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G |
Abl1 |
c-abl oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine; Imatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] |
CTD |
PMID:16849647 |
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NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239
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G |
Adcyap1 |
adenylate cyclase activating polypeptide 1 |
increases secretion multiple interactions |
ISO |
ADCYAP1 protein results in increased secretion of Histamine Dinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; Galanin inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; IL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] |
CTD |
PMID:11164953 |
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NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965
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G |
Adrb2 |
adrenergic receptor, beta 2 |
multiple interactions increases activity decreases response to substance |
ISO EXP |
Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein] Histamine results in increased activity of ADRB2 protein [Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine ADRB2 results in decreased susceptibility to Histamine Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; ICI 118551 inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine] |
CTD |
PMID:11164953 PMID:12198331 PMID:17196553 |
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NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] |
CTD |
PMID:9609743 |
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NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
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G |
Alox5ap |
arachidonate 5-lipoxygenase activating protein |
multiple interactions |
ISO |
ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] |
CTD |
PMID:9609743 |
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NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963
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G |
Ambp |
alpha 1 microglobulin/bikunin precursor |
decreases secretion |
ISO |
AMBP protein results in decreased secretion of Histamine |
CTD |
PMID:9579392 |
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NCBI chr 4:63,061,512...63,072,409
Ensembl chr 4:63,061,512...63,073,036
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G |
Aoc1 |
amine oxidase, copper-containing 1 |
increases metabolic processing |
ISO |
AOC1 protein results in increased metabolism of Histamine |
CTD |
PMID:12072962 |
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NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122
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G |
Aqp5 |
aquaporin 5 |
affects localization decreases expression multiple interactions |
ISO |
Histamine affects the localization of AQP5 protein Histamine results in decreased expression of AQP5 protein Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in decreased expression of AQP5 protein] |
CTD |
PMID:19443731 PMID:29452068 |
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NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710
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G |
Bax |
BCL2-associated X protein |
increases expression |
ISO |
Histamine results in increased expression of BAX mRNA |
CTD |
PMID:36565801 |
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
decreases expression |
ISO |
Histamine results in decreased expression of BCL2 mRNA |
CTD |
PMID:36565801 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bcr |
BCR activator of RhoGEF and GTPase |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine; Imatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] |
CTD |
PMID:16849647 |
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NCBI chr10:74,896,384...75,020,753
Ensembl chr10:74,896,424...75,020,753
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G |
Calca |
calcitonin/calcitonin-related polypeptide, alpha |
multiple interactions increases secretion |
ISO |
[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] |
CTD |
PMID:11166334 PMID:12791437 PMID:14991081 |
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NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
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G |
Casp3 |
caspase 3 |
increases expression |
ISO |
Histamine results in increased expression of CASP3 mRNA; Histamine results in increased expression of CASP3 protein |
CTD |
PMID:36565801 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Cat |
catalase |
affects expression decreases activity |
EXP ISO |
Histamine affects the expression of CAT protein Histamine results in decreased activity of CAT protein |
CTD |
PMID:17729160 PMID:36565801 |
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Lipopolysaccharides promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein] |
CTD |
PMID:11336536 |
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NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
[HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein |
CTD |
PMID:22363581 |
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NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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G |
Cd14 |
CD14 antigen |
affects expression multiple interactions |
ISO |
Histamine affects the expression of CD14 protein HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein] |
CTD |
PMID:14499251 |
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NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
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G |
Cd40 |
CD40 antigen |
multiple interactions |
ISO |
[alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein |
CTD |
PMID:11306145 |
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NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
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G |
Cd80 |
CD80 antigen |
multiple interactions |
ISO |
Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] |
CTD |
PMID:12538815 |
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NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
[HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein |
CTD |
PMID:22363581 |
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NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
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G |
Cdkn1a |
cyclin dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein |
CTD |
PMID:22363581 |
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NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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G |
Cdkn1b |
cyclin dependent kinase inhibitor 1B |
multiple interactions |
ISO |
[HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein |
CTD |
PMID:22363581 |
