein] |
CTD |
PMID:11454723 PMID:11752233 PMID:16271822 PMID:17012224 PMID:17090139 PMID:20930378 PMID:21053930 PMID:21482471 PMID:26657896 PMID:31621310 More...
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Apigenin results in decreased activity of CYP1A2 protein |
CTD |
PMID:20806393 PMID:21053930 PMID:29753067 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity increases expression multiple interactions increases chemical synthesis |
ISO |
Apigenin results in decreased activity of CYP1B1 protein Apigenin results in increased expression of CYP1B1 mRNA Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CYP1B1 protein results in increased chemical synthesis of Apigenin [CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin; Apigenin binds to and results in decreased activity of CYP1B1 protein |
CTD |
PMID:16271822 PMID:19666078 PMID:20930378 PMID:21053930 PMID:21482471 PMID:31621310 More...
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NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions decreases activity |
ISO |
Apigenin inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein] Apigenin results in decreased activity of CYP2E1 protein |
CTD |
PMID:28803762 PMID:29753067 |
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NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] Apigenin results in decreased activity of CYP3A4 protein |
CTD |
PMID:21053930 PMID:29753067 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] |
CTD |
PMID:20493918 |
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NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] |
CTD |
PMID:28803762 |
|
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
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G |
Dhrs11 |
dehydrogenase/reductase 11 |
decreases activity |
ISO |
Apigenin results in decreased activity of DHRS11 protein |
CTD |
PMID:30926317 |
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NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein] |
CTD |
PMID:28389404 |
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NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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G |
Duox1 |
dual oxidase 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of DUOX1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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G |
Eif5b |
eukaryotic translation initiation factor 5B |
increases expression |
ISO |
Apigenin results in increased expression of EIF5B mRNA |
CTD |
PMID:22359648 |
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NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:40,222,898...40,277,482
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] |
CTD |
PMID:20153296 |
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NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Epo |
erythropoietin |
increases expression |
ISO |
Apigenin results in increased expression of EPO mRNA |
CTD |
PMID:37348668 |
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NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
[Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein |
CTD |
PMID:19885610 |
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NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:20493918 |
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NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
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G |
Erp29 |
endoplasmic reticulum protein 29 |
increases expression |
ISO |
Apigenin results in increased expression of ERP29 mRNA |
CTD |
PMID:22359648 |
|
NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases phosphorylation increases activity decreases expression affects binding |
ISO EXP |
Apigenin binds to and results in increased activity of ESR1 protein; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA] Apigenin results in increased phosphorylation of ESR1 protein Apigenin results in increased activity of ESR1 protein Apigenin results in decreased expression of ESR1 protein Apigenin binds to ESR1 protein |
CTD |
PMID:14579009 PMID:16118406 PMID:16541309 PMID:16860978 PMID:17323972 PMID:23384675 PMID:28396216 PMID:29162470 PMID:33049310 More...
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NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding increases activity |
ISO |
Apigenin binds to and results in increased activity of ESR2 protein; Apigenin inhibits the reaction [Estradiol binds to ESR2 protein] Apigenin binds to ESR2 protein Apigenin results in increased activity of ESR2 protein |
CTD |
PMID:9751507 PMID:12224631 PMID:16118406 PMID:16860978 PMID:17132221 PMID:33049310 More...
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NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
Apigenin inhibits the reaction [F2 protein results in increased localization of Calcium] |
CTD |
PMID:19814731 |
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NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
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G |
Fas |
Fas cell surface death receptor |
decreases expression multiple interactions |
ISO EXP |
Apigenin results in decreased expression of FAS mRNA Apigenin inhibits the reaction [Isoproterenol results in increased expression of FAS protein] |
CTD |
PMID:18359623 PMID:30152906 |
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NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Alcohols results in increased expression of FASN protein] |
CTD |
PMID:28803762 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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G |
Fbp1 |
fructose-bisphosphatase 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of FBP1 mRNA |
CTD |
PMID:18331776 |
|
NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,208,031...2,230,071
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] |
CTD |
PMID:26800359 |
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NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
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G |
Fn1 |
fibronectin 1 |
increases expression |
ISO |
Apigenin results in increased expression of FN1 protein |
CTD |
PMID:26408079 |
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NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of FOS protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] |
CTD |
PMID:15322261 PMID:22634262 |
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NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G |
Frmd4a |
FERM domain containing 4A |
increases expression |
ISO |
Apigenin results in increased expression of FRMD4A mRNA |
CTD |
PMID:22359648 |
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NCBI chr17:73,667,787...74,258,487
Ensembl chr17:73,667,789...74,258,687
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression multiple interactions |
ISO |
Apigenin results in increased expression of FTH1 mRNA; Apigenin results in increased expression of FTH1 protein Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTH1 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTH1 protein] |
CTD |
PMID:35500696 |
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NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTL mRNA] |
CTD |
PMID:35500696 |
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NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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G |
Gata3 |
GATA binding protein 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in increased expression of GATA3 mRNA]; Apigenin inhibits the reaction [Ovalbumin results in increased expression of GATA3 protein] |
CTD |
PMID:36350155 |
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NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO EXP |
Apigenin results in increased expression of GCLC mRNA [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide Apigenin results in increased expression of GCLC mRNA; Apigenin results in increased expression of GCLC protein |
CTD |
PMID:11864778 PMID:22864849 |
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NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
EXP |
Apigenin results in increased expression of GCLM mRNA; Apigenin results in increased expression of GCLM protein [Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide |
CTD |
PMID:22864849 |
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NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdnf |
glial cell derived neurotrophic factor |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] |
CTD |
PMID:28389404 |
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NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209
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G |
Gli1 |
GLI family zinc finger 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of GLI1 mRNA; Apigenin results in decreased expression of GLI1 protein |
CTD |
PMID:20395211 |
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NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Methotrexate results in increased activity of GPT protein] |
CTD |
PMID:33845614 |
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NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression |
ISO |
Apigenin results in increased expression of GPX1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx4 |
glutathione peroxidase 4 |
increases expression multiple interactions affects binding |
ISO |
Apigenin results in increased expression of GPX4 mRNA; Apigenin results in increased expression of GPX4 protein Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 protein] Apigenin binds to GPX4 protein |
CTD |
PMID:35500696 |
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NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
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G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [Apigenin results in increased expression of GREB1 mRNA] |
CTD |
PMID:33405908 |
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NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
Apigenin inhibits the reaction [Rotenone results in decreased activity of GSR protein] Apigenin inhibits the reaction [Alcohols results in decreased expression of GSR protein] |
CTD |
PMID:28389404 PMID:28803762 |
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NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Gypa |
glycophorin A |
increases expression |
ISO |
Apigenin results in increased expression of GYPA protein |
CTD |
PMID:25058688 |
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NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
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G |
Hbegf |
heparin-binding EGF-like growth factor |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] |
CTD |
PMID:26800359 |
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NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441
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G |
Hexa |
hexosaminidase subunit alpha |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in increased secretion of HEXA protein] Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein] |
CTD |
PMID:36350155 |
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NCBI chr 8:68,832,524...68,857,462
Ensembl chr 8:59,936,660...59,962,013
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression increases expression multiple interactions decreases activity |
ISO EXP |
Apigenin results in decreased expression of HIF1A protein Apigenin results in increased expression of HIF1A mRNA; Apigenin results in increased expression of HIF1A protein Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]] Apigenin results in decreased activity of HIF1A protein [Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein; Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Apigenin results in decreased degradation of and results in increased expression of HIF1A protein modified form; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein]; Cycloheximide affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein] |
CTD |
PMID:15947208 PMID:19958256 PMID:20153296 PMID:31930969 PMID:35513012 PMID:37348668 More...
