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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:manganese atom
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Accession:CHEBI:18291 term browser browse the term
Definition:A manganese group element atom that has formula Mn.
Synonyms:related_synonym: 25Mn;   Formula=Mn;   InChI=1S/Mn;   InChIKey=PWHULOQIROXLJO-UHFFFAOYSA-N;   Mangan;   Manganese;   Mn;   SMILES=[Mn];   manganeso;   manganum
 alt_id: CHEBI:13382;   CHEBI:25153;   CHEBI:6681
 xref: CAS:7439-96-5;   KEGG:C00034
 xref_mesh: MESH:D008345
 xref: WebElements:Mn


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manganese atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 decreases expression ISO Manganese results in decreased expression of ABCA5 mRNA CTD PMID:17175027 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
JBrowse link
G Abca9 ATP binding cassette subfamily A member 9 increases expression ISO Manganese results in increased expression of ABCA9 mRNA CTD PMID:17175027 NCBI chr10:98,412,263...98,472,258
Ensembl chr10:98,412,263...98,469,799
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases activity
increases expression
multiple interactions
ISO
EXP
Manganese results in increased activity of ABCB1 protein
Manganese results in increased expression of ABCB1A mRNA
[Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate
CTD PMID:2900677, PMID:26745496 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions EXP Manganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]] CTD PMID:12069597 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein CTD PMID:32659473 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Abi2 abl-interactor 2 increases expression ISO Manganese results in increased expression of ABI2 mRNA CTD PMID:17175027 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Manganese results in decreased expression of ACAT2 mRNA CTD PMID:23499988 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
EXP
ISO
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Taurine inhibits the reaction [Manganese results in increased activity of ACHE protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form
CTD PMID:24885898, PMID:30738988, PMID:30844427, PMID:32445656 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aco1 aconitase 1 decreases activity
increases activity
multiple interactions
EXP
ISO
Manganese results in decreased activity of ACO1 protein
Manganese results in increased activity of ACO1 protein
Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]
CTD PMID:16386771, PMID:16545456, PMID:16568477, PMID:16729984, PMID:17469137 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Manganese results in decreased expression of ACO2 mRNA; Manganese results in decreased expression of ACO2 protein
CTD PMID:9675333, PMID:16625280, PMID:17469137 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP Manganese results in decreased expression of ACTA1 mRNA CTD PMID:26745496 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Actr3 actin related protein 3 affects expression EXP Manganese affects the expression of ACTR3 protein CTD PMID:24885898 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 increases expression EXP Manganese results in increased expression of ADGRE1 mRNA CTD PMID:20224926 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Adm adrenomedullin increases expression ISO Manganese results in increased expression of ADM mRNA CTD PMID:17175027 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Afp alpha-fetoprotein decreases expression EXP Manganese results in decreased expression of AFP mRNA CTD PMID:26745496 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akap7 A-kinase anchoring protein 7 decreases expression ISO Manganese results in decreased expression of AKAP7 mRNA CTD PMID:17175027 NCBI chr 1:21,129,213...21,263,850
Ensembl chr 1:21,141,970...21,263,850
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
increases phosphorylation
ISO
EXP
Manganese results in decreased expression of AKT1 protein
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
Manganese results in increased phosphorylation of AKT1 protein
CTD PMID:17043766, PMID:24845367, PMID:31676349 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Angpt2 angiopoietin 2 decreases expression EXP Manganese results in decreased expression of ANGPT2 mRNA CTD PMID:26745496 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Manganese results in increased expression of ANGPTL4 mRNA CTD PMID:17175027 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ap3b2 adaptor related protein complex 3 subunit beta 2 increases expression ISO Manganese results in increased expression of AP3B2 mRNA CTD PMID:17175027 NCBI chr 1:143,284,041...143,315,846
Ensembl chr 1:143,283,996...143,315,633
JBrowse link
G App amyloid beta precursor protein increases expression ISO Manganese results in increased expression of APP mRNA CTD PMID:18583042 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein] CTD PMID:20648640 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Arg1 arginase 1 affects binding ISO
EXP
Manganese binds to ARG1 protein CTD PMID:15248756, PMID:18802628 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Manganese results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Arhgef4 Rho guanine nucleotide exchange factor 4 increases expression ISO Manganese results in increased expression of ARHGEF4 mRNA CTD PMID:17175027 NCBI chr 9:41,160,562...41,305,015
Ensembl chr 9:41,295,909...41,302,501
JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation
multiple interactions
EXP Manganese results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]
CTD PMID:16787641 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Atf6 activating transcription factor 6 decreases expression ISO Manganese results in decreased expression of ATF6 mRNA CTD PMID:17175027 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO Manganese results in decreased expression of ATM mRNA CTD PMID:17175027 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 decreases expression EXP Manganese results in decreased expression of ATOH8 mRNA CTD PMID:26745496 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
JBrowse link
G Atp13a2 ATPase cation transporting 13A2 affects response to substance
decreases response to substance
ISO ATP13A2 gene polymorphism affects the susceptibility to Manganese
ATP13A2 protein results in decreased susceptibility to Manganese
CTD PMID:22285144, PMID:22847264 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression
increases methylation
ISO Manganese results in decreased expression of ATP1A3 mRNA
Manganese results in increased methylation of ATP1A3 promoter
CTD PMID:23976782 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp7a ATPase copper transporting alpha affects localization
decreases expression
EXP Manganese affects the localization of ATP7A protein
Manganese results in decreased expression of ATP7A mRNA; Manganese results in decreased expression of ATP7A protein
CTD PMID:24614235 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta increases phosphorylation
decreases expression
affects localization
ISO
EXP
Manganese results in increased phosphorylation of ATP7B protein
Manganese results in decreased expression of ATP7B mRNA; Manganese results in decreased expression of ATP7B protein
Manganese affects the localization of ATP7B protein
CTD PMID:19405516, PMID:24614235 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 decreases expression ISO Manganese results in decreased expression of ATP8A1 mRNA CTD PMID:17175027 NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311
JBrowse link
G Bace1 beta-secretase 1 increases expression ISO Manganese results in increased expression of BACE1 mRNA CTD PMID:18583042 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
CTD PMID:25027559, PMID:25791630, PMID:30844427, PMID:30951808, PMID:31161640, PMID:31676349 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein] CTD PMID:30844427, PMID:30951808, PMID:31161640, PMID:31676349 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Manganese results in decreased expression of BCL2L1 protein
[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]
CTD PMID:25791630 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP
ISO
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]
Manganese results in decreased expression of BDNF mRNA; Manganese results in decreased expression of BDNF protein
CTD PMID:17827730, PMID:25099302, PMID:29205667, PMID:30951808, PMID:31161640, PMID:32659473 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO Manganese results in decreased expression of BUB1 mRNA CTD PMID:17175027 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Ca8 carbonic anhydrase 8 increases expression EXP Manganese results in increased expression of CAR8 mRNA CTD PMID:26745496 NCBI chr 5:21,249,018...21,345,810
Ensembl chr 5:21,249,020...21,345,810
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO Manganese results in increased expression of CALCOCO2 mRNA CTD PMID:17175027 NCBI chr10:83,935,087...83,963,750 JBrowse link
G Calr calreticulin affects expression EXP Manganese affects the expression of CALR protein CTD PMID:24885898 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases phosphorylation EXP Manganese results in decreased phosphorylation of CAMK2A protein CTD PMID:26616912 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Capn1 calpain 1 increases activity
multiple interactions
EXP Manganese results in increased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]
CTD PMID:21985864 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage
EXP
ISO
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased expression of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 protein]
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]
Manganese results in increased expression of CASP3 mRNA; Manganese results in increased expression of CASP3 protein
CTD PMID:11933051, PMID:16787641, PMID:21985864, PMID:22427945, PMID:22841634, PMID:22975163, PMID:25027559, PMID:25416158, PMID:30844427, PMID:30991096, PMID:31161640, PMID:31676349, PMID:32574669 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity EXP Manganese results in increased activity of CASP7 protein CTD PMID:22427945 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
EXP Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein] CTD PMID:31161640 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions
EXP
ISO
Manganese results in increased cleavage of CASP9 protein
Manganese results in increased activity of CASP9 protein
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]
CTD PMID:16787641, PMID:25416158 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO
EXP
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
Manganese results in decreased activity of CAT protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Manganese results in decreased activity of CAT protein]
CTD PMID:16595185, PMID:17176674, PMID:23339144, PMID:25817889, PMID:30844427, PMID:32445656 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 decreases expression ISO Manganese results in decreased expression of CAV1 mRNA; Manganese results in decreased expression of CAV1 protein CTD PMID:23499988, PMID:23597857 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cav3 caveolin 3 decreases expression ISO Manganese results in decreased expression of CAV3 mRNA; Manganese results in decreased expression of CAV3 protein CTD PMID:23597857 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Manganese results in increased expression of CCL2 mRNA CTD PMID:19782702 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Manganese results in increased expression of CCL7 mRNA CTD PMID:17175027 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccna1 cyclin A1 increases expression EXP Manganese results in increased expression of CCNA1 mRNA CTD PMID:26745496 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Manganese results in decreased expression of CCNB2 mRNA CTD PMID:17175027 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Manganese results in increased expression of CCND1 mRNA CTD PMID:23997110 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd48 Cd48 molecule increases expression ISO Manganese results in increased expression of CD48 mRNA CTD PMID:17175027 NCBI chr13:90,116,601...90,140,371
Ensembl chr13:90,116,843...90,140,371
JBrowse link
G Cd8b CD8b molecule increases expression ISO Manganese results in increased expression of CD8B mRNA; Manganese results in increased expression of CD8B1 mRNA CTD PMID:17175027 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO Manganese results in decreased expression of CDKN2C mRNA CTD PMID:17175027 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Manganese results in decreased expression of CDKN3 mRNA CTD PMID:17175027 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO Manganese results in increased expression of CEBPD mRNA CTD PMID:17175027 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 increases expression ISO Manganese results in increased expression of CELSR1 mRNA CTD PMID:17175027 NCBI chr 7:126,774,010...126,914,085
Ensembl chr 7:126,775,516...126,913,585
JBrowse link
G Cep128 centrosomal protein 128 decreases expression ISO Manganese results in decreased expression of CEP128 mRNA CTD PMID:17175027 NCBI chr 6:114,759,474...115,158,004
Ensembl chr 6:114,759,474...115,157,854
JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions
EXP
ISO
Manganese results in decreased activity of CHAT protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein
Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]
CTD PMID:24885898, PMID:30738988 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Manganese results in decreased expression of CKS2 mRNA CTD PMID:17175027 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cldn23 claudin 23 increases expression EXP Manganese results in increased expression of CLDN23 mRNA CTD PMID:26745496 NCBI chr16:59,988,603...59,990,327
Ensembl chr16:59,988,603...59,990,326
JBrowse link
G Cln6 CLN6, transmembrane ER protein increases abundance ISO CLN6 gene mutant form results in increased abundance of Manganese CTD PMID:23789114 NCBI chr 8:67,733,215...67,748,170
Ensembl chr 8:67,733,215...67,748,172
JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO Manganese results in decreased expression of CNOT2 mRNA CTD PMID:17175027 NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like increases expression ISO Manganese results in increased expression of CNOT6L mRNA CTD PMID:17175027 NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586
JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO Manganese results in decreased expression of COL12A1 mRNA CTD PMID:17175027 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Cpm carboxypeptidase M decreases expression ISO Manganese results in decreased expression of CPM mRNA CTD PMID:17175027 NCBI chr 7:60,654,350...60,714,620
Ensembl chr 7:60,654,350...60,714,620
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
decreases phosphorylation