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NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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G |
Chrm3 |
cholinergic receptor, muscarinic 3, cardiac |
multiple interactions affects response to substance |
EXP |
CHRM3 protein affects the reaction [Histamine results in increased secretion of Acids] CHRM3 protein affects the susceptibility to Histamine |
CTD |
PMID:14724830 |
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NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
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G |
Clca1 |
chloride channel accessory 1 |
increases expression |
ISO |
Histamine results in increased expression of CLCA1 mRNA |
CTD |
PMID:17622767 |
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NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases phosphorylation multiple interactions |
ISO |
Histamine results in decreased phosphorylation of CREB1 protein Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:29452068 |
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NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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G |
Csf1 |
colony stimulating factor 1 (macrophage) |
decreases expression |
EXP |
Histamine results in decreased expression of CSF1 mRNA |
CTD |
PMID:9657254 |
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NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785
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G |
Csf2 |
colony stimulating factor 2 (granulocyte-macrophage) |
increases expression increases secretion multiple interactions |
ISO |
Histamine results in increased expression of CSF2 protein CSF2 results in increased secretion of Histamine Histamine results in increased secretion of CSF2 protein Particulate Matter analog promotes the reaction [Histamine results in increased secretion of CSF2 protein]; Vehicle Emissions analog promotes the reaction [Histamine results in increased secretion of CSF2 protein] |
CTD |
PMID:9606035 PMID:9685678 PMID:9856766 PMID:10051702 |
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NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
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G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
multiple interactions increases secretion increases expression |
ISO |
[Histamine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; Cyclosporine inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Dexamethasone inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Dexamethasone inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of CXCL8 protein]; Histamine results in increased activity of [CXCL8 protein binds to RELA protein]; L 655238 inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Leukotriene B4 inhibits the reaction [zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 protein]]; Lipopolysaccharides promotes the reaction [Histamine results in increased expression of CXCL8 protein]; MK-886 inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; MK-886 inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; Particulate Matter analog promotes the reaction [Histamine results in increased secretion of CXCL8 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of CXCL8 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CXCL8 protein]; Vehicle Emissions analog promotes the reaction [Histamine results in increased secretion of CXCL8 protein]; zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 protein] Histamine results in increased expression of CXCL8 mRNA; Histamine results in increased expression of CXCL8 protein |
CTD |
PMID:9609743 PMID:10051702 PMID:11336536 PMID:29452068 PMID:29594315 |
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NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] |
CTD |
PMID:12906840 |
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NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein] |
CTD |
PMID:17656145 |
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NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
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G |
F3 |
coagulation factor III |
multiple interactions increases expression increases activity |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of F3]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]; [Histamine co-treated with splitomicin] results in increased expression of F3 protein; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]; pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]; Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of F3]; SB 203580 inhibits the reaction [Histamine results in increased expression of F3]; wortmannin promotes the reaction [Histamine results in increased expression of F3] Histamine results in increased expression of F3 mRNA; Histamine results in increased expression of F3 protein |
CTD |
PMID:16009787 PMID:20978007 PMID:25569083 |
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NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
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G |
Fcer1a |
Fc receptor, IgE, high affinity I, alpha polypeptide |
affects secretion |
ISO |
FCER1A polymorphism affects the secretion of Histamine |
CTD |
PMID:17125826 |
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NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
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G |
Fgf1 |
fibroblast growth factor 1 |
increases expression |
ISO |
Histamine results in increased expression of FGF1 protein |
CTD |
PMID:15264218 |
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NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
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G |
Fos |
FBJ osteosarcoma oncogene |
multiple interactions |
ISO |
[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] |
CTD |
PMID:9187264 |
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NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
Gast |
gastrin |
affects abundance increases secretion affects activity multiple interactions |
EXP ISO |
GAST protein affects the abundance of Histamine GAST protein modified form results in increased secretion of Histamine; GAST protein results in increased secretion of Histamine Histamine affects the activity of GAST protein [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]; alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine]; CXCL8 protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine]; Galanin inhibits the reaction [GAST protein results in increased secretion of Histamine]; Impromidine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]; Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Urethane inhibits the reaction [GAST protein results in increased secretion of Histamine] |
CTD |
PMID:2470453 PMID:10864877 PMID:11164953 PMID:12190085 PMID:12893847 PMID:14642791 PMID:16378173 More...