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NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] |
CTD |
PMID:36055550 |
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NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein] [Apigenin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide Apigenin results in increased expression of HMOX1 mRNA; Apigenin results in increased expression of HMOX1 protein Apigenin results in decreased expression of HMOX1 protein |
CTD |
PMID:16109301 PMID:22864849 |
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
decreases expression |
EXP |
Apigenin results in decreased expression of HSD17B7 mRNA |
CTD |
PMID:31201582 |
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NCBI chr13:84,702,875...84,722,810
Ensembl chr13:82,173,179...82,190,017
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] |
CTD |
PMID:23370353 |
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NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:186,095,897...186,101,852
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein] |
CTD |
PMID:20493918 |
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NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
decreases expression |
ISO |
Apigenin results in decreased expression of HSPA1A mRNA |
CTD |
PMID:22359648 |
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NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
affects expression |
ISO |
Apigenin affects the expression of HSPA1B mRNA |
CTD |
PMID:22359648 |
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NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
decreases expression |
ISO |
Apigenin results in decreased expression of HSPA1L mRNA |
CTD |
PMID:22359648 |
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NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,848,843...3,855,571
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
decreases expression |
ISO |
Apigenin results in decreased expression of HSPA2 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions decreases expression |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] Apigenin results in decreased expression of HSPA5 mRNA |
CTD |
PMID:20493918 PMID:22359648 |
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NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
decreases expression |
ISO |
Apigenin results in decreased expression of HSPA8 mRNA; Apigenin results in decreased expression of HSPA8 protein |
CTD |
PMID:22359648 |
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NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:15113938 PMID:15322261 PMID:16987811 |
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NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G |
Idh3a |
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha |
decreases expression |
ISO |
Apigenin results in decreased expression of IDH3A mRNA |
CTD |
PMID:22359648 |
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NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:54,971,740...54,991,084
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP ISO |
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] Apigenin inhibits the reaction [Ovalbumin results in decreased secretion of IFNG protein] |
CTD |
PMID:18090225 PMID:36350155 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin results in decreased expression of and results in decreased activity of IKBKB protein; Apigenin results in decreased phosphorylation of and results in decreased activity of IKBKB protein; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]] Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of IKBKB protein] Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:24148603 PMID:25557508 PMID:25935278 PMID:36350155 |
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NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] Apigenin inhibits the reaction [nickel chloride results in increased expression of IL10 protein] |
CTD |
PMID:16934226 PMID:30016632 |
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NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B protein]] |
CTD |
PMID:28673093 |
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NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] |
CTD |
PMID:36350155 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Bleomycin results in increased expression of IL1A mRNA] |
CTD |
PMID:32554301 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA] Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Poly dA-dT results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin promotes the reaction [Antigens, Bacterial results in increased cleavage of and results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein] |
CTD |
PMID:15985724 PMID:18090225 PMID:24134915 PMID:25557508 PMID:25935278 PMID:29960001 PMID:30016632 PMID:32554301 PMID:35373622 PMID:36055550 PMID:36350155 More...
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il33 |
interleukin 33 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; Apigenin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] |
CTD |
PMID:37545493 |
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NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
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G |
Il4 |
interleukin 4 |
decreases expression multiple interactions |
ISO |
Apigenin results in decreased expression of IL4 protein Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein] Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] |
CTD |
PMID:16343431 PMID:36350155 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] |
CTD |
PMID:36350155 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA] Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] |
CTD |
PMID:24134915 PMID:25557508 PMID:25935278 PMID:28389404 PMID:30016632 PMID:30152906 PMID:32554301 PMID:36055550 PMID:36350155 More...