multiple interactions
decreases expression
EXP
ISO
Manganese results in increased phosphorylation of CREB1 protein
Manganese results in decreased phosphorylation of CREB1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]
CTD PMID:16787641, PMID:29205667, PMID:30951808, PMID:31161640, PMID:31676349, PMID:32659473 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP] CTD PMID:2153673 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crym crystallin, mu affects expression EXP Manganese affects the expression of CRYM protein CTD PMID:24885898 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Manganese results in increased expression of CSRP3 mRNA CTD PMID:26745496 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Ctnna1 catenin alpha 1 decreases expression ISO Manganese results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Manganese results in decreased expression of CTNNB1 mRNA CTD PMID:17175027 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Manganese results in decreased expression of CXCL12 mRNA CTD PMID:23499988 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Manganese results in increased expression of CXCL14 mRNA CTD PMID:17175027 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO
EXP
Manganese results in increased expression of CXCL2 mRNA CTD PMID:17175027, PMID:19782702, PMID:20224926 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Manganese results in increased expression of CXCL6 mRNA CTD PMID:17175027 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO
EXP
SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein] CTD PMID:25416158 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Manganese results in decreased expression of CYP11A1 protein CTD PMID:25981801 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP Manganese results in decreased expression of CYP26B1 mRNA CTD PMID:26745496 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance ISO CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases activity
EXP [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Manganese results in increased activity of CYP7A1 protein
CTD PMID:12700418 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dach2 dachshund family transcription factor 2 increases expression ISO Manganese results in increased expression of DACH2 mRNA CTD PMID:17175027 NCBI chr  X:84,924,570...85,484,150
Ensembl chr  X:85,338,928...85,483,719
JBrowse link
G Dctn3 dynactin subunit 3 affects expression EXP Manganese affects the expression of DCTN3 protein CTD PMID:24885898 NCBI chr 5:58,098,706...58,106,706
Ensembl chr 5:58,098,706...58,106,706
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression
multiple interactions
ISO Manganese deficiency results in decreased expression of DDAH1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]
CTD PMID:21312047 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Manganese results in increased expression of DDIT3 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA
Manganese results in increased expression of DDIT3 mRNA
CTD PMID:21477646, PMID:23499988, PMID:32574669 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression EXP Manganese results in decreased expression of DLD protein CTD PMID:25981801 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Dnah14 dynein axonemal heavy chain 14 decreases expression ISO Manganese results in decreased expression of DNAH14 mRNA CTD PMID:17175027 NCBI chr13:99,886,373...100,072,674
NCBI chr13:101,936,210...101,973,640
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Manganese results in decreased expression of DNPH1 mRNA CTD PMID:17175027 NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503
JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases expression ISO Manganese results in increased expression of DPP4 mRNA CTD PMID:17175027 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Dr1 down-regulator of transcription 1 decreases expression ISO Manganese results in decreased expression of DR1 mRNA CTD PMID:17175027 NCBI chr14:2,463,651...2,475,004
Ensembl chr14:2,463,643...2,474,780
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP Manganese results in decreased expression of DRD2 mRNA CTD PMID:20224926 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression EXP Manganese results in increased expression of DSCAML1 mRNA CTD PMID:26745496 NCBI chr 8:49,733,835...50,056,115
Ensembl chr 8:49,737,798...50,055,560
JBrowse link
G Dspp dentin sialophosphoprotein increases expression ISO Manganese results in increased expression of DSPP mRNA CTD PMID:17175027 NCBI chr14:6,926,972...6,933,079
Ensembl chr14:6,926,976...6,933,070
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
decreases expression
ISO [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 mRNA; [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 protein
Manganese results in decreased expression of DUSP1 mRNA; Manganese results in decreased expression of DUSP1 protein
CTD PMID:20589745 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Manganese results in increased expression of EIF2A protein CTD PMID:21477646 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein CTD PMID:32574669 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein CTD PMID:32574669 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Elf1 E74 like ETS transcription factor 1 decreases expression ISO Manganese results in decreased expression of ELF1 mRNA CTD PMID:17175027 NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343
JBrowse link
G Eml2 EMAP like 2 increases expression ISO Manganese results in increased expression of EML2 mRNA CTD PMID:17175027 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
JBrowse link
G Eno1 enolase 1 decreases activity ISO Manganese results in decreased activity of ENO1 protein CTD PMID:22191580 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epo erythropoietin increases glycosylation ISO Manganese results in increased glycosylation of EPO protein CTD PMID:16937399 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase decreases expression ISO Manganese results in decreased expression of ERCC6L mRNA CTD PMID:17175027 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099
JBrowse link
G Ereg epiregulin increases expression ISO Manganese results in increased expression of EREG mRNA CTD PMID:17175027 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Erich1 glutamate-rich 1 increases expression ISO Manganese results in increased expression of ERICH1 mRNA CTD PMID:17175027 NCBI chr16:80,601,873...80,667,774
Ensembl chr16:80,601,973...80,667,781
JBrowse link
G Esr1 estrogen receptor 1 increases expression EXP Manganese results in increased expression of ESR1 protein CTD PMID:24845367 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Exoc6 exocyst complex component 6 decreases expression ISO Manganese results in decreased expression of EXOC6 mRNA CTD PMID:17175027 NCBI chr 1:256,211,879...256,369,318
Ensembl chr 1:256,226,179...256,368,813
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Manganese results in decreased expression of EYA4 mRNA CTD PMID:17175027 NCBI chr 1:23,237,617...23,611,580
Ensembl chr 1:23,409,408...23,610,164
JBrowse link
G F2 coagulation factor II multiple interactions
increases uptake
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]; Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]; Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]; Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese] CTD PMID:2125206 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fa2h fatty acid 2-hydroxylase increases expression EXP Manganese results in increased expression of FA2H mRNA CTD PMID:26745496 NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression EXP Manganese results in decreased expression of FAM107A mRNA CTD PMID:26745496 NCBI chr15:18,399,145...18,415,959
Ensembl chr15:18,399,515...18,415,965
JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression EXP Manganese results in decreased expression of FAM180A mRNA CTD PMID:26745496 NCBI chr 4:62,845,054...62,860,361
Ensembl chr 4:62,844,971...62,860,446
JBrowse link
G Fancf FA complementation group F decreases expression ISO Manganese results in decreased expression of FANCF mRNA CTD PMID:17175027 NCBI chr 1:107,229,516...107,232,321
Ensembl chr 1:107,231,292...107,232,305
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia decreases expression EXP Manganese results in decreased expression of FCGR1A mRNA CTD PMID:26745496 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 decreases expression EXP Manganese results in decreased expression of FGFBP1 mRNA CTD PMID:26745496 NCBI chr14:71,647,429...71,650,359
Ensembl chr14:71,649,274...71,650,354
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases expression ISO Manganese results in decreased expression of FHL1 mRNA CTD PMID:17175027 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Fibin fin bud initiation factor homolog increases expression ISO Manganese results in increased expression of FIBIN mRNA CTD PMID:21615908 NCBI chr 3:101,545,207...101,547,478
Ensembl chr 3:101,545,208...101,547,478
JBrowse link
G Flcn folliculin increases expression ISO Manganese results in increased expression of FLCN mRNA CTD PMID:17175027 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP
ISO
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]
Manganese results in decreased expression of FOS protein
CTD PMID:17043766, PMID:17827730, PMID:22561169 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxn4 forkhead box N4 increases expression EXP Manganese results in increased expression of FOXN4 mRNA CTD PMID:26745496 NCBI chr12:48,101,012...48,121,281
Ensembl chr12:48,101,673...48,121,270
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]; Manganese results in increased expression of and results in increased phosphorylation of FOXO3 protein; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] CTD PMID:24787138 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Manganese results in increased expression of FOXP2 mRNA CTD PMID:17175027 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
increases expression
EXP Manganese results in decreased expression of FTH1 mRNA; Manganese results in decreased expression of FTH1 protein
Manganese results in increased expression of FTH1 protein
CTD PMID:16545456, PMID:16568477, PMID:16740617, PMID:17469137 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression ISO Manganese results in increased expression of FXYD2 mRNA CTD PMID:17175027 NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein CTD PMID:32659473 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein CTD PMID:32659473 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Manganese results in increased expression of GABRG2 mRNA CTD PMID:17175027 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Manganese results in increased expression of GADD45A mRNA CTD PMID:23499988 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression ISO Manganese results in increased expression of GAL mRNA CTD PMID:17175027 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gcfc2 GC-rich sequence DNA-binding factor 2 decreases expression ISO Manganese results in decreased expression of GCFC2 mRNA CTD PMID:17175027 NCBI chr 4:112,662,556...112,700,505
Ensembl chr 4:112,662,609...112,699,711
JBrowse link
G Gdap2 ganglioside-induced differentiation-associated-protein 2 increases expression ISO Manganese results in increased expression of GDAP2 mRNA CTD PMID:17175027 NCBI chr 2:202,470,485...202,526,849
Ensembl chr 2:202,470,487...202,526,849
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Manganese results in increased expression of GDF15 mRNA CTD PMID:17175027 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
affects expression
increases expression
EXP
ISO
Manganese results in decreased expression of GFAP mRNA
Manganese affects the expression of GFAP protein
Manganese results in increased expression of GFAP mRNA; Manganese results in increased expression of GFAP protein
CTD PMID:19782702, PMID:20224926, PMID:23832297, PMID:24885898 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression EXP Manganese results in decreased expression of GJA5 mRNA CTD PMID:26745496 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gldn gliomedin decreases expression EXP Manganese results in decreased expression of GLDN mRNA CTD PMID:26745496 NCBI chr 8:58,870,516...58,914,605
Ensembl chr 8:58,870,516...58,914,603
JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression
multiple interactions
ISO Manganese deficiency results in decreased expression of GLUD1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]
CTD PMID:21312047 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Glul glutamate-ammonia ligase affects expression
decreases expression
EXP Manganese affects the expression of GLUL mRNA; Manganese affects the expression of GLUL protein
Manganese results in decreased expression of GLUL mRNA; Manganese results in decreased expression of GLUL protein
CTD PMID:16842851, PMID:16943606 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression EXP Manganese results in increased expression of GNRH1 mRNA CTD PMID:23997110 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions EXP [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in decreased susceptibility to Manganese CTD PMID:22645130 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpr18 G protein-coupled receptor 18 decreases expression EXP Manganese results in decreased expression of GPR18 mRNA CTD PMID:26745496 NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907
JBrowse link
G Gpr34 G protein-coupled receptor 34 decreases expression EXP Manganese results in decreased expression of GPR34 mRNA CTD PMID:26745496 NCBI chr  X:10,022,986...10,043,504
Ensembl chr  X:10,023,489...10,031,167
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Manganese results in decreased expression of GRIN1 mRNA; Manganese results in decreased expression of GRIN1 protein CTD PMID:19643132, PMID:29205667 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Manganese results in decreased expression of GRIN2A mRNA; Manganese results in decreased expression of GRIN2A protein CTD PMID:19643132, PMID:29205667 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP Manganese results in decreased expression of GRIN2B mRNA; Manganese results in decreased expression of GRIN2B protein CTD PMID:19643132, PMID:29205667 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions
ISO
EXP
Manganese results in decreased expression of GSR mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein
CTD PMID:17175027, PMID:17176674, PMID:32445656 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 gene polymorphism affects the susceptibility to Manganese CTD PMID:30930959 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gtf2h1 general transcription factor IIH subunit 1 decreases expression ISO Manganese results in decreased expression of GTF2H1 mRNA CTD PMID:17175027 NCBI chr 1:102,849,618...102,877,939
Ensembl chr 1:102,849,889...102,877,944