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NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
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G |
Ghrl |
ghrelin |
multiple interactions |
ISO |
Histamine affects the reaction [GHRL protein results in increased secretion of Acids] |
CTD |
PMID:16838121 |
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NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841
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G |
Gusb |
glucuronidase, beta |
multiple interactions increases expression |
ISO |
fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; fexofenadine inhibits the reaction [Histamine results in increased expression of GUSB protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein] |
CTD |
PMID:11238657 |
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NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
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G |
Hdc |
histidine decarboxylase |
increases chemical synthesis multiple interactions |
ISO |
HDC protein results in increased chemical synthesis of Histamine [troglitazone results in decreased expression of HDC mRNA] which results in decreased secretion of Histamine |
CTD |
PMID:11834241 PMID:17075268 |
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NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
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G |
Hnmt |
histamine N-methyltransferase |
increases methylation multiple interactions |
ISO |
HNMT protein results in increased methylation of Histamine SK&F 91488 inhibits the reaction [HNMT protein results in increased methylation of Histamine] |
CTD |
PMID:7943261 |
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NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406
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G |
Hrh1 |
histamine receptor H1 |
increases activity affects binding multiple interactions increases expression affects response to substance |
ISO EXP |
Histamine results in increased activity of HRH1 protein HRH1 protein binds to Histamine 1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; [Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium; [HRH1 protein binds to Histamine] which results in increased import of Calcium; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein; Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]; Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]; HRH1 protein affects the reaction [Histamine results in increased transport of fluorescein isothiocyanate bovine serum albumin]; HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]; HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]; HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]; HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]; Quercetin inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]; Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]] HRH1 protein affects the susceptibility to Histamine [epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; [Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein; [Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium; [Tripelennamine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; Histamine binds to and results in increased activity of HRH1 protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] |
CTD |
PMID:2419744 PMID:11238657 PMID:11306145 PMID:11527950 PMID:12095164 PMID:12147327 PMID:12832840 PMID:15167971 PMID:16143415 PMID:16354729 PMID:18360087 PMID:19215234 PMID:20040740 PMID:23333628 PMID:32061592 More...
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NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
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G |
Hrh2 |
histamine receptor H2 |
multiple interactions increases activity affects localization affects expression |
ISO EXP |
[Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Histamine affects the localization of HRH2 protein] which affects the degradation of HRH2 protein; [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA; [Histamine binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP; [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in increased activity of HRH2 protein] which results in increased abundance of Histamine]; Burimamide inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Histamine binds to and results in increased activity of HRH2 protein; HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]; tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein] [[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine; [roxatidine acetate binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine; [thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]; Histamine binds to and results in increased activity of HRH2 protein; Histamine inhibits the reaction [tiotidine binds to HRH2 protein] HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]; HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein] Histamine affects the expression of HRH2 protein |
CTD |
PMID:9187264 PMID:9681472 PMID:9819373 PMID:10569698 PMID:11306145 PMID:11640976 PMID:11752121 PMID:12010879 PMID:12235264 PMID:12832840 PMID:14499251 PMID:15843518 PMID:15961859 PMID:16143415 PMID:16723495 PMID:19215234 PMID:19277450 PMID:22926047 More...
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NCBI chr13:54,345,990...54,390,201
Ensembl chr13:54,346,148...54,390,199
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G |
Hrh3 |
histamine receptor H3 |
multiple interactions |
ISO EXP |
Histamine binds to and results in increased activity of HRH3 protein Histamine binds to Hrh3 protein; Histamine inhibits the reaction [N-methylhistamine binds to Hrh3 protein] [Histamine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium; Histamine binds to and results in increased activity of HRH3 protein |
CTD RGD |
PMID:12706455 PMID:10869375 |
RGD:632981 |
NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281
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G |
Hrh4 |
histamine receptor H4 |
multiple interactions increases response to substance increases activity |
ISO |
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to Histamine]; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein; [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein; Histamine binds to and results in increased activity of HRH4 protein; Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein] |
CTD |
PMID:11181941 PMID:15843518 PMID:22363581 |
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NCBI chr18:13,140,039...13,156,758
Ensembl chr18:13,140,047...13,155,939
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] |
CTD |
PMID:11752121 PMID:12364868 PMID:12538815 |
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NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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G |
Ifng |
interferon gamma |
multiple interactions affects expression |
ISO EXP |
[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA; [Histamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]; Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]] Histamine affects the expression of IFNG protein |
CTD |
PMID:10569698 PMID:11752121 PMID:12364868 PMID:17346280 PMID:19277450 PMID:29594315 More...
