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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,4-dithiothreitol
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Accession:CHEBI:18320 term browser browse the term
Definition:The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.
Synonyms:exact_synonym: rel-(2R,3R)-1,4-disulfanylbutane-2,3-diol
 related_synonym: (R*,R*)-1,4-dimercapto-2,3-butanediol;   Cleland's reagent;   DL-threo-1,4-Dimercapto-2,3-butanediol;   DTL;   DTT;   Dithiothreitol;   Dithiotreitol;   Formula=C4H10O2S2;   InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2;   InChIKey=VHJLVAABSRFDPM-UHFFFAOYSA-N;   SMILES=OC(CS)C(O)CS;   rac-Dithiothreitol;   threo-1,4-Dimercapto-2,3-butanediol
 alt_id: CHEBI:11174;   CHEBI:23854;   CHEBI:4664
 xref: Beilstein:8144556;   CAS:3483-12-3;   DrugBank:DB04447;   KEGG:C00265;   LINCS:LSM-36870
 xref_mesh: MESH:D004229
 xref: PMID:16901854;   PMID:18022205;   PMID:23673948;   PMID:24124079;   PMID:7592847


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1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
increases activity
ISO
EXP
Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]
CTD PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 PMID:23933410 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor multiple interactions EXP Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] CTD PMID:6323860 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
increases reduction
EXP
ISO
Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]
CTD PMID:15025511 PMID:25349987 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Dithiothreitol results in increased expression of ATF3 mRNA CTD PMID:17332266 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Dithiothreitol results in increased expression of ATF4 mRNA CTD PMID:27226639 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:18022205 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calu calumenin increases expression ISO Dithiothreitol results in increased expression of CALU protein CTD PMID:21692457 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
CTD PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 PMID:11226294 PMID:26124276 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] CTD PMID:11226294 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977 PMID:32493877 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] CTD PMID:21256830 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Dithiothreitol results in decreased expression of CCND1 mRNA CTD PMID:17332266 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Dithiothreitol results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] CTD PMID:16280210 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Dithiothreitol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]
CTD PMID:17332266 PMID:27226639 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein
CTD PMID:12486162 PMID:25321315 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein] CTD PMID:30385349 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein
CTD PMID:12486162 PMID:25321315 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] CTD PMID:22403704 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases activity ISO Dithiothreitol results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of FGF21 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]
CTD PMID:27226639 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Dithiothreitol results in increased expression of GADD45A mRNA CTD PMID:17332266 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] CTD PMID:14695184 PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
CTD PMID:24489685 PMID:26111761 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862 PMID:26859423 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein CTD PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:25321315 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]
CTD PMID:17067557 PMID:20584749 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] CTD PMID:14762100 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Dithiothreitol results in increased expression of INHBE mRNA CTD PMID:22935518 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24853401 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]
CTD PMID:11035063 PMID:23370007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204 PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Msrb2 methionine sulfoxide reductase B2 increases reduction ISO Dithiothreitol results in increased reduction of MSRB2 protein CTD PMID:16735467 NCBI chr17:86,066,841...86,148,131
Ensembl chr17:86,066,833...86,148,130
JBrowse link
G Msrb3 methionine sulfoxide reductase B3 increases reduction ISO Dithiothreitol results in increased reduction of MSRB3 protein CTD PMID:16735467 NCBI chr 7:62,850,506...62,972,487
Ensembl chr 7:62,850,515...62,972,084
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nat1 N-acetyltransferase 1 increases activity
multiple interactions
ISO Dithiothreitol results in increased activity of NAT1 protein
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]
CTD PMID:22835378 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] CTD PMID:24489685 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
CTD PMID:9281604 PMID:14762100 PMID:16219905 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]
CTD PMID:17067557 PMID:19509257 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
CTD PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] CTD PMID:24489685 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
CTD PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrgn neurogranin multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] CTD PMID:21241739 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 increases activity ISO Dithiothreitol results in increased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]
CTD PMID:11035063 PMID:18022205 PMID:20438634 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO Dithiothreitol results in increased expression of PDCD6IP protein CTD PMID:21692457 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Dithiothreitol results in increased expression of PLOD3 protein CTD PMID:21692457 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Dithiothreitol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] CTD PMID:20584749 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP
ISO
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]
CTD PMID:16781456 PMID:32493877 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Dithiothreitol results in increased expression of RCN2 protein CTD PMID:21692457 NCBI chr 8:60,709,851...60,726,938
Ensembl chr 8:60,709,851...60,726,936
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
Dithiothreitol results in increased activity of RELA protein
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
CTD PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 2:189,981,650...189,985,109 JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Sod1 superoxide dismutase 1 affects folding
multiple interactions
ISO Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]
CTD PMID:22867017 PMID:26694608 PMID:26699812 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] CTD PMID:26699812 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
CTD PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] CTD PMID:17555331 PMID:25446071 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein
