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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
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Accession:CHEBI:18313 term browser browse the term
Definition:A glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the trisaccharide component.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1-{[alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamide
 related_synonym: Burkitt's lymphoma antigen, bla-CD77;   CTH;   D-Galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide;   Formula=C37H66NO18R;   Gal-alpha1->4Gal-beta1->4Glc-beta1->1'Cer;   Gal-alpha1->4LacCer;   Galalpha1-4Galbeta1-4Glcbeta1-1'ceramide;   Gb3;   Gb3Cer;   GbOSe3Cer;   Globotriosylceramide;   SMILES=[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O)O)O)OC[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC(=O)*;   Trihexosylceramide;   alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer;   alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer;   alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide;   ceramide trihexoside;   globoside Gb3Cer (d18:1(4E));   globotriaosylceramide;   globotrihexosylceramide
 alt_id: CHEBI:12310;   CHEBI:12948;   CHEBI:14310;   CHEBI:16839;   CHEBI:20962;   CHEBI:20969;   CHEBI:27113;   CHEBI:4148;   CHEBI:9719
 xref: CAS:71965-57-6;   KEGG:C04737;   KEGG:G00093
 xref_mesh: MESH:C018549
 xref: MetaCyc:D-GALACTOSYL-14-D-GALACTOSYL-14-D-;   PMID:11437603;   PMID:11525645;   PMID:11946769;   PMID:12227795;   PMID:15113548;   PMID:1528196;   PMID:16120140;   PMID:1724444;   PMID:17258170;   PMID:17674039;   PMID:18176841;   PMID:18810447;   PMID:19655181;   PMID:20424866;   PMID:20623712;   PMID:2120125;   PMID:21252262;   PMID:21376640;   PMID:2448252;   PMID:2456994;   PMID:2500499;   PMID:2960671;   PMID:7691279;   PMID:7841803


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alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases chemical synthesis
ISO Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide] CTD PMID:14662772 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]] CTD PMID:16819191 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide] CTD PMID:16819191 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antigen 114
          alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3
            alpha-D-Gal-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N- acylsphingosine + 0
            alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/26:1(17Z)) 0
            alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-hexacosanoylceramide 0
            beta-D-GlcNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-ceramide(d18:1(4E)) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                ceramide 108
                                                  oligoglycosylceramide 3
                                                    glycotriaosylceramide 3
                                                      alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3
                                                        alpha-D-Gal-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N- acylsphingosine + 0
                                                        alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/26:1(17Z)) 0
                                                        alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-hexacosanoylceramide 0
                                                        beta-D-GlcNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-ceramide(d18:1(4E)) 0
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