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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-dithiothreitol
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Accession:CHEBI:18320 term browser browse the term
Definition:The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.
Synonyms:exact_synonym: rel-(2R,3R)-1,4-disulfanylbutane-2,3-diol
 related_synonym: (R*,R*)-1,4-dimercapto-2,3-butanediol;   Cleland's reagent;   DL-threo-1,4-Dimercapto-2,3-butanediol;   DTL;   DTT;   Dithiothreitol;   Dithiotreitol;   Formula=C4H10O2S2;   InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2;   InChIKey=VHJLVAABSRFDPM-UHFFFAOYSA-N;   SMILES=OC(CS)C(O)CS;   rac-Dithiothreitol;   threo-1,4-Dimercapto-2,3-butanediol
 alt_id: CHEBI:11174;   CHEBI:23854;   CHEBI:4664
 xref: Beilstein:8144556;   CAS:3483-12-3;   DrugBank:DB04447;   KEGG:C00265;   LINCS:LSM-36870
 xref_mesh: MESH:D004229
 xref: PMID:16901854;   PMID:18022205;   PMID:23673948;   PMID:24124079;   PMID:7592847


show annotations for term's descendants           Sort by:
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554 		JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      chemical role 824
        reducing agent 3
          1,4-dithiothreitol 3
            D-1,4-dithiothreitol 0
            L-1,4-dithiothreitol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    main group molecular entity 5012
                      s-block molecular entity 4970
                        hydrogen molecular entity 4964
                          hydrides 4544
                            inorganic hydride 403
                              chalcogen hydride 29
                                sulfur hydride 24
                                  hydrogen sulfide 25
                                    thiol group 24
                                      thiol 24
                                        1,4-dimercaptobutane-2,3-diol 3
                                          1,4-dithiothreitol 3
                                            D-1,4-dithiothreitol 0
                                            L-1,4-dithiothreitol 3
paths to the root