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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron atom
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Accession:CHEBI:18248 term browser browse the term
Definition:An iron group element atom that has atomic number 26.
Synonyms:related_synonym: 26Fe;   Eisen;   Fe;   Formula=Fe;   InChI=1S/Fe;   InChIKey=XEEYBQQBJWHFJM-UHFFFAOYSA-N;   SMILES=[Fe];   fer;   ferrum;   hierro;   iron
 alt_id: CHEBI:13322;   CHEBI:24872;   CHEBI:5974
 xref: CAS:7439-89-6;   DrugBank:DB01592;   HMDB:HMDB0015531;   KEGG:C00023
 xref_mesh: MESH:D007501
 xref: Reaxys:4122945;   WebElements:Fe


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iron atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Iron] CTD PMID:16679408 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects metabolic processing ISO ABCG2 protein affects the metabolism of Iron CTD PMID:17194590 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 multiple interactions EXP Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron] CTD PMID:16908409 NCBI chr13:99,004,942...99,035,520
Ensembl chr13:99,004,942...99,035,519
JBrowse link
G Aco1 aconitase 1 multiple interactions
affects metabolic processing
ISO
EXP
Iron inhibits the reaction [nickel chloride results in increased activity of ACO1 protein]; Iron inhibits the reaction [Nickel results in increased activity of ACO1 protein]
[Deferoxamine results in decreased abundance of Iron] which results in increased activity of ACO1 protein
ACO1 protein affects the metabolism of Iron
CTD PMID:15893546, PMID:16039939, PMID:16877034, PMID:17194590 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 multiple interactions
increases activity
EXP [[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron; ACO2 protein affects the reaction [Paraquat results in increased abundance of Iron]; Iron deficiency promotes the reaction [Clofibrate results in increased expression of ACO2 protein]; Iron inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron results in increased activity of ACO2 protein
CTD PMID:9675333, PMID:11969379, PMID:16162655, PMID:21517855 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP Iron deficiency results in decreased expression of ACSF2 mRNA CTD PMID:16629162 NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Iron deficiency results in decreased expression of ACSL1 mRNA CTD PMID:19821111 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression EXP Iron deficiency results in decreased expression of ACSL3 mRNA CTD PMID:19821111 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 decreases expression ISO Iron deficiency results in decreased expression of ADGRG1 mRNA CTD PMID:20368581 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674
JBrowse link
G Ahsp alpha hemoglobin stabilizing protein multiple interactions ISO AHSP protein binds to and affects the folding of and affects the stability of [HBA1 protein binds to Iron] CTD PMID:16901899 NCBI chr 1:199,720,038...199,721,010
Ensembl chr 1:199,720,038...199,721,010
JBrowse link
G Akap13 A-kinase anchoring protein 13 decreases expression EXP Iron deficiency results in decreased expression of AKAP13 mRNA CTD PMID:16629162 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression ISO Iron results in increased expression of ALAS2 mRNA CTD PMID:16424395 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [[Iron co-treated with Bicarbonates] results in increased abundance of Malondialdehyde]; ALB protein inhibits the reaction [[Iron co-treated with Phosphates] results in increased abundance of Malondialdehyde] CTD PMID:16027354 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Iron deficiency results in decreased expression of ALDOC mRNA CTD PMID:20368581 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Ankrd22 ankyrin repeat domain 22 increases expression ISO Iron deficiency results in increased expression of ANKRD22 mRNA CTD PMID:20368581 NCBI chr 1:252,430,750...252,461,346
Ensembl chr 1:252,429,677...252,461,461
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression EXP
ISO
Iron deficiency results in increased expression of ANKRD37 mRNA CTD PMID:16629162, PMID:23776592 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Iron deficiency results in decreased expression of ANXA1 mRNA CTD PMID:19821111 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 increases expression ISO Iron deficiency results in increased expression of ANXA2 mRNA CTD PMID:20368581 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Ap1s3 adaptor related protein complex 1 subunit sigma 3 decreases expression ISO Iron deficiency results in decreased expression of AP1S3 mRNA CTD PMID:20368581 NCBI chr 9:85,386,752...85,445,977
Ensembl chr 9:85,387,065...85,445,939
JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in decreased expression of AP2A1 mRNA CTD PMID:24619124 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Apoe apolipoprotein E increases response to substance ISO APOE gene polymorphism results in increased susceptibility to Iron CTD PMID:15993987 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Apoh apolipoprotein H decreases expression EXP Iron deficiency results in decreased expression of APOH mRNA CTD PMID:19821111 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G App amyloid beta precursor protein increases uptake
increases expression
ISO Iron results in increased uptake of APP protein
Iron results in increased expression of APP mRNA
CTD PMID:15993987, PMID:16308480 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp4 aquaporin 4 increases expression
multiple interactions
EXP
ISO
Iron deficiency results in increased expression of AQP4 mRNA
[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 mRNA; [ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein; SB 203580 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; U 0126 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; Vitamin E inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]
CTD PMID:16629162, PMID:30914277 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Arid3b AT-rich interaction domain 3B increases expression ISO Iron deficiency results in increased expression of ARID3B mRNA CTD PMID:20368581 NCBI chr 8:62,569,601...62,616,837
Ensembl chr 8:62,569,528...62,616,828
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter] CTD PMID:10777486 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Iron deficiency results in increased expression of ARRDC3 mRNA CTD PMID:20368581 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Atm ATM serine/threonine kinase affects response to substance
affects abundance
multiple interactions
ISO ATM protein affects the susceptibility to Iron
ATM protein affects the abundance of Iron
Iron results in increased phosphorylation of and results in increased activity of ATM protein
CTD PMID:15336622, PMID:16959548 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp7a ATPase copper transporting alpha affects metabolic processing
increases expression
multiple interactions
affects transport
decreases oxidation
increases response to substance
ISO
EXP
ATP7A protein mutant form affects the metabolism of Iron
Iron deficiency results in increased expression of ATP7A; Iron deficiency results in increased expression of ATP7A mRNA; Iron deficiency results in increased expression of ATP7A protein
[Iron deficiency results in increased expression of ATP7A] which results in increased abundance of Copper
ATP7A mutant form affects the transport of Iron
ATP7A gene mutant form results in decreased oxidation of Iron
ATP7A gene mutant form results in increased susceptibility to Iron deficiency
[ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Copper; [ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Iron; ATP7A gene mutant form promotes the reaction [Iron deficiency results in increased expression of MT1 mRNA]; Iron deficiency inhibits the reaction [ATP7A gene mutant form results in decreased oxidation of Iron]
CTD PMID:16629162, PMID:21852364, PMID:23174565, PMID:23776592, PMID:23814049, PMID:24089420, PMID:24174620, PMID:25247420 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta increases abundance EXP ATP7B gene mutant form results in increased abundance of Iron CTD PMID:15911138 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G B2m beta-2 microglobulin multiple interactions
affects metabolic processing
ISO [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron
B2M protein affects the metabolism of Iron
CTD PMID:16841247, PMID:17194590 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein] CTD PMID:30626086 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein] CTD PMID:30626086 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein] CTD PMID:19620254 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein] CTD PMID:19620254, PMID:27916511, PMID:30626086 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Iron deficiency results in increased expression of BCL3 mRNA CTD PMID:20368581 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases abundance
increases expression
decreases expression
increases abundance
ISO
EXP
BMP6 protein results in decreased abundance of Iron
Iron results in increased expression of BMP6 mRNA
Iron deficiency results in decreased expression of BMP6 mRNA
BMP6 gene mutant form results in increased abundance of Iron
CTD PMID:19252486, PMID:19252488, PMID:20164366 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Iron deficiency results in increased expression of BNIP3 mRNA CTD PMID:23776592 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Calr calreticulin increases expression ISO Iron results in increased expression of CALR mRNA; Iron results in increased expression of CALR protein CTD PMID:11500943 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of CASP3 protein] CTD PMID:19620254, PMID:27916511, PMID:30626086, PMID:31678598 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO
EXP
Iron deficiency inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron promotes the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron promotes the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Iron promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CAT protein]
Iron results in decreased activity of CAT protein
CTD PMID:12065085, PMID:12067571, PMID:12504893, PMID:17176674, PMID:22534743 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 affects localization EXP Iron affects the localization of CAV1 protein CTD PMID:17172471 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO
EXP
Iron deficiency results in increased expression of CCL2 mRNA
[Iron co-treated with Diethylnitrosamine] results in increased expression of CCL2 mRNA; Iron promotes the reaction [[Copper co-treated with Diethylnitrosamine] results in increased expression of CCL2 mRNA]
CTD PMID:20302851, PMID:20368581 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CCL3 mRNA CTD PMID:22198552 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Iron deficiency results in increased expression of CCL5 mRNA CTD PMID:20368581 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP
ISO
Iron deficiency results in increased expression of CCND1 mRNA; Iron results in increased expression of CCND1; Iron results in increased expression of CCND1 mRNA; Iron results in increased expression of CCND1 protein CTD PMID:16629162, PMID:16890145, PMID:22649188 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Iron deficiency results in increased expression of CCNG2 mRNA CTD PMID:20368581 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO Iron deficiency results in increased expression of CCPG1 mRNA CTD PMID:20368581 NCBI chr 8:79,660,634...79,692,044
Ensembl chr 8:79,660,657...79,692,039
JBrowse link
G Ccsap centriole, cilia and spindle-associated protein increases expression ISO Iron deficiency results in increased expression of CCSAP mRNA CTD PMID:20368581 NCBI chr19:56,615,326...56,634,031
Ensembl chr19:56,617,399...56,633,633
JBrowse link
G Cd109 CD109 molecule increases expression ISO Iron deficiency results in increased expression of CD109 mRNA CTD PMID:20368581 NCBI chr 8:85,951,420...86,065,411
Ensembl chr 8:85,951,191...86,065,409
JBrowse link
G Cd14 CD14 molecule multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Iron deficiency results in increased expression of CD14 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Iron deficiency results in increased expression of CD14 protein]; Vitamin D promotes the reaction [Iron deficiency results in increased expression of CD14 protein] CTD PMID:20368581 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd1d1 CD1d1 molecule decreases expression EXP Iron deficiency results in decreased expression of CD1D1 mRNA CTD PMID:19821111 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Cd300a Cd300a molecule increases expression ISO Iron deficiency results in increased expression of CD300A mRNA CTD PMID:20368581 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Cd36 CD36 molecule decreases expression EXP Iron deficiency results in decreased expression of CD36 mRNA CTD PMID:16629162, PMID:19821111 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd70 Cd70 molecule increases expression ISO Iron deficiency results in increased expression of CD70 mRNA CTD PMID:20368581 NCBI chr 9:9,842,585...9,845,728
Ensembl chr 9:9,842,585...9,845,728
JBrowse link
G Cd74 CD74 molecule decreases expression ISO Iron deficiency results in decreased expression of CD74 mRNA CTD PMID:20368581 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase decreases expression EXP Iron deficiency results in decreased expression of CDIPT mRNA CTD PMID:19821111 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CDKN1A mRNA CTD PMID:22198552 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression EXP Iron deficiency results in decreased expression of CDKN1C mRNA CTD PMID:16629162 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdo1 cysteine dioxygenase type 1 multiple interactions EXP Iron binds to and results in increased activity of CDO1 protein CTD PMID:16611640 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Cdrt4 CMT1A duplicated region transcript 4 increases expression ISO Iron deficiency results in increased expression of CDRT4 mRNA CTD PMID:20368581 NCBI chr10:49,368,183...49,400,284
Ensembl chr10:49,368,314...49,400,193
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 decreases expression EXP Iron deficiency results in decreased expression of CDS1 mRNA CTD PMID:19821111 NCBI chr14:9,396,511...9,456,964
Ensembl chr14:9,396,512...9,456,990
JBrowse link
G Cel carboxyl ester lipase increases expression EXP Iron deficiency results in increased expression of CEL mRNA CTD PMID:19821111 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of CHEK2 mRNA CTD PMID:22198552 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chi3l1 chitinase 3 like 1 decreases expression ISO Iron deficiency results in decreased expression of CHI3L1 mRNA CTD PMID:20368581 NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in decreased expression of CHRND mRNA CTD PMID:24619124 NCBI chr 9:94,286,550...94,294,968
Ensembl chr 9:94,286,550...94,294,968
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Iron results in increased activity of [CHUK protein binds to IKBKB protein]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cldn2 claudin 2 increases expression EXP Iron deficiency results in increased expression of CLDN2 mRNA CTD PMID:16629162 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Clps colipase increases expression EXP Iron deficiency results in increased expression of CLPS mRNA CTD PMID:19821111 NCBI chr20:5,803,447...5,806,107
Ensembl chr20:5,803,383...5,806,097
JBrowse link
G Cnn3 calponin 3 increases expression EXP Iron deficiency results in increased expression of CNN3 mRNA CTD PMID:16629162 NCBI chr 2:225,005,069...225,036,179
Ensembl chr 2:225,005,019...225,036,188
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Iron promotes the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA] CTD PMID:11306436 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cp ceruloplasmin increases abundance
multiple interactions
increases activity
increases oxidation
increases expression
decreases export
affects binding
ISO
EXP
CP gene mutant form results in increased abundance of Iron
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]
Iron deficiency results in increased activity of CP promoter
CP protein results in increased oxidation of Iron
Iron deficiency results in increased expression of CP protein; Iron deficiency results in increased expression of CP protein modified form
CP gene mutant form results in decreased export of Iron
CP protein binds to [TF protein binds to Iron]
[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein; ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter]
[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in increased expression of CP protein]
CTD PMID:10777486, PMID:12572680, PMID:16988052, PMID:19061943, PMID:20655381, PMID:20801540, PMID:21049900, PMID:22457245, PMID:22534743, PMID:23814049 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CSF2 mRNA CTD PMID:22198552 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cstf2t cleavage stimulation factor subunit 2, tau variant decreases expression ISO Iron deficiency results in decreased expression of CSTF2T mRNA CTD PMID:20368581 NCBI chr 1:249,574,954...249,578,520