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Manganese results in decreased expression of HAMP mRNA CTD PMID:29020610 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to HDAC1 protein] CTD PMID:24469401 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Heph hephaestin increases expression ISO Manganese results in increased expression of HEPH mRNA CTD PMID:17175027 NCBI chr  X:65,377,313...65,658,479
Ensembl chr  X:65,563,122...65,658,516
JBrowse link
G Hfe homeostatic iron regulator affects abundance ISO HFE protein affects the abundance of Manganese CTD PMID:18317567 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO Manganese results in increased expression of and results in increased activity of HIF1A protein
Manganese results in increased expression of HIF1A mRNA
CTD PMID:16386771, PMID:17175027 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor decreases expression ISO Manganese results in decreased expression of HIF1AN mRNA CTD PMID:17175027 NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases activity
EXP [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein
Manganese results in increased activity of HMGCR protein
CTD PMID:12700418 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Manganese results in decreased expression of HMGCS2 mRNA CTD PMID:26745496 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Manganese results in increased expression of HMOX1 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]
CTD PMID:11181820, PMID:18948096, PMID:23832297, PMID:32574669 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Manganese results in decreased expression of HOXB9 mRNA CTD PMID:17175027 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO
EXP
Manganese results in increased expression of HSPA5 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA
CTD PMID:21477646, PMID:32574669 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in increased expression of HSPA8 protein CTD PMID:16600465 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]] CTD PMID:21126535 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htt huntingtin decreases uptake
multiple interactions
decreases response to substance
decreases abundance
ISO
EXP
HTT protein mutant form results in decreased uptake of Manganese
Manganese results in decreased phosphorylation of and results in increased expression of HTT protein
HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein]; HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein]; Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein]
HTT gene mutant form results in decreased susceptibility to Manganese
HTT gene mutant form results in decreased abundance of Manganese
CTD PMID:19845833, PMID:20547568, PMID:22191580, PMID:25099302 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Manganese results in increased expression of ID2 mRNA CTD PMID:17175027 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha affects binding ISO Manganese binds to IDH3A protein CTD PMID:16737955 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma affects binding ISO Manganese binds to IDH3G protein CTD PMID:16737955 NCBI chr  X:156,999,803...157,008,735
Ensembl chr  X:156,999,826...157,008,733
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; [Lipopolysaccharides co-treated with IFNG protein co-treated with Manganese] results in decreased abundance of Nitric Oxide; [pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [SB 203580 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [U 0126 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]
Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]
CTD PMID:16168523, PMID:16488514 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12a interleukin 12A increases expression ISO Manganese results in increased expression of IL12A mRNA CTD PMID:17175027 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Manganese results in increased expression of IL1B mRNA CTD PMID:19782702 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Manganese results in decreased expression of IL1RL1 mRNA CTD PMID:26745496 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein] CTD PMID:22561169 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases expression
increases uptake
multiple interactions
increases secretion
ISO
EXP
Manganese results in increased expression of IL6 mRNA; Manganese results in increased expression of IL6 protein
IL6 protein results in increased uptake of Manganese
[IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese; [IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese
Manganese results in increased secretion of IL6 protein
[Manganese co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA
CTD PMID:17065364, PMID:19263519, PMID:20224926, PMID:20589745, PMID:24576911 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il7 interleukin 7 increases expression ISO Manganese results in increased expression of IL7 mRNA CTD PMID:17175027 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein]; [Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein] CTD PMID:2542339, PMID:31555879 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions
decreases expression
EXP
ISO
[Manganese co-treated with INS1 protein] results in increased phosphorylation of INSR protein
Manganese deficiency results in decreased expression of INSR protein
[Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]
CTD PMID:1321133, PMID:2204694, PMID:2542339 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Ireb2 iron responsive element binding protein 2 decreases activity
increases expression
EXP Manganese results in decreased activity of IREB2 protein
Manganese results in increased expression of IREB2 protein
CTD PMID:16568477, PMID:17469137 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Irs4 insulin receptor substrate 4 multiple interactions EXP [Manganese co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein CTD PMID:1321133 NCBI chr  X:113,003,824...113,018,088 JBrowse link
G Itga3 integrin subunit alpha 3 increases expression ISO Manganese results in increased expression of ITGA3 mRNA CTD PMID:17175027 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Manganese results in increased expression of ITGAM mRNA CTD PMID:20224926 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb1 integrin subunit beta 1 increases activity EXP Manganese results in increased activity of ITGB1 protein CTD PMID:10820171, PMID:16606368 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression ISO Manganese results in increased expression of ITGB5 mRNA CTD PMID:17175027 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO Manganese promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 multiple interactions ISO Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO
EXP
Manganese results in decreased expression of JUN protein
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; NEPP11 compound inhibits the reaction [Manganese results in increased phosphorylation of JUN protein]
CTD PMID:15342272, PMID:17043766, PMID:17827730, PMID:22561169 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 increases expression ISO Manganese results in increased expression of KCNIP3 mRNA CTD PMID:17175027 NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO KCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ11 protein
CTD PMID:17189350, PMID:32659473 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 increases expression ISO Manganese results in increased expression of KCNJ3 mRNA CTD PMID:17175027 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ8 protein CTD PMID:32659473 NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304
JBrowse link
G Kera keratocan increases expression EXP Manganese results in increased expression of KERA mRNA CTD PMID:26745496 NCBI chr 7:38,858,062...38,865,515
Ensembl chr 7:38,858,062...38,865,515
JBrowse link
G Khsrp KH-type splicing regulatory protein multiple interactions
increases expression
EXP KHSRP protein affects the reaction [Manganese results in increased expression of TP53 protein]
Manganese results in increased expression of KHSRP protein
CTD PMID:25027559 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor increases expression EXP Manganese results in increased expression of KISS1 mRNA CTD PMID:23997110 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
JBrowse link
G Kiss1r KISS1 receptor increases expression EXP Manganese results in increased expression of KISS1R mRNA CTD PMID:23997110 NCBI chr 7:12,606,210...12,609,868
Ensembl chr 7:12,606,210...12,609,868
JBrowse link
G Klf4 Kruppel like factor 4 increases expression ISO Manganese results in increased expression of KLF4 mRNA CTD PMID:17175027 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Manganese results in decreased expression of KLF9 mRNA CTD PMID:17175027 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Ldhb lactate dehydrogenase B affects expression EXP Manganese affects the expression of LDHB protein CTD PMID:24885898 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Lep leptin decreases abundance ISO LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lman2 lectin, mannose-binding 2 increases expression ISO Manganese results in increased expression of LMAN2 mRNA CTD PMID:17175027 NCBI chr17:9,798,136...9,815,820
Ensembl chr17:9,797,907...9,816,139
JBrowse link
G LOC100360841 ribosomal protein L37-like decreases expression ISO Manganese results in decreased expression of RPL37 mRNA CTD PMID:27329587 NCBI chr 9:69,790,829...69,791,199
Ensembl chr 9:69,790,831...69,791,196
JBrowse link
G LOC100911804 apolipoprotein L3-like increases expression ISO Manganese results in increased expression of APOL2 mRNA CTD PMID:17175027 NCBI chr 7:118,979,230...118,986,699
Ensembl chr 7:118,979,608...118,983,984
JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Manganese results in increased expression of LRAT mRNA CTD PMID:26745496 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases response to substance
multiple interactions
ISO LRRK2 mutant form results in increased susceptibility to Manganese
LRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]
CTD PMID:23628791 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Maf MAF bZIP transcription factor increases expression EXP Manganese results in increased expression of MAF mRNA CTD PMID:23997110 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Maged2 MAGE family member D2 decreases expression ISO Manganese results in decreased expression of MAGED2 mRNA CTD PMID:23499988 NCBI chr 5:33,174,539...33,182,715
Ensembl chr 5:33,174,542...33,182,715
JBrowse link
G Mall mal, T-cell differentiation protein-like decreases expression EXP Manganese results in decreased expression of MALL mRNA CTD PMID:26745496 NCBI chr 3:120,272,583...120,307,090
Ensembl chr 3:120,272,583...120,306,551
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions
decreases phosphorylation
ISO [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein; Lipopolysaccharides promotes the reaction [Manganese results in increased activity of MAP2K4 protein]; Manganese promotes the reaction [Lipopolysaccharides results in increased activity of MAP2K4 protein]; Manganese results in increased activity of and results in increased phosphorylation of MAP2K4 protein
Manganese results in decreased phosphorylation of MAP2K4 protein
CTD PMID:20589745 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 multiple interactions EXP MAP3K14 protein affects the reaction [Manganese promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]] CTD PMID:15010209 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
Manganese inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]
Manganese results in increased phosphorylation of MAPK1 protein
Manganese results in decreased phosphorylation of MAPK1 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Manganese results in increased phosphorylation of MAPK1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; Deferoxamine promotes the reaction [Manganese results in increased phosphorylation of MAPK1 protein]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Manganese results in increased phosphorylation of MAPK1 protein]
CTD PMID:11933051, PMID:16488514, PMID:16787641, PMID:17043766, PMID:17045426, PMID:17055454, PMID:22427945, PMID:24787138, PMID:24845367, PMID:25981801, PMID:31676349, PMID:32574669 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO Manganese results in decreased phosphorylation of MAPK14 protein CTD PMID:17043766 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
Manganese inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]
Manganese results in increased phosphorylation of MAPK3 protein
Manganese results in decreased phosphorylation of MAPK3 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Manganese results in increased phosphorylation of MAPK3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; Deferoxamine promotes the reaction [Manganese results in increased phosphorylation of MAPK3 protein]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Manganese results in increased phosphorylation of MAPK3 protein]
CTD PMID:11933051, PMID:16488514, PMID:16787641, PMID:17043766, PMID:17045426, PMID:17055454, PMID:22427945, PMID:24787138, PMID:24845367, PMID:25981801, PMID:31676349, PMID:32574669 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO
EXP
Manganese results in increased phosphorylation of MAPK8 protein
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein]
CTD PMID:17045426, PMID:30951808, PMID:32574669 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Manganese results in increased phosphorylation of MAPK9 protein
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]
CTD PMID:17045426, PMID:22561169 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mbp myelin basic protein increases expression ISO Manganese results in increased expression of MBP mRNA CTD PMID:17175027 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mchr1 melanin-concentrating hormone receptor 1 increases expression ISO Manganese results in increased expression of MCHR1 mRNA CTD PMID:17175027 NCBI chr 7:122,456,846...122,459,324
Ensembl chr 7:122,456,799...122,459,960
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Manganese results in decreased expression of MCM4 mRNA CTD PMID:17175027 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO Manganese results in decreased expression of MCM5 mRNA CTD PMID:17175027 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 increases expression EXP Manganese results in increased expression of MCOLN3 mRNA CTD PMID:26745496 NCBI chr 2:251,930,532...252,007,722
Ensembl chr 2:251,983,339...252,007,560
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
decreases expression
EXP [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]
Manganese results in decreased expression of MDM2 protein
CTD PMID:25791630 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Me3 malic enzyme 3 increases expression ISO Manganese results in increased expression of ME3 mRNA CTD PMID:17175027 NCBI chr 1:153,861,535...154,058,608
Ensembl chr 1:153,861,569...154,056,654
JBrowse link
