The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by a 3-oxo-1,3-dihydro-2H-indol-2-ylidene group at position 3. It is the active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases and chronic myeloid leukemia.
indirubin binds to and results in increased activity of AHR protein indirubin binds to AHR protein AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1A1 protein]; AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1B1 protein]; indirubin binds to and results in increased activity of AHR protein; indirubin promotes the reaction [AHR protein binds to ARNT protein]; indirubin promotes the reaction [AHR protein binds to CYP1A1 promoter]; indirubin results in increased localization of and results in increased degradation of AHR protein indirubin results in increased activity of AHR protein
[[tetraarsenic tetrasulfide co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]
[arsenic disulfide co-treated with indirubin] results in increased expression of and results in increased cleavage of BAX protein; [arsenic disulfide co-treated with indirubin] results in increased expression of BAX mRNA
indirubin results in decreased expression of CDK2 protein indirubin inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] indirubin results in decreased activity of CDK2 protein [tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein]
indirubin results in increased expression of CDKN1B protein indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]]
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein]
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein]
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein]
AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1A1 protein]; indirubin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; indirubin promotes the reaction [AHR protein binds to CYP1A1 promoter] indirubin results in increased expression of CYP1A1 mRNA; indirubin results in increased expression of CYP1A1 protein indirubin binds to and results in decreased activity of CYP1A1 protein; indirubin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] indirubin results in increased activity of CYP1A1 protein CYP1A1 protein results in increased metabolism of indirubin
CYP1B1 protein results in increased metabolism of indirubin indirubin results in increased expression of CYP1B1 mRNA indirubin results in increased expression of CYP1B1 mRNA; indirubin results in increased expression of CYP1B1 protein AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1B1 protein]
indirubin results in decreased phosphorylation of H1F2 protein [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]
[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein]
[tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]
indirubin inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein
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