Ensembl chr 1:249,574,954...249,578,520
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 decreases expression EXP Iron deficiency results in decreased expression of CTNNBIP1 mRNA CTD PMID:19821111 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CXCL1 protein CTD PMID:22198552 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CXCL2 protein CTD PMID:22198552 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cybrd1 cytochrome b reductase 1 decreases expression
increases expression
ISO
EXP
Iron results in decreased expression of CYBRD1 protein
Iron deficiency results in increased expression of CYBRD1 mRNA
Iron results in increased expression of CYBRD1 protein
CTD PMID:16629162, PMID:18815723, PMID:19821111, PMID:21540277, PMID:23776592, PMID:23814049 NCBI chr 3:57,718,496...57,745,749
Ensembl chr 3:57,718,364...57,746,097
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 decreases expression EXP Iron deficiency results in decreased expression of CYP2B15 mRNA CTD PMID:16629162 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358
JBrowse link
G Cytip cytohesin 1 interacting protein increases expression ISO Iron deficiency results in increased expression of CYTIP mRNA CTD PMID:20368581 NCBI chr 3:44,150,494...44,225,723
Ensembl chr 3:44,150,992...44,177,689
JBrowse link
G Dapl1 death associated protein-like 1 decreases expression EXP Iron deficiency results in decreased expression of DAPL1 mRNA CTD PMID:16629162 NCBI chr 3:45,538,408...45,559,281
Ensembl chr 3:45,538,797...45,559,331
JBrowse link
G Daxx death-domain associated protein increases expression ISO Iron results in increased expression of DAXX mRNA CTD PMID:16308480 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Iron deficiency results in increased expression of DDIT3 mRNA
[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of DDIT3 mRNA
CTD PMID:20368581, PMID:22198552 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Defa5 defensin alpha 5 increases expression EXP Iron deficiency results in increased expression of DEFA6 mRNA CTD PMID:16629162 NCBI chr16:75,338,050...75,340,401
Ensembl chr16:75,338,052...75,340,360
JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression EXP Iron deficiency results in increased expression of DGKA mRNA CTD PMID:19821111 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression EXP Iron deficiency results in increased expression of DLC1 mRNA CTD PMID:16629162 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Iron deficiency results in increased expression of DOCK10 mRNA CTD PMID:20368581 NCBI chr 9:86,424,638...86,571,854
NCBI chr 9:86,312,470...86,423,054
Ensembl chr 9:86,312,501...86,571,870
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein CTD PMID:22479410 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein CTD PMID:22479410 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of E2F1 mRNA CTD PMID:22198552 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Iron deficiency results in increased expression of E2F8 mRNA CTD PMID:20368581 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein] CTD PMID:20302851 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase increases expression EXP Iron deficiency results in increased expression of EEF2K mRNA CTD PMID:16629162 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 affects binding ISO Iron binds to EGLN1 protein CTD PMID:16649251 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Iron deficiency results in increased expression of EGLN3 mRNA CTD PMID:16629162 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
EXP Iron deficiency results in increased expression of EGR1 mRNA
[Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of EGR1 mRNA
CTD PMID:16629162, PMID:24619124 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elane elastase, neutrophil expressed decreases expression ISO Iron deficiency results in decreased expression of ELANE mRNA CTD PMID:20368581 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Iron deficiency results in increased expression of EMP1 mRNA CTD PMID:20368581 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions
increases expression
ISO
EXP
Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein]; Iron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]
Iron deficiency results in increased expression of EPAS1 protein
CTD PMID:17973296, PMID:23814049 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Epo erythropoietin affects response to substance ISO Iron affects the susceptibility to EPO protein CTD PMID:24806658 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Exoc6 exocyst complex component 6 affects metabolic processing ISO EXOC6 protein affects the metabolism of Iron CTD PMID:17194590 NCBI chr 1:256,211,879...256,369,318
Ensembl chr 1:256,226,179...256,368,813
JBrowse link
G F13a1 coagulation factor XIII A1 chain decreases expression ISO Iron deficiency results in decreased expression of F13A1 mRNA CTD PMID:20368581 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G F2 coagulation factor II decreases activity ISO Iron results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression EXP Iron deficiency results in increased expression of FABP2 mRNA CTD PMID:19821111 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression EXP Iron deficiency results in increased expression of FABP6 mRNA CTD PMID:19821111 NCBI chr10:29,191,621...29,196,593
Ensembl chr10:29,191,623...29,196,563
JBrowse link
G Fam117b family with sequence similarity 117, member B increases expression EXP Iron deficiency results in increased expression of FAM117B mRNA CTD PMID:16629162 NCBI chr 9:66,716,969...66,784,487
Ensembl chr 9:66,716,969...66,784,487
JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase decreases expression ISO Iron deficiency results in decreased expression of FAM20C mRNA CTD PMID:20368581 NCBI chr12:17,913,771...17,972,733
Ensembl chr12:17,913,767...17,972,737
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in decreased expression of FBXW5 mRNA CTD PMID:24619124 NCBI chr 3:2,726,705...2,731,213
Ensembl chr 3:2,727,254...2,731,212
JBrowse link
G Fech ferrochelatase multiple interactions ISO [Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron; [Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron; [Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron; heme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]
[pyridoxal isonicotinoyl hydrazone results in decreased abundance of Iron] which results in decreased expression of FECH protein
CTD PMID:15078340, PMID:30517741 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO Iron binds to and inhibits the reaction [NEIL1 protein binds to FEN1 protein] CTD PMID:20622253 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Flot1 flotillin 1 increases expression ISO Iron deficiency results in increased expression of FLOT1 mRNA CTD PMID:20368581 NCBI chr20:3,427,890...3,438,418
Ensembl chr20:3,427,880...3,438,396
JBrowse link
G Fn3k fructosamine 3 kinase multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of FN3K mRNA CTD PMID:24619124 NCBI chr10:110,626,462...110,642,262
Ensembl chr10:110,631,494...110,642,260
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta increases expression EXP Iron deficiency results in increased expression of FNTB mRNA CTD PMID:16629162 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of FOS mRNA CTD PMID:24619124 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fth1 ferritin heavy chain 1 affects binding
multiple interactions
increases expression
affects metabolic processing
decreases expression
affects abundance
ISO
EXP
Iron binds to FTH1 protein
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTH1 mRNA; Iron deficiency promotes the reaction [Vitamin A deficiency results in decreased expression of FTH1 protein]
Iron results in increased expression of FTH1 mRNA
FTH1 protein affects the metabolism of Iron
Iron results in decreased expression of FTH1 mRNA
FTH1 protein affects the abundance of Iron
[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; FTH1 protein inhibits the reaction [Iron results in increased abundance of Reactive Oxygen Species]
[[NBD peptide, mouse results in decreased expression of FTH1 mRNA] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species
CTD PMID:15893546, PMID:16424395, PMID:16448386, PMID:16988052, PMID:17070541, PMID:17194590, PMID:18931039, PMID:19258503, PMID:22154532 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
decreases expression
affects binding
decreases uptake
ISO
EXP
2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA; Deferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; Deferoxamine inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Paraquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Razoxane inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Vitamin K 3 promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]
Iron results in increased expression of FTL1 mRNA
Iron results in decreased expression of FTL1 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA; [Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA]
[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA; [Iron co-treated with Ethanol] results in increased expression of FTL1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of FTL1 mRNA]; Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of FTL1 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of FTL1 mRNA]
FTL protein mutant form results in decreased uptake of Iron
CTD PMID:12393473, PMID:12644586, PMID:15893546, PMID:16424395, PMID:16822677, PMID:16988052, PMID:19061943, PMID:20302851, PMID:24569067 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Ftmt ferritin mitochondrial multiple interactions
affects localization
affects binding
ISO 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; 2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; [diallyl trisulfide results in decreased expression of FTMT protein] which results in increased abundance of Iron; Deferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]; Deferoxamine inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Paraquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Razoxane inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]; Vitamin K 3 promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]
FTMT protein affects the localization of Iron
CTD PMID:12644586, PMID:16757684, PMID:21616139 NCBI chr18:47,294,292...47,295,541
Ensembl chr18:47,294,292...47,295,541
JBrowse link
G Fxn frataxin increases metabolic processing
increases abundance
affects metabolic processing
affects binding
ISO FXN protein results in increased metabolism of Iron
FXN gene mutant form results in increased abundance of Iron
FXN protein affects the metabolism of Iron
Iron binds to FXN protein
CTD PMID:16120311, PMID:16911956, PMID:17101455, PMID:17194590 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Iron deficiency results in decreased expression of G6PC mRNA CTD PMID:16629162 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions
decreases expression
EXP [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein
Iron deficiency results in decreased expression of GABBR2 mRNA; Iron deficiency results in decreased expression of GABBR2 protein
CTD PMID:18771689 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
increases expression
multiple interactions
EXP Iron deficiency results in decreased expression of GABRA1 mRNA
Iron deficiency results in increased expression of GABRA1 protein
[Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein
CTD PMID:18771689 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gar1 GAR1 ribonucleoprotein increases expression EXP Iron deficiency results in increased expression of GAR1 mRNA CTD PMID:16629162 NCBI chr 2:235,250,453...235,258,464
Ensembl chr 2:235,250,453...235,257,731
JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of GAS1 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA CTD PMID:12393473 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gas7 growth arrest specific 7 increases expression ISO Iron deficiency results in increased expression of GAS7 mRNA CTD PMID:20368581 NCBI chr10:54,010,723...54,240,805
Ensembl chr10:54,126,486...54,236,476
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
decreases expression
multiple interactions
EXP
ISO
Iron results in increased activity of GCLC protein
Iron results in decreased expression of GCLC mRNA
Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA]
CTD PMID:17189828, PMID:19073151 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
decreases expression
ISO Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLM mRNA] CTD PMID:19073151 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gkn1 gastrokine 1 increases expression EXP Iron deficiency results in increased expression of GKN1 mRNA CTD PMID:16629162 NCBI chr 4:119,143,070...119,148,358
Ensembl chr 4:119,143,070...119,148,358
JBrowse link
G Gkn2 gastrokine 2 increases expression EXP Iron deficiency results in increased expression of GKN2 mRNA CTD PMID:16629162 NCBI chr 4:119,131,255...119,177,329
Ensembl chr 4:119,171,245...119,177,329
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases activity
EXP Capsaicin inhibits the reaction [Iron results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] CTD PMID:16956363 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Iron deficiency results in increased expression of GPAM mRNA CTD PMID:16629162 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gpr34 G protein-coupled receptor 34 increases expression ISO Iron deficiency results in increased expression of GPR34 mRNA CTD PMID:20368581 NCBI chr  X:10,022,986...10,043,504
Ensembl chr  X:10,023,489...10,031,167
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression EXP Iron deficiency results in increased expression of GPRC5A mRNA CTD PMID:16629162 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP
ISO
Capsaicin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]
Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein]
CTD PMID:16956363, PMID:27916511 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance
multiple interactions
ISO
EXP
GPX1 protein results in decreased susceptibility to Iron
[Iron co-treated with Hydrogen Peroxide] results in decreased expression of and results in decreased activity of GPX1 protein
CTD PMID:16721761, PMID:17280487 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Iron deficiency results in increased expression of GPX2 mRNA CTD PMID:16629162 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron] CTD PMID:19620254 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
ISO
EXP
Iron deficiency inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]; Iron promotes the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein
Iron results in decreased activity of GSR protein
CTD PMID:12067571, PMID:12504893, PMID:17176674 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase multiple interactions
decreases expression
ISO Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA] CTD PMID:19073151 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression
decreases expression
EXP
ISO
[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in decreased expression of GSTA2 mRNA
Iron results in increased expression of GSTA1 mRNA; Iron results in increased expression of GSTA1 protein
Iron results in decreased expression of GSTA1 protein
CTD PMID:11755321, PMID:20302851 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP Iron results in increased expression of and results in increased activity of GSTA4 protein CTD PMID:7878679 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTA5 mRNA CTD PMID:20302851 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression
decreases expression
ISO Iron results in increased expression of GSTA1 mRNA; Iron results in increased expression of GSTA1 protein
Iron results in decreased expression of GSTA1 protein
CTD PMID:11755321 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression
increases expression
ISO Iron results in decreased expression of GSTM1 protein
Iron results in increased expression of GSTM1 mRNA; Iron results in increased expression of GSTM1 protein
CTD PMID:11755321 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions EXP [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTM3 mRNA CTD PMID:20302851 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G H3f4 H3.4 histone increases methylation
multiple interactions
ISO Iron results in increased methylation of H3-4 protein
[[Iron co-treated with Ketoglutaric Acids] results in increased activity of KDM3A protein] which results in decreased methylation of H3-4 protein
CTD PMID:16603237, PMID:21385672 NCBI chr10:45,304,696...45,305,106 JBrowse link
G Hamp hepcidin antimicrobial peptide decreases secretion
increases expression
decreases expression
affects expression
multiple interactions
affects metabolic processing
ISO
EXP
HAMP protein results in decreased secretion of Iron
Iron results in increased expression of HAMP protein
Iron results in increased expression of HAMP mRNA
Iron deficiency results in decreased expression of HAMP mRNA
Iron affects the expression of HAMP mRNA
[Acetaminophen results in decreased expression of HAMP mRNA] which results in increased abundance of Iron; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]
