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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gamma-tocopherol
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Accession:CHEBI:18185 term browser browse the term
Definition:A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.
Synonyms:exact_synonym: (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
 related_synonym: (2R)-3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol;   (2R,4'R,8'R)-gamma-tocopherol;   (R,R,R)-gamma-tocopherol;   7,8-dimethyltocol;   D-gamma-tocopherol;   E308;   Formula=C28H48O2;   InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1;   InChIKey=QUEDXNHFTDJVIY-DQCZWYHMSA-N;   RRR-gamma-tocopherol;   SMILES=CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2cc(O)c(C)c(C)c2O1
 alt_id: CHEBI:10579;   CHEBI:12406;   CHEBI:24199;   MESH:D024504
 xref: AGR:IND605428769;   AGR:IND607289207;   CAS:54-28-4;   Chemspider:83708;   DrugBank:DB15394;   FooDB:FDB002431;   HMDB:HMDB0001492;   KEGG:C02483;   KNApSAcK:C00007365;   LIPID_MAPS_instance:LMPR02020065
 xref_mesh: MESH:D024505
 xref: MetaCyc:GAMA-TOCOPHEROL;   PMID:10875465;   PMID:1146729;   PMID:11811542;   PMID:14871472;   PMID:14988604;   PMID:15189696;   PMID:15190048;   PMID:15213374;   PMID:15256801;   PMID:15493460;   PMID:15753151;   PMID:15932790;   PMID:16115338;   PMID:16336861;   PMID:16384840;   PMID:16400056;   PMID:16481153;   PMID:16875031;   PMID:17823432;   PMID:18582912;   PMID:19838939;   PMID:22411374;   PMID:22513202;   PMID:22607470;   PMID:22888664;   PMID:23429409;   PMID:2388136;   PMID:23993952;   PMID:25501796;   PMID:25916693;   PMID:28211759;   PMID:28506847;   PMID:28629117;   PMID:30361021;   PMID:31136626;   PMID:31583056;   PMID:31957471;   PMID:32065446;   PMID:32197490;   PMID:32488024;   PMID:33352218;   PMID:33549947;   PMID:6618108;   PMID:6875389;   PMID:6959572;   PMID:8514270;   PMID:9537614;   PMID:9808643;   Reaxys:93072;   Wikipedia:Gamma-Tocopherol


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gamma-tocopherol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions		 ISO Tocopherols results in decreased activity of ABCC1 protein
Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]		 CTD PMID:15617835 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Alb albumin multiple interactions EXP gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA] CTD PMID:19389874 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G App amyloid beta precursor protein decreases abundance
multiple interactions		 EXP APP protein modified form results in decreased abundance of Tocopherols
resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols]		 CTD PMID:25654502 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor decreases expression
decreases activity		 ISO [Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein
Tocopherols results in decreased activity of AR protein		 CTD PMID:12032296 PMID:16302272 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arf3 ARF GTPase 3 increases expression ISO Tocopherols results in increased expression of ARF3 mRNA CTD PMID:17654050 NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002 		JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO Tocopherols results in increased expression of ASPM mRNA CTD PMID:17056531 NCBI chr13:53,625,584...53,674,489
Ensembl chr13:51,074,849...51,123,755 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression ISO Tocopherols results in increased expression of ATP1A2 mRNA CTD PMID:17654050 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression ISO Tocopherols results in increased expression of ATP1B2 mRNA CTD PMID:17654050 NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,318,701...54,324,933 		JBrowse link
G Aurka aurora kinase A increases expression ISO Tocopherols results in increased expression of AURKA mRNA CTD PMID:17056531 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
increases expression
multiple interactions		 ISO BAX protein results in increased susceptibility to Tocopherols
gamma-Tocopherol results in increased expression of BAX mRNA
[Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA		 CTD PMID:16001965 PMID:31587439 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases response to substance
decreases expression
multiple interactions		 ISO Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Tocopherols
gamma-Tocopherol results in decreased expression of BCL2 mRNA
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA		 CTD PMID:8970189 PMID:16001965 PMID:31587439 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Tocopherols results in increased expression of BIRC5 mRNA CTD PMID:17056531 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma increases expression ISO Tocopherols results in increased expression of CAMK2G mRNA CTD PMID:17654050 NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,504,085...3,563,050 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in increased activity of CASP3 protein
thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein]