G Mia MIA SH3 domain containing increases expression ISO Manganese results in increased expression of MIA mRNA CTD PMID:17175027 NCBI chr 1:83,991,577...83,993,270
Ensembl chr 1:83,991,578...83,993,270
JBrowse link
G Mid1 midline 1 decreases expression
increases methylation
ISO Manganese results in decreased expression of MID1 mRNA
Manganese results in increased methylation of MID1 promoter
CTD PMID:23976782 NCBI chr  X:25,458,782...25,839,941
Ensembl chr  X:25,458,771...25,628,272
JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR125B1 mRNA CTD PMID:31555879 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir582 microRNA 582 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR582 mRNA CTD PMID:31555879 NCBI chr 2:40,863,750...40,863,830
Ensembl chr 2:40,863,750...40,863,830
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP Manganese results in increased expression of MMP13 mRNA CTD PMID:26745496 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO Manganese results in decreased expression of MMP14 protein CTD PMID:17043766 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Manganese results in decreased expression of MMP2 protein CTD PMID:17043766 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Manganese results in increased expression of MMP3 mRNA CTD PMID:26745496 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of MPO protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein] CTD PMID:30844427 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Manganese results in decreased expression of MSH6 mRNA CTD PMID:17175027 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [MT1 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased abundance of Manganese CTD PMID:26770886 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [MT2 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased abundance of Manganese CTD PMID:26770886 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtm1 myotubularin 1 decreases expression ISO Manganese results in decreased expression of MTM1 mRNA CTD PMID:17175027 NCBI chr 6:18,821,821...18,840,449
Ensembl chr 6:18,821,815...18,839,409
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
increases expression
increases phosphorylation
ISO
EXP
Manganese results in decreased phosphorylation of MTOR protein
Manganese results in increased expression of MTOR mRNA
Manganese results in increased phosphorylation of MTOR protein
CTD PMID:17043766, PMID:23997110 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myh2 myosin heavy chain 2 decreases expression EXP Manganese results in decreased expression of MYH2 mRNA CTD PMID:26745496 NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myom1 myomesin 1 increases expression ISO Manganese results in increased expression of MYOM1 mRNA CTD PMID:17175027 NCBI chr 9:119,353,840...119,469,196
Ensembl chr 9:119,353,840...119,468,715
JBrowse link
G Myt1l myelin transcription factor 1-like increases expression ISO
EXP
Manganese results in increased expression of MYT1L mRNA CTD PMID:17175027, PMID:26745496 NCBI chr 6:48,452,385...48,843,443
Ensembl chr 6:48,452,369...48,857,936
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Manganese results in increased expression of NAMPT mRNA CTD PMID:17175027 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Manganese results in increased expression of NDRG1 protein CTD PMID:16386771 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nefl neurofilament light multiple interactions
increases expression
ISO HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein] CTD PMID:22191580 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
Manganese results in increased expression of and results in increased localization of NFE2L2 protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Manganese
CTD PMID:17573173, PMID:23764462 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfib nuclear factor I/B increases expression ISO Manganese results in increased expression of NFIB mRNA CTD PMID:17175027 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
G Nfix nuclear factor I X decreases expression ISO Manganese results in decreased expression of NFIX mRNA CTD PMID:17175027 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; MAP3K14 protein affects the reaction [Manganese promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 mRNA]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 protein]
CTD PMID:15010209, PMID:16168523, PMID:16488514 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta decreases expression ISO Manganese results in decreased expression of NFYB mRNA CTD PMID:17175027 NCBI chr 7:27,081,667...27,097,481
Ensembl chr 7:27,081,667...27,097,479
JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; [Manganese co-treated with NGF protein] results in decreased expression of PPM1D protein; [Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein; [Manganese co-treated with NGF protein] results in increased expression of and affects the localization of TP53 protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased phosphorylation of and results in increased expression of TP53 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein] CTD PMID:25448048, PMID:25791630 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nmt1 N-myristoyltransferase 1 multiple interactions ISO [Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased activity of NMT1 protein CTD PMID:16600465 NCBI chr10:91,126,689...91,160,721
Ensembl chr10:91,126,689...91,160,720
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases activity ISO Manganese results in increased activity of NNMT protein CTD PMID:22249857 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP Manganese results in decreased expression of NOS1 mRNA CTD PMID:16476481 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases methylation
increases expression
decreases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 mRNA]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 protein]
Manganese results in decreased methylation of NOS2 exon
Manganese results in increased expression of NOS2 mRNA; Manganese results in increased expression of NOS2 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [Manganese results in increased abundance of Reactive Oxygen Species] promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Manganese results in increased expression of and results in increased activity of NOS2 protein; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
Manganese results in decreased activity of NOS2 protein
CTD PMID:15010209, PMID:16168523, PMID:16417967, PMID:16488514, PMID:16551646, PMID:17827730, PMID:18335517, PMID:19812365, PMID:20224926, PMID:20798247, PMID:23832297, PMID:24777576, PMID:25634431 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Manganese inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein] CTD PMID:21300668 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Notch4 notch receptor 4 decreases expression ISO Manganese results in decreased expression of NOTCH4 mRNA CTD PMID:17175027 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Manganese results in decreased expression of NPPA mRNA CTD PMID:17175027 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP Manganese results in increased activity of NQO1 protein CTD PMID:17573173 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression
increases methylation
ISO Manganese results in decreased expression of NR2F1 mRNA
Manganese results in increased methylation of NR2F1 promoter
CTD PMID:23976782 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894
JBrowse link
G Nrg2 neuregulin 2 increases expression ISO Manganese results in increased expression of NRG2 mRNA CTD PMID:17175027 NCBI chr18:28,835,391...29,015,552
Ensembl chr18:28,835,417...29,015,552
JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Manganese results in increased expression of NRP1 mRNA CTD PMID:17175027 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTF3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTF3 protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTF3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
CTD PMID:31676349 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases expression EXP Manganese results in decreased expression of NTRK1 protein CTD PMID:17029596 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 multiple interactions ISO NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein]
CTD PMID:31676349 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Manganese results in decreased expression of NUCKS1 mRNA CTD PMID:17175027 NCBI chr13:48,679,726...48,709,663
Ensembl chr13:48,679,774...48,705,575
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]]; Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO Manganese results in decreased expression of OGG1 mRNA CTD PMID:22641096 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Olfm1 olfactomedin 1 increases expression ISO Manganese results in increased expression of OLFM1 mRNA CTD PMID:17175027 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]; Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]] CTD PMID:2162496 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein] CTD PMID:2162496 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]] CTD PMID:2162496 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression
multiple interactions
increases metabolic processing
EXP Manganese results in increased expression of P4HB mRNA
Manganese affects the reaction [P4HB protein binds to SNCA protein]; Manganese results in increased expression of and results in increased activity of P4HB protein
Manganese results in increased metabolism of P4HB protein
CTD PMID:24777576 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Pappa1 pappalysin 1 increases expression ISO Manganese results in increased expression of PAPPA mRNA CTD PMID:17175027 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Park7 Parkinsonism associated deglycase decreases expression EXP Manganese results in decreased expression of PARK7 protein CTD PMID:20798247 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP [Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]
Manganese results in increased cleavage of PARP1 protein
CTD PMID:25448048, PMID:25791630 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 increases expression ISO Manganese results in increased expression of PARP14 mRNA CTD PMID:23499988 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link
G Pcdh7 protocadherin 7 increases expression ISO Manganese results in increased expression of PCDH7 mRNA CTD PMID:17175027 NCBI chr14:54,649,054...55,081,632
Ensembl chr14:55,072,200...55,081,551
JBrowse link
G Pcdha6 protocadherin alpha 6 increases expression ISO Manganese results in increased expression of PCDHA6 mRNA CTD PMID:17175027 NCBI chr18:29,987,206...30,215,896
Ensembl chr18:29,987,206...30,215,897
JBrowse link
G Pde4b phosphodiesterase 4B increases expression
multiple interactions
EXP Manganese results in increased expression of PDE4B protein
Rolipram inhibits the reaction [Manganese results in increased expression of PDE4B protein]
CTD PMID:31161640 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde6b phosphodiesterase 6B increases expression EXP Manganese results in increased expression of PDE6B mRNA CTD PMID:26745496 NCBI chr14:2,328,690...2,371,913
Ensembl chr14:2,328,750...2,371,883
JBrowse link
G Pde6h phosphodiesterase 6H increases expression EXP Manganese results in increased expression of PDE6H mRNA CTD PMID:26745496 NCBI chr 4:170,947,723...170,963,046
Ensembl chr 4:170,958,196...170,963,046
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO Manganese results in increased expression of PDK1 mRNA CTD PMID:17175027 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pgf placental growth factor increases expression ISO Manganese results in increased expression of PGF mRNA CTD PMID:17175027 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 decreases expression ISO Manganese results in decreased expression of PHTF1 mRNA CTD PMID:17175027 NCBI chr 2:206,452,115...206,518,387
Ensembl chr 2:206,454,208...206,493,030
JBrowse link
G Plce1 phospholipase C, epsilon 1 increases expression ISO Manganese results in increased expression of PLCE1 mRNA CTD PMID:17175027 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Pln phospholamban decreases expression ISO Manganese results in decreased expression of PLN mRNA CTD PMID:17175027 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Pnlip pancreatic lipase increases expression EXP Manganese results in increased expression of PNLIP mRNA CTD PMID:26745496 NCBI chr 1:279,798,187...279,811,372
Ensembl chr 1:279,798,187...279,811,372
JBrowse link
G Pou1f1 POU class 1 homeobox 1 increases expression ISO Manganese results in increased expression of POU1F1 mRNA CTD PMID:17175027 NCBI chr11:2,645,659...2,662,581
Ensembl chr11:2,645,865...2,662,579
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane binds to and results in increased activity of PPARG protein] inhibits the reaction [Manganese results in increased chemical synthesis of Nitric Oxide] CTD PMID:18041089 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Manganese results in increased expression of PPARGC1A protein CTD PMID:24787138 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression
multiple interactions
EXP Manganese results in decreased expression of PPM1D protein
[Manganese co-treated with NGF protein] results in decreased expression of PPM1D protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]
CTD PMID:25791630 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases phosphorylation EXP Manganese results in increased phosphorylation of PPP1R1B protein CTD PMID:22427945 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prdx6 peroxiredoxin 6 affects expression EXP Manganese affects the expression of PRDX6 protein CTD PMID:24885898 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO Manganese results in decreased expression of PRIM1 mRNA CTD PMID:17175027 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO Manganese results in decreased expression of PRIM2 mRNA CTD PMID:17175027 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression
multiple interactions
EXP Manganese results in decreased expression of PRKACA protein
[manganese chloride results in increased abundance of Manganese] which results in increased activity of PRKACA protein
CTD PMID:25981801, PMID:30951808 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkca protein kinase C, alpha increases phosphorylation
decreases expression
EXP Manganese results in increased phosphorylation of PRKCA protein
Manganese results in decreased expression of PRKCA protein
CTD PMID:21812036, PMID:25981801 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation
multiple interactions
EXP
ISO
Manganese results in increased phosphorylation of PRKCD protein
SNCA protein inhibits the reaction [Manganese results in increased cleavage of and results in increased activity of PRKCD protein]
Manganese promotes the reaction [PRKCD protein binds to SLC1A5 protein]; Manganese promotes the reaction [PRKCD protein binds to SLC38A3 protein]; Manganese results in increased cleavage of and results in increased activity of PRKCD protein