HAMP protein affects the metabolism of Iron
[IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Iron; Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]
CTD PMID:11113132, PMID:16460831, PMID:16574947, PMID:16648237, PMID:17116712, PMID:17194590, PMID:17255318, PMID:19061943, PMID:20655381, PMID:21540277, PMID:22457245, PMID:22610607, PMID:22659129 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO AHSP protein binds to and affects the folding of and affects the stability of [HBA1 protein binds to Iron] CTD PMID:16901899 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions
affects abundance
ISO [HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA
HBB-B1 protein affects the abundance of Iron
CTD PMID:17018382 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions ISO Iron binds to and results in increased activity of HDAC8 protein CTD PMID:16681389 NCBI chr  X:72,163,777...72,370,058
Ensembl chr  X:72,163,777...72,370,044
JBrowse link
G Heph hephaestin affects metabolic processing
multiple interactions
ISO
EXP
HEPH protein affects the metabolism of Iron
[Zinc results in decreased expression of HEPH protein] which results in decreased uptake of Iron
CTD PMID:16614402, PMID:17194590 NCBI chr  X:65,377,313...65,658,479
Ensembl chr  X:65,563,122...65,658,516
JBrowse link
G Hfe homeostatic iron regulator increases uptake
affects abundance
multiple interactions
affects metabolic processing
decreases uptake
affects response to substance
increases abundance
ISO HFE gene mutant form results in increased uptake of Iron
HFE protein affects the abundance of Iron
[HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron
HFE protein affects the metabolism of Iron
HFE protein results in decreased uptake of Iron
[HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron; [HFE protein binds to TFR2 protein] which affects the susceptibility to Iron; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]; TNF gene SNP promotes the reaction [HFE protein mutant form results in increased uptake of Iron]
HFE protein affects the susceptibility to Iron
HFE gene polymorphism affects the abundance of Iron; HFE protein affects the abundance of Iron
HFE gene mutant form results in increased abundance of Iron; HFE gene polymorphism results in increased abundance of Iron
CTD PMID:10085150, PMID:12393473, PMID:16793930, PMID:16823846, PMID:16841247, PMID:16877869, PMID:16893896, PMID:17047092, PMID:17101320, PMID:17194590, PMID:18317567, PMID:22383097 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases response to substance
decreases metabolic processing
ISO
EXP
[Deferoxamine results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Quercetin results in decreased abundance of Iron] which results in increased expression of HIF1A protein; Iron inhibits the reaction [galangin results in increased expression of HIF1A protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; Iron inhibits the reaction [Nickel results in increased stability of HIF1A protein]; Iron inhibits the reaction [Quercetin results in increased expression of and affects the localization of HIF1A protein]; Iron inhibits the reaction [Quercetin results in increased expression of HIF1A protein]
Iron deficiency results in decreased expression of HIF1A mRNA
HIF1A protein results in increased susceptibility to Iron
HIF1A gene mutant form results in decreased metabolism of Iron
CTD PMID:12393473, PMID:16629162, PMID:16787915, PMID:16877034, PMID:17364964, PMID:17973296, PMID:19263519, PMID:19729006 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hjv hemojuvelin BMP co-receptor affects metabolic processing ISO HJV protein affects the metabolism of Iron CTD PMID:17194590 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Iron deficiency results in decreased expression of HMGCS2 mRNA CTD PMID:16629162 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases metabolic processing
increases expression
EXP
ISO
[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of HMOX1 mRNA; [Iron co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein]
HMOX1 protein results in increased metabolism of Iron
[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HMOX1 mRNA; [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Iron; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; [Particulate Matter results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Iron promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]
Iron deficiency results in increased expression of HMOX1 mRNA; Iron results in increased expression of HMOX1 protein
CTD PMID:12393473, PMID:15602829, PMID:16439612, PMID:16629162, PMID:19136476, PMID:20302851, PMID:20709802, PMID:20888885, PMID:26419736 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase increases expression ISO Iron deficiency results in increased expression of HPGDS mRNA CTD PMID:20368581 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
affects localization
EXP HRAS protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]
Iron affects the localization of HRAS protein
CTD PMID:17172471 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsbp1l1 heat shock factor binding protein 1-like 1 decreases expression ISO Iron deficiency results in decreased expression of HSBP1L1 mRNA CTD PMID:20368581 NCBI chr18:76,748,067...76,754,642
Ensembl chr18:76,748,067...76,753,902
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPA1A mRNA CTD PMID:22198552 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPA1L mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPA8 mRNA CTD PMID:22198552 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPA9 mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPB1 mRNA CTD PMID:22198552 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions EXP
ISO
[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPH1 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPH1 mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA
CTD PMID:12393473, PMID:22198552 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Htt huntingtin decreases uptake ISO HTT protein mutant form results in decreased uptake of Iron CTD PMID:20547568 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12633744 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Iron deficiency results in decreased expression of IDI1 mRNA CTD PMID:19821111 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifng interferon gamma multiple interactions ISO Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein]; Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ift172 intraflagellar transport 172 increases expression EXP Iron deficiency results in increased expression of SLB mRNA CTD PMID:16629162 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP IGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Iron] CTD PMID:15745444 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression EXP Iron deficiency results in increased expression of IGFBP3 mRNA CTD PMID:16629162 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]; Iron results in increased activity of [CHUK protein binds to IKBKB protein]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of IL1A mRNA; [Iron co-treated with Diethylnitrosamine] results in increased expression of IL1A mRNA CTD PMID:20302851 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of IL1B mRNA; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of IL1B protein; lipopolysaccharide A promotes the reaction [Iron results in increased secretion of IL1B protein]
[Particulate Matter results in increased abundance of Iron] which results in increased secretion of IL1B protein
CTD PMID:16958088, PMID:22198552, PMID:32007923 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO
EXP
[IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Iron
Iron results in increased secretion of IL6 protein
[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of IL6 mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of IL6 mRNA; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of IL6 mRNA
CTD PMID:16460831, PMID:20302851, PMID:22198552, PMID:26416317 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Iqcd IQ motif containing D increases expression ISO Iron deficiency results in increased expression of IQCD mRNA CTD PMID:20368581 NCBI chr12:41,490,451...41,507,416
Ensembl chr12:41,490,801...41,497,610
JBrowse link
G Ireb2 iron responsive element binding protein 2 affects metabolic processing
increases activity
multiple interactions
ISO
EXP
IREB2 protein affects the metabolism of Iron
Iron deficiency results in increased activity of IREB2 protein
Clofibrate inhibits the reaction [Iron deficiency results in increased activity of IREB2 protein]
CTD PMID:11969379, PMID:17194590 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression ISO Iron deficiency results in decreased expression of IRF8 mRNA CTD PMID:20368581 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640
JBrowse link
G Itga6 integrin subunit alpha 6 increases expression EXP Iron deficiency results in increased expression of ITGA6 mRNA CTD PMID:16629162 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
ISO Iron deficiency results in increased expression of ITGAM mRNA; Iron deficiency results in increased expression of ITGAM protein
Vitamin D promotes the reaction [Iron deficiency results in increased expression of ITGAM protein]
CTD PMID:20368581 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Iron deficiency results in increased expression of ITGB2 mRNA CTD PMID:20368581 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itln1 intelectin 1 multiple interactions ISO ITLN1 protein binds to and results in increased uptake of Iron CTD PMID:16936804 NCBI chr13:89,919,570...89,929,774
Ensembl chr13:89,919,667...89,929,770
JBrowse link
G Jazf1 JAZF zinc finger 1 increases expression ISO Iron deficiency results in increased expression of JAZF1 mRNA CTD PMID:20368581 NCBI chr 4:82,834,181...83,141,430
Ensembl chr 4:82,836,260...83,137,527
JBrowse link
G Jchain joining chain of multimeric IgA and IgM increases expression EXP Iron deficiency results in increased expression of JCHAIN mRNA CTD PMID:16629162 NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Iron deficiency results in increased expression of JUN mRNA
[Deferoxamine results in decreased abundance of Iron] which results in increased expression of JUN mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
CTD PMID:12393473, PMID:20368581 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 increases expression EXP Iron deficiency results in increased expression of KCNE3 mRNA CTD PMID:16629162 NCBI chr 1:165,189,934...165,196,949
Ensembl chr 1:165,189,985...165,196,948
JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO [[Iron co-treated with Ketoglutaric Acids] results in increased activity of KDM3A protein] which results in decreased methylation of H3-4 protein CTD PMID:16603237 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Iron deficiency results in decreased expression of KIT mRNA CTD PMID:20368581 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klhdc7b kelch domain containing 7B increases expression ISO Iron deficiency results in increased expression of KLHDC7B mRNA CTD PMID:20368581 NCBI chr 7:130,357,589...130,359,529
Ensembl chr 7:130,357,643...130,359,448
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Iron deficiency results in increased expression of LAMC2 mRNA CTD PMID:16629162 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Lamp5 lysosomal-associated membrane protein family, member 5 decreases expression ISO Iron deficiency results in decreased expression of LAMP5 mRNA CTD PMID:20368581 NCBI chr 3:129,012,677...129,031,522
Ensembl chr 3:129,018,592...129,031,521
JBrowse link
G Lcn2 lipocalin 2 affects metabolic processing
increases expression
ISO LCN2 protein affects the metabolism of Iron
Iron results in increased expression of LCN2 mRNA; Iron results in increased expression of LCN2 protein
CTD PMID:17194590, PMID:17350462 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lig3 DNA ligase 3 decreases activity ISO Iron results in decreased activity of LIG3 protein CTD PMID:20622253 NCBI chr10:70,134,734...70,158,051
Ensembl chr10:70,134,729...70,158,055
JBrowse link
G LOC100360841 ribosomal protein L37-like decreases expression ISO Iron results in decreased expression of RPL37 mRNA CTD PMID:27329587 NCBI chr 9:69,790,829...69,791,199
Ensembl chr 9:69,790,831...69,791,196
JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 decreases expression EXP Iron deficiency results in decreased expression of LPAR1 mRNA CTD PMID:19821111 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Lrrc25 leucine rich repeat containing 25 increases expression ISO Iron deficiency results in increased expression of LRRC25 mRNA CTD PMID:20368581 NCBI chr16:20,556,973...20,563,773
Ensembl chr16:20,558,222...20,562,399
JBrowse link
G Lta lymphotoxin alpha multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of LTA mRNA CTD PMID:22198552 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ly75 lymphocyte antigen 75 decreases expression ISO Iron deficiency results in decreased expression of LY75 mRNA CTD PMID:20368581 NCBI chr 3:46,369,749...46,457,182
Ensembl chr 3:46,365,165...46,457,201
JBrowse link
G Lypla1 lysophospholipase 1 decreases expression EXP Iron deficiency results in decreased expression of LYPLA1 mRNA CTD PMID:19821111 NCBI chr 5:14,559,333...14,588,447
Ensembl chr 5:14,559,334...14,588,422
JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Iron deficiency results in decreased expression of MAOA mRNA CTD PMID:16629162 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Iron affects the reaction [Deferoxamine results in increased expression of MAP1LC3B protein]; Iron affects the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of MAP1LC3B protein] CTD PMID:25301941 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions
increases phosphorylation
EXP Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein]; Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 multiple interactions EXP MAP3K14 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [Iron results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions
increases activity
affects localization
EXP Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]; Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [Iron results in increased secretion of TNF protein]
Iron affects the localization of MAP3K7 protein
CTD PMID:17172471 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; [Vanadium co-treated with Iron] results in increased phosphorylation of MAPK1 protein; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]
[ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein
Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:11306436, PMID:16728372, PMID:17172471, PMID:23100159, PMID:30914277 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; [Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein; [Vanadium co-treated with Iron] results in increased phosphorylation of MAPK3 protein; deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; Iron promotes the reaction [Asbestos, Amosite results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]
[ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein
[Iron co-treated with Arsenic] results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD PMID:11306436, PMID:16728372, PMID:17172471, PMID:23100159, PMID:30914277 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression EXP Iron deficiency results in increased expression of MARCKS mRNA CTD PMID:16629162 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mcemp1 mast cell-expressed membrane protein 1 increases expression ISO Iron deficiency results in increased expression of MCEMP1 mRNA CTD PMID:20368581 NCBI chr12:2,211,970...2,217,005
Ensembl chr12:2,213,471...2,217,433
JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 multiple interactions
increases expression
ISO [Ethanol co-treated with Iron] results in increased expression of MCOLN1 mRNA; [Ethanol co-treated with Iron] results in increased expression of MCOLN1 protein; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of MCOLN1 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of MCOLN1 protein]; Quercetin inhibits the reaction [Iron results in increased expression of MCOLN1 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of MCOLN1 protein]
Iron results in increased expression of MCOLN1 mRNA; Iron results in increased expression of MCOLN1 protein
CTD PMID:24569067 NCBI chr12:2,054,629...2,068,682
Ensembl chr12:2,054,680...2,068,682
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Iron deficiency results in increased expression of MCTP1 mRNA CTD PMID:20368581 NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Iron deficiency results in increased expression of ME1 mRNA CTD PMID:20368581 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA CTD PMID:22198552 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Miox myo-inositol oxygenase affects binding ISO [MIOX protein binds to Iron] which binds to Inositol CTD PMID:17012379 NCBI chr 7:130,308,707...130,311,205
Ensembl chr 7:130,308,532...130,313,727
JBrowse link
G Mir196b microRNA 196b multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Iron] which results in increased expression of MIR196B mRNA CTD PMID:27506416 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein] CTD PMID:19136476 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP [Hexachlorocyclohexane co-treated with Iron] results in increased activity of MPO protein
