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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-oxo-L-proline
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Accession:CHEBI:18183 term browser browse the term
Definition:An optically active form of 5-oxoproline having L-configuration.
Synonyms:exact_synonym: (2S)-5-oxopyrrolidine-2-carboxylic acid
 related_synonym: (S)-(-)-2-pyrrolidone-5-carboxylic acid;   (S)-pyroglutamic acid;   5-Pyrrolidone-2-carboxylic acid;   Formula=C5H7NO3;   InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1;   InChIKey=ODHCTXKNWHHXJC-VKHMYHEASA-N;   L-5-Pyrrolidone-2-carboxylic acid;   L-Pyroglutamic acid;   PYROGLUTAMIC ACID;   Pyroglutamate;   SMILES=OC(=O)[C@@H]1CCC(=O)N1;   pidolic acid
 alt_id: CHEBI:12153;   CHEBI:20619;   CHEBI:2113;   CHEBI:44704
 xref: Beilstein:5251861;   Beilstein:82132;   CAS:98-79-3;   DrugBank:DB03088;   Gmelin:1125330;   HMDB:HMDB0000267;   KEGG:C01879;   KNApSAcK:C00007403
 xref_mesh: MESH:D011761
 xref: MetaCyc:5-OXOPROLINE;   PDBeChem:PCA;   PMID:17439666;   PMID:22560249;   PMID:22619187;   Reaxys:82132;   Wikipedia:Pyroglutamic_acid;   YMDB:YMDB00107
 cyclic_relationship: is_conjugate_acid_of CHEBI:58402;   is_enantiomer_of CHEBI:16924


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5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
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G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        osmolyte 2045
          compatible osmolytes 353
            L-proline 271
              L-proline derivative 255
                5-oxo-L-proline 2
                  5-oxo-L-proline residue 0
                  N-terminal 5-oxo-L-proline residue 0
                  pyroglutamylglycine 0
                  pyroglutamylvaline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                lactam 8048
                                                  gamma-lactam 6282
                                                    pyrrolidin-2-ones 140
                                                      5-oxoproline 2
                                                        5-oxo-L-proline 2
                                                          5-oxo-L-proline residue 0
                                                          N-terminal 5-oxo-L-proline residue 0
                                                          pyroglutamylglycine 0
                                                          pyroglutamylvaline 0
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