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NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Terfenadine inhibits the reaction [Histamine results in increased expression of IL10 protein] |
CTD |
PMID:11752121 PMID:12925206 |
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NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il12a |
interleukin 12a |
multiple interactions increases expression decreases expression |
ISO |
[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein] Histamine results in increased expression of IL12A protein Histamine results in decreased expression of IL12A mRNA; Histamine results in decreased expression of IL12A protein |
CTD |
PMID:9819373 PMID:11752121 PMID:12364868 PMID:15843518 |
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NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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G |
Il12b |
interleukin 12b |
decreases expression increases expression multiple interactions |
ISO |
Histamine results in decreased expression of IL12B mRNA; Histamine results in decreased expression of IL12B protein Histamine results in increased expression of IL12B protein [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein] |
CTD |
PMID:9819373 PMID:11752121 PMID:12364868 PMID:15843518 |
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NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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G |
Il16 |
interleukin 16 |
multiple interactions increases expression |
ISO |
Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]; HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]; thioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein] |
CTD |
PMID:12235264 |
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NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934
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G |
Il18 |
interleukin 18 |
multiple interactions increases expression |
ISO EXP |
[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein] |
CTD |
PMID:11752121 PMID:12364868 PMID:16723495 |
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NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
IL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] Histamine results in increased expression of IL1B mRNA |
CTD |
PMID:11164953 PMID:36565801 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il2 |
interleukin 2 |
multiple interactions |
EXP ISO |
Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] [Histamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA |
CTD |
PMID:19277450 PMID:29594315 |
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NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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G |
Il4 |
interleukin 4 |
multiple interactions increases response to substance |
EXP |
Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]] IL4 protein results in increased susceptibility to Histamine |
CTD |
PMID:12370375 PMID:19277450 |
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NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Terfenadine inhibits the reaction [Histamine results in increased expression of IL5 protein] |
CTD |
PMID:12925206 |
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NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
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G |
Il6 |
interleukin 6 |
multiple interactions increases secretion increases expression |
ISO EXP |
Calcimycin inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]; Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]; Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]; fexofenadine inhibits the reaction [Histamine results in increased expression of IL6 protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]; Lipopolysaccharides promotes the reaction [Histamine results in increased expression of IL6 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of IL6 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein] Histamine results in increased expression of IL6 mRNA; Histamine results in increased expression of IL6 protein |
CTD |
PMID:9657254 PMID:9856766 PMID:11238657 PMID:11336536 PMID:29452068 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Itga2 |
integrin alpha 2 |
multiple interactions |
ISO |
ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] |
CTD |
PMID:18234883 |
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NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636
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G |
Kcnq2 |
potassium voltage-gated channel, subfamily Q, member 2 |
multiple interactions |
ISO |
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] |
CTD |
PMID:12147327 |
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NCBI chr 2:180,717,372...180,777,368
Ensembl chr 2:180,717,372...180,777,093
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G |
Kcnq3 |
potassium voltage-gated channel, subfamily Q, member 3 |
multiple interactions |
ISO |
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] |
CTD |
PMID:12147327 |
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NCBI chr15:65,858,223...66,158,485
Ensembl chr15:65,858,236...66,158,491
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G |
Kng1 |
kininogen 1 |
multiple interactions |
ISO |
[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] |
CTD |
PMID:11166334 PMID:12791437 PMID:18234883 |
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NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
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G |
Ltc4s |
leukotriene C4 synthase |
decreases response to substance |
ISO |
LTC4S polymorphism results in decreased susceptibility to Histamine |
CTD |
PMID:19862937 |
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NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
[Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein; Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:11181941 PMID:16009787 PMID:17656145 PMID:21179406 PMID:30310171 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
[Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein; Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:11181941 PMID:16009787 PMID:17656145 PMID:21179406 PMID:30310171 |