Iron results in increased activity of MPO protein
CTD PMID:11141352 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ms4a6a membrane spanning 4-domains A6A decreases expression ISO Iron deficiency results in decreased expression of MS4A6A mRNA CTD PMID:20368581 NCBI chr 1:227,919,284...227,932,637
Ensembl chr 1:227,919,301...227,932,603
JBrowse link
G Ms4a7 membrane spanning 4-domains A7 increases expression EXP Iron deficiency results in increased expression of MS4A7 mRNA CTD PMID:16629162 NCBI chr 1:227,490,777...227,506,819
Ensembl chr 1:227,490,777...227,506,822
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP
ISO
Iron deficiency results in increased expression of MT1A; Iron deficiency results in increased expression of MT1A mRNA
Iron deficiency results in increased expression of MT1 mRNA
ATP7A gene mutant form promotes the reaction [Iron deficiency results in increased expression of MT1 mRNA]
[Zinc co-treated with Iron] results in increased expression of and affects the localization of MT1A protein; Iron results in increased expression of and affects the localization of MT1A protein
CTD PMID:16629162, PMID:17241390, PMID:21852364, PMID:23776592, PMID:24089420 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions
affects abundance
increases expression
ISO
EXP
[Deferoxamine results in decreased abundance of Iron] which results in increased expression of MT2A mRNA; [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA
MT2A gene SNP affects the abundance of Iron
Iron deficiency results in increased expression of MT2 mRNA
[Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein; Iron results in increased expression of and affects the localization of MT2A protein
Iron deficiency results in increased expression of MT2A mRNA
CTD PMID:12393473, PMID:16629162, PMID:17241390, PMID:21328412, PMID:24089420 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP Iron deficiency results in increased expression of MVD mRNA CTD PMID:19821111 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Deferoxamine results in decreased abundance of Iron] which results in decreased expression of MYC mRNA; [Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA CTD PMID:12393473 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone binds to Iron] which results in increased expression of NDRG1 protein; NDRG1 protein results in decreased susceptibility to [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone binds to Iron] CTD PMID:24532803 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 affects expression ISO Iron affects the expression of NDUFS1 protein CTD PMID:11313346 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression EXP Iron deficiency results in increased expression of NEDD9 mRNA CTD PMID:16629162 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]; Iron binds to and affects the folding of and results in decreased activity of NEIL1 protein; Iron binds to and inhibits the reaction [NEIL1 protein binds to FEN1 protein]; Iron binds to and inhibits the reaction [NEIL1 protein binds to POLB protein] CTD PMID:20622253 NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102
JBrowse link
G Neil2 nei-like DNA glycosylase 2 multiple interactions ISO Iron binds to and results in decreased activity of NEIL2 protein CTD PMID:20622253 NCBI chr15:46,371,780...46,382,730
Ensembl chr15:46,372,485...46,381,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity
EXP
ISO
[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of NFE2L2 mRNA
[Particulate Matter results in increased abundance of Iron] which affects the localization of NFE2L2 protein; [Particulate Matter results in increased abundance of Iron] which results in increased expression of NFE2L2 mRNA
Iron results in increased activity of NFE2L2 promoter
NFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron]
CTD PMID:20302851, PMID:21303654, PMID:21643505, PMID:26419736 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Iron deficiency results in increased expression of NFIL3 mRNA CTD PMID:20368581 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of NFKBIA protein]; [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in decreased expression of NFKBIA mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNA; HRAS protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of NFKBIA protein]; U 0126 inhibits the reaction [Iron results in increased phosphorylation of NFKBIA protein] CTD PMID:17172471, PMID:20302851 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngb neuroglobin decreases uptake ISO NGB protein results in decreased uptake of Iron CTD PMID:19154338 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 increases expression ISO Iron deficiency results in increased expression of NLRC4 mRNA CTD PMID:20368581 NCBI chr 6:22,167,874...22,194,755
Ensembl chr 6:22,167,919...22,194,250
JBrowse link
G Nmt2 N-myristoyltransferase 2 multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of NMT2 mRNA CTD PMID:24619124 NCBI chr17:78,919,235...78,966,013
Ensembl chr17:78,921,793...78,962,476
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
[Aluminum co-treated with Iron] results in increased expression of NOS2 protein; [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of NOS2 mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of NOS2 mRNA; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of NOS2 mRNA
Iron inhibits the reaction [Asbestos, Crocidolite results in increased expression of NOS2 mRNA]; Iron inhibits the reaction [Asbestos, Crocidolite results in increased expression of NOS2 protein]
CTD PMID:11461780, PMID:16728372, PMID:20302851, PMID:22198552 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 decreases abundance ISO NPC1 gene mutant form results in decreased abundance of Iron CTD PMID:24901380 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction
multiple interactions
ISO NQO1 protein results in increased reduction of Iron
[Particulate Matter results in increased abundance of Iron] which results in increased expression of NQO1 mRNA
CTD PMID:17178108, PMID:26419736 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ocln occludin multiple interactions EXP Iron inhibits the reaction [Lead results in decreased expression of OCLN mRNA]; Iron inhibits the reaction [Lead results in decreased expression of OCLN protein] CTD PMID:17234227 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
ISO Iron affects the reaction [3-chloroperbenzoic acid results in increased activity of ODC1 protein]; Iron deficiency inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron promotes the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron promotes the reaction [Hydrogen Peroxide results in increased activity of ODC1 protein]; Iron promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Iron results in increased activity of ODC1 protein
CTD PMID:7653998, PMID:12065085, PMID:12067571, PMID:12504893 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Opn3 opsin 3 decreases expression ISO Iron deficiency results in decreased expression of OPN3 mRNA CTD PMID:20368581 NCBI chr13:93,716,481...93,746,994
Ensembl chr13:93,716,481...93,746,994
JBrowse link
G Osbpl11 oxysterol binding protein-like 11 increases expression ISO Iron deficiency results in increased expression of OSBPL11 mRNA CTD PMID:20368581 NCBI chr11:70,770,509...70,855,425
Ensembl chr11:70,770,507...70,833,577
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO Iron deficiency results in increased expression of P2RX7 mRNA CTD PMID:20368581 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression EXP Iron deficiency results in increased expression of P4HA1 mRNA CTD PMID:16629162 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G P4htm prolyl 4-hydroxylase, transmembrane multiple interactions ISO Iron inhibits the reaction [manganese chloride results in decreased activity of P4HTM protein] CTD PMID:19263519 NCBI chr 8:117,364,895...117,383,275
Ensembl chr 8:117,365,101...117,382,715
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein] CTD PMID:30626086, PMID:31678598 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcgf5 polycomb group ring finger 5 increases expression ISO Iron deficiency results in increased expression of PCGF5 mRNA CTD PMID:20368581 NCBI chr 1:254,974,688...255,090,925
Ensembl chr 1:254,974,789...255,086,207
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP Iron deficiency results in decreased expression of PCK1 mRNA CTD PMID:16629162 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Iron deficiency results in increased expression of PCNA mRNA CTD PMID:16629162 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression EXP Iron deficiency results in decreased expression of PCTP mRNA CTD PMID:19821111 NCBI chr10:77,491,445...77,537,268
Ensembl chr10:77,491,454...77,512,032
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA] CTD PMID:11306436, PMID:12475806 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP Iron deficiency results in increased expression of PDK4 mRNA CTD PMID:16629162 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO [cobaltous chloride results in decreased abundance of Iron] which results in increased expression of PFKFB4 mRNA; [Deferoxamine results in decreased abundance of Iron] which results in increased expression of PFKFB4 mRNA CTD PMID:16025159 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 decreases expression EXP Iron deficiency results in decreased expression of PHOSPHO1 mRNA CTD PMID:16629162 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta increases expression EXP Iron deficiency results in increased expression of PIK3C2B mRNA CTD PMID:16629162 NCBI chr13:49,848,939...49,909,404
Ensembl chr13:49,850,189...49,911,202
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [Iron results in increased secretion of TNF protein] CTD PMID:17172471 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO Iron deficiency results in increased expression of PIM1 mRNA CTD PMID:20368581 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta increases expression ISO Iron deficiency results in increased expression of PIP5K1B mRNA CTD PMID:20368581 NCBI chr 1:242,168,462...242,441,247
Ensembl chr 1:242,168,462...242,441,247
JBrowse link
G Pla2g1b phospholipase A2 group IB increases expression EXP Iron deficiency results in increased expression of PLA2G1B mRNA CTD PMID:19821111 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases expression EXP Iron deficiency results in decreased expression of PLA2G4A mRNA CTD PMID:19821111 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plaa phospholipase A2, activating protein decreases expression EXP Iron deficiency results in decreased expression of PLAA mRNA CTD PMID:19821111 NCBI chr 5:113,548,913...113,578,928
Ensembl chr 5:113,548,913...113,578,928
JBrowse link
G Pld4 phospholipase D family, member 4 decreases expression ISO Iron deficiency results in decreased expression of PLD4 mRNA CTD PMID:20368581 NCBI chr 6:137,323,713...137,331,231
Ensembl chr 6:137,323,713...137,331,231
JBrowse link
G Plpp1 phospholipid phosphatase 1 increases expression ISO Iron deficiency results in increased expression of PLPP1 mRNA CTD PMID:20368581 NCBI chr 2:44,664,076...44,726,820
Ensembl chr 2:44,664,124...44,726,689
JBrowse link
G Plscr1 phospholipid scramblase 1 decreases expression EXP Iron deficiency results in decreased expression of PLSCR1 mRNA CTD PMID:19821111 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression
multiple interactions
ISO
EXP
Iron deficiency results in increased expression of PMP22 mRNA
[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of PMP22 mRNA; [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA
CTD PMID:12393473, PMID:16629162, PMID:20368581 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Pmvk phosphomevalonate kinase increases expression EXP Iron deficiency results in increased expression of PMVK mRNA CTD PMID:19821111 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
G Pnlip pancreatic lipase increases expression EXP Iron deficiency results in increased expression of PNLIP mRNA CTD PMID:19821111 NCBI chr 1:279,798,187...279,811,372
Ensembl chr 1:279,798,187...279,811,372
JBrowse link
G Pnliprp1 pancreatic lipase-related protein 1 increases expression EXP Iron deficiency results in increased expression of PNLIPRP1 mRNA CTD PMID:19821111 NCBI chr 1:279,867,034...279,882,663
Ensembl chr 1:279,867,034...279,882,663
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases expression EXP Iron deficiency results in decreased expression of PNLIPRP2 mRNA CTD PMID:16629162 NCBI chr 1:279,896,973...279,927,600
Ensembl chr 1:279,896,973...279,927,600
JBrowse link
G Poglut2 protein O-glucosyltransferase 2 increases expression ISO Iron deficiency results in increased expression of POGLUT2 mRNA CTD PMID:20368581 NCBI chr 9:50,872,492...50,884,596
Ensembl chr 9:50,872,492...50,884,596
JBrowse link
G Polb DNA polymerase beta multiple interactions ISO Iron binds to and inhibits the reaction [NEIL1 protein binds to POLB protein] CTD PMID:20622253 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
JBrowse link
G Polr3e RNA polymerase III subunit E multiple interactions EXP [Tungsten co-treated with Nickel co-treated with Iron] results in increased expression of POLR3E mRNA CTD PMID:24619124 NCBI chr 1:190,852,954...190,881,539
Ensembl chr 1:190,852,985...190,881,108
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP
[Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein; [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein; Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [[Iron co-treated with POR protein] results in increased metabolism of Paraquat] which results in increased abundance of Hydroxyl Radical; [Iron co-treated with POR protein] results in increased metabolism of Diquat; [Iron co-treated with POR protein] results in increased metabolism of Paraquat CTD PMID:21215309 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Iron deficiency results in increased expression of PPARG mRNA CTD PMID:20368581 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B increases expression ISO Iron deficiency results in increased expression of PPP1R16B mRNA CTD PMID:20368581 NCBI chr 3:155,160,474...155,267,002
Ensembl chr 3:155,160,481...155,262,941
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases expression EXP Iron deficiency results in increased expression of PPP1R1B mRNA CTD PMID:16629162 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 decreases expression ISO Iron deficiency results in decreased expression of PRG3 mRNA CTD PMID:20368581 NCBI chr 3:72,395,194...72,401,254
Ensembl chr 3:72,395,218...72,401,318
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases expression EXP Iron deficiency results in decreased expression of PRKAA1 mRNA CTD PMID:19821111 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prnp prion protein multiple interactions
decreases abundance
ISO [Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]; Iron, Dietary inhibits the reaction [PRNP gene mutant form results in decreased abundance of Iron] CTD PMID:16595185, PMID:23478311 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Prtn3 proteinase 3 decreases expression ISO Iron deficiency results in decreased expression of PRTN3 mRNA CTD PMID:20368581 NCBI chr 7:12,643,712...12,646,951
Ensembl chr 7:12,643,516...12,646,960
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of PTGS2 protein CTD PMID:20302851 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Iron deficiency results in increased expression of PTX3 mRNA CTD PMID:20368581 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Rab30 RAB30, member RAS oncogene family decreases expression EXP Iron deficiency results in decreased expression of RAB30 mRNA CTD PMID:16629162 NCBI chr 1:157,573,344...157,667,973
Ensembl chr 1:157,573,324...157,660,008
JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron] CTD PMID:16908409 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rbp7 retinol binding protein 7 increases expression EXP Iron deficiency results in increased expression of RBP7 mRNA CTD PMID:16629162 NCBI chr 5:166,278,214...166,282,832
Ensembl chr 5:166,278,187...166,282,831
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Iron deficiency results in increased expression of RELB mRNA CTD PMID:20368581 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Retn resistin increases expression ISO Iron deficiency results in increased expression of RETN mRNA CTD PMID:20368581 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Iron deficiency results in increased expression of RGS1 mRNA CTD PMID:20368581 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Iron deficiency results in increased expression of RGS2 mRNA CTD PMID:20368581 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhob ras homolog family member B increases expression EXP Iron deficiency results in increased expression of RHOB mRNA CTD PMID:16629162 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rnase4 ribonuclease A family member 4 increases expression ISO Iron deficiency results in increased expression of RNASE4 mRNA CTD PMID:20368581 NCBI chr15:28,018,040...28,035,395
