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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydrogen halide
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Accession:CHEBI:18140 term browser browse the term
Synonyms:related_synonym: Formula=HX;   HX;   SMILES=[F,Cl,Br,I];   hydrogen halides
 alt_id: CHEBI:13368;   CHEBI:37140;   CHEBI:5599



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hydrogen chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
increases expression
EXP 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein] CTD PMID:15044056 PMID:15607125 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aqp4 aquaporin 4 increases expression EXP Hydrochloric Acid results in increased expression of AQP4 protein CTD PMID:18406487 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Areg amphiregulin decreases expression ISO Hydrochloric Acid results in decreased expression of AREG mRNA CTD PMID:15046208 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO Hydrochloric Acid results in increased expression of BAG3 mRNA CTD PMID:15046208 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Hydrochloric Acid results in increased expression of BGLAP CTD PMID:17183249 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA CTD PMID:29618784 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance EXP CALCA protein affects the susceptibility to Hydrochloric Acid CTD PMID:19483072 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 decreases expression ISO Hydrochloric Acid results in decreased expression of CASP3 protein modified form CTD PMID:15046208 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 decreases expression ISO Hydrochloric Acid results in decreased expression of CASP9 mRNA CTD PMID:15046208 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP
ISO
CAT protein inhibits the reaction [Hydrochloric Acid results in increased susceptibility to Indomethacin]
[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein]
CTD PMID:1887894 PMID:32531310 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 protein]
Hydrochloric Acid results in increased expression of CCL2 mRNA; Hydrochloric Acid results in increased expression of CCL2 protein
CTD PMID:16129981 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of CCL4 mRNA; Hydrochloric Acid results in increased expression of CCL4 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 protein]
CTD PMID:16129981 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccna1 cyclin A1 increases expression ISO Hydrochloric Acid results in increased expression of CCNA1 mRNA CTD PMID:15046208 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Hydrochloric Acid results in increased expression of CCND1 mRNA CTD PMID:15046208 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydrochloric Acid results in increased expression of CCNE1 mRNA CTD PMID:15046208 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Hydrochloric Acid results in increased expression of CCNE2 mRNA CTD PMID:15046208 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein] CTD PMID:29743441 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects localization ISO Hydrochloric Acid affects the localization of CDKN1B protein CTD PMID:20818264 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression EXP Hydrochloric Acid results in decreased expression of CHRM3 protein CTD PMID:20719367 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression
EXP JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 mRNA]
Hydrochloric Acid results in increased expression of CXCL1 mRNA; Hydrochloric Acid results in increased expression of CXCL1 protein
CTD PMID:15044056 PMID:16129981 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of CXCL2 mRNA; Hydrochloric Acid results in increased expression of CXCL2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 protein]
CTD PMID:16129981 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]
CTD PMID:29618784 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Dpys dihydropyrimidinase increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of DPYS mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]
CTD PMID:29618784 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Hydrochloric Acid results in decreased expression of DUSP2 mRNA CTD PMID:15046208 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
JBrowse link
G Dusp8 dual specificity phosphatase 8 decreases expression ISO Hydrochloric Acid results in decreased expression of DUSP8 mRNA CTD PMID:15046208 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Hydrochloric Acid results in increased expression of E2F5 mRNA CTD PMID:15046208 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Edn1 endothelin 1 increases expression EXP Hydrochloric Acid results in increased expression of EDN1 protein CTD PMID:19262391 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Efna4 ephrin A4 increases expression ISO Hydrochloric Acid results in increased expression of EFNA4 mRNA CTD PMID:15046208 NCBI chr 2:174,748,729...174,752,979
Ensembl chr 2:174,748,724...174,752,979
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
EXP Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Hydrochloric Acid results in increased expression of EMP1 mRNA CTD PMID:15046208 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Hydrochloric Acid results in decreased expression of FGF2 mRNA CTD PMID:15046208 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO Hydrochloric Acid results in increased expression of FGFR3 mRNA CTD PMID:15046208 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein; Capsaicin inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; Hexamethonium inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; SB 222200 affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]; vofopitant affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]
Hydrochloric Acid results in increased expression of FOS mRNA; Hydrochloric Acid results in increased expression of FOS protein
CTD PMID:11730984 PMID:12588467 PMID:12928072 PMID:14750966 PMID:16162281 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Hydrochloric Acid results in decreased expression of FOSL2 mRNA CTD PMID:15046208 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO Hydrochloric Acid results in decreased expression of GADD45A mRNA CTD PMID:15046208 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA] CTD PMID:29618784 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA] CTD PMID:29618784 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gls glutaminase multiple interactions
