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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:18319 term browser browse the term
Definition:A 1-(phosphoribosyl)imidazolecarboxamide resulting from the formal condesation of the darboxy group of 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid with the amino group of L-aspartic acid.
Synonyms:exact_synonym: (2S)-2-[5-amino-1-(5-O-phosphono-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid;   N-{[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl}-L-aspartic acid
 related_synonym: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid;   (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate;   1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole;   1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole;   5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole;   Formula=C13H19N4O12P;   InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1;   InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N;   SAICA riboside;   SMILES=Nc1c(ncn1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC(O)=O)C(O)=O;   Succino-AICAR;   succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5-phosphate;   succinylaminoimidazolecarboxamide ribose-5'-phosphate
 alt_id: CHEBI:11028;   CHEBI:18965;   CHEBI:572;   CHEBI:78110
 xref: CAS:3031-95-6;   HMDB:HMDB0000797;   KEGG:C04823
 xref_mesh: MESH:C020635
 xref: MetaCyc:P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE;   PMID:23086999;   PMID:24606918;   Wikipedia:Phosphoribosylaminoimidazolesuccinocarboxamide
 cyclic_relationship: is_conjugate_acid_of CHEBI:58443

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SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase M1/2 multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            anti-ulcer drug 796
              succinic acid 226
                SAICAR 1
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      chalcogen 19732
                        oxygen atom 19674
                          oxygen molecular entity 19674
                            hydroxides 19454
                              oxoacid 18744
                                pnictogen oxoacid 11007
                                  phosphorus oxoacid 9818
                                    phosphoric acids 8644
                                      phosphoric acid 8639
                                        phosphoric acid derivative 8348
                                          phosphate 8348
                                            organic phosphate 8342
                                              carbohydrate phosphate 1832
                                                phospho sugar 1680
                                                  aldose phosphate 1678
                                                    aldopentose phosphate 1670
                                                      ribose phosphate 1664
                                                        1-(phosphoribosyl)imidazole 106
                                                          1-(phosphoribosyl)imidazolecarboxamide 106
                                                            SAICAR 1
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