Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoeugenol
go back to main search page
Accession:CHEBI:18224 term browser browse the term
Definition:A phenylpropanoid that is an isomer of eugenol in which the allyl substituent is replaced by a prop-1-enyl group.
Synonyms:exact_synonym: 2-methoxy-4-(prop-1-en-1-yl)phenol
 related_synonym: 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene;   1-Hydroxy-2-methoxy-4-propenylbenzene;   2-Methoxy-4-propenylphenol;   3-Methoxy-4-hydroxypropenylbenzene;   4-Hydroxy-3-methoxypropenylbenzene;   4-Propenylguaiacol;   Formula=C10H12O2;   InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3-7,11H,1-2H3;   InChIKey=BJIOGJUNALELMI-UHFFFAOYSA-N;   Propenylguaiacol;   SMILES=COc1cc(C=CC)ccc1O
 alt_id: CHEBI:14466;   CHEBI:6007
 xref: Beilstein:1909602;   CAS:97-54-1;   Gmelin:2235523;   KEGG:C10469
 xref_mesh: MESH:C036643
 xref: PMID:11033063;   PMID:17573874;   PMID:17698059;   PMID:18416757;   PMID:21969073;   PMID:21989800;   PMID:22613214;   PMID:22671430;   PMID:22686307;   PMID:22827268;   PMID:23047101;   PMID:23161090;   PMID:23281757;   PMID:23286982;   PMID:23306890;   PMID:23391906;   PMID:23627552;   PMID:29079364;   PMID:9084914;   Reaxys:1909602;   Wikipedia:Isoeugenol


show annotations for term's descendants           Sort by:
 
isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor increases activity
affects localization
multiple interactions
EXP isoeugenol results in increased activity of AHR protein
isoeugenol affects the localization of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AHRR aryl-hydrocarbon receptor repressor increases expression EXP isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 5:321,714...438,285
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases expression EXP isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression
increases activity
EXP isoeugenol results in increased expression of AKR1C2 mRNA
isoeugenol results in increased activity of AKR1C2 promoter
CTD PMID:20491607, PMID:21195160 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AR androgen receptor affects binding ISO isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G CAT catalase increases expression EXP isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases secretion EXP isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL27 C-C motif chemokine ligand 27 increases expression EXP isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 9:34,661,890...34,662,657
Ensembl chr 9:34,661,880...34,664,048
JBrowse link
G CD274 CD274 molecule increases expression EXP isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP [Indomethacin co-treated with isoeugenol] results in increased expression of CXCL8 mRNA; KT 5720 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]
isoeugenol results in increased expression of CXCL8 mRNA; isoeugenol results in increased expression of CXCL8 protein
CTD PMID:21284934, PMID:21920952, PMID:21969073, PMID:25617811, PMID:31734321 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G FECH ferrochelatase increases expression EXP isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
G FTL ferritin light chain increases expression EXP isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression EXP isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP
ISO
isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP isoeugenol results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G IFNG interferon gamma increases secretion ISO isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL18 interleukin 18 increases expression EXP isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha increases expression ISO isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL2 interleukin 2 multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 increases secretion ISO isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAFG MAF bZIP transcription factor G increases expression EXP isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G ME1 malic enzyme 1 increases expression EXP isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MT1X metallothionein 1X increases expression EXP isoeugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OR5D18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr11:55,819,630...55,820,571
Ensembl chr11:55,819,607...55,820,597
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:10871845, PMID:17698059 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G TLR2 toll like receptor 2 increases expression EXP isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP
ISO
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRIM16 tripartite motif containing 16 multiple interactions
increases expression
EXP [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr17:15,627,966...15,684,311
Ensembl chr17:15,627,960...15,684,311
JBrowse link
G TXN2 thioredoxin 2 increases expression EXP isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP
ISO
isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases expression EXP isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G ZFP36 ZFP36 ring finger protein increases expression
multiple interactions
EXP isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
JBrowse link
trans-isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor affects localization
increases activity
multiple interactions
EXP isoeugenol affects the localization of AHR protein
isoeugenol results in increased activity of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AHRR aryl-hydrocarbon receptor repressor increases expression EXP isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 5:321,714...438,285
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases expression EXP isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression
increases activity
EXP isoeugenol results in increased expression of AKR1C2 mRNA
isoeugenol results in increased activity of AKR1C2 promoter
CTD PMID:20491607, PMID:21195160 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AR androgen receptor affects binding ISO isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G CAT catalase increases expression EXP isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases secretion EXP isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL27 C-C motif chemokine ligand 27 increases expression EXP isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 9:34,661,890...34,662,657
Ensembl chr 9:34,661,880...34,664,048
JBrowse link
G CD274 CD274 molecule increases expression EXP isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP [Indomethacin co-treated with isoeugenol] results in increased expression of CXCL8 mRNA; KT 5720 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of CXCL8 mRNA]
isoeugenol results in increased expression of CXCL8 mRNA; isoeugenol results in increased expression of CXCL8 protein
CTD PMID:21284934, PMID:21920952, PMID:21969073, PMID:25617811, PMID:31734321 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G FECH ferrochelatase increases expression EXP isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
G FTL ferritin light chain increases expression EXP isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression EXP isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP
ISO
isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP isoeugenol results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G IFNG interferon gamma increases secretion ISO isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL18 interleukin 18 increases expression EXP isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha increases expression ISO isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL2 interleukin 2 multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 increases secretion ISO isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAFG MAF bZIP transcription factor G increases expression EXP isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G ME1 malic enzyme 1 increases expression EXP isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MT1X metallothionein 1X increases expression EXP isoeugenol results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OR5D18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr11:55,819,630...55,820,571
Ensembl chr11:55,819,607...55,820,597
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:10871845, PMID:17698059 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G TLR2 toll like receptor 2 increases expression EXP isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP
ISO
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRIM16 tripartite motif containing 16 multiple interactions
increases expression
EXP [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr17:15,627,966...15,684,311
Ensembl chr17:15,627,960...15,684,311
JBrowse link
G TXN2 thioredoxin 2 increases expression EXP isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP
ISO
isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases expression EXP isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G ZFP36 ZFP36 ring finger protein increases expression
multiple interactions
EXP isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24358
    role 24265
      biological role 24232
        aetiopathogenetic role 23021
          sensitiser 10283
            isoeugenol 64
              3-methylisoeugenol 0
              5-methylisoeugenol 0
              6-methylisoeugenol 0
              cis-isoeugenol 0
              isoeugenol sulfate 0
              trans-isoeugenol + 64
Path 2
Term Annotations click to browse term
  CHEBI ontology 24358
    subatomic particle 24314
      composite particle 24314
        hadron 24314
          baryon 24314
            nucleon 24314
              atomic nucleus 24314
                atom 24314
                  main group element atom 24159
                    p-block element atom 24159
                      carbon group element atom 23935
                        carbon atom 23891
                          organic molecular entity 23891
                            organic molecule 23768
                              organic cyclic compound 23036
                                carbocyclic compound 21564
                                  benzenoid aromatic compound 19125
                                    benzenes 18649
                                      methoxybenzenes 1983
                                        monomethoxybenzene 1890
                                          guaiacols 1511
                                            guaiacol 1461
                                              isoeugenol 64
                                                3-methylisoeugenol 0
                                                5-methylisoeugenol 0
                                                6-methylisoeugenol 0
                                                cis-isoeugenol 0
                                                isoeugenol sulfate 0
                                                trans-isoeugenol + 64
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.