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Histamine inhibits the reaction [decamethrin results in decreased nitrosation of MAPK8 protein] |
CTD |
PMID:25299849 |
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NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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G |
Mmp1b |
matrix metallopeptidase 1b (interstitial collagenase) |
multiple interactions increases secretion increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased secretion of MMP1 protein]; EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; RTKI cpd inhibits the reaction [Histamine results in increased secretion of MMP1 protein] |
CTD |
PMID:9856766 PMID:17656145 |
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NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
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G |
Muc5ac |
mucin 5, subtypes A and C, tracheobronchial/gastric |
multiple interactions increases secretion increases expression |
ISO |
Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]; Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of MUC5AC protein] Histamine results in increased expression of MUC5AC mRNA; Histamine results in increased expression of MUC5AC protein |
CTD |
PMID:17622767 PMID:29452068 |
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NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
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G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
multiple interactions affects localization |
ISO |
Histamine promotes the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein] Histamine affects the localization of NFKB1 protein |
CTD |
PMID:11336536 |
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NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
multiple interactions increases phosphorylation |
ISO |
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:29452068 |
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NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] |
CTD |
PMID:15167971 |
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NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
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G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions increases expression increases phosphorylation |
ISO |
[PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein]; Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]; STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein] Histamine results in increased expression of NOS2 protein |
CTD |
PMID:21145922 PMID:36565801 |
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NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Nos3 |
nitric oxide synthase 3, endothelial cell |
multiple interactions |
ISO |
Histamine inhibits the reaction [decamethrin results in decreased expression of NOS3 protein] |
CTD |
PMID:25299849 |
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NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
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G |
Ntf3 |
neurotrophin 3 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; ciproxifan inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; KN 62 inhibits the reaction [Histamine results in increased expression of NTF3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pertussis Toxin inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Histamine results in increased expression of NTF3 protein]; thioperamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Triprolidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] Histamine results in increased expression of NTF3 mRNA; Histamine results in increased expression of NTF3 protein |
CTD |
PMID:21276809 |
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NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873
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G |
Pcna |
proliferating cell nuclear antigen |
affects expression |
EXP |
Histamine affects the expression of PCNA protein |
CTD |
PMID:17729160 |
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NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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G |
Pde4b |
phosphodiesterase 4B, cAMP specific |
multiple interactions increases expression |
ISO |
Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] |
CTD |
PMID:11131300 |
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NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456
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G |
Pla2g4a |
phospholipase A2, group IVA (cytosolic, calcium-dependent) |
multiple interactions increases expression |
ISO |
Dexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] |
CTD |
PMID:9609743 |
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NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041
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G |
Ppp3ca |
protein phosphatase 3, catalytic subunit, alpha isoform |
increases expression |
ISO |
Histamine results in increased expression of PPP3CA protein |
CTD |
PMID:30310171 |
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NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
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G |
Prkaa1 |
protein kinase, AMP-activated, alpha 1 catalytic subunit |
multiple interactions |
ISO |
[PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] |
CTD |
PMID:21145922 |
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NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
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G |
Prkaa2 |
protein kinase, AMP-activated, alpha 2 catalytic subunit |
multiple interactions |
ISO |
[PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] |
CTD |
PMID:21145922 |
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NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
epigallocatechin gallate inhibits the reaction [Histamine results in increased phosphorylation of PRKCD protein]; Histamine results in increased phosphorylation of and affects the localization of PRKCD protein; Quercetin inhibits the reaction [Histamine results in increased phosphorylation of and affects the localization of PRKCD protein] |
CTD |
PMID:23333628 |
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NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
ISO |
[SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Histamine results in increased secretion of Acids] |
CTD |
PMID:16299412 |
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NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] Histamine results in increased expression of PTGS2 mRNA |
CTD |
PMID:20040740 PMID:36565801 |
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NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Ptprc |
protein tyrosine phosphatase receptor type C |
multiple interactions |
ISO |
[alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of PTPRC protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein |
CTD |
PMID:11306145 |
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NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
affects localization increases phosphorylation multiple interactions |
ISO |
Histamine affects the localization of RELA protein Histamine results in increased phosphorylation of RELA protein Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]; Histamine promotes the reaction [Lipopolysaccharides affects the localization of RELA protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; Histamine results in increased activity of [CXCL8 protein binds to RELA protein] |
CTD |
PMID:9609743 PMID:11336536 PMID:29452068 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Slc18a1 |
solute carrier family 18 (vesicular monoamine), member 1 |
multiple interactions |
ISO |
Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] |
CTD |
PMID:8245983 |
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NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887
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G |
Slc18a2 |
solute carrier family 18 (vesicular monoamine), member 2 |
multiple interactions affects binding increases secretion |
ISO |
Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine] Histamine binds to SLC18A2 protein |
CTD |
PMID:7912402 PMID:14642791 |
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NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
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G |
Slc22a3 |
solute carrier family 22 (organic cation transporter), member 3 |
multiple interactions increases uptake increases transport affects uptake |
ISO |
Corticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Estradiol inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine] SLC22A3 protein results in increased uptake of Histamine SLC22A3 protein polymorphism affects the uptake of Histamine |
CTD |
PMID:12411423 PMID:16928864 PMID:20562519 PMID:20858707 |
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NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
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G |
Slc29a4 |
solute carrier family 29 (nucleoside transporters), member 4 |
increases uptake |
ISO |
SLC29A4 protein results in increased uptake of Histamine |
CTD |
PMID:20858707 |
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NCBI chr 5:142,678,226...142,708,245
Ensembl chr 5:142,678,267...142,708,245
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G |
Slc47a1 |
solute carrier family 47, member 1 |
multiple interactions |
ISO |
Histamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171
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G |
Slc47a2 |
solute carrier family 47, member 2 |
multiple interactions |
ISO |
Histamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686
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G |
Sod1 |
superoxide dismutase 1, soluble |
affects expression |
EXP |
Histamine affects the expression of SOD1 protein |
CTD |
PMID:17729160 |
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NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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G |
Sst |
somatostatin |
multiple interactions |
ISO |
SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine] |
CTD |
PMID:11164953 |
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NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708
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G |
Stat6 |
signal transducer and activator of transcription 6 |
increases expression |
ISO |
Histamine results in increased expression of STAT6 protein |
CTD |
PMID:12755381 |
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NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
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G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions increases phosphorylation |
ISO |
STK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein] Histamine results in increased phosphorylation of STK11 protein |
CTD |
PMID:21145922 |
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NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516
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G |
Taar1 |
trace amine-associated receptor 1 |
increases activity multiple interactions |
EXP |
Histamine results in increased activity of TAAR1 protein [Histamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP |
CTD |
PMID:19725810 |
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NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367
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G |
Tac1 |
tachykinin 1 |
multiple interactions increases secretion |
ISO |
Nedocromil inhibits the reaction [TAC1 protein results in increased secretion of Histamine]; Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine] Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] |
CTD |
PMID:1707400 PMID:9291295 PMID:11166334 PMID:18234883 |
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NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
ISO |
Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] |
CTD |
PMID:20040740 |
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NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO EXP |
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CXCL8 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein] Histamine results in increased expression of TNF mRNA; Histamine results in increased expression of TNF protein TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine] Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]] |
CTD |
PMID:11164953 PMID:11336536 PMID:11752121 PMID:12538815 PMID:14499251 PMID:19277450 PMID:36565801 More...
