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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydrogen
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Accession:CHEBI:18276 term browser browse the term
Definition:An elemental molecule consisting of two hydrogens joined by a single bond.
Synonyms:related_synonym: E-949;   E949;   Formula=H2;   H2;   Hydrogen;   InChI=1S/H2/h1H;   InChIKey=UFHFLCQGNIYNRP-UHFFFAOYSA-N;   SMILES=[H][H];   molecular hydrogen
 alt_id: CHEBI:13350;   CHEBI:25363;   CHEBI:5785
 xref: CAS:1333-74-0;   Gmelin:3;   HMDB:HMDB0001362;   KEGG:C00282
 xref_mesh: MESH:D006859
 xref: MetaCyc:HYDROGEN-MOLECULE;   MolBase:748;   PMID:15303745;   PMID:16517646;   PMID:18706888;   PMID:19905000;   PMID:19908827;   PMID:20568549;   PMID:24171421;   Reaxys:3587189;   Wikipedia:Hydrogen


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dihydrogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:26271894 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases expression		 ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of CAT mRNA]
Hydrogen results in increased expression of CAT mRNA; Hydrogen results in increased expression of CAT protein		 CTD PMID:26271894 PMID:32955216 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]
Hydrogen results in increased expression of FOXO3 protein		 CTD PMID:26271894 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLM mRNA] CTD PMID:32955216 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of GFAP protein] CTD PMID:30236991 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GPX1 mRNA] CTD PMID:32955216 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of LDHA mRNA] CTD PMID:32955216 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of NOX4 mRNA] CTD PMID:32955216 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein] CTD PMID:30236991 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SCD1 mRNA] CTD PMID:32955216 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions		 ISO Hydrogen results in increased expression of SIRT1 protein
dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]		 CTD PMID:26271894 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 ISO [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]
Hydrogen results in increased expression of SOD1 mRNA; Hydrogen results in increased expression of SOD1 protein		 CTD PMID:26271894 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO Hydrogen results in increased expression of SOD2 protein
Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA]
Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]		 CTD PMID:26271894 PMID:32955216 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
diprotium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:26271894 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases expression		 ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of CAT mRNA]
Hydrogen results in increased expression of CAT mRNA; Hydrogen results in increased expression of CAT protein		 CTD PMID:26271894 PMID:32955216 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]
Hydrogen results in increased expression of FOXO3 protein		 CTD PMID:26271894 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLM mRNA] CTD PMID:32955216 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of GFAP protein] CTD PMID:30236991 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GPX1 mRNA] CTD PMID:32955216 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of LDHA mRNA] CTD PMID:32955216 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of NOX4 mRNA] CTD PMID:32955216 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein] CTD PMID:30236991 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SCD1 mRNA] CTD PMID:32955216 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions		 ISO Hydrogen results in increased expression of SIRT1 protein
dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]		 CTD PMID:26271894 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 ISO [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]
Hydrogen results in increased expression of SOD1 mRNA; Hydrogen results in increased expression of SOD1 protein		 CTD PMID:26271894 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO Hydrogen results in increased expression of SOD2 protein
Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA]
Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]		 CTD PMID:26271894 PMID:32955216 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      chemical role 19421
        antioxidant 15726
          dihydrogen 17
            H group 0
            dideuterium 0
            diprotium 17
            ditritium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    main group molecular entity 19761
                      s-block molecular entity 19612
                        hydrogen molecular entity 19601
                          elemental hydrogen 17
                            dihydrogen 17
                              H group 0
                              dideuterium 0
                              diprotium 17
                              ditritium 0
paths to the root