CTD PMID:21812036, PMID:25416158 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkd1 protein kinase D1 increases expression ISO Manganese results in increased expression of PRKD1 mRNA CTD PMID:17175027 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression
increases expression
affects response to substance
decreases transport
EXP
ISO
Manganese results in decreased expression of PRKN mRNA
Manganese results in increased expression of PRKN protein
PRKN gene mutant form affects the susceptibility to Manganese
PRKN protein results in decreased transport of Manganese
CTD PMID:19781568, PMID:20089134, PMID:20798247, PMID:22841634, PMID:28826884 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prl prolactin decreases expression
multiple interactions
ISO Manganese results in decreased expression of PRL protein
Manganese inhibits the reaction [PRL protein binds to PRLR protein]
CTD PMID:6197504, PMID:19595304 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prl7a3 prolactin family 7, subfamily a, member 3 increases expression EXP Manganese results in increased expression of PRL7A3 mRNA CTD PMID:26745496 NCBI chr17:39,032,661...39,045,326
Ensembl chr17:39,032,661...39,045,326
JBrowse link
G Prlr prolactin receptor multiple interactions ISO Manganese inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Prnp prion protein increases stability
affects binding
multiple interactions
ISO Manganese results in increased stability of PRNP protein
PRNP protein binds to Manganese
[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]; [[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
CTD PMID:16595185, PMID:20176619 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Manganese results in increased expression of PTGS2 mRNA; Manganese results in increased expression of PTGS2 protein
[Manganese co-treated with Lipopolysaccharides] results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of PTGS2 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of PTGS2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of PTGS2 protein]
CTD PMID:17175027, PMID:17827730, PMID:20589745, PMID:30844427 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases expression ISO Manganese results in decreased expression of PTK2B mRNA CTD PMID:17175027 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Manganese results in increased expression of PTX3 mRNA CTD PMID:17175027 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Pvalb parvalbumin decreases expression
increases methylation
ISO Manganese results in decreased expression of PVALB mRNA
Manganese results in increased methylation of PVALB promoter
CTD PMID:23976782 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Pvr PVR cell adhesion molecule decreases expression ISO Manganese results in decreased expression of PVR mRNA CTD PMID:17175027 NCBI chr 1:80,820,306...80,835,712
Ensembl chr 1:80,820,050...80,835,701
JBrowse link
G Rab21 RAB21, member RAS oncogene family decreases expression ISO Manganese results in decreased expression of RAB21 mRNA CTD PMID:17175027 NCBI chr 7:58,261,985...58,286,770
Ensembl chr 7:58,261,992...58,286,770
JBrowse link
G Rab23 RAB23, member RAS oncogene family decreases expression ISO Manganese results in decreased expression of RAB23 mRNA CTD PMID:17175027 NCBI chr 9:38,469,784...38,496,185
Ensembl chr 9:38,470,298...38,495,176
JBrowse link
G Rab3d RAB3D, member RAS oncogene family decreases expression ISO Manganese results in decreased expression of RAB3D mRNA CTD PMID:23499988 NCBI chr 8:22,920,238...22,929,368
Ensembl chr 8:22,918,699...22,929,294
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
EXP Manganese affects the localization of RELA protein
1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese affects the localization of RELA protein]; Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to RELA protein]
CTD PMID:22645130, PMID:24469401 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO Manganese results in decreased expression of RFC5 mRNA CTD PMID:17175027 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Manganese results in increased expression of RGS2 mRNA CTD PMID:17175027 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression ISO Manganese results in decreased expression of RGS5 mRNA CTD PMID:17175027 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G Rgs6 regulator of G-protein signaling 6 increases expression ISO Manganese results in increased expression of RGS6 mRNA CTD PMID:17175027 NCBI chr 6:106,310,442...106,598,668
Ensembl chr 6:106,496,992...106,602,139
JBrowse link
G Rheb Ras homolog, mTORC1 binding increases expression EXP Manganese results in increased expression of RHEB mRNA CTD PMID:23997110 NCBI chr 4:6,827,429...6,873,384
Ensembl chr 4:6,827,429...6,873,383
JBrowse link
G Rnf145 ring finger protein 145 increases expression ISO Manganese results in increased expression of RNF145 mRNA CTD PMID:17175027 NCBI chr10:30,169,147...30,207,505
Ensembl chr10:30,169,257...30,207,498
JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions
increases uptake
decreases uptake
ISO [retinylamine results in decreased activity of RPE65 protein] which results in decreased uptake of Manganese; Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]
RPE65 protein results in increased uptake of Manganese
CTD PMID:19060264 NCBI chr 2:266,141,581...266,169,197
Ensembl chr 2:266,141,581...266,169,197
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO Manganese results in increased expression of S100A6 mRNA CTD PMID:17175027 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 multiple interactions ISO Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein] CTD PMID:22191580 NCBI chr 1:78,277,524...78,333,281
Ensembl chr 1:78,277,515...78,333,321
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 increases expression ISO Manganese results in increased expression of SCN3B mRNA CTD PMID:17175027 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 decreases expression EXP Manganese results in decreased expression of SCN7A mRNA CTD PMID:26745496 NCBI chr 3:52,775,779...52,877,365
Ensembl chr 3:52,777,214...52,849,907
JBrowse link
G Scrn1 secernin 1 affects expression EXP Manganese affects the expression of SCRN1 protein CTD PMID:24885898 NCBI chr 4:84,678,978...84,740,701
Ensembl chr 4:84,678,975...84,740,909
JBrowse link
G Sdcbp2 syndecan binding protein 2 decreases expression ISO Manganese results in decreased expression of SDCBP2 mRNA CTD PMID:17175027 NCBI chr 3:147,073,160...147,101,917
Ensembl chr 3:147,073,160...147,101,911
JBrowse link
G Serpinb2 serpin family B member 2 increases expression EXP Manganese results in increased expression of SERPINB2 mRNA CTD PMID:26745496 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpine1 serpin family E member 1 increases stability ISO Manganese results in increased stability of SERPINE1 protein CTD PMID:21280127, PMID:21280128 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sftpb surfactant protein B increases expression ISO Manganese results in increased expression of SFTPB mRNA CTD PMID:17175027 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
JBrowse link
G Sfxn5 sideroflexin 5 increases expression ISO Manganese results in increased expression of SFXN5 mRNA CTD PMID:17175027 NCBI chr 4:116,995,238...117,111,548
Ensembl chr 4:116,993,914...117,111,653
JBrowse link
G Sirt2 sirtuin 2 increases expression ISO Manganese results in increased expression of SIRT2 mRNA CTD PMID:17175027 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Six3 SIX homeobox 3 increases expression ISO Manganese results in increased expression of SIX3 mRNA CTD PMID:17175027 NCBI chr 6:8,886,730...8,891,094
Ensembl chr 6:8,886,591...8,889,925
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
increases uptake
increases abundance
increases expression
decreases metabolic processing
decreases uptake
EXP
ISO
[[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [Deferoxamine co-treated with Manganese] results in increased expression of SLC11A2; [manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; [Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]; Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]; SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron]
SLC11A2 results in increased uptake of Manganese
SLC11A2 protein results in increased abundance of Manganese
Manganese results in increased expression of SLC11A2 mRNA; Manganese results in increased expression of SLC11A2 protein
[Deferoxamine results in increased expression of SLC11A2 protein] which results in increased uptake of Manganese; Manganese inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]
SLC11A2 protein mutant form results in decreased metabolism of Manganese
SLC11A2 protein mutant form results in decreased uptake of Manganese
CTD PMID:11933051, PMID:16705042, PMID:16729984, PMID:17116743, PMID:17175027, PMID:18849539, PMID:19782702, PMID:20224926, PMID:22736759, PMID:23764342, PMID:23997110, PMID:25575534, PMID:25772431 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
increases oxidation
increases expression
EXP 1,3-dimethylthiourea inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; 1,3-dimethylthiourea inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Vitamin E inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Vitamin E inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression ISO Manganese results in increased expression of SLC16A3 mRNA CTD PMID:17175027 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression EXP Manganese results in decreased expression of SLC18A2 mRNA CTD PMID:20224926 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
decreases expression
EXP
ISO
1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]; Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Manganese promotes the reaction [YY1 protein binds to SLC1A2 promoter]; romidepsin inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; trichostatin A inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; vorinostat inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; YY1 protein affects the reaction [Manganese results in decreased expression of SLC1A2 mRNA]
Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]
Manganese results in decreased expression of SLC1A2 mRNA; Manganese results in decreased expression of SLC1A2 protein
CTD PMID:22645130, PMID:24469401, PMID:28610743 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc1a3 solute carrier family 1 member 3 multiple interactions
decreases expression
EXP
ISO
Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]; Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]
Manganese results in decreased expression of SLC1A3 mRNA; Manganese results in decreased expression of SLC1A3 protein
Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]
CTD PMID:19453300, PMID:28610743 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Slc1a5 solute carrier family 1 member 5 multiple interactions EXP Manganese promotes the reaction [PRKCD protein binds to SLC1A5 protein] CTD PMID:21812036 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a15 solute carrier family 22, member 15 decreases expression ISO Manganese results in decreased expression of SLC22A15 mRNA CTD PMID:17175027 NCBI chr 2:204,281,638...204,344,026
Ensembl chr 2:204,281,638...204,341,676
JBrowse link
G Slc2a13 solute carrier family 2 member 13 increases expression ISO Manganese results in increased expression of SLC2A13 mRNA CTD PMID:17175027 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Slc30a10 solute carrier family 30, member 10 multiple interactions
decreases expression
increases secretion
increases abundance
decreases abundance
affects transport
ISO [IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese; [IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese; Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]
Manganese results in decreased expression of SLC30A10 mRNA
SLC30A10 protein results in increased secretion of Manganese
SLC30A10 gene mutant form results in increased abundance of Manganese; SLC30A10 gene SNP results in increased abundance of Manganese
SLC30A10 gene SNP results in decreased abundance of Manganese
SLC30A10 gene SNP affects the transport of Manganese
CTD PMID:22926781, PMID:24576911, PMID:26025379, PMID:26628504, PMID:28860195, PMID:29020610 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
G Slc38a1 solute carrier family 38, member 1 decreases expression EXP Manganese results in decreased expression of SLC38A1 mRNA CTD PMID:17468184 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Slc38a10 solute carrier family 38, member 10 increases expression ISO Manganese results in increased expression of SLC38A10 mRNA CTD PMID:17175027 NCBI chr10:109,284,054...109,333,907
Ensembl chr10:109,284,957...109,333,899
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions
decreases expression
EXP Manganese promotes the reaction [PRKCD protein binds to SLC38A3 protein]
Manganese results in decreased expression of SLC38A3 mRNA
CTD PMID:17468184, PMID:21812036 NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366
JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression
multiple interactions
affects uptake
increases import
ISO Manganese results in increased expression of SLC39A14 mRNA
SLC39A14 protein results in increased import of and results in increased secretion of Manganese
SLC39A14 protein affects the uptake of Manganese
SLC39A14 protein results in increased import of Manganese
CTD PMID:17065364, PMID:22898811, PMID:24576911, PMID:28860195 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions
affects transport
increases import
increases uptake
ISO
EXP
Manganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]; SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]
SLC39A8 gene SNP affects the transport of Manganese; SLC39A8 SNP affects the transport of Manganese
Manganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]
SLC39A8 protein results in increased import of Manganese
SLC39A8 protein results in increased uptake of Manganese
CTD PMID:16638970, PMID:22898811, PMID:26025379, PMID:28917719 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions
decreases expression
increases export
ISO Cobalt inhibits the reaction [SLC40A1 protein results in increased export of Manganese]; Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]; Nickel inhibits the reaction [SLC40A1 protein results in increased export of Manganese]
Manganese results in decreased expression of SLC40A1 mRNA
CTD PMID:22178646, PMID:29020610 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc4a10 solute carrier family 4 member 10 decreases expression ISO Manganese results in decreased expression of SLC4A10 mRNA CTD PMID:17175027 NCBI chr 3:47,995,812...48,287,897
Ensembl chr 3:47,995,959...48,287,910
JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC5A7 mRNA CTD PMID:30738988 NCBI chr 9:5,294,377...5,330,822
Ensembl chr 9:5,294,381...5,330,815
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
affects localization