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Ucp2 |
uncoupling protein 2 (mitochondrial, proton carrier) |
decreases secretion affects secretion affects abundance |
ISO EXP |
UCP2 protein results in decreased secretion of Histamine UCP2 protein affects the secretion of Histamine UCP2 protein affects the abundance of Histamine |
CTD |
PMID:19846869 |
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NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
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G |
Vip |
vasoactive intestinal polypeptide |
increases secretion |
ISO |
VIP protein results in increased secretion of Histamine |
CTD |
PMID:11164953 |
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NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
4-methylhistamine results in decreased expression of CCL2 protein |
CTD |
PMID:17507084 |
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NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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G |
Cd14 |
CD14 antigen |
multiple interactions |
ISO |
[4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein |
CTD |
PMID:14499251 |
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NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
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G |
Cd80 |
CD80 antigen |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] |
CTD |
PMID:12538815 |
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NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
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G |
Hrh2 |
histamine receptor H2 |
multiple interactions |
ISO |
4-methylhistamine binds to and results in increased activity of HRH2 protein; [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein |
CTD |
PMID:14499251 |
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NCBI chr13:54,345,990...54,390,201
Ensembl chr13:54,346,148...54,390,199
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G |
Hrh4 |
histamine receptor H4 |
multiple interactions |
ISO |
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 4-methylhistamine binds to and results in increased activity of HRH4 protein; [4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium |
CTD |
PMID:17507084 |
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NCBI chr18:13,140,039...13,156,758
Ensembl chr18:13,140,047...13,155,939
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] |
CTD |
PMID:11752121 PMID:12364868 PMID:12538815 |
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NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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G |
Ifng |
interferon gamma |
affects expression multiple interactions |
ISO |
4-methylhistamine affects the expression of IFNG protein 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein] |
CTD |
PMID:11752121 PMID:12364868 PMID:17346280 |
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NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] |
CTD |
PMID:11752121 |
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NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il12a |
interleukin 12a |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:11752121 PMID:12364868 |
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NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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G |
Il12b |
interleukin 12b |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:11752121 PMID:12364868 |
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NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein] |
CTD |
PMID:11752121 PMID:12364868 |
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NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:11752121 PMID:12538815 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Gal |
galanin and GMAP prepropeptide |
decreases expression |
ISO |
alpha-methylhistamine results in decreased expression of GAL mRNA |
CTD |
PMID:11956952 |
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NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544
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G |
Gast |
gastrin |
multiple interactions |
ISO |
alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine] |
CTD |
PMID:2470453 |
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NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
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G |
Hdc |
histidine decarboxylase |
decreases expression |
ISO |
alpha-methylhistamine results in decreased expression of HDC mRNA |
CTD |
PMID:11956952 |
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NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
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G |
Hrh3 |
histamine receptor H3 |
multiple interactions affects binding |
ISO |
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein] alpha-methylhistamine binds to HRH3 protein 6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]; Endocannabinoids inhibits the reaction [alpha-methylhistamine binds to and results in increased activity of HRH3 protein]; Histamine H3 Antagonists inhibits the reaction [alpha-methylhistamine binds to HRH3 protein] |
CTD |
PMID:11956952 PMID:21634396 PMID:30102254 PMID:31369746 |
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NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281
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G |
Hrh4 |
histamine receptor H4 |
multiple interactions |
ISO |
[alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; alpha-methylhistamine binds to and results in increased activity of HRH4 protein; HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] |
CTD |
PMID:11181941 PMID:12235264 |
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NCBI chr18:13,140,039...13,156,758
Ensembl chr18:13,140,047...13,155,939
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G |
Ifng |
interferon gamma |
affects expression |
ISO |
alpha-methylhistamine affects the expression of IFNG protein |
CTD |
PMID:17346280 |
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NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Il16 |
interleukin 16 |
multiple interactions increases expression |
ISO |
HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] |
CTD |
PMID:12235264 |
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NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL1B protein]] |
CTD |
PMID:31369746 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]] |
CTD |
PMID:31369746 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
EXP |
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]] |
CTD |
PMID:31369746 |
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NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]] |
CTD |
PMID:31369746 |
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NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
EXP |
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of RELA protein]] |
CTD |
PMID:31369746 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of TNF protein]] |
CTD |
PMID:31369746 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
F3 |
coagulation factor III |
increases expression |
ISO |
histamine phosphate results in increased expression of F3 protein |
CTD |
PMID:25569083 |
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NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
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G |
Aoc1 |
amine oxidase, copper-containing 1 |
increases metabolic processing |
ISO |
AOC1 protein results in increased metabolism of tele-methylhistamine |
CTD |
PMID:12072962 |
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NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122
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G |
Hrh3 |
histamine receptor H3 |
affects binding |
ISO |
N(tele)-methylhistamine binds to Hrh3 protein |
RGD |
PMID:10869375 |
RGD:632981 |
NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281
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