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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:arsenic acid
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Accession:CHEBI:18231 term browser browse the term
Definition:An arsenic oxoacid comprising one oxo group and three hydroxy groups attached to a central arsenic atom.
Synonyms:exact_synonym: tetraoxoarsenic acid;   trihydrogen tetraoxoarsenate;   trihydroxidooxidoarsenic
 related_synonym: Formula=AsH3O4;   Formula=H3AsO4;   H3AsO4;   InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5);   InChIKey=DJHGAFSJWGLOIV-UHFFFAOYSA-N;   Orthoarsenic acid;   SMILES=O[As](O)(O)=O;   [AsO(OH)3];   arsoric acid
 alt_id: CHEBI:22631;   CHEBI:2843
 xref: CAS:7778-39-4;   Gmelin:2294;   KEGG:C01478
 xref_mesh: MESH:C025657
 xref: PPDB:2913
 cyclic_relationship: is_conjugate_acid_of CHEBI:22629;   is_conjugate_acid_of CHEBI:48600


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arsenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to arsenic acid; ABCC1 results in decreased susceptibility to arsenic acid CTD PMID:7954421, PMID:21918036, PMID:29752257 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [arsenic acid results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO arsenic acid results in decreased phosphorylation of AKT1 protein CTD PMID:26763397 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase decreases activity EXP arsenic acid results in decreased activity of ALAD protein CTD PMID:15202869 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G As3mt arsenite methyltransferase affects abundance
affects methylation
affects metabolic processing
affects secretion
multiple interactions
ISO
EXP
AS3MT protein affects the abundance of arsenic acid
AS3MT protein affects the methylation of arsenic acid
AS3MT protein affects the metabolism of arsenic acid
AS3MT protein affects the secretion of arsenic acid
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]
CTD PMID:15606138, PMID:19691357 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO arsenic acid results in increased expression of BCL2 mRNA CTD PMID:8946558 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp12 caspase 12 increases activity EXP arsenic acid results in increased activity of CASP12 protein CTD PMID:18226606 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Cat catalase multiple interactions EXP [CAT protein results in decreased oxidation of arsenite] which results in decreased chemical synthesis of arsenic acid CTD PMID:18619986 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
increases expression
ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of COL3A1 mRNA] CTD PMID:18296743 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO arsenic acid results in increased expression of CXCL1 mRNA CTD PMID:18296743 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO arsenic acid results in decreased expression of DPP4 mRNA CTD PMID:29355690 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO arsenic acid results in increased phosphorylation of EGFR protein
EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]
CTD PMID:14674888 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elk1 ETS transcription factor ELK1 increases activity EXP arsenic acid results in increased activity of ELK1 protein CTD PMID:10445758 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Folr2 folate receptor beta decreases response to substance ISO FOLR2 results in decreased susceptibility to arsenic acid CTD PMID:14745917 NCBI chr 1:166,915,045...166,933,377
Ensembl chr 1:166,915,045...166,919,302
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP arsenic acid results in increased expression of FOS CTD PMID:10445758 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 affects localization ISO arsenic acid affects the localization of FOXO1 protein CTD PMID:26763397 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 affects localization ISO arsenic acid affects the localization of FOXO3 protein CTD PMID:26763397 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Glb1 galactosidase, beta 1 increases activity ISO arsenic acid results in increased activity of GLB1 protein CTD PMID:26763397 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO arsenic acid results in increased expression of GPX1 mRNA; arsenic acid results in increased expression of GPX1 protein CTD PMID:19429247 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO arsenic acid results in decreased expression of GPX2 mRNA CTD PMID:19429247 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO arsenic acid results in increased expression of GPX4 mRNA; arsenic acid results in increased expression of GPX4 protein CTD PMID:19429247 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions ISO arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein] CTD PMID:14674888 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression EXP arsenic acid analog results in decreased expression of GRIA1 mRNA CTD PMID:19761793 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP arsenic acid analog results in decreased expression of GRIA2 mRNA CTD PMID:19761793 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases reduction ISO GSTO1 protein results in increased reduction of arsenic acid CTD PMID:16930657 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP arsenic acid results in increased expression of HMOX1 protein CTD PMID:18226606 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects methylation ISO arsenic acid affects the methylation of HSD11B1 gene CTD PMID:26855884 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO arsenic acid results in increased expression of HSD11B2 mRNA CTD PMID:26855884 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of IL6 mRNA] CTD PMID:18296743 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases activity ISO arsenic acid results in increased activity of MAP2K1 protein CTD PMID:14674888 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases activity ISO arsenic acid results in increased activity of MAP2K2 protein CTD PMID:14674888 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions
