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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoeugenol
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Accession:CHEBI:18224 term browser browse the term
Definition:A phenylpropanoid that is an isomer of eugenol in which the allyl substituent is replaced by a prop-1-enyl group.
Synonyms:exact_synonym: 2-methoxy-4-(prop-1-en-1-yl)phenol
 related_synonym: 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene;   1-Hydroxy-2-methoxy-4-propenylbenzene;   2-Methoxy-4-propenylphenol;   3-Methoxy-4-hydroxypropenylbenzene;   4-Hydroxy-3-methoxypropenylbenzene;   4-Propenylguaiacol;   Formula=C10H12O2;   InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3-7,11H,1-2H3;   InChIKey=BJIOGJUNALELMI-UHFFFAOYSA-N;   Propenylguaiacol;   SMILES=COc1cc(C=CC)ccc1O
 alt_id: CHEBI:14466;   CHEBI:6007
 xref: Beilstein:1909602;   CAS:97-54-1;   Gmelin:2235523;   KEGG:C10469
 xref_mesh: MESH:C036643
 xref: PMID:11033063;   PMID:17573874;   PMID:17698059;   PMID:18416757;   PMID:21969073;   PMID:21989800;   PMID:22613214;   PMID:22671430;   PMID:22686307;   PMID:22827268;   PMID:23047101;   PMID:23161090;   PMID:23281757;   PMID:23286982;   PMID:23306890;   PMID:23391906;   PMID:23627552;   PMID:29079364;   PMID:9084914;   Reaxys:1909602;   Wikipedia:Isoeugenol


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isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor increases activity
affects localization
multiple interactions
ISO isoeugenol results in increased activity of AHR protein
isoeugenol affects the localization of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr13:74,211,118...74,292,331
Ensembl chr13:74,211,118...74,292,331
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases expression ISO isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases activity
increases expression
ISO isoeugenol results in increased activity of AKR1C2 promoter
isoeugenol results in increased expression of AKR1C2 mRNA
CTD PMID:20491607, PMID:21195160 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Ar androgen receptor affects binding ISO isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Cat catalase increases expression ISO isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases secretion ISO isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl27a chemokine (C-C motif) ligand 27A increases expression ISO isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 4:41,769,467...41,774,225
Ensembl chr 4:41,769,467...41,774,247
JBrowse link
G Cd274 CD274 antigen increases expression ISO isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of CXCL8 mRNA; KT 5720 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]
isoeugenol results in increased expression of CXCL8 mRNA; isoeugenol results in increased expression of CXCL8 protein
CTD PMID:21284934, PMID:21920952, PMID:21969073, PMID:25617811, PMID:31734321 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression EXP isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Fech ferrochelatase increases expression ISO isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gsr glutathione reductase increases expression ISO isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Ifng interferon gamma increases secretion EXP isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il18 interleukin 18 increases expression ISO isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il2 interleukin 2 multiple interactions
increases secretion
EXP isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 increases secretion EXP isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,791,536...139,802,653
Ensembl chr 5:139,791,513...139,802,653
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mt1 metallothionein 1 increases expression ISO isoeugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Olfr73 olfactory receptor 73 multiple interactions EXP isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr 2:88,034,196...88,035,137
Ensembl chr 2:88,032,288...88,037,699
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:10871845, PMID:17698059 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trim16 tripartite motif-containing 16 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr11:62,820,198...62,842,948
Ensembl chr11:62,820,231...62,850,808
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO
EXP
isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Zfp36 zinc finger protein 36 increases expression
multiple interactions
ISO isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr 7:28,376,784...28,379,228
Ensembl chr 7:28,376,784...28,380,253
JBrowse link
trans-isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor affects localization
increases activity
multiple interactions
ISO isoeugenol affects the localization of AHR protein
isoeugenol results in increased activity of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr13:74,211,118...74,292,331
Ensembl chr13:74,211,118...74,292,331
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases expression ISO isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases activity
increases expression
ISO isoeugenol results in increased activity of AKR1C2 promoter
isoeugenol results in increased expression of AKR1C2 mRNA
CTD PMID:20491607, PMID:21195160 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Ar androgen receptor affects binding ISO isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Cat catalase increases expression ISO isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases secretion ISO isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl27a chemokine (C-C motif) ligand 27A increases expression ISO isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 4:41,769,467...41,774,225
Ensembl chr 4:41,769,467...41,774,247
JBrowse link
G Cd274 CD274 antigen increases expression ISO isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of CXCL8 mRNA; KT 5720 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]
isoeugenol results in increased expression of CXCL8 mRNA; isoeugenol results in increased expression of CXCL8 protein
CTD PMID:21284934, PMID:21920952, PMID:21969073, PMID:25617811, PMID:31734321 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression EXP isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Fech ferrochelatase increases expression ISO isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gsr glutathione reductase increases expression ISO isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Ifng interferon gamma increases secretion EXP isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il18 interleukin 18 increases expression ISO isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il2 interleukin 2 multiple interactions
increases secretion
EXP isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 increases secretion EXP isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,791,536...139,802,653
Ensembl chr 5:139,791,513...139,802,653
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mt1 metallothionein 1 increases expression ISO isoeugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Olfr73 olfactory receptor 73 multiple interactions EXP isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr 2:88,034,196...88,035,137
Ensembl chr 2:88,032,288...88,037,699
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:10871845, PMID:17698059 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trim16 tripartite motif-containing 16 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr11:62,820,198...62,842,948
Ensembl chr11:62,820,231...62,850,808
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO
EXP
isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Zfp36 zinc finger protein 36 increases expression
multiple interactions
ISO isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr 7:28,376,784...28,379,228
Ensembl chr 7:28,376,784...28,380,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21475
    role 21452
      biological role 21451
        aetiopathogenetic role 20539
          sensitiser 9997
            isoeugenol 62
              3-methylisoeugenol 0
              5-methylisoeugenol 0
              6-methylisoeugenol 0
              cis-isoeugenol 0
              isoeugenol sulfate 0
              trans-isoeugenol + 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 21475
    subatomic particle 21460
      composite particle 21460
        hadron 21460
          baryon 21460
            nucleon 21460
              atomic nucleus 21460
                atom 21460
                  main group element atom 21360
                    p-block element atom 21360
                      carbon group element atom 21147
                        carbon atom 21045
                          organic molecular entity 21045
                            organic molecule 20935
                              organic cyclic compound 20496
                                carbocyclic compound 19120
                                  benzenoid aromatic compound 17778
                                    benzenes 17404
                                      methoxybenzenes 1848
                                        monomethoxybenzene 1750
                                          guaiacols 1372
                                            guaiacol 1323
                                              isoeugenol 62
                                                3-methylisoeugenol 0
                                                5-methylisoeugenol 0
                                                6-methylisoeugenol 0
                                                cis-isoeugenol 0
                                                isoeugenol sulfate 0
                                                trans-isoeugenol + 62
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.