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP ISO |
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein] Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Apigenin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] |
CTD |
PMID:18090225 PMID:18591783 |
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NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] |
CTD |
PMID:15322261 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
multiple interactions |
EXP |
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]] |
CTD |
PMID:31930969 |
|
NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:159,350,097...159,357,697
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G |
Kdm3a |
lysine demethylase 3A |
increases expression |
ISO |
Apigenin results in increased expression of KDM3A mRNA |
CTD |
PMID:22359648 |
|
NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:103,630,908...103,675,073
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
[Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of KDR protein |
CTD |
PMID:35513012 |
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NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
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G |
Lamb2 |
laminin subunit beta 2 |
increases expression |
ISO |
Apigenin results in increased expression of LAMB2 protein |
CTD |
PMID:26408079 |
|
NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:109,178,409...109,190,549
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G |
Lep |
leptin |
increases expression |
ISO |
Apigenin results in increased expression of LEP mRNA; Apigenin results in increased expression of LEP protein |
CTD |
PMID:18359623 |
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NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Lmbr1l |
limb development membrane protein 1-like |
increases expression |
ISO |
Apigenin results in increased expression of LMBR1L mRNA |
CTD |
PMID:22359648 |
|
NCBI chr 7:130,061,136...130,078,101
Ensembl chr 7:130,061,136...130,076,381
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G |
Lpcat3 |
lysophosphatidylcholine acyltransferase 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LPCAT3 mRNA] |
CTD |
PMID:35500696 |
|
NCBI chr 4:159,154,690...159,196,176
Ensembl chr 4:157,468,290...157,509,880
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G |
Lrrc26 |
leucine rich repeat containing 26 |
increases expression |
ISO |
Apigenin results in increased expression of LRRC26 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 3:28,500,517...28,501,843
Ensembl chr 3:8,102,361...8,103,687
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G |
Ltbp1 |
latent transforming growth factor beta binding protein 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of LTBP1 mRNA |
CTD |
PMID:22359648 |
|
NCBI chr 6:25,781,625...26,177,346
Ensembl chr 6:20,029,629...20,425,349
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G |
Ltf |
lactotransferrin |
increases expression |
EXP |
Apigenin results in increased expression of LTF protein |
CTD |
PMID:24487097 |
|
NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:29247770 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation increases activity |
ISO EXP |
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin results in increased phosphorylation of and results in increased activity of MAPK1 protein Apigenin results in decreased phosphorylation of MAPK1 protein Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] Apigenin results in increased activity of MAPK1 protein |
CTD |
PMID:15322261 PMID:19647729 PMID:22864849 PMID:25557508 PMID:27468969 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO EXP |
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Apigenin results in increased phosphorylation of and results in increased activity of MAPK3 protein Apigenin results in decreased phosphorylation of MAPK3 protein Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:19647729 PMID:25557508 PMID:27468969 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of MAPK8 protein] |
CTD |
PMID:25557508 PMID:35373622 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:25557508 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression multiple interactions |
ISO |
Apigenin results in decreased expression of MCL1 mRNA Apigenin promotes the reaction [Fluorouracil results in decreased expression of MCL1 mRNA]; Fluorouracil promotes the reaction [Apigenin results in decreased expression of MCL1 mRNA] |
CTD |
PMID:28025107 |
|
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
decreases phosphorylation |
ISO |
Apigenin results in decreased phosphorylation of MET protein |
CTD |
PMID:27468969 |
|
NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876
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G |
Mib1 |
MIB E3 ubiquitin protein ligase 1 |
increases expression |
ISO |
Apigenin results in increased expression of MIB1 mRNA |
CTD |
PMID:22359648 |
|
NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689
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G |
Mmp1 |
matrix metallopeptidase 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of MMP1 mRNA; Apigenin results in decreased expression of MMP1 protein |
CTD |
PMID:21112745 |
|
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
Apigenin results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:26408079 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA] |
CTD |
PMID:32554301 |
|
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] |
CTD |
PMID:22634262 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpg |
N-methylpurine-DNA glycosylase |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of MPG protein] |
CTD |
PMID:35373622 |
|
NCBI chr10:15,900,697...15,906,981
Ensembl chr10:15,395,782...15,402,520
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 protein] |
CTD |
PMID:30107153 |
|
Ensembl chr MT:7,919...8,599
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G |
Mt-atp8 |
mitochondrially encoded ATP synthase membrane subunit 8 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 protein] |
CTD |
PMID:30107153 |
|
Ensembl chr MT:7,758...7,961
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G |
Mybl1 |
MYB proto-oncogene like 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [Apigenin results in increased expression of MYBL1 mRNA] |
CTD |
PMID:33405908 |
|
NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:9,582,934...9,618,183
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]] Apigenin inhibits the reaction [Ovalbumin results in increased expression of MYD88 protein] |
CTD |
PMID:36055550 PMID:36350155 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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G |
Nanog |
Nanog homeobox |
decreases expression |
ISO |
Apigenin results in decreased expression of NANOG protein |
CTD |
PMID:27468969 |
|
NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116
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G |
Ndufa4 |
Ndufa4, mitochondrial complex associated |
multiple interactions |
EXP |
Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of NDUFA4 mRNA] |
CTD |
PMID:30107153 |
|
NCBI chr 4:40,968,391...40,975,559
Ensembl chr 4:40,002,216...40,023,920
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G |
Neo1 |
neogenin 1 |
increases expression |
ISO |
Apigenin results in increased expression of NEO1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 8:68,169,711...68,322,158
Ensembl chr 8:59,275,569...59,430,348
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G |
Nfat5 |
nuclear factor of activated T-cells 5 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA] |
CTD |
PMID:26800359 |
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NCBI chr19:52,108,982...52,196,418
Ensembl chr19:35,199,016...35,286,675
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G |
Nfe2 |
nuclear factor, erythroid 2 |
decreases expression |
EXP |
Apigenin results in decreased expression of NFE2 mRNA |
CTD |
PMID:31201582 |
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NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:134,382,761...134,390,108
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Apigenin affects the localization of and results in increased activity of NFE2L2 protein |
CTD |
PMID:22864849 |
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions affects localization |
EXP ISO |
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA] Apigenin affects the localization of NFKB1 protein Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein] |
CTD |
PMID:18090225 PMID:24148603 PMID:28389404 |
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 protein] |
CTD |
PMID:25557508 |
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NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions affects degradation |
ISO EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]] Apigenin affects the degradation of NFKBIA protein Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in decreased expression of NFKBIA protein] Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:15322261 PMID:16934226 PMID:18090225 PMID:24148603 PMID:25557508 PMID:25935278 PMID:36350155 More...
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NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] |
CTD |
PMID:15322261 |
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NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]] |
CTD |
PMID:36055550 |
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NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA] |
CTD |
PMID:11343698 PMID:12512693 PMID:16934226 PMID:18090225 PMID:28389404 PMID:30152906 PMID:33845614 More...