multiple interactions
increases response to substance
EXP
ISO
Manganese results in decreased expression of SLC6A3 protein
Manganese affects the localization of SLC6A3 protein
LRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]
SLC6A3 protein results in increased susceptibility to Manganese
CTD PMID:16571372, PMID:18206288, PMID:23313730, PMID:23628791 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression EXP Manganese results in increased expression of SLC6A6 mRNA CTD PMID:20832424 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP Manganese results in decreased expression of SLCO1A4 mRNA CTD PMID:26745496 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Smim14 small integral membrane protein 14 increases expression ISO Manganese results in increased expression of SMIM14 mRNA CTD PMID:17175027 NCBI chr14:44,413,636...44,460,044
Ensembl chr14:44,413,636...44,457,239
JBrowse link
G Snca synuclein alpha increases expression
multiple interactions
EXP
ISO
Manganese results in increased expression of SNCA mRNA
Manganese affects the reaction [P4HB protein binds to SNCA protein]; Manganese promotes the reaction [SNCA protein binds to and results in increased expression of SNCA protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of SNCA protein; Manganese promotes the reaction [SNCA protein binds to SNCA protein]; SNCA gene inhibits the reaction [DJR-1.1 mutant form results in increased transport of and results in increased abundance of Manganese]; SNCA gene inhibits the reaction [PDR-1 mutant form results in increased transport of and results in increased abundance of Manganese]; SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein]; SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]; SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]; SNCA protein inhibits the reaction [Manganese results in increased cleavage of and results in increased activity of PRKCD protein]
CTD PMID:19781568, PMID:24452053, PMID:24777576, PMID:25416158, PMID:32659473 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 increases uptake ISO SOD1 protein results in increased uptake of Manganese CTD PMID:19074809 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
increases activity
multiple interactions
ISO
EXP
Manganese results in increased expression of SOD2 mRNA; Manganese results in increased expression of SOD2 protein
Manganese results in increased activity of SOD2 protein
2-oxothiazolidine-4-carboxylic acid promotes the reaction [Manganese results in increased expression of SOD2 protein]; Manganese inhibits the reaction [Cadmium Chloride results in decreased activity of SOD2 protein]
Paroxetine inhibits the reaction [Manganese deficiency results in increased expression of SOD2 protein]
CTD PMID:12204541, PMID:17175027, PMID:18317567, PMID:19093460, PMID:21312047, PMID:24787138, PMID:27701121 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sort1 sortilin 1 decreases expression ISO Manganese results in decreased expression of SORT1 mRNA CTD PMID:17175027 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Sostdc1 sclerostin domain containing 1 decreases expression EXP Manganese results in decreased expression of SOSTDC1 mRNA CTD PMID:26745496 NCBI chr 6:55,812,820...55,816,994
Ensembl chr 6:55,812,747...55,817,066
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:22975163 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Spa17 sperm autoantigenic protein 17 decreases expression ISO Manganese results in decreased expression of SPA17 mRNA CTD PMID:17175027 NCBI chr 8:40,066,954...40,078,131
Ensembl chr 8:40,067,076...40,078,165
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions
increases cleavage
EXP aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein] CTD PMID:21985864 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased expression of SRC protein CTD PMID:16600465 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Manganese results in decreased expression of STAR protein CTD PMID:25981801 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stox1 storkhead box 1 decreases expression ISO Manganese results in decreased expression of STOX1 mRNA CTD PMID:17175027 NCBI chr20:32,276,857...32,353,677
Ensembl chr20:32,276,658...32,353,677
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 increases expression ISO Manganese results in increased expression of SULT1C1 mRNA CTD PMID:17175027 NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892
JBrowse link
G Syn1 synapsin I increases phosphorylation EXP Manganese results in increased phosphorylation of SYN1 protein CTD PMID:20224926 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 affects binding ISO Manganese binds to TAB1 protein CTD PMID:16879102 NCBI chr 7:121,350,953...121,382,100
Ensembl chr 7:121,350,965...121,382,088
JBrowse link
G Tacr1 tachykinin receptor 1 decreases expression ISO Manganese results in decreased expression of TACR1 mRNA CTD PMID:17175027 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Manganese results in decreased expression of TAGLN2 mRNA CTD PMID:17175027 NCBI chr13:90,807,196...90,814,119
Ensembl chr13:90,807,199...90,814,119
JBrowse link
G Tbx18 T-box transcription factor 18 increases expression ISO Manganese results in increased expression of TBX18 mRNA CTD PMID:17175027 NCBI chr 8:95,359,354...95,387,363
Ensembl chr 8:95,359,354...95,387,363
JBrowse link
G Tcim transcriptional and immune response regulator increases expression ISO Manganese results in increased expression of TCIM mRNA CTD PMID:17175027 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179
JBrowse link
G Tf transferrin increases uptake
multiple interactions
affects binding
EXP
ISO
Manganese results in increased uptake of TF protein
[Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Manganese binds to TF protein] which results in decreased uptake of Manganese
[Iron deficiency co-treated with Manganese] results in increased expression of TF protein
Manganese binds to TF protein; TF protein binds to Manganese
CTD PMID:8782865, PMID:17060373, PMID:17469137, PMID:18546093 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression EXP Manganese results in increased expression of TFAP2A protein CTD PMID:24845367 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tfap2b transcription factor AP-2 beta increases expression ISO Manganese results in increased expression of TFAP2B mRNA CTD PMID:17175027 NCBI chr 9:25,410,669...25,440,568
Ensembl chr 9:25,410,669...25,440,411
JBrowse link
G Tfrc transferrin receptor increases expression EXP
ISO
Manganese results in increased expression of TFRC mRNA; Manganese results in increased expression of TFRC protein CTD PMID:16545456, PMID:16568477, PMID:16705042, PMID:16740617, PMID:17469137, PMID:23499988 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Manganese results in decreased expression of TGFB1 mRNA CTD PMID:16476481, PMID:19453300 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Manganese results in decreased expression of TGFBR1 mRNA CTD PMID:17175027 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Manganese results in decreased expression of TH mRNA; Manganese results in decreased expression of TH protein CTD PMID:16943606, PMID:19781568, PMID:20224926, PMID:20798247 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tmem255b transmembrane protein 255B increases expression EXP Manganese results in increased expression of TMEM255B mRNA CTD PMID:26745496 NCBI chr16:81,181,095...81,209,429
Ensembl chr16:81,189,073...81,209,429
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; Manganese inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]
Manganese results in increased expression of TNF mRNA; Manganese results in increased expression of TNF protein
[Manganese co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]
CTD PMID:16168523, PMID:16488514, PMID:18547589, PMID:19782702, PMID:20224926, PMID:20589745, PMID:20798247, PMID:24469401 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO Manganese promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] CTD PMID:16768462 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Manganese results in increased expression of TNFRSF25 mRNA CTD PMID:17175027 NCBI chr 5:169,288,419...169,293,137
Ensembl chr 5:169,288,871...169,293,137
JBrowse link
G Tnrc6a trinucleotide repeat containing adaptor 6A increases expression ISO Manganese results in increased expression of TNRC6A mRNA CTD PMID:17175027 NCBI chr 1:192,991,584...193,146,403
Ensembl chr 1:193,076,430...193,146,394
JBrowse link
G Tp53 tumor protein p53 increases response to substance
increases expression
multiple interactions
EXP TP53 protein results in increased susceptibility to Manganese
Manganese results in increased expression of TP53 mRNA; Manganese results in increased expression of TP53 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of TP53 protein; [Manganese co-treated with NGF protein] results in increased expression of and affects the localization of TP53 protein; [Manganese co-treated with NGF protein] results in increased phosphorylation of and results in increased expression of TP53 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of TP53 protein]; KHSRP protein affects the reaction [Manganese results in increased expression of TP53 protein]; Manganese results in increased phosphorylation of and results in increased expression of TP53 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]
CTD PMID:23997110, PMID:24845367, PMID:25027559, PMID:25448048, PMID:25791630, PMID:30844427 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO Manganese results in increased expression of TPCN1 mRNA CTD PMID:17175027 NCBI chr12:41,507,784...41,566,847
Ensembl chr12:41,543,696...41,566,847
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases transport
increases uptake
multiple interactions
ISO
EXP
TRPC6 protein results in increased transport of Manganese
TRPC6 protein results in increased uptake of Manganese
1,2-dioctanoylglycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]; 1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese]; Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]
CTD PMID:11179201, PMID:11535132 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Trpm1 transient receptor potential cation channel, subfamily M, member 1 increases expression ISO Manganese results in increased expression of TRPM1 mRNA CTD PMID:17175027 NCBI chr 1:124,983,391...125,101,759
Ensembl chr 1:124,983,452...125,099,573
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 increases expression ISO Manganese results in increased expression of TRPM4 mRNA CTD PMID:17175027 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases uptake EXP TRPM7 protein results in increased uptake of Manganese CTD PMID:16428268 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 decreases expression ISO Manganese results in decreased expression of TRPV3 mRNA CTD PMID:17175027 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 increases uptake ISO TRPV6 protein results in increased uptake of Manganese CTD PMID:21146870 NCBI chr 4:70,918,631...70,934,291
Ensembl chr 4:70,918,632...70,934,295
JBrowse link
G Tsga10 testis specific 10 increases expression ISO Manganese results in increased expression of TSGA10 mRNA CTD PMID:17175027 NCBI chr 9:44,351,655...44,456,576
Ensembl chr 9:44,351,951...44,456,554
JBrowse link
G Tshz2 teashirt zinc finger homeobox 2 increases expression ISO Manganese results in increased expression of TSHZ2 mRNA CTD PMID:17175027 NCBI chr 3:166,469,752...166,748,558
Ensembl chr 3:166,743,544...166,746,597
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO
EXP
Manganese results in decreased expression of TYRP1 mRNA CTD PMID:17175027, PMID:26745496 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 decreases expression ISO Manganese results in decreased expression of UBA52 mRNA CTD PMID:27329587 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ubqln1 ubiquilin 1 multiple interactions
decreases expression
ISO HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein] CTD PMID:22191580 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 decreases expression EXP Manganese results in decreased expression of UCHL1 protein CTD PMID:20798247 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Ucn urocortin multiple interactions EXP astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]]; UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese] CTD PMID:17885217 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
G Usp15 ubiquitin specific peptidase 15 decreases expression ISO Manganese results in decreased expression of USP15 mRNA CTD PMID:17175027 NCBI chr 7:66,595,707...66,687,707
Ensembl chr 7:66,595,742...66,687,278
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression ISO Manganese results in increased expression of USP18 mRNA CTD PMID:23499988 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
JBrowse link
G Usp45 ubiquitin specific peptidase 45 decreases expression ISO Manganese results in decreased expression of USP45 mRNA CTD PMID:17175027 NCBI chr 5:35,916,763...35,984,525
Ensembl chr 5:35,916,804...35,984,524
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression ISO Manganese deficiency results in increased expression of VDAC1 protein CTD PMID:21312047 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Manganese results in increased expression of VEGFA mRNA CTD PMID:17175027, PMID:17467022 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vnn3 vanin 3 increases expression EXP Manganese results in increased expression of VNN3 mRNA CTD PMID:26745496 NCBI chr 1:22,649,114...22,661,376
Ensembl chr 1:22,649,081...22,661,377
JBrowse link
G Vps13a vacuolar protein sorting 13 homolog A decreases expression ISO Manganese results in decreased expression of VPS13A mRNA CTD PMID:17175027 NCBI chr 1:235,352,513...235,813,597
Ensembl chr 1:235,653,121...235,813,030
JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO Manganese results in decreased expression of WT1 mRNA CTD PMID:17175027 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased expression of XBP1 protein alternative form; [manganese chloride results in increased abundance of Manganese] which results in increased splicing of XBP1 mRNA CTD PMID:32574669 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Yy1 YY1 transcription factor multiple interactions
increases expression
EXP Manganese promotes the reaction [YY1 protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to RELA protein]; Manganese promotes the reaction [YY1 protein binds to SLC1A2 promoter]; YY1 protein affects the reaction [Manganese results in decreased expression of SLC1A2 mRNA]
Manganese results in increased expression of YY1 mRNA; Manganese results in increased expression of YY1 protein
CTD PMID:24469401 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link
G Zfp41 zinc finger protein 41 increases expression ISO Manganese results in increased expression of ZFP41 mRNA CTD PMID:17175027 NCBI chr 7:116,653,618...116,665,414
Ensembl chr 7:116,653,664...116,661,942
JBrowse link