Ensembl chr15:28,018,040...28,035,389
Ensembl chr15:28,018,040...28,035,389
JBrowse link
G Ropn1l rhophilin associated tail protein 1-like decreases expression ISO Iron deficiency results in decreased expression of ROPN1L mRNA CTD PMID:20368581 NCBI chr 2:84,520,421...84,531,192
Ensembl chr 2:84,520,421...84,531,342
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO [Iron co-treated with Oxygen] binds to RRM2 protein CTD PMID:16829694 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G RT1-Bb RT1 class II, locus Bb increases expression EXP Iron deficiency results in increased expression of RT1-BB mRNA CTD PMID:16629162 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Iron deficiency results in increased expression of RT1-DB1 mRNA CTD PMID:16629162 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression EXP Iron deficiency results in decreased expression of S100A9 mRNA CTD PMID:16629162 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression
decreases expression
EXP Iron deficiency results in increased expression of SCD2 mRNA
Iron deficiency results in decreased expression of SCD2 mRNA
CTD PMID:16629162, PMID:19821111 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Scp2 sterol carrier protein 2 decreases expression EXP Iron deficiency results in decreased expression of SCP2 mRNA CTD PMID:19821111 NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
JBrowse link
G Sele selectin E multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:12633744 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO Iron deficiency results in increased expression of SERPINB8 mRNA CTD PMID:20368581 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Sesn3 sestrin 3 decreases expression ISO Iron deficiency results in decreased expression of SESN3 mRNA CTD PMID:20368581 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Ska1 spindle and kinetochore associated complex subunit 1 increases expression ISO Iron deficiency results in increased expression of SKA1 mRNA CTD PMID:20368581 NCBI chr18:70,174,316...70,184,368
Ensembl chr18:70,173,944...70,184,337
JBrowse link
G Slc11a1 solute carrier family 11 member 1 multiple interactions ISO [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA CTD PMID:16988052 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
affects abundance
increases expression
increases uptake
increases transport
decreases expression
decreases uptake
affects metabolic processing
decreases transport
ISO
EXP
[Deferoxamine results in decreased abundance of Iron] which results in increased expression of SLC11A2 mRNA; [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron; cupric chloride inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]; Dronabinol inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]; ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]; prolinedithiocarbamate inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]
SLC11A2 gene SNP affects the abundance of Iron
Iron deficiency results in increased expression of SLC11A2 mRNA; Iron results in increased expression of SLC11A2 mRNA; Iron results in increased expression of SLC11A2 protein
SLC11A2 protein alternative form results in increased uptake of Iron; SLC11A2 protein results in increased uptake of Iron
SLC11A2 protein results in increased transport of Iron
Iron results in decreased expression of SLC11A2 protein
SLC11A2 gene mutant form results in decreased uptake of Iron; SLC11A2 protein mutant form results in decreased uptake of Iron
SLC11A2 protein affects the metabolism of Iron
Iron deficiency results in increased expression of SLC11A2 mRNA; Iron deficiency results in increased expression of SLC11A2 protein; Iron results in increased expression of SLC11A2 mRNA; Iron results in increased expression of SLC11A2 protein
[Doxorubicin results in increased expression of SLC11A2 protein] which results in increased uptake of Iron; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]; Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Metals promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]; SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron]
SLC11A2 gene mutant form results in decreased transport of Iron
[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA; [Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC11A2 protein]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein]; Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 protein]
CTD PMID:11439223, PMID:12220667, PMID:12388109, PMID:12393473, PMID:15157939, PMID:15908475, PMID:16629162, PMID:16648237, PMID:16841247, PMID:16908409, PMID:16984886, PMID:17060373, PMID:17116712, PMID:17116743, PMID:17194590, PMID:18648087, PMID:18815723, PMID:18849539, PMID:19061943, PMID:19821111, PMID:21540277, PMID:22666436, PMID:23776592, PMID:23814049, PMID:24089420, PMID:24569067, PMID:25483413 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression EXP Iron deficiency results in increased expression of SLC12A2 mRNA CTD PMID:16629162 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression EXP Iron deficiency results in increased expression of SLC23A2 mRNA CTD PMID:16629162 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Slc26a11 solute carrier family 26 member 11 increases expression ISO Iron deficiency results in increased expression of SLC26A11 mRNA CTD PMID:20368581 NCBI chr10:108,479,105...108,504,188
Ensembl chr10:108,480,368...108,503,706
JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression ISO
EXP
Iron deficiency results in decreased expression of SLC2A5 mRNA CTD PMID:16629162, PMID:20368581 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Iron deficiency results in decreased expression of SLC34A2 mRNA CTD PMID:16629162 NCBI chr14:60,257,211...60,276,516
Ensembl chr14:60,256,712...60,276,794
JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases uptake
increases import
increases expression
multiple interactions
ISO SLC39A14 protein results in increased uptake of Iron
SLC39A14 protein results in increased import of Iron
Iron results in increased expression of SLC39A14 mRNA; Iron results in increased expression of SLC39A14 protein
4,7-diphenylphenanthroline sulfonate inhibits the reaction [SLC39A14 protein results in increased uptake of Iron]; [Ethanol co-treated with Iron] results in increased expression of SLC39A14 mRNA; [Ethanol co-treated with Iron] results in increased expression of SLC39A14 protein; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC39A14 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC39A14 protein]; Quercetin inhibits the reaction [Iron results in increased expression of SLC39A14 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of SLC39A14 protein]
CTD PMID:16950869, PMID:22898811, PMID:24569067 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Slc39a8 solute carrier family 39 member 8 increases import
multiple interactions
ISO
EXP
SLC39A8 protein results in increased import of Iron
Cobalt inhibits the reaction [SLC39A8 protein results in increased import of Iron]; Iron inhibits the reaction [SLC39A8 protein results in increased import of Zinc]; Iron results in increased expression of and affects the localization of SLC39A8 protein; Manganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]; Zinc inhibits the reaction [SLC39A8 protein results in increased import of Iron]
Protons affects the reaction [SLC39A8 protein results in increased import of Iron]
CTD PMID:22898811 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions
decreases expression
increases expression
increases export
decreases export
affects metabolic processing
ISO
EXP
[HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 mRNA]; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 protein]; NFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron]
Iron results in decreased expression of SLC40A1 protein
Iron deficiency results in increased expression of SLC40A1 mRNA
[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein; Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]; Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]
SLC40A1 protein mutant form results in increased export of Iron; SLC40A1 protein results in increased export of Iron
SLC40A1 protein mutant form results in decreased export of Iron
SLC40A1 protein affects the metabolism of Iron
Iron deficiency results in increased expression of SLC40A1 mRNA; Iron results in increased expression of SLC40A1 mRNA
CTD PMID:16457665, PMID:16565419, PMID:16648237, PMID:17018382, PMID:17194590, PMID:18648087, PMID:19061943, PMID:19821111, PMID:19913091, PMID:20655381, PMID:21303654, PMID:21540277, PMID:22178646, PMID:22659129, PMID:23776592 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions
increases expression
decreases expression
EXP [Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of SLC6A1 protein; [Iron deficiency co-treated with manganese chloride] results in increased expression of SLC6A1 mRNA
Iron deficiency results in increased expression of SLC6A1 mRNA
Iron deficiency results in decreased expression of SLC6A1 protein
CTD PMID:18771689 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP [manganese chloride co-treated with Iron deficiency] results in decreased expression of SLC6A3 protein CTD PMID:22479410 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Iron deficiency results in decreased expression of SLPI mRNA CTD PMID:20368581 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Smim3 small integral membrane protein 3 increases expression EXP Iron deficiency results in increased expression of SMIM3 mRNA CTD PMID:16629162 NCBI chr18:55,744,809...55,797,186
Ensembl chr18:55,744,810...55,771,730
JBrowse link
G Snapc1 small nuclear RNA activating complex, polypeptide 1 increases expression EXP Iron deficiency results in increased expression of SNAPC1 mRNA CTD PMID:16629162 NCBI chr 6:96,871,675...96,893,422
Ensembl chr 6:96,871,625...96,893,444
JBrowse link
G Snca synuclein alpha multiple interactions
increases response to substance
affects localization
ISO Cytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Iron]
EUK-189 results in decreased susceptibility to [Iron co-treated with Paraquat co-treated with SNCA gene mutant form]
Iron affects the localization of SNCA protein
CTD PMID:12401952, PMID:14535945, PMID:21039522, PMID:27324791 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects abundance
ISO
EXP
SOD1 protein inhibits the reaction [Asbestos, Crocidolite results in increased uptake of Iron]
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD1 protein]
SOD1 protein affects the abundance of Iron
[Corn Oil co-treated with Iron] results in decreased activity of SOD1 protein; Iron promotes the reaction [Corn Oil results in decreased activity of SOD1 protein]
CTD PMID:16272461, PMID:17194920, PMID:19482077, PMID:22534743 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects abundance
ISO
EXP
Deferoxamine inhibits the reaction [SOD2 protein affects the reaction [Ethanol results in increased abundance of Iron]]; SOD2 protein affects the reaction [Ethanol results in increased abundance of Iron]
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD2 protein]
SOD2 protein polymorphism affects the abundance of Iron
Iron results in decreased expression of and results in decreased activity of SOD2 protein
CTD PMID:18760346, PMID:19063909, PMID:22534743 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sord sorbitol dehydrogenase affects abundance EXP SORD protein affects the abundance of Iron CTD PMID:18549825 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Sort1 sortilin 1 increases expression ISO Iron deficiency results in increased expression of SORT1 mRNA CTD PMID:20368581 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression EXP Iron deficiency results in increased expression of SOX9 mRNA CTD PMID:16629162 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp6 Sp6 transcription factor increases expression EXP Iron deficiency results in increased expression of SP6 mRNA CTD PMID:16629162 NCBI chr10:84,950,751...84,961,368
Ensembl chr10:84,955,864...84,960,045
JBrowse link
G Spr sepiapterin reductase increases expression EXP Iron deficiency results in increased expression of SPR mRNA CTD PMID:16629162 NCBI chr 4:116,912,343...116,916,073
Ensembl chr 4:116,912,351...116,916,236
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Iron co-treated with Deferoxamine] results in increased expression of SQSTM1 protein; Iron affects the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of SQSTM1 protein] CTD PMID:25301941 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:23100159 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Steap2 STEAP2 metalloreductase increases reduction
increases uptake
ISO STEAP2 protein results in increased reduction of Iron
STEAP2 protein results in increased uptake of Iron
CTD PMID:16609065 NCBI chr 4:25,506,604...25,527,088
Ensembl chr 4:25,507,463...25,527,087
JBrowse link
G Steap3 STEAP3 metalloreductase affects metabolic processing
increases uptake
increases reduction
ISO STEAP3 protein affects the metabolism of Iron
STEAP3 protein results in increased uptake of Iron
STEAP3 protein results in increased reduction of Iron
CTD PMID:16609065, PMID:17194590 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Steap4 STEAP4 metalloreductase increases reduction
increases uptake
ISO STEAP4 protein results in increased reduction of Iron
STEAP4 protein results in increased uptake of Iron
CTD PMID:16609065 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO STK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]] CTD PMID:19620254 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Sulf2 sulfatase 2 increases expression ISO Iron deficiency results in increased expression of SULF2 mRNA CTD PMID:20368581 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 decreases expression ISO Iron deficiency results in decreased expression of TASL mRNA CTD PMID:20368581 NCBI chr  X:54,390,733...54,409,466
Ensembl chr  X:54,390,733...54,409,466
JBrowse link
G Tert telomerase reverse transcriptase increases activity EXP Iron results in increased activity of TERT protein CTD PMID:17189828 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tes testin LIM domain protein increases expression ISO Iron deficiency results in increased expression of TES mRNA CTD PMID:20368581 NCBI chr 4:44,321,883...44,360,407
Ensembl chr 4:44,321,883...44,360,405
JBrowse link
G Tf transferrin multiple interactions
affects binding
increases expression
increases uptake
affects metabolic processing
ISO
EXP
[Aluminum binds to TF protein] which results in decreased uptake of Iron; [Iron binds to TF protein] which results in decreased uptake of Iron; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Iron; ammonium ferric sulfate promotes the reaction [TF protein results in increased uptake of Iron]; cobaltous chloride inhibits the reaction [TF protein results in increased uptake of Iron]; cuprous chloride inhibits the reaction [TF protein results in increased uptake of Iron]; ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron]; ferric chloride promotes the reaction [TF protein results in increased uptake of Iron]; ferrous sulfate promotes the reaction [TF protein results in increased uptake of Iron]; gallium nitrate promotes the reaction [TF protein results in increased uptake of Iron]; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and affects the transport of Iron; zinc chloride inhibits the reaction [TF protein results in increased uptake of Iron]
[Iron binds to TF protein] which binds to TFRC protein; [TF protein binds to Iron] which binds to TFRC protein; CP protein binds to [TF protein binds to Iron]; Iron binds to TF protein; TF protein binds to Iron
Iron deficiency results in increased expression of TF protein
[Iron deficiency co-treated with Manganese] results in increased expression of TF protein; [Melatonin results in increased expression of TF protein] which affects the abundance of Iron; [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron; Copper deficiency results in decreased expression of [Iron binds to TF protein]
TRF protein affects the metabolism of Iron
CTD PMID:2039817, PMID:2308257, PMID:8782865, PMID:11193083, PMID:11335103, PMID:15214510, PMID:16564538, PMID:16793765, PMID:16819174, PMID:16988841, PMID:17060373, PMID:17194590, PMID:17266333, PMID:17327678, PMID:18571630, PMID:19859668, PMID:20164366, PMID:21049900, PMID:22873711 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tff1 trefoil factor 1 increases expression EXP Iron deficiency results in increased expression of TFF1 mRNA CTD PMID:16629162 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tfr2 transferrin receptor 2 multiple interactions
decreases expression
affects metabolic processing
increases uptake
affects response to substance
ISO
EXP
[HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of TFR2 protein]
Iron deficiency results in decreased expression of TFR2 protein
TFR2 protein affects the metabolism of Iron
TFR2 protein mutant form results in increased uptake of Iron
TFR2 protein affects the susceptibility to Iron
[HFE protein binds to TFR2 protein] which affects the susceptibility to Iron
CTD PMID:16893896, PMID:16935854, PMID:17018382, PMID:17194590, PMID:17241880, PMID:19061943, PMID:20164366, PMID:22383097, PMID:22457245 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
G Tfrc transferrin receptor increases expression