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] |
CTD |
PMID:25257666 |
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NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity multiple interactions |
ISO |
Apigenin results in increased activity of NR1I2 protein Apigenin binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 PMID:33049310 |
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NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
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G |
Nsdhl |
NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL |
decreases expression |
EXP |
Apigenin results in decreased expression of NSDHL mRNA |
CTD |
PMID:31201582 |
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NCBI chr X:155,817,301...155,848,224
Ensembl chr X:150,775,080...150,807,142
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G |
P2rx7 |
purinergic receptor P2X 7 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein] |
CTD |
PMID:25935278 |
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NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619
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G |
Pank2 |
pantothenate kinase 2 |
decreases expression |
ISO |
Apigenin results in decreased expression of PANK2 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 3:138,936,448...138,974,196
Ensembl chr 3:118,483,444...118,518,320
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of PARP1 protein] [Apigenin co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile] results in increased cleavage of PARP1 protein; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased cleavage of PARP1 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein Apigenin results in increased cleavage of PARP1 protein |
CTD |
PMID:20493918 PMID:22155090 PMID:24070738 PMID:24148603 PMID:29247770 |
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein] |
CTD |
PMID:26872304 |
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NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
ISO |
[Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of PDGFRB protein |
CTD |
PMID:35513012 |
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NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
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G |
Pgr |
progesterone receptor |
affects binding multiple interactions |
ISO |
Apigenin binds to PGR protein Apigenin inhibits the reaction [Progesterone binds to PGR protein] |
CTD |
PMID:14579009 |
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NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
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G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] |
CTD |
PMID:25388478 |
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NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
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G |
Pkmyt1 |
protein kinase, membrane associated tyrosine/threonine 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of PKMYT1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
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G |
Polr2h |
RNA polymerase II, I and III subunit H |
increases expression |
ISO |
Apigenin results in increased expression of POLR2H mRNA |
CTD |
PMID:22359648 |
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NCBI chr11:93,696,423...93,701,902
Ensembl chr11:80,192,032...80,197,515 Ensembl chr10:80,192,032...80,197,515
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G |
Pou5f1 |
POU class 5 homeobox 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of POU5F1 protein |
CTD |
PMID:22906706 |
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NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Alcohols results in decreased expression of PPARA protein] |
CTD |
PMID:28803762 |
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NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
ISO |
Apigenin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] Apigenin results in decreased expression of PPARG mRNA |
CTD |
PMID:11343698 PMID:18359623 PMID:33049310 |
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NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] |
CTD |
PMID:16873680 |
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NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
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G |
Prom1 |
prominin 1 |
decreases expression |
ISO |
Apigenin results in decreased expression of PROM1 protein |
CTD |
PMID:27468969 |
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NCBI chr14:71,202,303...71,307,008
Ensembl chr14:66,990,160...67,094,527
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G |
Prpsap1 |
phosphoribosyl pyrophosphate synthetase-associated protein 1 |
increases expression |
ISO |
Apigenin results in increased expression of PRPSAP1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751
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G |
Psca |
prostate stem cell antigen |
decreases expression |
ISO |
Apigenin results in decreased expression of PSCA mRNA |
CTD |
PMID:18331776 |
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NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases expression |
ISO EXP |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] Apigenin results in decreased expression of PTGS2 protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] Apigenin affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] |
CTD |
PMID:11343698 PMID:16552572 PMID:30152906 PMID:35500696 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2b |
protein tyrosine kinase 2 beta |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] |
CTD |
PMID:29960001 |
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NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] |
CTD |
PMID:29960001 |
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NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955
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G |
Ranbp10 |
RAN binding protein 10 |
increases expression |
ISO |
Apigenin results in increased expression of RANBP10 mRNA |
CTD |
PMID:22359648 |
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NCBI chr19:50,565,924...50,626,720
Ensembl chr19:33,656,046...33,717,033
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases expression multiple interactions affects localization |
ISO EXP |
Apigenin results in increased expression of RELA protein Apigenin inhibits the reaction [Alcohols results in increased expression of RELA protein] Apigenin affects the localization of RELA protein Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein] Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein] |
CTD |
PMID:15090468 PMID:15113938 PMID:18090225 PMID:22634262 PMID:24148603 PMID:25935278 PMID:28803762 More...
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Rnase3 |
ribonuclease A family member 3 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in increased secretion of RNASE3 protein] |
CTD |
PMID:36350155 |
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NCBI chr15:26,985,399...26,986,269
Ensembl chr15:24,511,891...24,512,790
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
Apigenin results in decreased expression of RPS6KB1 protein |
CTD |
PMID:15947208 |
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NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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G |
S1pr1 |
sphingosine-1-phosphate receptor 1 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR1 protein] |
CTD |
PMID:25557508 |
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NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681
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G |
S1pr2 |
sphingosine-1-phosphate receptor 2 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR2 protein] |
CTD |
PMID:25557508 |
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NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:19,502,627...19,523,574
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G |
S1pr3 |
sphingosine-1-phosphate receptor 3 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR3 protein] |
CTD |
PMID:25557508 |
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NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
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G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
multiple interactions |
EXP |
Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of SDHA mRNA] |
CTD |
PMID:30107153 |
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NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:28,940,164...28,961,535
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G |
Sele |
selectin E |
multiple interactions |
ISO |
Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein] |
CTD |
PMID:15113938 PMID:16987811 |
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NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741
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G |
Sf3b2 |
splicing factor 3b, subunit 2 |
increases expression |
ISO |
Apigenin results in increased expression of SF3B2 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 1:211,999,777...212,040,686
Ensembl chr 1:202,570,423...202,590,759
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G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
Apigenin binds to SHBG protein |
CTD |
PMID:25349334 |
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NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057
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G |
Slain2 |
SLAIN motif family, member 2 |
increases expression |
ISO |
Apigenin results in increased expression of SLAIN2 mRNA |
CTD |
PMID:22359648 |
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NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP |
[Apigenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate |
CTD |
PMID:17108059 |
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NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions decreases expression |
ISO |
Apigenin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] Apigenin results in decreased expression of SLC2A1 mRNA; Apigenin results in decreased expression of SLC2A1 protein |
CTD |
PMID:36870413 PMID:37437745 |
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NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416
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G |
Slc2a3 |
solute carrier family 2 member 3 |
