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G
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Abcb1a
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ATP binding cassette subfamily B member 1A
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decreases activity multiple interactions increases expression
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ISO
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5-methoxypsoralen results in decreased activity of ABCB1 protein [5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin] 5-methoxypsoralen results in increased expression of ABCB1 mRNA
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CTD |
PMID:29079042 |
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NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G
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Abcc1
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ATP binding cassette subfamily C member 1
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increases expression
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ISO
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5-methoxypsoralen results in increased expression of ABCC1 mRNA
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CTD |
PMID:29079042 |
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NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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G
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Abcc2
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ATP binding cassette subfamily C member 2
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multiple interactions decreases expression decreases activity
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ISO
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[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCC2 protein]; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin] 5-methoxypsoralen results in decreased expression of ABCC2 mRNA
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CTD |
PMID:29079042 |
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NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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G
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Abcg2
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ATP binding cassette subfamily G member 2
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decreases activity increases expression multiple interactions
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ISO
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5-methoxypsoralen results in decreased activity of ABCG2 protein 5-methoxypsoralen results in increased expression of ABCG2 mRNA [5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]
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CTD |
PMID:29079042 |
|
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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G
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Akt1
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AKT serine/threonine kinase 1
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decreases phosphorylation multiple interactions
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ISO EXP
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5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein] 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of AKT1 protein]
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CTD |
PMID:30576070 PMID:35815753 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G
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App
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amyloid beta precursor protein
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multiple interactions
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ISO
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5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]
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CTD |
PMID:34428446 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G
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Bax
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BCL2 associated X, apoptosis regulator
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increases expression
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ISO
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5-Methoxypsoralen results in increased expression of BAX protein
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CTD |
PMID:30576070 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
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G
|
Bbc3
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Bcl-2 binding component 3
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multiple interactions increases expression
|
ISO
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pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]
|
CTD |
PMID:30576070 |
|
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
|
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G
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Bdnf
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brain-derived neurotrophic factor
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multiple interactions
|
ISO
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5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]
|
CTD |
PMID:34428446 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
|
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G
|
Becn1
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beclin 1
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multiple interactions
|
ISO
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5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of BECN1 protein modified form]
|
CTD |
PMID:34428446 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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G
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Bmp2
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bone morphogenetic protein 2
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multiple interactions increases expression
|
ISO
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA] 5-methoxypsoralen results in increased expression of BMP2 mRNA
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CTD |
PMID:17980360 |
|
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
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G
|
Casp3
|
caspase 3
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increases cleavage multiple interactions
|
ISO
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5-Methoxypsoralen results in increased cleavage of CASP3 protein pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]
|
CTD |
PMID:30576070 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
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G
|
Casp9
|
caspase 9
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increases cleavage multiple interactions
|
ISO
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5-Methoxypsoralen results in increased cleavage of CASP9 protein pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]
|
CTD |
PMID:30576070 |
|
Ensembl chr 5:154,109,046...154,126,626
|
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G
|
Cat
|
catalase
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multiple interactions
|
EXP
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5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
|
CTD |
PMID:35815753 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G
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Ccnd1
|
cyclin D1
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multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of CCND1 mRNA]
|
CTD |
PMID:34428446 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G
|
Ccne1
|
cyclin E1
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decreases expression
|
ISO
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5-Methoxypsoralen results in decreased expression of CCNE1 protein
|
CTD |
PMID:30576070 |
|
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
|
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G
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Cdk2
|
cyclin dependent kinase 2
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decreases expression
|
ISO
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5-Methoxypsoralen results in decreased expression of CDK2 protein
|
CTD |
PMID:30576070 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
|
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G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression multiple interactions
|
ISO
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5-Methoxypsoralen results in increased expression of CDKN1A protein pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]
|
CTD |
PMID:30576070 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Ctnnb1
|
catenin beta 1
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multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased phosphorylation of CTNNB1 protein]
|
CTD |
PMID:34428446 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
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multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
|
CTD |
PMID:34428446 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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|
G
|
Il1b
|
interleukin 1 beta
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multiple interactions
|
EXP
|
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]
|
CTD |
PMID:35815753 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il23a
|
interleukin 23 subunit alpha
|
multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of IL23A protein]
|
CTD |
PMID:34428446 |
|
NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923
|
|
G
|
Il27
|
interleukin 27
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multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of IL27 protein]
|
CTD |
PMID:34428446 |
|
NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:181,173,372...181,178,582
|
|
G
|
Il6
|
interleukin 6
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multiple interactions
|
EXP
|
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]
|
CTD |
PMID:35815753 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
increases phosphorylation
|
ISO
|
5-methoxypsoralen results in increased phosphorylation of MAPK1 protein
|
CTD |
PMID:17980360 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
increases phosphorylation
|
ISO
|
5-methoxypsoralen results in increased phosphorylation of MAPK3 protein
|
CTD |
PMID:17980360 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
|
Mapt
|
microtubule-associated protein tau
|
multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form]
|
CTD |
PMID:34428446 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
|
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G
|
Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form]
|
CTD |
PMID:34428446 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions
|
EXP
|
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of NOS3 protein]
|
CTD |
PMID:35815753 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
|
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G
|
Ppp2ca
|
protein phosphatase 2 catalytic subunit alpha
|
multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form]
|
CTD |
PMID:34428446 |
|
NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862
|
|
G
|
Prkg1
|
protein kinase cGMP-dependent 1
|
multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein]
|
CTD |
PMID:34428446 |
|
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
|
|
G
|
Pten
|
phosphatase and tensin homolog
|
multiple interactions increases expression
|
ISO
|
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein]
|
CTD |
PMID:30576070 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
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5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of RELA protein modified form]
|
CTD |
PMID:34428446 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Smad1
|
SMAD family member 1
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increases phosphorylation
|
ISO
|
5-methoxypsoralen results in increased phosphorylation of SMAD1 protein
|
CTD |
PMID:17980360 |
|
NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651
|
|
G
|
Smad5
|
SMAD family member 5
|
increases phosphorylation
|
ISO
|
5-methoxypsoralen results in increased phosphorylation of SMAD5 protein
|
CTD |
PMID:17980360 |
|
NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
|
|
G
|
Smad9
|
SMAD family member 9
|
increases phosphorylation
|
ISO
|
5-methoxypsoralen results in increased phosphorylation of SMAD9 protein
|
CTD |
PMID:17980360 |
|
NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP
|
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
|
CTD |
PMID:35815753 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
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G
|
Tnni3
|
troponin I3, cardiac type
|
multiple interactions
|
EXP
|
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]
|
CTD |
PMID:35815753 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
|
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G
|
Tnnt2
|
troponin T2, cardiac type
|
multiple interactions
|
EXP
|
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]
|
CTD |
PMID:35815753 |
|
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions affects activity
|
ISO
|
5-Methoxypsoralen results in increased expression of and results in increased phosphorylation of TP53 protein 5-Methoxypsoralen metabolite affects the activity of TP53 protein
|
CTD |
PMID:30576070 PMID:35435491 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
multiple interactions
|
EXP ISO
|
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]
|
CTD |
PMID:17599282 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Wnt3a
|
Wnt family member 3A
|
multiple interactions
|
ISO
|
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of WNT3A protein]
|
CTD |
PMID:34428446 |
|
NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324
|
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