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]		 CTD PMID:15596715 PMID:22389237 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO gamma-Tocopherol results in increased activity of CASP9 protein CTD PMID:15596715 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase increases expression ISO gamma-Tocopherol results in increased expression of CAT protein CTD PMID:19115203 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Tocopherols results in increased expression of CCNB2 mRNA CTD PMID:17056531 NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO gamma-Tocopherol results in decreased expression of CCND1 mRNA; gamma-Tocopherol results in decreased expression of CCND1 protein; Tocopherols results in decreased expression of CCND1 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCND1 mRNA		 CTD PMID:12368234 PMID:12504091 PMID:31587439 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Tocopherols results in decreased expression of CCND3 protein CTD PMID:12504091 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions		 ISO gamma-Tocopherol results in decreased expression of CCNE1 mRNA; gamma-Tocopherol results in decreased expression of CCNE1 protein; Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCNE1 mRNA		 CTD PMID:12368234 PMID:12504091 PMID:31587439 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Tocopherols results in increased expression of CDC6 mRNA CTD PMID:17056531 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Tocopherols results in increased expression of CDK1 mRNA CTD PMID:17056531 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Tocopherols results in decreased expression of CDK2 protein CTD PMID:12504091 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein CTD PMID:12504091 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Tocopherols results in increased expression of CDK5R1 mRNA CTD PMID:17654050 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO gamma-Tocopherol results in decreased expression of CDKN1A protein CTD PMID:12368234 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO gamma-Tocopherol results in decreased expression of CDKN1B protein CTD PMID:12368234 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO gamma-Tocopherol results in decreased expression of CDKN2A protein CTD PMID:12368234 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Clec4e C-type lectin domain family 4, member E increases expression ISO Tocopherols results in increased expression of CLEC4E mRNA CTD PMID:17056531 NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:156,607,614...156,612,767 		JBrowse link
G Cplx1 complexin 1 increases expression ISO Tocopherols results in increased expression of CPLX1 mRNA CTD PMID:17654050 NCBI chr14:1,329,073...1,360,781 JBrowse link
G Cplx2 complexin 2 increases expression ISO Tocopherols results in increased expression of CPLX2 mRNA CTD PMID:17654050 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 multiple interactions ISO [Tretinoin co-treated with gamma-Tocopherol] results in increased expression of CRABP2 mRNA CTD PMID:15225641 NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein CTD PMID:18191645 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression ISO Tocopherols results in increased expression of CSF1R mRNA CTD PMID:17056531 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO Tocopherols results in increased expression of CSRP2 mRNA CTD PMID:17056531 NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:46,348,686...46,367,745 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] CTD PMID:22389237 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression ISO Tocopherols results in increased expression of DNAJC5 mRNA CTD PMID:17654050 NCBI chr 3:188,999,508...189,033,455
Ensembl chr 3:168,621,969...168,655,935 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Tocopherols results in increased expression of E2F1 protein CTD PMID:15883045 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Egr1 early growth response 1 decreases activity ISO Tocopherols results in decreased activity of EGR1 protein CTD PMID:15878867 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] CTD PMID:22389237 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] CTD PMID:22389237 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fcer1a Fc epsilon receptor Ia increases expression ISO Tocopherols results in increased expression of FCER1A mRNA CTD PMID:17056531 NCBI chr13:88,218,427...88,224,723
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase increases expression ISO Tocopherols results in increased expression of FES mRNA CTD PMID:17056531 NCBI chr 1:143,746,945...143,756,181
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Tocopherols results in decreased expression of FGF1 mRNA CTD PMID:15878867 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Tocopherols results in decreased expression of FGF2 mRNA CTD PMID:15878867 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO Tocopherols results in decreased expression of FGFR1 mRNA CTD PMID:15144885 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fkbp9 FKBP prolyl isomerase 9 increases expression ISO Tocopherols results in increased expression of FKBP9 mRNA CTD PMID:17056531 NCBI chr 4:87,436,439...87,486,909