multiple interactions decreases expression |
ISO |
[Apigenin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA Apigenin results in decreased expression of SLC2A3 mRNA; Apigenin results in decreased expression of SLC2A3 protein |
CTD |
PMID:20153296 PMID:37437745 |
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NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] |
CTD |
PMID:18591783 |
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NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
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G |
Slc3a2 |
solute carrier family 3 member 2 |
multiple interactions decreases expression |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC3A2 mRNA] Apigenin results in decreased expression of SLC3A2 mRNA |
CTD |
PMID:35500696 |
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NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931
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G |
Slc5a1 |
solute carrier family 5 member 1 |
multiple interactions |
ISO |
Apigenin analog inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] |
CTD |
PMID:17495124 |
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NCBI chr14:81,778,495...81,843,084
Ensembl chr14:77,553,843...77,618,547
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G |
Slc7a11 |
solute carrier family 7 member 11 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC7A11 mRNA] |
CTD |
PMID:35500696 |
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NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] |
CTD |
PMID:22394605 |
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NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981
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G |
Slf2 |
SMC5-SMC6 complex localization factor 2 |
decreases expression |
ISO |
Apigenin results in decreased expression of SLF2 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 1:253,731,979...253,794,577
Ensembl chr 1:243,782,246...243,845,250
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G |
Snca |
synuclein alpha |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:28389404 |
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NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
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G |
Socs3 |
suppressor of cytokine signaling 3 |
increases expression |
ISO |
Apigenin results in increased expression of SOCS3 mRNA |
CTD |
PMID:23782265 |
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NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression multiple interactions |
ISO |
Apigenin results in decreased expression of SOD1 mRNA; Apigenin results in decreased expression of SOD1 protein Apigenin inhibits the reaction [Methotrexate results in decreased activity of SOD1 protein] |
CTD |
PMID:22359648 PMID:33845614 |
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G |
Sox2 |
SRY-box transcription factor 2 |
decreases expression |
ISO |
Apigenin results in decreased expression of SOX2 protein |
CTD |
PMID:27468969 |
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NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338
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G |
Sphk1 |
sphingosine kinase 1 |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] |
CTD |
PMID:25557508 |
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NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240
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G |
Sptbn1 |
spectrin, beta, non-erythrocytic 1 |
increases expression |
ISO |
Apigenin results in increased expression of SPTBN1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr14:108,042,629...108,217,884
Ensembl chr14:103,842,684...104,008,507
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] |
CTD |
PMID:28803762 |
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NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation multiple interactions |
ISO |
Apigenin results in decreased phosphorylation of STAT3 protein Apigenin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:20153296 PMID:27468969 |
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NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases sulfation |
ISO |
SULT1A1 protein SNP results in increased sulfation of Apigenin |
CTD |
PMID:17293380 |
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NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult1e1 |
sulfotransferase family 1E member 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] |
CTD |
PMID:22414680 |
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NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,422,324...20,439,275
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G |
Syk |
spleen associated tyrosine kinase |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] |
CTD |
PMID:29960001 |
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NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410
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G |
Tbx21 |
T-box transcription factor 21 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in decreased expression of TBX21 mRNA]; Apigenin inhibits the reaction [Ovalbumin results in decreased expression of TBX21 protein] |
CTD |
PMID:36350155 |
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NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831
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G |
Tecr |
trans-2,3-enoyl-CoA reductase |
increases expression |
ISO |
Apigenin results in increased expression of TECR mRNA |
CTD |
PMID:22359648 |
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NCBI chr19:41,431,422...41,472,880
Ensembl chr19:24,541,615...24,568,168
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G |
Tfpt |
TCF3 fusion partner |
decreases expression |
ISO |
Apigenin results in decreased expression of TFPT mRNA |
CTD |
PMID:22359648 |
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NCBI chr 1:74,502,994...74,512,766
Ensembl chr 1:65,582,359...65,611,689
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G |
Tfrc |
transferrin receptor |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TFRC protein] |
CTD |
PMID:35500696 |
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NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
Apigenin inhibits the reaction [Rotenone results in decreased expression of TH protein] |
CTD |
PMID:28389404 |
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NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Apigenin binds to and results in increased activity of THRA protein |
CTD |
PMID:33049310 |
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NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions |
ISO |
Apigenin binds to and results in increased activity of THRB protein |
CTD |
PMID:33049310 |
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NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]] Apigenin inhibits the reaction [Ovalbumin results in increased expression of TLR4 protein] |
CTD |
PMID:36350155 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G |
Tm7sf2 |
transmembrane 7 superfamily member 2 |
decreases expression |
EXP |
Apigenin results in decreased expression of TM7SF2 mRNA |
CTD |
PMID:31201582 |
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NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO EXP |
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Apigenin promotes the reaction [hydroxygenkwanin results in increased expression of TNF protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased expression of TNF protein] Apigenin inhibits the reaction [Alcohols results in increased expression of TNF protein]; Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA] |
CTD |
PMID:15113938 PMID:15322261 PMID:15985724 PMID:16987811 PMID:24144774 PMID:24148603 PMID:25557508 PMID:25935278 PMID:28389404 PMID:28803762 PMID:30016632 PMID:30152906 PMID:35373622 PMID:36055550 PMID:36350155 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases response to substance |
ISO |
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein |
CTD |
PMID:29247770 |
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NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp53 |
tumor protein p53 |
multiple interactions affects activity increases expression |
ISO |
TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein] Apigenin affects the activity of TP53 protein Apigenin results in increased expression of TP53 protein |
CTD |
PMID:11790449 PMID:16023288 PMID:35435491 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53i3 |
tumor protein p53 inducible protein 3 |
increases expression |
ISO |
Apigenin results in increased expression of TP53I3 mRNA; Apigenin results in increased expression of TP53I3 protein |
CTD |
PMID:19397994 |
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NCBI chr 6:33,537,779...33,545,204
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G |
Tp63 |
tumor protein p63 |
increases expression |
ISO |
Apigenin results in increased expression of TP63 protein |
CTD |
PMID:19397994 |
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NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398
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G |
Tp73 |
tumor protein p73 |
increases expression |
ISO |
Apigenin results in increased expression of TP73 protein |
CTD |
PMID:19397994 |
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NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Ovalbumin results in increased expression of TRAF6 protein] Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]] |
CTD |
PMID:36350155 |
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NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
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G |
Tubb5 |
tubulin, beta 5 class I |
increases expression |
ISO |
Apigenin results in increased expression of TUBB5 mRNA |
CTD |
PMID:22359648 |
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NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940
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G |
Tyr |
tyrosinase |
increases expression |
ISO |
Apigenin results in increased expression of TYR mRNA |
CTD |
PMID:21071833 |
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NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression increases glucuronidation multiple interactions |
ISO |
Apigenin results in increased expression of UGT1A1 mRNA UGT1A1 protein results in increased glucuronidation of Apigenin 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA]; [sulforaphane co-treated with Apigenin] results in increased expression of UGT1A1 mRNA |