ISO arsenic acid results in increased activity of MAPK1 protein
EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]
CTD PMID:14674888 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
ISO EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein] CTD PMID:14674888 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP
ISO
arsenic acid results in increased expression of MYC
arsenic acid results in increased expression of MYC mRNA
CTD PMID:10445758, PMID:29355690 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO arsenic acid affects the localization of NFE2L2 protein
Sodium Selenite promotes the reaction [arsenic acid affects the localization of NFE2L2 protein]
CTD PMID:19429247 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases methylation
increases expression
ISO arsenic acid results in decreased methylation of NR3C1 gene
arsenic acid results in increased expression of NR3C1 mRNA
CTD PMID:26855884 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Otc ornithine transcarbamylase increases reduction EXP OTC protein results in increased reduction of arsenic acid CTD PMID:19248796 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO PAPSS1 protein binds to and affects the metabolism of arsenic acid CTD PMID:15065880 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772
JBrowse link
G Pnp purine nucleoside phosphorylase increases reduction
increases metabolic processing
multiple interactions
ISO PNP protein results in increased reduction of arsenic acid
PNP protein results in increased metabolism of arsenic acid
[PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite
CTD PMID:12928150, PMID:15929903 NCBI chr15:27,875,883...27,883,566
Ensembl chr15:27,875,911...27,883,350
JBrowse link
G Selenof selenoprotein F decreases expression ISO arsenic acid results in decreased expression of SELENOF mRNA CTD PMID:19429247 NCBI chr 2:250,600,823...250,633,903
Ensembl chr 2:250,600,823...250,633,897
JBrowse link
G Selenoh selenoprotein H decreases expression ISO arsenic acid results in decreased expression of SELENOH mRNA CTD PMID:19429247 NCBI chr 3:72,070,342...72,071,909
Ensembl chr 3:72,070,390...72,071,895
JBrowse link
G Selenoi selenoprotein I decreases expression ISO arsenic acid results in decreased expression of SELENOI mRNA CTD PMID:19429247 NCBI chr 6:27,473,748...27,512,287
Ensembl chr 6:27,473,748...27,512,287
JBrowse link
G Selenok selenoprotein K decreases expression ISO arsenic acid results in decreased expression of SELENOK mRNA CTD PMID:19429247 NCBI chr16:6,035,926...6,044,240
Ensembl chr16:6,035,926...6,044,239
JBrowse link
G Selenom selenoprotein M decreases expression ISO arsenic acid results in decreased expression of SELENOM mRNA CTD PMID:19429247 NCBI chr14:83,752,393...83,754,975
Ensembl chr14:83,752,393...83,754,973
JBrowse link
G Selenos selenoprotein S decreases expression ISO arsenic acid results in decreased expression of SELENOS mRNA CTD PMID:19429247 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Shc1 SHC adaptor protein 1 increases phosphorylation
multiple interactions
ISO arsenic acid results in increased phosphorylation of SHC1 protein
arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein]
CTD PMID:14674888 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Si sucrase-isomaltase decreases expression ISO arsenic acid results in decreased expression of SI mRNA CTD PMID:29355690 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348
JBrowse link
G Snca synuclein alpha decreases expression EXP arsenic acid results in decreased expression of SNCA CTD PMID:25639566 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Stk4 serine/threonine kinase 4 increases phosphorylation ISO arsenic acid results in increased phosphorylation of STK4 protein CTD PMID:26763397 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of TIMP1 mRNA] CTD PMID:18296743 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO arsenic acid results in increased expression of TIMP2 mRNA CTD PMID:18296743 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
ISO arsenic acid results in increased secretion of TNF protein
arsenic acid results in increased expression of TNF mRNA
CTD PMID:9548797, PMID:18296743 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO arsenic acid results in increased expression of TRP53 mRNA CTD PMID:8946558 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity
multiple interactions
increases expression
ISO arsenic acid results in increased activity of TXNRD1 protein
Sodium Selenite promotes the reaction [arsenic acid results in increased activity of TXNRD1 protein]
arsenic acid results in increased expression of TXNRD1 mRNA; arsenic acid results in increased expression of TXNRD1 protein
CTD PMID:19429247 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vil1 villin 1 decreases expression ISO arsenic acid results in decreased expression of VIL1 mRNA CTD PMID:29355690 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        metalloid atom 12072
          arsenic atom 10422
            arsenic molecular entity 10422
              arsenic oxoacid 3499
                arsenic acid 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              oxoacid 18241
                                pnictogen oxoacid 10179
                                  arsenic oxoacid 3499
                                    arsenic acid 55
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.