Ensembl chr 4:86,106,282...86,156,721 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein CTD PMID:8970189 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] CTD PMID:22389237 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression ISO Tocopherols results in increased expression of GRIA2 mRNA CTD PMID:17654050 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression ISO Tocopherols results in increased expression of GRIN1 mRNA CTD PMID:17654050 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in increased expression of GSTM1 mRNA; gamma-Tocopherol results in increased expression of GSTM1 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]		 CTD PMID:19115203 PMID:22389237 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases activity ISO Tocopherols results in decreased activity of GSTO1 protein CTD PMID:16781109 NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Haspin histone H3 associated protein kinase increases expression ISO Tocopherols results in increased expression of HASPIN mRNA CTD PMID:17056531 NCBI chr10:58,246,244...58,249,031
Ensembl chr10:57,747,573...57,750,512 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in increased expression of HMOX1 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]		 CTD PMID:19115203 PMID:22389237 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein CTD PMID:8970189 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif20a kinesin family member 20A increases expression ISO Tocopherols results in increased expression of KIF20A mRNA CTD PMID:17056531 NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,230,230...26,238,780 		JBrowse link
G Kif4a kinesin family member 4A increases expression ISO Tocopherols results in increased expression of KIF4 mRNA CTD PMID:17056531 NCBI chr  X:69,761,803...69,864,335
Ensembl chr  X:65,721,779...65,824,139 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions		 ISO [Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of KLK3 mRNA; Tocopherols results in decreased expression of KLK3 protein
Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]; Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]		 CTD PMID:12032296 PMID:16302272 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA] CTD PMID:19389874 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
decreases activity		 ISO Tocopherols results in decreased expression of MYC mRNA
Tocopherols results in decreased activity of MYC protein		 CTD PMID:8970189 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Napb NSF attachment protein beta increases expression ISO Tocopherols results in increased expression of NAPB mRNA CTD PMID:17654050 NCBI chr 3:156,585,394...156,632,418
Ensembl chr 3:136,133,428...136,179,345 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in increased expression of NFE2L2 mRNA; gamma-Tocopherol results in increased expression of NFE2L2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]		 CTD PMID:19115203 PMID:22389237 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] CTD PMID:22389237 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase increases expression ISO Tocopherols results in increased expression of NSF mRNA CTD PMID:17654050 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression		 EXP [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]
Tocopherols results in decreased expression of PCNA		 CTD PMID:17927505 PMID:22389237 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in increased expression of PPARG mRNA; gamma-Tocopherol results in increased expression of PPARG protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]		 CTD PMID:14521714 PMID:22389237 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO Tocopherols results in increased expression of PRTN3 mRNA CTD PMID:17056531 NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in decreased activity of PTGS2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]		 CTD PMID:15225597 PMID:22389237 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O increases expression ISO Tocopherols results in increased expression of PTPRO mRNA CTD PMID:17056531 NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:170,164,431...170,374,771 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Tocopherols results in increased expression of RAB11B mRNA CTD PMID:17654050 NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family increases expression ISO Tocopherols results in increased expression of RAB3A mRNA CTD PMID:17654050 NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Rab6b RAB6B, member RAS oncogene family increases expression ISO Tocopherols results in increased expression of RAB6B mRNA CTD PMID:17654050 NCBI chr 8:112,574,223...112,642,911