CTD |
PMID:14557274 PMID:15090468 PMID:29584932 PMID:31621310 |
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NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Apigenin |
CTD |
PMID:14557274 |
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NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b15 |
UDP glucuronosyltransferase family 2 member B15 |
increases metabolic processing |
EXP |
UGT2B15 protein results in increased metabolism of Apigenin |
CTD |
PMID:7574722 |
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NCBI chr14:21,122,866...21,138,450
Ensembl chr14:20,768,015...20,783,589
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G |
Uqcrq |
ubiquinol-cytochrome c reductase, complex III subunit VII |
multiple interactions |
EXP |
Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of UQCRQ mRNA] |
CTD |
PMID:30107153 |
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NCBI chr10:38,086,691...38,093,871
Ensembl chr10:37,586,888...37,589,169
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G |
Usp48 |
ubiquitin specific peptidase 48 |
increases expression |
ISO |
Apigenin results in increased expression of USP48 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 5:149,800,189...149,867,838
Ensembl chr 5:149,800,179...149,867,719
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G |
Utrn |
utrophin |
increases expression |
ISO |
Apigenin results in increased expression of UTRN mRNA |
CTD |
PMID:22028826 |
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NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:15113938 PMID:16987811 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression multiple interactions |
ISO |
Apigenin results in decreased expression of VEGFA mRNA; Apigenin results in decreased expression of VEGFA protein [Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA protein; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Apigenin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein] |
CTD |
PMID:15947208 PMID:20153296 PMID:35513012 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G |
Zcrb1 |
zinc finger CCHC-type and RNA binding motif containing 1 |
increases expression |
ISO |
Apigenin results in increased expression of ZCRB1 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 7:124,525,227...124,538,564
Ensembl chr 7:124,524,870...124,571,261
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G |
Zfp110 |
zinc finger protein 110 |
increases expression |
ISO |
Apigenin results in increased expression of ZFP110 mRNA |
CTD |
PMID:22359648 |
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NCBI chr 1:82,509,563...82,533,294
Ensembl chr 1:73,445,336...73,461,086
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
acacetin results in decreased expression of CCNB1 protein |
CTD |
PMID:36740148 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
acacetin results in decreased expression of CCNE1 protein |
CTD |
PMID:36740148 |
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NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
acacetin results in decreased expression of CDC25C protein |
CTD |
PMID:36740148 |
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NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
acacetin results in decreased expression of CDK1 protein |
CTD |
PMID:36740148 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
acacetin results in decreased expression of CDK2 protein |
CTD |
PMID:36740148 |
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NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
acacetin results in increased expression of CDKN1A protein |
CTD |
PMID:36740148 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Chek1 |
checkpoint kinase 1 |
increases expression |
ISO |
acacetin results in increased expression of CHK1 protein |
CTD |
PMID:36740148 |
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NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing increases expression decreases activity |
ISO |
CYP1A1 protein results in increased metabolism of acacetin acacetin results in increased expression of CYP1A1 mRNA acacetin results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO EXP |
acacetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 PMID:32738202 |
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing increases expression decreases activity multiple interactions |
ISO |
CYP1B1 protein results in increased metabolism of acacetin acacetin results in increased expression of CYP1B1 mRNA acacetin results in decreased activity of CYP1B1 protein acacetin binds to and results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 |
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NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases activity |
EXP |
acacetin results in decreased activity of CYP2B1 protein |
CTD |
PMID:32738202 |
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NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases activity |
EXP |
acacetin results in decreased activity of CYP2C11 protein |
CTD |
PMID:32738202 |
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NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
EXP |
acacetin results in decreased activity of CYP2E1 protein |
CTD |
PMID:32738202 |
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NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity multiple interactions increases expression |
EXP ISO |
acacetin results in decreased activity of CYP3A2 protein acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] acacetin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:21053930 PMID:29933105 PMID:32738202 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Fadd |
Fas associated via death domain |
decreases expression |
ISO |
acacetin results in decreased expression of FADD protein |
CTD |
PMID:36740148 |
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NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:36740148 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
acacetin results in increased phosphorylation of MAPK3 protein Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:36740148 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity increases expression multiple interactions |
ISO |
acacetin results in increased activity of NR1I2 protein acacetin results in increased expression of NR1I2 mRNA acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein] |
CTD |
PMID:25455453 PMID:29933105 |
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NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
acacetin results in increased expression of PARP1 protein |
CTD |
PMID:36740148 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
increases expression |
ISO |
acacetin results in increased expression of RIPK1 protein |
CTD |
PMID:36740148 |
|
NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
increases expression |
ISO |
acacetin results in increased expression of RIPK3 protein |
CTD |
PMID:36740148 |
|
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
acacetin results in increased expression of UGT1A1 mRNA |
CTD |
PMID:31621310 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Gypa |
glycophorin A |
increases expression |
ISO |
apigetrin results in increased expression of GYPA protein |
CTD |
PMID:25058688 |
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NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP1 protein] |
CTD |
PMID:34481870 |
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NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]] |
CTD |
PMID:34481870 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing decreases activity |
ISO |
CYP1A1 protein results in increased metabolism of genkwanin genkwanin results in decreased activity of CYP1A1 protein |
CTD |
PMID:19666078 PMID:21482471 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of genkwanin |
CTD |
PMID:19666078 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing multiple interactions |
ISO |
CYP1B1 protein results in increased metabolism of genkwanin [CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin |
CTD |
PMID:19666078 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] |
CTD |
PMID:34481870 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
hinokiflavone results in increased expression of BAX protein |
CTD |
PMID:30575109 PMID:32252563 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
hinokiflavone results in decreased expression of BCL2 protein |
CTD |
PMID:30575109 PMID:32252563 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
increases expression increases cleavage |
ISO |
hinokiflavone results in increased expression of CASP3 protein hinokiflavone results in increased cleavage of CASP3 protein |
CTD |
PMID:30575109 PMID:32252563 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein] |
CTD |
PMID:8882428 |
|
NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein] |
CTD |
PMID:8882428 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:29673161 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29673161 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29673161 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein |
CTD |
PMID:29635122 PMID:30575109 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
hinokiflavone results in decreased expression of MMP9 protein hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein |
CTD |
PMID:29635122 PMID:30575109 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:29673161 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Prpf40a |
pre-mRNA processing factor 40 homolog A |
increases sumoylation |
ISO |
hinokiflavone results in increased sumoylation of PRPF40A protein |
CTD |
PMID:28884683 |
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NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886
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G |
Ptgds |
prostaglandin D2 synthase |
affects binding |
ISO |
hinokiflavone binds to PTGDS protein |
CTD |
PMID:26456343 |
|
NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:8,281,899...8,284,833
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:29673161 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:29673161 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Senp1 |
SUMO specific peptidase 1 |
decreases activity |
ISO |
hinokiflavone results in decreased activity of SENP1 protein |
CTD |
PMID:28884683 |
|
NCBI chr 7:131,042,237...131,105,826
Ensembl chr 7:129,165,774...129,221,598