CTD PMID:21984481 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] CTD PMID:19527742 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
increases activity
ISO
EXP
Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]
CTD PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 PMID:23933410 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor multiple interactions EXP Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] CTD PMID:6323860 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
increases reduction
EXP
ISO
Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]
CTD PMID:15025511 PMID:25349987 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Dithiothreitol results in increased expression of ATF3 mRNA CTD PMID:17332266 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Dithiothreitol results in increased expression of ATF4 mRNA CTD PMID:27226639 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:18022205 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calu calumenin increases expression ISO Dithiothreitol results in increased expression of CALU protein CTD PMID:21692457 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
CTD PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 PMID:11226294 PMID:26124276 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] CTD PMID:11226294 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977 PMID:32493877 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] CTD PMID:21256830 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Dithiothreitol results in decreased expression of CCND1 mRNA CTD PMID:17332266 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Dithiothreitol results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] CTD PMID:16280210 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Dithiothreitol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]
CTD PMID:17332266 PMID:27226639 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein
CTD PMID:12486162 PMID:25321315 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein] CTD PMID:30385349 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein
CTD PMID:12486162 PMID:25321315 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] CTD PMID:22403704 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases activity ISO Dithiothreitol results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of FGF21 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]
CTD PMID:27226639 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Dithiothreitol results in increased expression of GADD45A mRNA CTD PMID:17332266 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] CTD PMID:14695184 PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
CTD PMID:24489685 PMID:26111761 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862 PMID:26859423 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein CTD PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:25321315 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]
CTD PMID:17067557 PMID:20584749 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] CTD PMID:14762100 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Dithiothreitol results in increased expression of INHBE mRNA CTD PMID:22935518 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24853401 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
CTD PMID:11035063 PMID:23370007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204 PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Msrb2 methionine sulfoxide reductase B2 increases reduction ISO Dithiothreitol results in increased reduction of MSRB2 protein CTD PMID:16735467 NCBI chr17:86,066,841...86,148,131
Ensembl chr17:86,066,833...86,148,130
JBrowse link
G Msrb3 methionine sulfoxide reductase B3 increases reduction ISO Dithiothreitol results in increased reduction of MSRB3 protein CTD PMID:16735467 NCBI chr 7:62,850,506...62,972,487
Ensembl chr 7:62,850,515...62,972,084
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]
Dithiothreitol results in increased activity of NAT1 protein
CTD PMID:22835378 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] CTD PMID:24489685 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]
CTD PMID:9281604 PMID:14762100 PMID:16219905 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]
CTD PMID:17067557 PMID:19509257 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
CTD PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] CTD PMID:24489685 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
CTD PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrgn neurogranin multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] CTD PMID:21241739 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 increases activity ISO Dithiothreitol results in increased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]
CTD PMID:11035063 PMID:18022205 PMID:20438634 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO Dithiothreitol results in increased expression of PDCD6IP protein CTD PMID:21692457 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Dithiothreitol results in increased expression of PLOD3 protein CTD PMID:21692457 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Dithiothreitol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] CTD PMID:20584749 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP
ISO
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]
CTD PMID:16781456 PMID:32493877 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Dithiothreitol results in increased expression of RCN2 protein CTD PMID:21692457 NCBI chr 8:60,709,851...60,726,938
Ensembl chr 8:60,709,851...60,726,936
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol results in increased activity of RELA protein
Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
CTD PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 2:189,981,650...189,985,109 JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Sod1 superoxide dismutase 1 affects folding
multiple interactions
ISO Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]
CTD PMID:22867017 PMID:26694608 PMID:26699812 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] CTD PMID:26699812 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
CTD PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] CTD PMID:17555331 PMID:25446071 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein
CTD PMID:21984481 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] CTD PMID:19527742 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        reducing agent 188
          1,4-dithiothreitol 86
            D-1,4-dithiothreitol 0
            L-1,4-dithiothreitol 86
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19429
                        hydrogen molecular entity 19423
                          hydrides 18758
                            inorganic hydride 17453
                              chalcogen hydride 2454
                                sulfur hydride 2065
                                  hydrogen sulfide 2065
                                    thiol group 1950
                                      thiol 1950
                                        1,4-dimercaptobutane-2,3-diol 90
                                          1,4-dithiothreitol 86
                                            D-1,4-dithiothreitol 0
                                            L-1,4-dithiothreitol 86
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