Ensembl chr 8:103,695,631...103,805,732 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tocopherols results in decreased phosphorylation of RB1 protein CTD PMID:12504091 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression ISO Tocopherols results in increased expression of RRM1 mRNA CTD PMID:17056531 NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO Tocopherols results in increased expression of RRM2 mRNA CTD PMID:17056531 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Snca synuclein alpha increases expression ISO Tocopherols results in increased expression of SNCA mRNA CTD PMID:17654050 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sncb synuclein, beta increases expression ISO Tocopherols results in increased expression of SNCB mRNA CTD PMID:17654050 NCBI chr17:9,851,825...9,860,143
Ensembl chr17:9,846,802...9,855,012 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO gamma-Tocopherol results in increased expression of SOD1 protein CTD PMID:19115203 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Stx1a syntaxin 1A increases expression ISO Tocopherols results in increased expression of STX1A mRNA CTD PMID:17654050 NCBI chr12:27,278,517...27,306,547
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression ISO Tocopherols results in increased expression of STXBP1 mRNA CTD PMID:17654050 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a increases expression ISO Tocopherols results in increased expression of SV2A mRNA CTD PMID:17654050 NCBI chr 2:186,430,363...186,446,161
Ensembl chr 2:183,741,547...183,756,927 		JBrowse link
G Syn1 synapsin I increases expression ISO Tocopherols results in increased expression of SYN1 mRNA CTD PMID:17654050 NCBI chr  X:3,725,745...3,780,940
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Syn2 synapsin II increases expression ISO Tocopherols results in increased expression of SYN2 mRNA CTD PMID:17654050 NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:148,186,270...148,344,192 		JBrowse link
G Syngr1 synaptogyrin 1 increases expression ISO Tocopherols results in increased expression of SYNGR1 mRNA CTD PMID:17654050 NCBI chr 7:111,635,911...111,659,341
Ensembl chr 7:111,635,918...111,659,341 		JBrowse link
G Syp synaptophysin increases expression ISO Tocopherols results in increased expression of SYP mRNA CTD PMID:17654050 NCBI chr  X:17,521,348...17,536,449
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Syt11 synaptotagmin 11 increases expression ISO Tocopherols results in increased expression of SYT11 mRNA CTD PMID:17654050 NCBI chr 2:176,503,845...176,530,354
Ensembl chr 2:174,206,191...174,231,964 		JBrowse link
G Syt13 synaptotagmin 13 increases expression ISO Tocopherols results in increased expression of SYT13 mRNA CTD PMID:17654050 NCBI chr 3:99,332,554...99,372,960
Ensembl chr 3:78,877,114...78,917,392 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein
Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium]		 CTD PMID:17337591 PMID:18191645 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip2 TNF alpha induced protein 2 increases expression ISO Tocopherols results in increased expression of TNFAIP2 mRNA CTD PMID:17056531 NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:130,476,889...130,489,914 		JBrowse link
G Tp53 tumor protein p53 increases activity ISO Tocopherols results in increased activity of TP53 protein CTD PMID:15883045 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression ISO Tocopherols results in increased expression of TTC3 mRNA CTD PMID:17654050 NCBI chr11:47,158,766...47,258,612
Ensembl chr11:33,688,952...33,788,975 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions		 ISO
EXP		 gamma-Tocopherol results in increased expression of UGT1A1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]		 CTD PMID:19115203 PMID:22389237 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression ISO Tocopherols results in increased expression of VAMP1 mRNA CTD PMID:17654050 NCBI chr 4:159,698,894...159,705,582
Ensembl chr 4:158,012,663...158,019,349 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression ISO Tocopherols results in increased expression of VAMP2 mRNA CTD PMID:17654050 NCBI chr10:54,292,423...54,296,657
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vdr vitamin D receptor increases expression ISO Tocopherols results in increased expression of VDR mRNA CTD PMID:12032296 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      chemical role 19483
        antioxidant 16181
          vitamin E 1874
            gamma-tocopherol 99
              13-hydroxy-gamma-tocopherol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  oxacycle 17906
                                    benzopyran 11990
                                      1-benzopyran 11744
                                        chromanes 4027
                                          chromanol 1874
                                            chroman-6-ol 1874
                                              tocol 266
                                                tocopherol 242
                                                  gamma-tocopherol 99
                                                    13-hydroxy-gamma-tocopherol 0
paths to the root