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G |
Sf3a2 |
splicing factor 3A subunit 2 |
increases sumoylation |
ISO |
hinokiflavone results in increased sumoylation of SF3A2 protein |
CTD |
PMID:28884683 |
|
NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530
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G |
Sf3b1 |
splicing factor 3b, subunit 1 |
increases sumoylation |
ISO |
hinokiflavone results in increased sumoylation of SF3B1 protein |
CTD |
PMID:28884683 |
|
NCBI chr 9:63,986,829...64,026,723
Ensembl chr 9:56,492,403...56,532,300
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G |
Sf3b2 |
splicing factor 3b, subunit 2 |
increases sumoylation |
ISO |
hinokiflavone results in increased sumoylation of SF3B2 protein |
CTD |
PMID:28884683 |
|
NCBI chr 1:211,999,777...212,040,686
Ensembl chr 1:202,570,423...202,590,759
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G |
Snrpd2 |
small nuclear ribonucleoprotein D2 polypeptide |
increases sumoylation |
ISO |
hinokiflavone results in increased sumoylation of SNRPD2 protein |
CTD |
PMID:28884683 |
|
NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:78,798,377...78,803,351 Ensembl chr20:78,798,377...78,803,351
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G |
Sumo1 |
small ubiquitin-like modifier 1 |
increases localization |
ISO |
hinokiflavone results in increased localization of SUMO1 protein |
CTD |
PMID:28884683 |
|
NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:61,077,435...61,108,761
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G |
Sumo2 |
small ubiquitin-like modifier 2 |
increases localization |
ISO |
hinokiflavone results in increased localization of SUMO2 protein |
CTD |
PMID:28884683 |
|
NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513 Ensembl chr 5:100,686,797...100,784,513
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G |
Sumo3 |
small ubiquitin-like modifier 3 |
increases localization |
ISO |
hinokiflavone results in increased localization of SUMO3 protein |
CTD |
PMID:28884683 |
|
NCBI chr20:11,009,730...11,020,502
Ensembl chr20:11,007,148...11,020,877 Ensembl chr20:11,007,148...11,020,877
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein |
CTD |
PMID:30575109 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:29673161 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
U2surp |
U2 snRNP-associated SURP domain containing |
increases sumoylation |
ISO |
hinokiflavone results in increased sumoylation of U2SURP protein |
CTD |
PMID:28884683 |
|
NCBI chr 8:104,898,580...104,963,642
Ensembl chr 8:96,022,957...96,075,691
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] |
CTD |
PMID:30055130 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] |
CTD |
PMID:30055130 |
|
NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
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G |
Cxcl17 |
C-X-C motif chemokine ligand 17 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA] |
CTD |
PMID:32679548 |
|
NCBI chr 1:80,984,751...80,996,842
Ensembl chr 1:80,984,964...80,996,726
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [Imiquimod results in increased expression of CXCL1 mRNA] |
CTD |
PMID:32679548 |
|
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of TNF mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] |
CTD |
PMID:32679548 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
hispidulin inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA] |
CTD |
PMID:32679548 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18bp |
interleukin 18 binding protein |
multiple interactions |
ISO |
hispidulin inhibits the reaction [Imiquimod results in increased expression of IL18BP mRNA] hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA] |
CTD |
PMID:32679548 |
|
NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:156,372,883...156,374,963
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
hispidulin inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA] hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA] |
CTD |
PMID:32679548 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 mRNA] |
CTD |
PMID:31195760 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [Imiquimod results in increased expression of IL6 mRNA] |
CTD |
PMID:32679548 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] |
CTD |
PMID:30055130 |
|
NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum |
RGD |
PMID:29575334 |
RGD:149735333 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP ISO |
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22759588 PMID:32679548 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP ISO |
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22759588 PMID:32679548 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:32679548 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
hispidulin inhibits the reaction [Imiquimod results in increased expression of MPO protein] |
CTD |
PMID:32679548 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] |
CTD |
PMID:30055130 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] |
CTD |
PMID:32679548 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] |
CTD |
PMID:36870413 |
|
NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
decreases activity multiple interactions |
EXP |
hispidulin results in decreased activity of SLCO1B1 protein [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
|
NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:174,466,631...174,513,289
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G |
Syn1 |
synapsin I |
affects response to substance |
ISO |
SYN1 protein affects the susceptibility to hispidulin |
CTD |
PMID:22759588 |
|
NCBI chr X:3,725,745...3,780,940
Ensembl chr X:1,172,208...1,227,396
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of TNF mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] hispidulin inhibits the reaction [Imiquimod results in increased expression of TNF protein] |
CTD |
PMID:31195760 PMID:32679548 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
ISO |
isoscutellarein results in increased expression of ADIPOQ protein |
CTD |
PMID:30445784 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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G |
Lep |
leptin |
decreases expression |
ISO |
isoscutellarein results in decreased expression of LEP protein |
CTD |
PMID:30445784 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Rbp4 |
retinol binding protein 4 |
decreases expression |
ISO |
isoscutellarein results in decreased expression of RBP4 protein |
CTD |
PMID:30445784 |
|
NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399
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G |
Slc2a4 |
solute carrier family 2 member 4 |
increases expression |
ISO |
isoscutellarein results in increased expression of SLC2A4 protein |
CTD |
PMID:30445784 |
|
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
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G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
isoscutellarein results in decreased expression of TNF protein |
CTD |
PMID:30445784 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
isovitexin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] |
CTD |
PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[isovitexin results in increased expression of and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein; isovitexin inhibits the reaction [TNF protein results in decreased expression of AHR protein]; isovitexin results in increased expression of and results in increased activity of AHR protein |
CTD |
PMID:37263555 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
isovitexin results in decreased expression of CDK2 mRNA; isovitexin results in decreased expression of CDK2 protein |
CTD |
PMID:37939611 |
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NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
isovitexin results in increased expression of CDKN1A mRNA; isovitexin results in increased expression of CDKN1A protein |
CTD |
PMID:37939611 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
EXP |
isovitexin results in increased expression of CYP1A1 protein 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin results in increased expression of CYP1A1 protein]; [isovitexin results in increased expression of and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein |
CTD |
PMID:37263555 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein] |
CTD |
PMID:37263555 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein] |
CTD |
PMID:37263555 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
isovitexin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] |
CTD |
PMID:37263555 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of NFKBIA protein]]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:37263555 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G |
Ocln |
occludin |
multiple interactions |
EXP |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein] |
CTD |
PMID:37263555 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] |
CTD |
PMID:37263555 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
EXP |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein] |
CTD |
PMID:37263555 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein] 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of NFKBIA protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of AHR protein]; isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]; isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] |
CTD |
PMID:37263555 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
isovitexin results in increased expression of TP53 mRNA; isovitexin results in increased expression of TP53 protein |
CTD |
PMID:37939611 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation multiple interactions |
ISO |
pectolinarigenin results in increased phosphorylation of ATM protein TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] |
CTD |
PMID:37393350 |
|
NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein] |
CTD |
PMID:37393350 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
pectolinarigenin results in increased expression of H2AX protein TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein] |
CTD |
PMID:37393350 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases lipidation |
ISO |
Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:37393350 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
pectolinarigenin results in decreased expression of MKI67 protein |
CTD |
