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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,8-dihydroxyadenine
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Accession:CHEBI:183641 term browser browse the term
Definition:A member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism.
Synonyms:exact_synonym: 6-amino-9H-purine-2,8-diol
 related_synonym: 2,8-DHA;   6-amino-2,8-dihydroxypurine;   6-amino-purine-2,8-diol;   Formula=C5H5N5O2;   InChI=1S/C5H5N5O2/c6-2-1-3(9-4(11)7-1)10-5(12)8-2/h(H5,6,7,8,9,10,11,12);   InChIKey=XFBOJHLYDJZYSP-UHFFFAOYSA-N;   SMILES=NC1=NC(O)=NC2=C1N=C(O)N2
 xref: CAS:30377-37-8;   FooDB:FDB022018;   HMDB:HMDB0000401;   PMID:10481956;   PMID:15025810;   PMID:16713382;   PMID:20098761;   PMID:21553389;   PMID:23113528;   PMID:24359665;   PMID:24940675;   PMID:25307253;   PMID:26278213;   PMID:27447713;   PMID:27770717;   PMID:28466077;   PMID:28566603;   PMID:28717278;   PMID:29657221;   PMID:29861153;   PMID:30355577;   PMID:31378568;   PMID:31880754;   PMID:32086278;   PMID:32260098;   PMID:32399606;   PMID:32859011;   PMID:33273797;   PMID:33678741;   PMID:34044400;   PMID:34341261;   PMID:34610707;   Wikipedia:2\,8-Dihydroxyadenine
 cyclic_relationship: is_tautomer_of CHEBI:179632


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  CHEBI ontology 19921
    role 19896
      biological role 19894
        aetiopathogenetic role 19227
          nephrotoxic agent 11855
            2,8-dihydroxyadenine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic molecule 19764
                              organic cyclic compound 19572
                                organic heterocyclic compound 18905
                                  organic heteropolycyclic compound 18317
                                    organic heterobicyclic compound 17257
                                      imidazopyrimidine 7680
                                        purines 7679
                                          aminopurine 6653
                                            6-aminopurines 898
                                              adenine 894
                                                2,8-dihydroxyadenine 0
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