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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:18319 term browser browse the term
Definition:A 1-(phosphoribosyl)imidazolecarboxamide resulting from the formal condesation of the darboxy group of 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid with the amino group of L-aspartic acid.
Synonyms:exact_synonym: (2S)-2-[5-amino-1-(5-O-phosphono-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid;   N-{[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl}-L-aspartic acid
 related_synonym: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid;   (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate;   1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole;   1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole;   5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole;   Formula=C13H19N4O12P;   InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1;   InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N;   SAICA riboside;   SMILES=Nc1c(ncn1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC(O)=O)C(O)=O;   Succino-AICAR;   succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5-phosphate;   succinylaminoimidazolecarboxamide ribose-5'-phosphate
 alt_id: CHEBI:11028;   CHEBI:18965;   CHEBI:572;   CHEBI:78110
 xref: CAS:3031-95-6;   HMDB:HMDB0000797;   KEGG:C04823
 xref_mesh: MESH:C020635
 xref: MetaCyc:P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE;   PMID:23086999;   PMID:24606918;   Wikipedia:Phosphoribosylaminoimidazolesuccinocarboxamide
 cyclic_relationship: is_conjugate_acid_of CHEBI:58443

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SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase M1/2 multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            anti-ulcer drug 789
              succinic acid 222
                SAICAR 1
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                pnictogen oxoacid 10685
                                  phosphorus oxoacid 9666
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8172
                                          phosphate 8172
                                            organic phosphate 8171
                                              carbohydrate phosphate 1734
                                                phospho sugar 1659
                                                  aldose phosphate 1657
                                                    aldopentose phosphate 1651
                                                      ribose phosphate 1646
                                                        1-(phosphoribosyl)imidazole 101
                                                          1-(phosphoribosyl)imidazolecarboxamide 101
                                                            SAICAR 1
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