mancozeb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects activity EXP mancozeb affects the activity of ACHE protein CTD PMID:10641187 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actg1 actin, gamma 1 increases expression ISO mancozeb results in increased expression of ACTG1 protein CTD PMID:21375462 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein CTD PMID:19883720 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin decreases expression ISO mancozeb results in decreased expression of ALB protein CTD PMID:21375462 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP mancozeb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity EXP mancozeb results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Anxa2 annexin A2 decreases expression ISO mancozeb results in decreased expression of ANXA2 protein CTD PMID:21375462 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO mancozeb results in increased expression of APAF1 protein CTD PMID:22289270 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
ISO mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased activity of AR protein
CTD PMID:23871939 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
CTD PMID:22289270, PMID:27235710 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]
CTD PMID:16005924, PMID:22289270, PMID:27235710 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression ISO mancozeb results in increased expression of CAR3 protein CTD PMID:21375462 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO mancozeb results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]
mancozeb results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:22289270, PMID:22824503, PMID:30037311 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO mancozeb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO mancozeb results in increased activity of CASP8 protein CTD PMID:22289270, PMID:22824503 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO mancozeb results in increased activity of CASP9 protein
mancozeb results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:22289270, PMID:22824503 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD PMID:23024109, PMID:27235710, PMID:29283200, PMID:30037311 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein
CTD PMID:19883720, PMID:21375462 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO mancozeb results in increased phosphorylation of CDC25C protein CTD PMID:21375462 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mancozeb results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP mancozeb results in decreased activity of CYP1A1 protein CTD PMID:1946188 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP mancozeb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation ISO mancozeb results in increased phosphorylation of ELK1 protein CTD PMID:21375462 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO mancozeb results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO mancozeb results in increased expression of FAS protein CTD PMID:22289270 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO mancozeb results in increased expression of FASLG protein CTD PMID:22289270 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA] CTD PMID:27235710 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects activity EXP mancozeb affects the activity of GOT1 protein CTD PMID:10641187 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpt glutamic--pyruvic transaminase affects activity EXP mancozeb affects the activity of GPT protein CTD PMID:10641187 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]
CTD PMID:30037311 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO mancozeb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO mancozeb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression ISO mancozeb results in increased expression of HNRNPM protein CTD PMID:21375462 NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227
JBrowse link
G Ifng interferon gamma multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:15742816 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:16112155 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 affects expression ISO mancozeb affects the expression of IL2 protein CTD PMID:9012323 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kb15 type II keratin Kb15 decreases expression ISO mancozeb results in decreased expression of KRT6A protein CTD PMID:21375462 NCBI chr 7:143,208,034...143,217,771
Ensembl chr 7:143,208,527...143,217,535
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases activity EXP mancozeb results in increased activity of KCNQ2 protein CTD PMID:23542819 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor affects expression EXP mancozeb affects the expression of KISS1 mRNA CTD PMID:23660487 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein CTD PMID:21375462 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein CTD PMID:21375462 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression
ISO
EXP
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]
CTD PMID:16005924, PMID:19883720 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO mancozeb results in increased expression of NOS2 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]
CTD PMID:30037311 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA] CTD PMID:30037311 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO mancozeb results in increased activity of ODC1 protein CTD PMID:1733566 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases expression
ISO lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO mancozeb results in increased expression of PRDX2 protein CTD PMID:21375462 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prl prolactin multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of PRL protein CTD PMID:24530807 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions
ISO mancozeb results in increased expression of PTGES mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]
CTD PMID:27235710 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO mancozeb results in increased expression of PTGS2 protein CTD PMID:21375462 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Pvalb parvalbumin increases expression ISO mancozeb results in increased expression of PVALB protein CTD PMID:21375462 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
affects localization
multiple interactions
increases localization
ISO mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
mancozeb results in increased localization of RELA protein
CTD PMID:16112155, PMID:21375462, PMID:22289270, PMID:27235710 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO mancozeb results in increased expression of S100A6 protein CTD PMID:21375462 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO mancozeb results in increased expression of S100A9 protein CTD PMID:21375462 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO mancozeb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Sirt3 sirtuin 3 decreases activity ISO mancozeb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO mancozeb results in decreased expression of SOD1 protein CTD PMID:21375462 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tek TEK receptor tyrosine kinase increases activity ISO mancozeb results in increased activity of TEK protein CTD PMID:21251949 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
CTD PMID:15742816, PMID:15893782, PMID:16112155 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions
ISO mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]
CTD PMID:22369882, PMID:27235710 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO mancozeb results in increased expression of TPI1 protein CTD PMID:21375462 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP mancozeb results in decreased activity of TPO protein CTD PMID:9418944 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein CTD PMID:24530807 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of XRCC1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]
CTD PMID:27235710 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
maneb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Ache acetylcholinesterase decreases expression
multiple interactions
EXP
ISO
Maneb results in decreased expression of ACHE protein
[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA
CTD PMID:3868355, PMID:23017109 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNA CTD PMID:18386188 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 4:22,864,485...23,002,969
Ensembl chr 4:22,859,622...22,996,645
JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ADGRB1 mRNA CTD PMID:23017109 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ADGRG1 mRNA CTD PMID:18386188 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA CTD PMID:23017109 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Ago3 argonaute RISC catalytic component 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein] CTD PMID:28202386, PMID:32375810 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein; [Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA] CTD PMID:19883720, PMID:23963992 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP Maneb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity
multiple interactions
EXP
ISO
Maneb results in decreased activity of ALDH5A1 protein
[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]
CTD PMID:17010440, PMID:23963992 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ALDOC mRNA CTD PMID:18386188 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Amn amnion associated transmembrane protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AMN mRNA CTD PMID:22563483 NCBI chr 6:135,724,455...135,731,896
Ensembl chr 6:135,724,455...135,731,896
JBrowse link
G Ap3b2 adaptor related protein complex 3 subunit beta 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3B2 mRNA CTD PMID:18386188 NCBI chr 1:143,284,041...143,315,846
Ensembl chr 1:143,283,996...143,315,633
JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA CTD PMID:18386188 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984
JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA CTD PMID:23017109 NCBI chr 1:170,387,625...170,411,263
Ensembl chr 1:170,387,609...170,404,056
JBrowse link
G Arf3 ADP-ribosylation factor 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ARF3 mRNA CTD PMID:18386188 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Arg1 arginase 1 decreases expression
multiple interactions
ISO Maneb results in decreased expression of ARG1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA
CTD PMID:29568078, PMID:32194361, PMID:32375810 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA CTD PMID:23017109 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA CTD PMID:23017109 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein] CTD PMID:22292029 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP5G1 mRNA CTD PMID:18386188 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0B mRNA CTD PMID:18386188 NCBI chr 5:136,718,352...136,719,868
Ensembl chr 5:136,718,352...136,721,379
JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0C mRNA CTD PMID:18386188 NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077
JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr 7:77,678,853...77,716,658
Ensembl chr 7:77,678,968...77,716,408
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA CTD PMID:22563483 NCBI chr15:39,955,689...40,488,737
Ensembl chr15:40,000,322...40,428,800
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of BAD protein CTD PMID:15824117 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
affects response to substance
ISO [Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein; Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]; Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]
Maneb results in increased expression of BAK1 mRNA; Maneb results in increased expression of BAK1 protein
CTD PMID:18266926, PMID:23963992 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of BAX protein; BAX protein affects the susceptibility to [Paraquat co-treated with Maneb]
Maneb results in increased expression of BAX protein
[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA; [Paraquat co-treated with Maneb] results in increased expression of BAX protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]
CTD PMID:15824117, PMID:18266926, PMID:20964710, PMID:23963992 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Maneb results in increased expression of BBC3 protein CTD PMID:18266926 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO [Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]
Maneb results in increased expression of BCL2 mRNA; Maneb results in increased expression of BCL2 protein
CTD PMID:18266926, PMID:23963992 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression
multiple interactions
ISO Maneb results in increased expression of BCL2A1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of BCL2A1 protein
CTD PMID:18266926 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in decreased expression of BCL2L1 protein
Maneb results in increased expression of BCL2L1 mRNA
CTD PMID:15824117, PMID:18266926 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
ISO Maneb results in increased expression of BCL2L11 protein
[Paraquat co-treated with Maneb] results in increased expression of BCL2L11 protein
CTD PMID:18266926 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP
[Maneb co-treated with Paraquat] results in decreased expression of BDNF mRNA
[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA; [Paraquat co-treated with Maneb] results in decreased expression of BDNF protein
CTD PMID:23017109, PMID:27460631 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 increases expression ISO Maneb results in increased expression of BECN1 protein CTD PMID:22292029 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bicd1 BICD cargo adaptor 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA CTD PMID:22563483 NCBI chr 4:184,018,845...184,167,628
Ensembl chr 4:184,019,087...184,165,540
JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions
ISO Maneb results in increased expression of BID protein
[Maneb co-treated with Paraquat] results in increased expression of BID protein
CTD PMID:18266926 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bik BCL2-interacting killer increases expression
multiple interactions
ISO Maneb results in increased expression of BIK mRNA; Maneb results in increased expression of BIK protein
[Paraquat co-treated with Maneb] results in increased expression of BIK protein
CTD PMID:18266926 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA CTD PMID:23017109 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA CTD PMID:23017109 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Maneb results in increased expression of BNIP3 mRNA; Maneb results in increased expression of BNIP3 protein CTD PMID:18266926 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Maneb results in increased expression of BNIP3L mRNA CTD PMID:18266926 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of BRF1 mRNA CTD PMID:18386188 NCBI chr 6:137,762,230...137,808,573