affects binding
decreases expression
increases uptake
multiple interactions
affects expression
affects metabolic processing
ISO
EXP
Iron results in increased expression of TFRC protein
Iron deficiency results in increased expression of TFRC mRNA; Iron results in increased expression of TFRC mRNA
[Iron binds to TF protein] which binds to TFRC protein; [TF protein binds to Iron] which binds to TFRC protein
Iron deficiency results in increased expression of TFRC mRNA; Iron deficiency results in increased expression of TFRC protein
Iron results in decreased expression of TFRC mRNA
TFRC protein results in increased uptake of Iron
[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC protein; Clofibrate inhibits the reaction [Iron deficiency results in increased expression of TFRC mRNA]
Iron affects the expression of TFRC mRNA; Iron affects the expression of TFRC protein
TFRC protein affects the metabolism of Iron
[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA; [Iron co-treated with Ethanol] results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein; Iron inhibits the reaction [Diethylnitrosamine results in increased expression of TFRC protein]; Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of TFRC mRNA]
[Deferoxamine results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron; [GGTI 298 results in decreased expression of TFRC protein] which results in decreased uptake of Iron; [Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]
CTD PMID:10085150, PMID:11068183, PMID:11969379, PMID:12393473, PMID:16428268, PMID:16564538, PMID:16629162, PMID:16988052, PMID:16988136, PMID:17060373, PMID:17091493, PMID:17101452, PMID:17194590, PMID:18073202, PMID:19061943, PMID:19859668, PMID:20302851, PMID:22457245, PMID:23776592, PMID:24569067, PMID:24964743 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Iron promotes the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA] CTD PMID:11306436, PMID:12475806 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP Iron deficiency results in increased expression of TGIF1 mRNA CTD PMID:16629162 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tmem154 transmembrane protein 154 increases expression ISO Iron deficiency results in increased expression of TMEM154 mRNA CTD PMID:20368581 NCBI chr 2:183,674,361...183,714,232
Ensembl chr 2:183,674,522...183,711,812
JBrowse link
G Tmem252 transmembrane protein 252 increases expression EXP Iron deficiency results in increased expression of TMEM252 mRNA CTD PMID:16629162 NCBI chr 1:242,572,558...242,577,817
Ensembl chr 1:242,572,533...242,577,817
JBrowse link
G Tmem45b transmembrane protein 45b decreases expression EXP Iron deficiency results in decreased expression of TMEM45B mRNA CTD PMID:16629162 NCBI chr 8:32,563,872...32,609,212
Ensembl chr 8:32,563,874...32,609,212
JBrowse link
G Tmem86a transmembrane protein 86A increases expression EXP Iron deficiency results in increased expression of TMEM86A mRNA CTD PMID:16629162 NCBI chr 1:103,173,032...103,177,382
Ensembl chr 1:103,172,987...103,177,417
JBrowse link
G Tmprss6 transmembrane serine protease 6 affects abundance ISO TMPRSS6 gene SNP affects the abundance of Iron CTD PMID:19820698, PMID:19820699 NCBI chr 7:119,659,323...119,689,953
Ensembl chr 7:119,659,324...119,689,938
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases uptake
decreases abundance
increases secretion
increases expression
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased secretion of TNF protein]; [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of TNF protein; lipopolysaccharide A promotes the reaction [Iron results in increased secretion of TNF protein]; MAP3K14 protein affects the reaction [Iron results in increased secretion of TNF protein]; MAP3K7 protein affects the reaction [Iron results in increased secretion of TNF protein]; PIK3R1 protein affects the reaction [Iron results in increased secretion of TNF protein]; TNF protein affects the transport of and results in decreased abundance of Iron; U 0126 inhibits the reaction [Iron results in increased secretion of TNF protein]
TNF protein results in increased uptake of Iron
TNF protein results in decreased abundance of Iron
Iron results in increased expression of TNF mRNA
[Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; TNF gene SNP promotes the reaction [HFE protein mutant form results in increased uptake of Iron]
CTD PMID:10865941, PMID:12633744, PMID:16566752, PMID:16793930, PMID:16890145, PMID:16958088, PMID:17172471, PMID:19900513, PMID:22198552 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Iron deficiency results in increased expression of TNFSF10 mRNA CTD PMID:20368581 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tppp3 tubulin polymerization-promoting protein family member 3 increases expression EXP Iron deficiency results in increased expression of TPPP3 mRNA CTD PMID:16629162 NCBI chr19:37,424,323...37,428,075
Ensembl chr19:37,424,324...37,427,989
JBrowse link
G Treml2 triggering receptor expressed on myeloid cells-like 2 increases expression ISO Iron deficiency results in increased expression of TREML2 mRNA CTD PMID:20368581 NCBI chr 9:14,659,967...14,668,313
Ensembl chr 9:14,660,738...14,668,297
JBrowse link
G Trim27 tripartite motif-containing 27 increases expression EXP Iron deficiency results in increased expression of TRIM27 mRNA CTD PMID:16629162 NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases uptake ISO TRPC6 protein results in increased uptake of Iron CTD PMID:14640978 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Tshz1 teashirt zinc finger homeobox 1 increases expression EXP Iron deficiency results in increased expression of TSHZ1 mRNA CTD PMID:16629162 NCBI chr18:80,860,995...80,907,744
Ensembl chr18:80,862,372...80,865,584
JBrowse link
G Tshz3 teashirt zinc finger homeobox 3 increases expression ISO Iron deficiency results in increased expression of TSHZ3 mRNA CTD PMID:20368581 NCBI chr 1:92,703,180...92,775,020
Ensembl chr 1:92,703,080...92,774,975
JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO [3-aminopyridine-2-carboxaldehyde thiosemicarbazone binds to Iron] which results in increased oxidation of TXN2 protein CTD PMID:21195754 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 decreases expression ISO Iron deficiency results in decreased expression of UBE2E1 mRNA CTD PMID:20368581 NCBI chr15:8,124,869...8,178,252
Ensembl chr15:8,125,526...8,177,781
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of UGT1A6 mRNA CTD PMID:22198552 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression EXP Iron deficiency results in decreased expression of UGT2B17 mRNA CTD PMID:16629162 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 decreases expression EXP Iron deficiency results in decreased expression of UGT2B15 mRNA CTD PMID:16629162 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
G Urod uroporphyrinogen decarboxylase decreases activity
multiple interactions
ISO
EXP
Iron results in decreased activity of UROD protein
Iron inhibits the reaction [Ethinyl Estradiol results in increased activity of UROD protein]
CTD PMID:3945969, PMID:12030801 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12633744 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor increases expression ISO Iron deficiency results in increased expression of VDR mRNA CTD PMID:20368581 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vsig10l V-set and immunoglobulin domain containing 10 like decreases expression EXP Iron deficiency results in decreased expression of VSIG10L mRNA CTD PMID:16629162 NCBI chr 1:98,458,691...98,467,444
Ensembl chr 1:98,459,834...98,467,262
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Iron deficiency results in increased expression of WIPI1 mRNA CTD PMID:20368581 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Zfp503 zinc finger protein 503 increases expression EXP Iron deficiency results in increased expression of ZFP503 mRNA CTD PMID:16629162 NCBI chr15:2,374,582...2,378,370
Ensembl chr15:2,374,582...2,378,370
JBrowse link
ferbam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO ferbam results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
ferric ammonium citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 increases activity
decreases activity
ISO ferric ammonium citrate results in increased activity of ACO1 protein
ferric ammonium citrate results in decreased activity of ACO1 protein
CTD PMID:11054110, PMID:18073202 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 multiple interactions
increases activity
ISO ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
ferric ammonium citrate results in increased activity of ACO2 protein
CTD PMID:16625280 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:32283200 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein] CTD PMID:24862973 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Anxa3 annexin A3 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein] CTD PMID:19515424 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] CTD PMID:19515424 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO ferric ammonium citrate results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:17191120, PMID:26318285, PMID:27481217 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein] CTD PMID:12807743 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO ferric ammonium citrate results in decreased expression of COL1A1 mRNA CTD PMID:19735707 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:26318285, PMID:27481217 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:32283200 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein] CTD PMID:19515424 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions
ISO ferric ammonium citrate results in increased expression of F3 mRNA
Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]
CTD PMID:25858758 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein] CTD PMID:32283200 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA
ferric ammonium citrate results in increased expression of FTL1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]
CTD PMID:12393473, PMID:19913091 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein] CTD PMID:19515424 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein] CTD PMID:19515424 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression
ISO Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
ferric ammonium citrate results in increased expression of HMOX1 protein
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]
CTD PMID:12393473, PMID:16439612 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein] CTD PMID:19515424 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein] CTD PMID:19515424 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein] CTD PMID:24862973 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein] CTD PMID:24862973 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]] CTD PMID:32283200 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ireb2 iron responsive element binding protein 2 decreases expression
decreases activity
EXP
ISO
ferric ammonium citrate results in decreased expression of IREB2 protein
ferric ammonium citrate results in decreased activity of IREB2 protein
CTD PMID:11054110, PMID:17469137, PMID:18073202 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein] CTD PMID:17350462 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein
ferric ammonium citrate results in increased phosphorylation of MAPK1 protein
CTD PMID:17191120, PMID:25858758 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO ferric ammonium citrate results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein
ferric ammonium citrate results in increased phosphorylation of MAPK3 protein
CTD PMID:17191120, PMID:25858758 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein] CTD PMID:19515424 NCBI chr 9:49,647,257...49,704,828
Ensembl chr 9:49,647,257...49,704,828
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] CTD PMID:32283200 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA] CTD PMID:9826428 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Oga O-GlcNAcase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein] CTD PMID:24862973 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein] CTD PMID:19515424 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] CTD PMID:19515424 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein] CTD PMID:19515424 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Ppia peptidylprolyl isomerase A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein] CTD PMID:19515424 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA] CTD PMID:24862973 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein] CTD PMID:19515424 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A1 mRNA CTD PMID:11054110 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A2 mRNA CTD PMID:11054110 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression
multiple interactions
EXP
ISO
ferric ammonium citrate results in increased expression of SLC40A1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]
CTD PMID:19913091 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA] CTD PMID:24862973 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tf transferrin multiple interactions ISO ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron] CTD PMID:11335103 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfr2 transferrin receptor 2 decreases expression ISO ferric ammonium citrate results in decreased expression of TFR2 protein CTD PMID:25633564 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
ISO ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA
CTD PMID:11054110, PMID:12393473, PMID:16760464, PMID:18073202, PMID:25633564 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein] CTD PMID:24862973 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpd52l1 TPD52 like 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein] CTD PMID:19515424 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein] CTD PMID:19515424 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein] CTD PMID:32283200 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
ferric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatk apoptosis-associated tyrosine kinase increases expression ISO ferric oxide analog results in increased expression of AATK mRNA CTD PMID:25086211 NCBI chr10:109,184,338...109,224,455
Ensembl chr10:109,188,112...109,224,370
JBrowse link
G Ache acetylcholinesterase decreases activity ISO ferric oxide results in decreased activity of ACHE protein CTD PMID:28993115 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression ISO ferric oxide analog results in increased expression of ACSS2 mRNA CTD PMID:25086211 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 increases expression ISO ferric oxide analog results in increased expression of ADGRE1 mRNA CTD PMID:24525745 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Adm adrenomedullin increases expression ISO ferric oxide analog results in increased expression of ADM mRNA CTD PMID:25086211 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO ferric oxide analog results in increased expression of ADORA2B mRNA CTD PMID:25086211 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Ahnak2 AHNAK nucleoprotein 2 increases expression ISO ferric oxide analog results in increased expression of AHNAK2 mRNA CTD PMID:25086211 NCBI chr 6:137,335,273...137,380,219 JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO ferric oxide analog results in increased expression of AHRR mRNA CTD PMID:24525745 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Aig1 androgen-induced 1 increases expression ISO ferric oxide analog results in increased expression of AIG1 mRNA CTD PMID:25086211 NCBI chr 1:7,816,841...8,038,805
Ensembl chr 1:7,816,838...8,038,665
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of AKT1 protein CTD PMID:24847785 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO ferric oxide analog results in decreased expression of ALDH1L2 mRNA CTD PMID:25086211 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Ankrd12 ankyrin repeat domain 12 decreases expression ISO ferric oxide analog results in decreased expression of ANKRD12 mRNA CTD PMID:24525745 NCBI chr 9:113,605,683...113,682,482
Ensembl chr 9:113,605,657...113,682,482
JBrowse link
G Anln anillin, actin binding protein decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of ANLN mRNA
ferric oxide analog results in increased expression of ANLN mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Anxa3 annexin A3 decreases expression ISO ferric oxide analog results in decreased expression of ANXA3 mRNA CTD PMID:25086211 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Ap5b1 adaptor related protein complex 5 subunit beta 1 decreases expression ISO ferric oxide analog results in decreased expression of AP5B1 mRNA CTD PMID:25086211 NCBI chr 1:220,948,318...220,952,349
Ensembl chr 1:220,948,331...220,952,391
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 increases expression ISO ferric oxide analog results in increased expression of ARHGAP24 mRNA CTD PMID:25086211 NCBI chr14:8,383,211...8,600,526
Ensembl chr14:8,383,214...8,600,512
