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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methoxsalen
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Accession:CHEBI:18358 term browser browse the term
Definition:A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Synonyms:exact_synonym: 9-methoxy-7H-furo[3,2-g]chromen-7-one
 related_synonym: 6-hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone;   8-MOP;   8-MP;   8-Methoxyfuranocoumarin;   8-methoxy-2',3',6,7-furocoumarin;   8-methoxy-4',5':6,7-furocoumarin;   8-methoxy-[furano-3'.2':6.7-coumarin];   8-methoxypsoralen;   9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one;   Formula=C12H8O4;   InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3;   InChIKey=QXKHYNVANLEOEG-UHFFFAOYSA-N;   Meladinine;   Meloxine;   O-methylxanthotoxol;   Oxsoralen;   SMILES=COc1c2occc2cc2ccc(=O)oc12;   Ultra Mop;   Uvadex;   Xanthotoxin
 alt_id: CHEBI:10068;   CHEBI:101063;   CHEBI:12268;   CHEBI:12715;   CHEBI:21960;   CHEBI:27330;   CHEBI:27331;   CHEBI:40342
 xref: Beilstein:196453;   CAS:298-81-7;   DrugBank:DB00553;   Drug_Central:30;   HMDB:HMDB0014693;   KEGG:C01864;   KEGG:D00139;   KNApSAcK:C00000576;   LINCS:LSM-3410
 xref_mesh: MESH:D008730
 xref: PDBeChem:8MO;   PMID:15009205;   PMID:28166217;   PMID:7945434;   Patent:US2889337;   Reaxys:196453;   Wikipedia:Methoxsalen


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methoxsalen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Methoxsalen results in decreased expression of ABCB11 mRNA; Methoxsalen results in decreased expression of ABCB11 protein CTD PMID:28552422 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
increases expression		 ISO Methoxsalen results in decreased activity of ABCB1 protein
[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein]
Methoxsalen results in increased expression of ABCB1 mRNA		 CTD PMID:29079042 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO
EXP		 Methoxsalen results in decreased expression of ABCB4 mRNA
Methoxsalen results in decreased expression of ABCB4 mRNA; Methoxsalen results in decreased expression of ABCB4 protein		 CTD PMID:28552422 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Methoxsalen results in increased expression of ABCC1 mRNA CTD PMID:29079042 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression
decreases activity
multiple interactions		 ISO Methoxsalen results in decreased expression of ABCC2 mRNA
Methoxsalen results in decreased activity of ABCC2 protein
[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [Methoxsalen results in decreased activity of ABCC2 protein]		 CTD PMID:29079042 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP
ISO		 Methoxsalen results in increased expression of ABCC3 mRNA
Methoxsalen results in increased expression of ABCC3 protein		 CTD PMID:28552422 PMID:30419252 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression
increases expression		 ISO Methoxsalen affects the expression of ABCC4 protein
Methoxsalen results in increased expression of ABCC4 mRNA		 CTD PMID:22173200 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
decreases activity		 ISO [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]
Methoxsalen results in increased expression of ABCG2 mRNA		 CTD PMID:29079042 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions		 EXP
ISO		 Methoxsalen results in increased activity of AHR protein
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]		 CTD PMID:7702611 PMID:15670584 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Methoxsalen results in increased expression of BAX protein CTD PMID:22796345 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Methoxsalen inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]
Methoxsalen results in decreased expression of BCL2 protein		 CTD PMID:22743290 PMID:22796345 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions
decreases expression
decreases response to substance		 ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein]; BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]
Methoxsalen results in decreased expression of BHLHE40 mRNA; Methoxsalen results in decreased expression of BHLHE40 protein
BHLHE40 protein results in decreased susceptibility to Methoxsalen		 CTD PMID:22796345 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein] CTD PMID:22796345 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]; Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Methoxsalen results in decreased expression of and results in increased activity of CASP3 protein CTD PMID:22743290 PMID:22796345 PMID:23907605 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO Methoxsalen results in decreased expression of CASP8 protein CTD PMID:22796345 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Methoxsalen results in decreased expression of CASP9 protein CTD PMID:22796345 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] CTD PMID:15157999 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases expression		 ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]
Methoxsalen results in increased expression of CES2 mRNA; Methoxsalen results in increased expression of CES2 protein		 CTD PMID:17003103 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO
EXP		 Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
Methoxsalen results in decreased activity of CYP1A1 protein
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Methoxsalen results in increased expression of CYP1A1 mRNA
Methoxsalen results in increased expression of and results in decreased activity of CYP1A1 protein		 CTD PMID:7702611 PMID:9169082 PMID:15670584 PMID:18420780 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP1A2 protein CTD PMID:8819299 PMID:12814958 PMID:15879494 PMID:18420780 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Methoxsalen results in decreased activity of CYP1B1 protein CTD PMID:18420780 PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP Methoxsalen results in decreased expression of CYP27A1 mRNA CTD PMID:28552422 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 decreases activity