Ensembl chr 6:137,765,122...137,808,303
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Cacybp calcyclin binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CACYBP mRNA CTD PMID:18386188 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO
EXP
[Paraquat co-treated with Maneb] affects the expression of CAMP mRNA
[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA
CTD PMID:22563483, PMID:27460631 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Capn11 calpain 11 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 9:17,728,845...17,750,357
Ensembl chr 9:17,728,816...17,750,363
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA; [Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA] CTD PMID:23963992, PMID:32375810 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases activity ISO Maneb results in increased activity of CASP3 protein CTD PMID:22824503 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO Maneb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO Maneb results in increased activity of CASP8 protein CTD PMID:22824503 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO [Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA; [Paraquat co-treated with Maneb] results in increased expression of CASP9 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]
Maneb results in increased activity of CASP9 protein
CTD PMID:20964710, PMID:22824503, PMID:23963992 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO
EXP
Maneb results in decreased activity of CAT protein
[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA
CTD PMID:26210702, PMID:29859004 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc88a coiled coil domain containing 88A multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr14:113,771,093...113,936,376
Ensembl chr14:113,867,209...113,932,263
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA; [Paraquat co-treated with Maneb] affects the expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO
EXP
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
[Maneb co-treated with Paraquat] results in decreased expression of CCND1 mRNA
CTD PMID:19883720, PMID:29859004 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions EXP [Maneb co-treated with Paraquat] results in decreased expression of CCND2 mRNA CTD PMID:29859004 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cd34 CD34 molecule increases expression EXP Maneb results in increased expression of CD34 CTD PMID:25803990 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdhr4 cadherin-related family member 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 8:116,771,377...116,779,242 JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CDIPT mRNA CTD PMID:18386188 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA CTD PMID:23017109 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA CTD PMID:23017109 NCBI chr 3:149,835,953...149,870,429
Ensembl chr 3:149,703,848...149,870,413
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr 5:86,387,238...86,554,108
Ensembl chr 5:86,387,078...86,554,102
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA] CTD PMID:23963992 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
EXP [Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA
Maneb results in increased expression of CDKN2A mRNA
CTD PMID:29859004 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CEBPD mRNA CTD PMID:22563483 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cep290 centrosomal protein 290 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CEP290 mRNA CTD PMID:22563483 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA CTD PMID:23017109 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein] CTD PMID:29568078 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cirbp cold inducible RNA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CIRBP mRNA CTD PMID:18386188 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA] CTD PMID:23963992 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Clu clusterin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA CTD PMID:18386188 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cope COPI coat complex subunit epsilon multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA CTD PMID:18386188 NCBI chr16:20,863,141...20,873,516
Ensembl chr16:20,863,141...20,873,521
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX5A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX6A1 mRNA CTD PMID:18386188 NCBI chr12:47,024,442...47,027,495
Ensembl chr12:47,024,442...47,027,495
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2 mRNA CTD PMID:18386188 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2L mRNA CTD PMID:18386188 NCBI chr 6:6,695,807...6,709,790
Ensembl chr 6:6,695,827...6,709,783
JBrowse link
G Cplx1 complexin 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein CTD PMID:17532186 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP
[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form
CTD PMID:23963992, PMID:27460631 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crip2 cysteine-rich protein 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CRIP2 mRNA CTD PMID:18386188 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490
JBrowse link
G Crlf2 cytokine receptor-like factor 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr14:1,456,843...1,461,543
Ensembl chr14:1,456,844...1,461,543
JBrowse link
G Crot carnitine O-octanoyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CROT mRNA CTD PMID:18386188 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr14:1,462,292...1,467,264
Ensembl chr14:1,462,358...1,467,264
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA] CTD PMID:23963992 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]
CTD PMID:29568078, PMID:30797899, PMID:32375810 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CYC1 mRNA CTD PMID:18386188 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
decreases expression
increases expression
EXP
ISO
Maneb results in increased activity of CYP1A1 protein
Maneb results in decreased expression of CYP1A1 mRNA
Maneb results in increased expression of CYP1A1 mRNA; Maneb results in increased expression of CYP1A1 protein
CTD PMID:20888808, PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA] CTD PMID:23159886 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Maneb results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases expression
ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
increases expression
multiple interactions
increases activity
EXP
ISO
Maneb results in decreased activity of CYP2E1 protein
Maneb results in increased expression of CYP2E1 mRNA; Maneb results in increased expression of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein; [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Maneb results in increased expression of and results in increased activity of CYP2E1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]
Maneb results in increased activity of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; [Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
CTD PMID:11043497, PMID:16510128, PMID:20888808, PMID:20964710, PMID:23159886 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Maneb results in decreased expression of CYP7A1 mRNA CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dap3 death associated protein 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA CTD PMID:18386188 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Maneb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA CTD PMID:18386188 NCBI chr10:94,979,759...94,988,461
Ensembl chr10:94,980,928...94,988,461
JBrowse link
G Dgki diacylglycerol kinase, iota multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DGKI mRNA CTD PMID:22563483 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Maneb results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dip2b disco-interacting protein 2 homolog B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DIP2B mRNA CTD PMID:22563483 NCBI chr 7:141,702,034...141,878,945
Ensembl chr 7:141,702,038...141,879,951
JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA CTD PMID:23017109 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DLST protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dmrta2 DMRT-like family A2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 5:129,754,295...129,760,045
Ensembl chr 5:129,756,149...129,758,986
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DNAJB6 mRNA CTD PMID:18386188 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA CTD PMID:23017109 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein CTD PMID:22563483 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA CTD PMID:23017109 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of EEF1A1 mRNA CTD PMID:18386188 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
JBrowse link
G Efnb1 ephrin B1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 NCBI chr  X:68,891,227...68,904,034
Ensembl chr  X:68,891,227...68,904,038
JBrowse link
G Egr4 early growth response 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 1:175,883,362...175,895,510
Ensembl chr 1:175,883,363...175,895,510
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ENO1 protein; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:17532186, PMID:18386188, PMID:23562983 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Eno2 enolase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ENO2 protein CTD PMID:23562983 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Etl4 enhancer trap locus 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA CTD PMID:22563483 NCBI chr17:87,173,265...87,681,268
Ensembl chr17:87,274,944...87,681,317
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FAS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA] CTD PMID:23963992 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA CTD PMID:23017109 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA] CTD PMID:23963992 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP4 mRNA CTD PMID:18386188 NCBI chr 4:161,748,993...161,757,447
Ensembl chr 4:161,748,993...161,757,447
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA CTD PMID:18386188 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA; [Paraquat co-treated with Maneb] results in decreased expression of FOS protein
CTD PMID:23963992, PMID:27460631 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA CTD PMID:18386188 NCBI chr 8:49,676,520...49,703,419
Ensembl chr 8:49,676,540...49,703,419
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Maneb results in decreased expression of G6PC mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA CTD PMID:22563483 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gas5 growth arrest specific 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GAS5 mRNA CTD PMID:18386188 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
increases activity
ISO
EXP
[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA
Maneb results in increased activity of GCLC protein
CTD PMID:15527874, PMID:21402726 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of GFAP protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GH mRNA CTD PMID:22563483 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gm2a GM2 ganglioside activator multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GM2A mRNA CTD PMID:18386188 NCBI chr10:40,438,394...40,450,927
Ensembl chr10:40,438,356...40,450,930
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GMFB mRNA; [Paraquat co-treated with Maneb] results in decreased expression of GMFB protein CTD PMID:17532186 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gng5 G protein subunit gamma 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GNG5 mRNA CTD PMID:18386188 NCBI chr 2:252,359,976...252,368,473
Ensembl chr 2:252,359,976...252,368,473
JBrowse link
G Gngt2 G protein subunit gamma transducin 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GNGT2 mRNA CTD PMID:22563483 NCBI chr10:83,654,321...83,658,601
Ensembl chr10:83,655,460...83,658,589
JBrowse link
G Gpr27 G protein-coupled receptor 27 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GPR27 mRNA CTD PMID:22563483 NCBI chr 4:132,137,793...132,138,926
Ensembl chr 4:132,137,793...132,138,926
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G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
ISO
EXP
GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of GPX1 mRNA
Maneb results in decreased expression of GPX1 mRNA
CTD PMID:15824117, PMID:26210702, PMID:29859004 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions
ISO Maneb results in increased expression of GPX4 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein]; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]
CTD PMID:23764462, PMID:30797899 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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G Grb2 growth factor receptor bound protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
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G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
[Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein
CTD PMID:23159886, PMID:23764462 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Maneb results in increased expression of GSTA3 mRNA CTD PMID:20888808 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
increases activity
increases expression
EXP [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein; [Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Maneb results in increased expression of and results in increased activity of GSTA4 protein; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Silymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]
Maneb results in increased activity of GSTA4 protein
Maneb results in increased expression of GSTA4 mRNA; Maneb results in increased expression of GSTA4 protein
CTD PMID:20888808, PMID:23159886 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
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G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA] CTD PMID:23963992 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Guk1 guanylate kinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA CTD PMID:18386188 NCBI chr10:45,535,617...45,552,455
Ensembl chr10:45,535,627...45,543,897
JBrowse link
G H2ac20 H2A clustered histone 20 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2AC20 mRNA CTD PMID:22563483 NCBI chr 2:198,360,271...198,360,735
Ensembl chr 2:198,360,301...198,360,678
JBrowse link
G H2bc9 H2B clustered histone 9 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2BC9 mRNA CTD PMID:22563483 NCBI chr17:44,519,815...44,520,269
Ensembl chr17:44,519,860...44,520,240
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HBA-A1 mRNA CTD PMID:18386188 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO Maneb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO Maneb results in decreased activity of HDAC6 protein CTD PMID:21251949