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO ferric oxide analog results in increased expression of ATF3 protein CTD PMID:24068039 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg5 autophagy related 5 increases expression ISO ferric oxide analog results in increased expression of ATG5 protein CTD PMID:24068039 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G B3galnt1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) increases expression ISO ferric oxide analog results in increased expression of B3GALNT1 mRNA CTD PMID:24525745 NCBI chr 2:166,226,736...166,255,978
Ensembl chr 2:166,226,754...166,255,302
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
increases phosphorylation
ISO
EXP
bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]
ferric oxide results in increased expression of BAX protein
ferric oxide results in decreased expression of BAX protein
ferric oxide analog results in increased phosphorylation of BAX protein
CTD PMID:19421372, PMID:22995439, PMID:25086211, PMID:26991130 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation
increases expression
EXP
ISO
ferric oxide analog results in increased phosphorylation of BCL2 protein
ferric oxide analog results in increased expression of BCL2 protein
CTD PMID:22995439, PMID:25086211 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO ferric oxide analog results in increased expression of BCL2L11 mRNA; ferric oxide analog results in increased expression of BCL2L11 protein CTD PMID:24525745, PMID:25086211 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 increases expression ISO ferric oxide analog results in increased expression of BDH2 mRNA CTD PMID:25086211 NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
JBrowse link
G Becn1 beclin 1 decreases expression
increases expression
ISO ferric oxide results in decreased expression of BECN1 protein
ferric oxide analog results in increased expression of BECN1 protein
CTD PMID:24068039, PMID:25086211 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO ferric oxide analog results in increased expression of BHLHE40 mRNA CTD PMID:25086211 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Canx calnexin decreases expression ISO ferric oxide results in decreased expression of CANX protein CTD PMID:25086211 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]
ferric oxide results in increased cleavage of CASP3 protein
CTD PMID:19421372, PMID:26991130 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 increases expression ISO ferric oxide analog results in increased expression of CASTOR1 mRNA CTD PMID:25086211 NCBI chr14:84,447,552...84,457,396
Ensembl chr14:84,447,885...84,452,367
JBrowse link
G Cat catalase decreases activity
decreases expression
ISO ferric oxide results in decreased activity of CAT protein
ferric oxide results in decreased expression of CAT protein
CTD PMID:19699289, PMID:26991130, PMID:28993115 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc85b coiled-coil domain containing 85B increases expression ISO ferric oxide analog results in increased expression of CCDC85B mRNA CTD PMID:25086211 NCBI chr 1:220,835,647...220,837,220 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO ferric oxide results in increased secretion of CCL2 protein CTD PMID:24885771 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases secretion ISO ferric oxide results in increased secretion of CCL22 protein CTD PMID:24885771 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO ferric oxide results in increased secretion of CCL3 protein CTD PMID:24885771 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression
increases secretion
ISO ferric oxide analog results in decreased expression of CCL4 mRNA
ferric oxide results in increased secretion of CCL4 protein
CTD PMID:24525745, PMID:24885771 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases secretion ISO ferric oxide results in increased secretion of CCL7 protein CTD PMID:24885771 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Cd14 CD14 molecule decreases expression ISO ferric oxide analog results in decreased expression of CD14 mRNA CTD PMID:25086211 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd274 CD274 molecule increases expression ISO ferric oxide analog results in increased expression of CD274 mRNA CTD PMID:25086211 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd74 CD74 molecule decreases expression ISO ferric oxide analog results in decreased expression of CD74 mRNA CTD PMID:25086211 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cd83 CD83 molecule increases expression ISO ferric oxide analog results in increased expression of CD83 mRNA CTD PMID:24525745, PMID:25086211 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP ferric oxide analog results in increased expression of CDKN1A protein CTD PMID:22995439 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein CTD PMID:24847785 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO ferric oxide analog results in decreased expression of CDKN2A mRNA CTD PMID:24525745 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cep83 centrosomal protein 83 decreases expression ISO ferric oxide analog results in decreased expression of CEP83 mRNA CTD PMID:24525745 NCBI chr 7:35,739,553...35,847,618
Ensembl chr 7:35,773,928...35,847,617
JBrowse link
G Clec5a C-type lectin domain containing 5A decreases expression ISO ferric oxide analog results in decreased expression of CLEC5A mRNA CTD PMID:25086211 NCBI chr 4:68,810,330...68,819,921
Ensembl chr 4:68,808,359...68,819,928
JBrowse link
G Clk4 CDC-like kinase 4 increases expression ISO ferric oxide analog results in increased expression of CLK4 mRNA CTD PMID:25086211 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO ferric oxide analog results in decreased expression of COX6A2 mRNA CTD PMID:25086211 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
JBrowse link
G Csnk1e casein kinase 1, epsilon increases expression ISO ferric oxide analog results in increased expression of CSNK1E mRNA CTD PMID:25086211 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO ferric oxide analog results in decreased expression of CX3CR1 mRNA CTD PMID:25086211 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO ferric oxide analog results in increased expression of CXCR4 mRNA CTD PMID:25086211 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15211619 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of DDIT3 mRNA; ferric oxide analog results in increased expression of DDIT3 protein
ferric oxide analog results in decreased expression of DDIT3 mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO ferric oxide analog results in decreased expression of DDIT4 mRNA CTD PMID:24525745 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dgkg diacylglycerol kinase, gamma decreases expression ISO ferric oxide analog results in decreased expression of DGKG mRNA CTD PMID:25086211 NCBI chr11:81,971,585...82,165,111
Ensembl chr11:81,972,219...82,163,165
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO ferric oxide analog results in decreased expression of DUSP1 mRNA CTD PMID:25086211 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO ferric oxide analog results in increased expression of DUSP4 mRNA CTD PMID:25086211 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO ferric oxide analog results in decreased expression of EEF1A1 mRNA CTD PMID:25086211 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO ferric oxide analog results in increased phosphorylation of EGFR protein CTD PMID:24068039 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 decreases expression ISO ferric oxide analog results in decreased expression of EGR1 mRNA CTD PMID:25086211 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 increases expression ISO ferric oxide analog results in increased expression of EGR2 mRNA CTD PMID:24525745, PMID:25086211 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO ferric oxide analog results in decreased expression of EIF2AK2 mRNA CTD PMID:25086211 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eno2 enolase 2 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of ENO2 mRNA
ferric oxide analog results in decreased expression of ENO2 mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Epn2 epsin 2 increases expression ISO ferric oxide analog results in increased expression of EPN2 mRNA CTD PMID:25086211 NCBI chr10:47,795,496...47,857,373
Ensembl chr10:47,795,524...47,857,326
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ferric oxide analog results in increased expression of and results in increased phosphorylation of ERN1 protein CTD PMID:25086211 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fam214a family with sequence similarity 214, member A increases expression ISO ferric oxide analog results in increased expression of FAM214A mRNA CTD PMID:25086211 NCBI chr 8:81,863,619...81,941,548
Ensembl chr 8:81,863,619...81,941,536
JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression ISO ferric oxide analog results in increased expression of FBLIM1 mRNA CTD PMID:25086211 NCBI chr 5:160,122,466...160,158,921
Ensembl chr 5:160,122,425...160,158,386
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of FOS mRNA
ferric oxide analog results in increased expression of FOS mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fus FUS RNA binding protein decreases expression ISO ferric oxide analog results in decreased expression of FUS mRNA CTD PMID:25086211 NCBI chr 1:199,412,805...199,426,705
Ensembl chr 1:199,412,834...199,426,702
JBrowse link
G Fyb1 FYN binding protein 1 decreases expression ISO ferric oxide analog results in decreased expression of FYB mRNA CTD PMID:25086211 NCBI chr 2:55,834,904...55,983,805
Ensembl chr 2:55,835,151...55,983,804
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases phosphorylation EXP ferric oxide analog results in increased phosphorylation of GADD45A protein CTD PMID:22995439 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO ferric oxide analog results in increased expression of GADD45B mRNA CTD PMID:25086211 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO ferric oxide analog results in increased expression of GJA1 mRNA CTD PMID:25086211 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO ferric oxide analog results in increased expression of GPR183 mRNA CTD PMID:24525745 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Gpr84 G protein-coupled receptor 84 decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of GPR84 mRNA
ferric oxide analog results in increased expression of GPR84 mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 7:144,934,606...144,937,194
Ensembl chr 7:144,934,610...144,936,803
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Benzo(a)pyrene co-treated with ferric oxide] results in increased activity of GSR protein CTD PMID:11033230 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein] CTD PMID:27270449 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO ferric oxide analog results in decreased expression of H2BC9 mRNA CTD PMID:24525745, PMID:25086211 NCBI chr17:44,519,815...44,520,269
Ensembl chr17:44,519,860...44,520,240
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO ferric oxide analog results in increased expression of HBEGF mRNA CTD PMID:25086211 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Heatr3 HEAT repeat containing 3 decreases expression ISO ferric oxide analog results in decreased expression of HEATR3 mRNA CTD PMID:25086211 NCBI chr19:19,858,419...19,896,782
Ensembl chr19:19,858,416...19,896,421
JBrowse link
G Hebp1 heme binding protein 1 increases expression ISO ferric oxide analog results in increased expression of HEBP1 mRNA CTD PMID:25086211 NCBI chr 4:168,903,586...168,933,102
Ensembl chr 4:168,903,565...168,933,079
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO ferric oxide analog results in increased expression of HILPDA mRNA CTD PMID:25086211 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hist1h2bq histone cluster 1 H2B family member Q decreases expression ISO ferric oxide analog results in decreased expression of H2BC7 mRNA CTD PMID:24525745, PMID:25086211 NCBI chr17:43,679,925...43,689,311
Ensembl chr17:43,679,925...43,689,311
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E increases expression
decreases expression
ISO ferric oxide analog results in increased expression of H2BC21 mRNA
ferric oxide analog results in decreased expression of H2BC11 mRNA
CTD PMID:25086211 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378
JBrowse link
G Hist2h3c2 histone cluster 2 H3 family member C2 decreases expression ISO ferric oxide analog results in decreased expression of H3C1 mRNA CTD PMID:25086211 NCBI chr 2:198,390,024...198,418,075
Ensembl chr 2:198,417,619...198,418,029
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ferric oxide analog results in increased expression of HMOX1 mRNA CTD PMID:24525745, PMID:25086211 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 increases expression ISO ferric oxide analog results in increased expression of HSD3B7 mRNA CTD PMID:25086211 NCBI chr 1:199,248,084...199,251,745
Ensembl chr 1:199,248,470...199,251,740
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA1A mRNA CTD PMID:20540983 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA8 mRNA CTD PMID:20540983 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO ferric oxide results in decreased expression of HSPD1 protein CTD PMID:28077287 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hyal1 hyaluronidase 1 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of HYAL1 mRNA
ferric oxide analog results in decreased expression of HYAL1 mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO ferric oxide results in increased expression of ICAM1 protein CTD PMID:21439359 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Icam2 intercellular adhesion molecule 2 decreases expression ISO ferric oxide analog results in decreased expression of ICAM2 mRNA CTD PMID:25086211 NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO ferric oxide analog results in increased expression of ID1 mRNA CTD PMID:24525745 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO ferric oxide analog results in increased expression of ID3 mRNA CTD PMID:24525745 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha decreases expression ISO ferric oxide analog results in decreased expression of IL10RA mRNA CTD PMID:25086211 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO ferric oxide analog results in increased secretion of IL1B protein
ferric oxide results in increased secretion of IL1B protein
CTD PMID:24525745, PMID:24885771 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL2 protein CTD PMID:20540983 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL4 protein; ferric oxide inhibits the reaction [Ovalbumin results in increased expression of IL4 protein] CTD PMID:20540983, PMID:23147377 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL5 protein CTD PMID:20540983 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL6 protein
ferric oxide results in increased secretion of IL6 protein
ferric oxide analog results in increased secretion of IL6 protein
CTD PMID:20540983, PMID:24525745, PMID:24885771 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO ferric oxide analog results in decreased expression of IRF7 mRNA CTD PMID:25086211 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP ferric oxide analog results in increased phosphorylation of JUN protein CTD PMID:22995439 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression ISO ferric oxide analog results in decreased expression of KLF2 mRNA CTD PMID:25086211 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Klf4 Kruppel like factor 4 decreases expression ISO ferric oxide analog results in decreased expression of KLF4 mRNA CTD PMID:25086211 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein CTD PMID:24847785 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO ferric oxide analog results in increased expression of LAMP2 protein CTD PMID:25086211 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 decreases expression ISO ferric oxide analog results in decreased expression of LILR4B mRNA CTD PMID:24525745 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO ferric oxide analog results in increased expression of LIMA1 mRNA CTD PMID:25086211 NCBI chr 7:141,428,113...141,528,447
Ensembl chr 7:141,428,063...141,528,397
JBrowse link
G Lims2 LIM zinc finger domain containing 2 increases expression ISO ferric oxide analog results in increased expression of LIMS2 mRNA CTD PMID:25086211 NCBI chr18:24,707,951...24,746,159
Ensembl chr18:24,708,115...24,746,159
JBrowse link
G LOC684819 similar to H3 histone, family 2 isoform 2 decreases expression ISO ferric oxide analog results in decreased expression of H3C6 mRNA CTD PMID:25086211 NCBI chr17:43,794,397...43,795,493 JBrowse link
G Lst1 leukocyte specific transcript 1 decreases expression ISO ferric oxide analog results in decreased expression of LST1 mRNA CTD PMID:24525745 NCBI chr20:5,175,213...5,179,352
Ensembl chr20:5,176,016...5,179,263
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO ferric oxide analog results in decreased expression of LYZ2 mRNA CTD PMID:25086211 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mafb MAF bZIP transcription factor B increases expression ISO ferric oxide analog results in increased expression of MAFB mRNA CTD PMID:24525745 NCBI chr 3:156,338,993...156,340,913