PMID:37393350 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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G |
Sqstm1 |
sequestosome 1 |
increases expression multiple interactions |
ISO |
pectolinarigenin results in increased expression of SQSTM1 protein Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] |
CTD |
PMID:37393350 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
pectolinarigenin binds to and results in increased expression of TOP2A protein; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] |
CTD |
PMID:37393350 |
|
NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
pectolinarigenin results in increased expression of TP53 protein TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein] |
CTD |
PMID:37393350 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
increases expression |
ISO |
pectolinarigenin results in increased expression of TP53BP1 protein |
CTD |
PMID:37393350 |
|
NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:108,169,980...108,269,822
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation affects binding |
ISO |
UGT1A1 protein results in increased glucuronidation of pectolinarigenin pectolinarigenin binds to UGT1A1 protein |
CTD |
PMID:37797876 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
affects binding increases glucuronidation |
ISO |
pectolinarigenin binds to UGT1A3 protein UGT1A3 protein results in increased glucuronidation of pectolinarigenin |
CTD |
PMID:37797876 |
|
NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
affects binding increases glucuronidation |
ISO |
pectolinarigenin binds to UGT1A9 protein UGT1A9 protein results in increased glucuronidation of pectolinarigenin |
CTD |
PMID:37797876 |
|
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases glucuronidation |
ISO |
UGT2B17 protein results in increased glucuronidation of pectolinarigenin |
CTD |
PMID:37797876 |
|
NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
schaftoside inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin] |
CTD |
PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity affects metabolic processing multiple interactions |
ISO |
scutellarein results in decreased activity of CYP1A1 protein CYP1A1 protein affects the metabolism of scutellarein [CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin |
CTD |
PMID:19666078 PMID:21482471 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects metabolic processing |
ISO |
CYP1A2 protein affects the metabolism of scutellarein |
CTD |
PMID:19666078 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity affects metabolic processing multiple interactions |
ISO |
scutellarein results in decreased activity of CYP1B1 protein CYP1B1 protein affects the metabolism of scutellarein [CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin |
CTD |
PMID:19666078 PMID:21482471 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
App |
amyloid beta precursor protein |
multiple interactions |
EXP |
scutellarin inhibits the reaction [APP protein binds to APP protein] |
CTD |
PMID:17323972 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX protein] |
CTD |
PMID:34610774 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 protein] |
CTD |
PMID:34610774 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] |
CTD |
PMID:18442013 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Casp1 |
caspase 1 |
multiple interactions |
EXP |
scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA] |
CTD |
PMID:37081038 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein] scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 protein]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein] |
CTD |
PMID:18442013 PMID:34610774 PMID:36252740 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP9 protein] |
CTD |
PMID:34610774 |
|
Ensembl chr 5:154,109,046...154,126,626
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] |
CTD |
PMID:25192544 |
|
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
EXP |
scutellarin results in decreased expression of FGF2 protein |
CTD |
PMID:16297343 |
|
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
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G |
Gsdmd |
gasdermin D |
multiple interactions |
EXP |
scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein] |
CTD |
PMID:37081038 |
|
NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] |
CTD |
PMID:25192544 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:34610774 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of IKBKB protein] |
CTD |
PMID:34610774 |
|
NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] |
CTD |
PMID:37081038 |
|
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 mRNA] |
CTD |
PMID:34610774 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein] |
CTD |
PMID:36252740 |
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NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 protein] |
CTD |
PMID:34610774 |
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NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] |
CTD |
PMID:36252740 |
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NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] |
CTD |
PMID:25192544 |
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NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of MYD88 mRNA] |
CTD |
PMID:34610774 |
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NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein] |
CTD |
PMID:34610774 |
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 mRNA] |
CTD |
PMID:34610774 |
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFKBIB mRNA] |
CTD |
PMID:34610774 |
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NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] |
CTD |
PMID:37081038 |
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NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
EXP |
scutellarin results in decreased expression of NOS2 protein |
CTD |
PMID:16297343 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression |
EXP |
scutellarin results in increased expression of NOS3 protein |
CTD |
PMID:16297343 |
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NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NPPB protein] |
CTD |
PMID:34610774 |
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NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NQO1 mRNA] |
CTD |
PMID:34610774 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PARP1 mRNA] |
CTD |
PMID:34610774 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] |
CTD |
PMID:25192544 |
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NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G |
Pkm |
pyruvate kinase M1/2 |
increases activity |
ISO |
scutellarin results in increased activity of PKM protein |
CTD |
PMID:25388478 |
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NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
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G |
Pla2g2a |
phospholipase A2 group IIA |
affects activity |
ISO |
scutellarin affects the activity of PLA2G2A protein |
CTD |
PMID:8190018 |
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NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein] |
CTD |
PMID:34610774 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
multiple interactions |
ISO |
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein] |
CTD |
PMID:36252740 |
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NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TLR4 mRNA] |
CTD |
PMID:34610774 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein] |
CTD |
PMID:34610774 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression multiple interactions |
EXP ISO |
scutellarin results in decreased expression of VEGFA protein scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein] |
CTD |
PMID:16297343 PMID:25192544 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression |
ISO |
vitexin results in increased expression of ABCA1 mRNA |
CTD |
PMID:29545167 |
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NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
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G |
Apoe |
apolipoprotein E |
increases expression |
ISO |
vitexin results in increased expression of APOE mRNA |
CTD |
PMID:29545167 |
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NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions decreases expression |
ISO |
vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]; vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] vitexin results in decreased expression of APP mRNA; vitexin results in decreased expression of APP protein |
CTD |
PMID:29545167 PMID:32926499 |
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NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein] |
CTD |
PMID:29545167 |
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] |
CTD |
PMID:29545167 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein] |
CTD |
PMID:29545167 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA] |
CTD |
PMID:29545167 |
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NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
increases expression |
ISO |
vitexin results in increased expression of DHCR24 mRNA |
CTD |
PMID:29545167 |
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NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] |
CTD |
PMID:30365938 |
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NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:29545167 |
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA] |
CTD |
PMID:29545167 |
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NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein] |
CTD |
PMID:30365938 |
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NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:29545167 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression |
ISO |
vitexin results in increased expression of NR1H3 mRNA |
CTD |
PMID:29545167 |
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NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722
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G |
Ppid |
peptidylprolyl isomerase D |
multiple interactions |
ISO |
vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] |
CTD |
PMID:29545167 |
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NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:164,727,779...164,740,221
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