multiple interactions		 EXP
ISO		 Methoxsalen results in decreased activity of CYP2A1 protein
[Methoxsalen results in decreased activity of CYP2A13 protein] which results in decreased susceptibility to Skatole; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]		 CTD PMID:12814958 PMID:17671098 PMID:18669584 PMID:20795680 PMID:22743290 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2A3 protein
Methoxsalen results in decreased activity of CYP2A4 protein		 CTD PMID:15879494 PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2B1 protein
Methoxsalen results in decreased activity of CYP2B10 protein		 CTD PMID:15879494 PMID:18420780 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2C11 protein
Methoxsalen results in decreased activity of CYP2C9 protein		 CTD PMID:12814958 PMID:15879494 PMID:18420780 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP Methoxsalen results in decreased activity of CYP2C6V1 protein CTD PMID:12814958 PMID:15879494 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Methoxsalen results in decreased activity of CYP2C29 protein CTD PMID:18420780
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Methoxsalen results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2E1 protein CTD PMID:15879494 PMID:18420780 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
multiple interactions		 EXP
ISO		 Methoxsalen results in decreased activity of CYP3A2 protein
Methoxsalen results in increased expression of CYP3A4 mRNA; Methoxsalen results in increased expression of CYP3A4 protein
Methoxsalen results in decreased activity of CYP3A4 protein
Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]		 CTD PMID:15879494 PMID:17003103 PMID:18420780 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases activity EXP Methoxsalen results in decreased activity of CYP3A23-3A1 protein CTD PMID:15879494 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Methoxsalen results in decreased expression of CYP7A1 mRNA
Methoxsalen results in decreased expression of CYP7A1 protein
Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]
Methoxsalen results in increased expression of CYP7A1 protein		 CTD PMID:28552422 PMID:30419252 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Methoxsalen results in decreased expression of CYP8B1 mRNA CTD PMID:28552422 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Methoxsalen results in increased expression of GPT protein CTD PMID:28552422 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hal histidine ammonia lyase decreases activity ISO Methoxsalen results in decreased activity of HAL protein CTD PMID:20880231 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Methoxsalen results in decreased expression of NR0B2 mRNA
VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]		 CTD PMID:28552422 PMID:30419252 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Methoxsalen results in decreased expression of NR1H4 mRNA; Methoxsalen results in decreased expression of NR1H4 protein CTD PMID:28552422 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO
EXP		 NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]
Methoxsalen results in increased activity of NR1I2 protein		 CTD PMID:17003103 PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] CTD PMID:22743290 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Methoxsalen results in decreased expression of PPARA mRNA; Methoxsalen results in decreased expression of PPARA protein CTD PMID:28552422 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] CTD PMID:15157999 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Methoxsalen results in decreased expression of SLC10A1 mRNA; Methoxsalen results in decreased expression of SLC10A1 protein CTD PMID:28552422 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO Methoxsalen results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases expression
increases expression		 ISO Methoxsalen results in decreased expression of SLC22A2 mRNA
Methoxsalen results in increased expression of SLC22A2 protein		 CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO Methoxsalen results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO Methoxsalen results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO Methoxsalen results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 decreases expression
increases expression		 ISO Methoxsalen results in decreased expression of SLC2A9 protein
Methoxsalen results in increased expression of SLC2A9 mRNA		 CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Methoxsalen analog results in decreased expression of TNF protein CTD PMID:15052360 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Methoxsalen results in increased expression of TP53 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]		 CTD PMID:22796345 PMID:23907605 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression		 ISO Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]; VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]
Methoxsalen results in increased expression of VDR protein		 CTD PMID:30419252 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        reagent 17863
          cross-linking reagent 7515
            methoxsalen 57
              5-hydroxyxanthotoxin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  organic heteropolycyclic compound 18297
                                    organic heterotricyclic compound 15634
                                      furochromene 121
                                        furanocoumarin 121
                                          psoralens 112
                                            psoralen 98
                                              methoxsalen 57
                                                5-hydroxyxanthotoxin 0
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