Ensembl chr 3:156,339,004...156,340,913
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO ferric oxide analog results in increased expression of MAP1LC3A protein CTD PMID:25086211 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO ferric oxide analog results in increased expression of MAP1LC3B protein CTD PMID:24068039 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
ferric oxide analog results in increased phosphorylation of MAPK1 protein
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK1 protein
CTD PMID:24068039, PMID:24847785 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
ferric oxide analog results in increased phosphorylation of MAPK3 protein
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK3 protein
CTD PMID:24068039, PMID:24847785 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of MAT2A mRNA
ferric oxide analog results in increased expression of MAT2A mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Mef2c myocyte enhancer factor 2C decreases expression ISO ferric oxide analog results in decreased expression of MEF2C mRNA CTD PMID:25086211 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA CTD PMID:20540983 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp19 matrix metallopeptidase 19 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP19 mRNA CTD PMID:20540983 NCBI chr 7:3,216,392...3,224,202
Ensembl chr 7:3,216,497...3,224,201
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP2 mRNA CTD PMID:20540983 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp23 matrix metallopeptidase 23 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP23 mRNA CTD PMID:20540983 NCBI chr 5:173,078,811...173,082,834
Ensembl chr 5:173,078,590...173,081,839
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO ferric oxide results in increased expression of MMP7 protein CTD PMID:24885771 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Msmb microseminoprotein, beta affects expression ISO ferric oxide affects the expression of MSMB mRNA CTD PMID:28077287 NCBI chr16:8,280,275...8,300,853
Ensembl chr16:8,280,275...8,300,852
JBrowse link
G Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit increases expression ISO ferric oxide analog results in increased expression of NAA80 mRNA CTD PMID:25086211 NCBI chr 8:116,336,441...116,339,691
Ensembl chr 8:116,336,441...116,339,690
JBrowse link
G Nckap5l NCK-associated protein 5-like decreases expression ISO ferric oxide analog results in decreased expression of NCKAP5L mRNA CTD PMID:24525745 NCBI chr 7:141,081,943...141,093,924
Ensembl chr 7:141,081,943...141,095,691
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO ferric oxide analog results in increased expression of NDRG1 mRNA CTD PMID:25086211 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO ferric oxide analog results in increased expression of NEDD9 mRNA CTD PMID:24525745 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO ferric oxide results in increased expression of NOX4 protein CTD PMID:28077287, PMID:28993115 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Npm3 nucleophosmin/nucleoplasmin, 3 decreases expression ISO ferric oxide analog results in decreased expression of NPM3 mRNA CTD PMID:25086211 NCBI chr 1:265,504,105...265,506,080
Ensembl chr 1:265,504,575...265,506,046
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO ferric oxide analog results in decreased expression of NRP1 mRNA CTD PMID:25086211 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II increases expression ISO ferric oxide analog results in increased expression of NT5C2 mRNA CTD PMID:24525745 NCBI chr 1:266,652,966...266,782,935
Ensembl chr 1:266,659,519...266,782,910
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO ferric oxide analog results in decreased expression of NUPR1 mRNA CTD PMID:24525745 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 decreases expression ISO ferric oxide analog results in decreased expression of OAS2 mRNA CTD PMID:25086211 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO ferric oxide analog results in decreased expression of OASL1 mRNA CTD PMID:25086211 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO ferric oxide analog results in increased cleavage of PARP1 protein
ferric oxide results in decreased expression of and results in increased cleavage of PARP1 protein
ferric oxide results in increased cleavage of PARP1 protein
CTD PMID:26991130, PMID:27270449, PMID:28993115 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pate4 prostate and testis expressed 4 affects expression ISO ferric oxide affects the expression of PATE4 mRNA CTD PMID:28077287 NCBI chr 8:36,815,007...36,817,747
Ensembl chr 8:36,815,007...36,817,747
JBrowse link
G Pcdh7 protocadherin 7 decreases expression ISO ferric oxide analog results in decreased expression of PCDH7 mRNA CTD PMID:25086211 NCBI chr14:54,649,054...55,081,632
Ensembl chr14:55,072,200...55,081,551
JBrowse link
G Per2 period circadian regulator 2 increases expression ISO ferric oxide analog results in increased expression of PER2 mRNA CTD PMID:25086211 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 decreases expression ISO ferric oxide analog results in decreased expression of PES1 mRNA CTD PMID:25086211 NCBI chr14:84,211,600...84,227,980
Ensembl chr14:84,211,600...84,227,978
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO ferric oxide analog results in increased expression of PHLDA1 mRNA CTD PMID:25086211 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 increases expression ISO ferric oxide analog results in increased expression of PLEKHF1 mRNA CTD PMID:25086211 NCBI chr 1:94,609,041...94,616,565
Ensembl chr 1:94,609,377...94,610,854
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO ferric oxide analog results in increased expression of PLK2 mRNA CTD PMID:25086211 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO ferric oxide analog results in increased expression of PLK3 mRNA CTD PMID:25086211 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Plpbp pyridoxal phosphate binding protein increases expression ISO ferric oxide analog results in increased expression of PLPBP mRNA CTD PMID:25086211 NCBI chr16:69,164,654...69,176,245
Ensembl chr16:69,163,577...69,176,036
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO ferric oxide analog results in decreased expression of PPP1R15A mRNA CTD PMID:24525745 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prf1 perforin 1 decreases expression ISO ferric oxide analog results in decreased expression of PRF1 mRNA CTD PMID:24525745 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Prmt6 protein arginine methyltransferase 6 decreases expression ISO ferric oxide analog results in decreased expression of PRMT6 mRNA CTD PMID:25086211 NCBI chr 2:213,173,403...213,180,721
Ensembl chr 2:213,173,403...213,178,632
Ensembl chr 2:213,173,403...213,178,632
JBrowse link
G Prr18 proline rich 18 increases expression ISO ferric oxide analog results in increased expression of PRR18 mRNA CTD PMID:25086211 NCBI chr 1:52,989,076...52,994,843
Ensembl chr 1:52,991,287...52,992,213
JBrowse link
G Prr33 proline rich 33 decreases expression ISO ferric oxide analog results in decreased expression of PRR33 mRNA CTD PMID:25086211 NCBI chr 1:215,658,996...215,666,512
Ensembl chr 1:215,659,713...215,660,492
JBrowse link
G Rab15 RAB15, member RAS oncogene family increases expression ISO ferric oxide analog results in increased expression of RAB15 mRNA CTD PMID:25086211 NCBI chr 6:99,845,952...99,870,320
Ensembl chr 6:99,845,954...99,870,024
JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO ferric oxide analog results in decreased expression of RAD50 mRNA CTD PMID:24525745 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rbak RB-associated KRAB zinc finger increases expression ISO ferric oxide analog results in increased expression of RBAK mRNA CTD PMID:24525745 NCBI chr12:13,428,648...13,442,279
Ensembl chr12:13,428,685...13,442,286
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression ISO ferric oxide analog results in increased expression of RCAN1 mRNA CTD PMID:25086211 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rcbtb2 RCC1 and BTB domain containing protein 2 increases expression ISO ferric oxide analog results in increased expression of RCBTB2 mRNA CTD PMID:24525745 NCBI chr15:55,029,388...55,074,728
Ensembl chr15:55,034,033...55,073,437
JBrowse link
G Rilpl1 Rab interacting lysosomal protein-like 1 decreases expression ISO ferric oxide analog results in decreased expression of RILPL1 mRNA CTD PMID:24525745 NCBI chr12:37,490,320...37,528,393
Ensembl chr12:37,490,584...37,528,784
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein CTD PMID:24847785 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK3 protein CTD PMID:24847785 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-EB1 mRNA CTD PMID:20540983 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-T23 mRNA CTD PMID:20540983 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Rusc2 RUN and SH3 domain containing 2 increases expression ISO ferric oxide analog results in increased expression of RUSC2 mRNA CTD PMID:25086211 NCBI chr 5:58,860,444...58,883,152
Ensembl chr 5:58,855,773...58,882,096
JBrowse link
G Samd9 sterile alpha motif domain containing 9 decreases expression ISO ferric oxide analog results in decreased expression of SAMD9L mRNA CTD PMID:25086211 NCBI chr 4:28,304,967...28,324,637
Ensembl chr 4:28,305,002...28,310,178
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO ferric oxide analog results in decreased expression of SERPINB1A mRNA CTD PMID:24525745 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Skil SKI-like proto-oncogene increases expression ISO ferric oxide analog results in increased expression of SKIL mRNA CTD PMID:24525745 NCBI chr 2:115,862,932...115,891,304
Ensembl chr 2:115,866,701...115,891,097
JBrowse link
G Slamf8 SLAM family member 8 increases expression ISO ferric oxide analog results in increased expression of SLAMF8 mRNA CTD PMID:24525745 NCBI chr13:90,967,862...90,978,752
Ensembl chr13:90,967,739...90,977,734
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression ISO ferric oxide analog results in increased expression of SLC11A1 mRNA CTD PMID:25086211 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slc46a3 solute carrier family 46, member 3 decreases expression ISO ferric oxide analog results in decreased expression of SLC46A3 mRNA CTD PMID:25086211 NCBI chr12:8,725,479...8,741,944
Ensembl chr12:8,725,517...8,741,951
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA CTD PMID:20540983 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO ferric oxide analog results in increased expression of SOD1 protein CTD PMID:24068039 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO ferric oxide analog results in increased expression of SOD2 protein; ferric oxide results in increased expression of SOD2 protein CTD PMID:24068039, PMID:25086211, PMID:26991130 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spata24 spermatogenesis associated 24 decreases expression ISO ferric oxide analog results in decreased expression of SPATA24 mRNA CTD PMID:24525745 NCBI chr18:28,446,592...28,454,724
Ensembl chr18:28,446,589...28,454,756
JBrowse link
G Tatdn2 TatD DNase domain containing 2 decreases expression ISO ferric oxide analog results in decreased expression of TATDN2 mRNA CTD PMID:24525745 NCBI chr 4:145,653,299...145,669,343
Ensembl chr 4:145,653,602...145,669,343
JBrowse link
G Tbc1d2 TBC1 domain family, member 2 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of TBC1D2 mRNA
ferric oxide analog results in decreased expression of TBC1D2 mRNA
CTD PMID:24525745, PMID:25086211 NCBI chr 5:62,213,001...62,261,467
Ensembl chr 5:62,212,982...62,260,105
JBrowse link
G Tbxas1 thromboxane A synthase 1 increases expression ISO ferric oxide analog results in increased expression of TBXAS1 mRNA CTD PMID:24525745 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tf transferrin increases expression EXP ferric oxide results in increased expression of TF mRNA CTD PMID:16428268 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor decreases expression ISO ferric oxide analog results in decreased expression of TFRC mRNA CTD PMID:25086211 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfbi transforming growth factor, beta induced increases expression ISO ferric oxide analog results in increased expression of TGFBI mRNA CTD PMID:24525745 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO ferric oxide analog results in increased expression of TGM2 mRNA CTD PMID:25086211 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TIMP1 mRNA CTD PMID:20540983 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO ferric oxide results in increased expression of TIMP2 protein CTD PMID:24885771 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO ferric oxide analog results in increased expression of TLR2 mRNA CTD PMID:24525745 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem176a transmembrane protein 176A decreases expression ISO ferric oxide analog results in decreased expression of TMEM176A mRNA CTD PMID:25086211 NCBI chr 4:78,458,735...78,462,415
Ensembl chr 4:78,458,625...78,462,423
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TNF protein
ferric oxide results in increased secretion of TNF protein
ferric oxide analog results in increased secretion of TNF protein
CTD PMID:20540983, PMID:24068039, PMID:24525745, PMID:24885771 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression ISO ferric oxide results in increased expression of TNNI3 protein CTD PMID:28993115 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions
EXP ferric oxide analog results in increased phosphorylation of TP53 protein
[ferric oxide analog co-treated with Acrolein] results in increased expression of TP53 protein
CTD PMID:22995439, PMID:24847785 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO ferric oxide analog results in increased expression of TRP53INP1 mRNA CTD PMID:25086211 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tpr translocated promoter region, nuclear basket protein decreases expression ISO ferric oxide analog results in decreased expression of TPR mRNA CTD PMID:24525745 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO ferric oxide analog results in decreased expression of TRIB3 mRNA CTD PMID:24525745 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Ttpal alpha tocopherol transfer protein like decreases expression ISO ferric oxide analog results in decreased expression of TTPAL mRNA CTD PMID:25086211 NCBI chr 3:159,995,013...160,015,314
Ensembl chr 3:159,995,064...160,013,274
JBrowse link
G Tubb2b tubulin, beta 2B class IIb increases expression ISO ferric oxide analog results in increased expression of TUBB2B mRNA CTD PMID:24525745 NCBI chr17:31,441,640...31,444,687
Ensembl chr17:31,441,630...31,482,759
JBrowse link
G Wdfy3 WD repeat and FYVE domain containing 3 increases expression ISO ferric oxide analog results in increased expression of WDFY3 mRNA CTD PMID:24525745 NCBI chr14:9,169,409...9,384,835
Ensembl chr14:9,141,512...9,381,870
JBrowse link
G Yipf7 Yip1 domain family, member 7 increases expression ISO ferric oxide analog results in increased expression of YIPF7 mRNA CTD PMID:25086211 NCBI chr14:62,565,369...62,609,529
Ensembl chr14:62,567,745...62,595,854
JBrowse link
G Zbtb2 zinc finger and BTB domain containing 2 decreases expression ISO ferric oxide analog results in decreased expression of ZBTB2 mRNA CTD PMID:24525745 NCBI chr 1:40,914,175...40,933,586
Ensembl chr 1:40,914,171...40,921,508
JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression ISO ferric oxide analog results in increased expression of ZC3H13 mRNA CTD PMID:24525745 NCBI chr15:57,340,522...57,405,287
Ensembl chr15:57,340,579...57,405,287
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO ferric oxide analog results in increased expression of ZFP36 mRNA CTD PMID:24525745 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
ferric pyrophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tf transferrin multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein CTD PMID:16772442 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein CTD PMID:16772442 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
ferrichrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
ferricyanide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP hexacyanoferrate III results in increased expression of HMOX1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [hexacyanoferrate III results in increased expression of HMOX1 protein]
CTD PMID:16439612 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Por cytochrome p450 oxidoreductase increases reduction EXP POR protein results in increased reduction of hexacyanoferrate III CTD PMID:18678259 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression
multiple interactions
ISO Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]
CTD PMID:16336266 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]
CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:64,600,968...64,714,114
Ensembl chr11:64,601,029...64,714,252
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:27,835,346...27,919,285
Ensembl chr 6:27,887,797...27,915,563
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA
CTD PMID:15539406 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G