increases expression
ISO [Hydrochloric Acid results in decreased expression of GLS protein] which results in increased secretion of Ammonia
Hydrochloric Acid results in increased expression of GLS mRNA; Hydrochloric Acid results in increased expression of GLS protein
CTD PMID:20719974 PMID:29618784 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein] CTD PMID:20719974 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA] CTD PMID:29618784 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA] CTD PMID:29618784 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gtpbp2 GTP binding protein 2 decreases expression ISO Hydrochloric Acid results in decreased expression of GTPBP2 mRNA CTD PMID:15046208 NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA CTD PMID:29618784 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP beraprost inhibits the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein]; Capsaicin promotes the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein] CTD PMID:18617559 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 affects response to substance ISO HSF1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17189318 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects response to substance EXP HSPA1A protein affects the susceptibility to Hydrochloric Acid CTD PMID:16945336
G Hspa1b heat shock protein family A (Hsp70) member 1B affects response to substance EXP HSPA1B protein affects the susceptibility to Hydrochloric Acid CTD PMID:15338365 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
EXP
ISO
Hydrochloric Acid results in increased expression of ICAM1 mRNA
Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of ICAM1 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein]
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of ICAM1 mRNA]
CTD PMID:16129981 PMID:29743441 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Hydrochloric Acid results in increased expression of ID2 mRNA CTD PMID:15046208 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP
ISO
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]
Hydrochloric Acid results in increased expression of IL1B protein
CTD PMID:15309881 PMID:25478868 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il5 interleukin 5 increases expression EXP Hydrochloric Acid results in increased expression of IL5 protein CTD PMID:19951613 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]
Hydrochloric Acid results in increased expression of IL6 mRNA; Hydrochloric Acid results in increased expression of IL6 protein
CTD PMID:11850527 PMID:12771618 PMID:15044056 PMID:15607125 PMID:19951613 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases activity
decreases expression
EXP Hydrochloric Acid results in decreased activity of KCNA4 protein
Hydrochloric Acid results in decreased expression of KCNA4 protein
CTD PMID:19279288 NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
JBrowse link
G Kdm5b lysine demethylase 5B decreases expression ISO Hydrochloric Acid results in decreased expression of KDM5B mRNA CTD PMID:15046208 NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Hydrochloric Acid results in decreased expression of MCL1 mRNA CTD PMID:15046208 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO Hydrochloric Acid results in increased expression of MCM4 mRNA CTD PMID:15046208 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Mif macrophage migration inhibitory factor increases expression EXP Hydrochloric Acid results in increased expression of MIF mRNA; Hydrochloric Acid results in increased expression of MIF protein CTD PMID:12853844 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression EXP Hydrochloric Acid results in increased expression of MMP1 protein CTD PMID:11850527 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
EXP
ISO
Hydrochloric Acid results in increased activity of MPO protein
[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein; [Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein; [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]
CTD PMID:11574821 PMID:15309881 PMID:25478868 PMID:27780710 PMID:32006539 More... NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
multiple interactions
increases response to substance
EXP
ISO
Hydrochloric Acid results in increased localization of NFE2L2 protein
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]
CTD PMID:18617559 PMID:29618784 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
affects response to substance
EXP
ISO
pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]
NOS2 protein affects the susceptibility to Hydrochloric Acid
CTD PMID:11574821 PMID:12646421 PMID:12771618 PMID:18573544 PMID:24122261 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP Hydrochloric Acid results in decreased expression of NOS3 protein CTD PMID:12771618 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 affects response to substance ISO NOX1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:21339339 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of NQO1 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]
CTD PMID:29618784 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Hydrochloric Acid results in increased expression of PCK1 protein CTD PMID:20719974 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydrochloric Acid results in increased expression of PCNA mRNA CTD PMID:15046208 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pga5 pepsinogen A5 multiple interactions EXP [Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein CTD PMID:12928072 NCBI chr 1:207,317,021...207,327,156
Ensembl chr 1:207,317,021...207,327,156
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel multiple interactions ISO Hydrochloric Acid results in decreased activity of [PKD2 protein binds to PKD2 protein] CTD PMID:19193631 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Hydrochloric Acid results in decreased expression of PLPP3 mRNA CTD PMID:15046208 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases response to substance
multiple interactions
ISO PTGS1 results in decreased susceptibility to Hydrochloric Acid
PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin]
CTD PMID:15236176 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
[[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein
Hydrochloric Acid results in increased expression of PTGS2 mRNA; Hydrochloric Acid results in increased expression of PTGS2 protein
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Hydrochloric Acid co-treated with Piroxicam] results in increased expression of PTGS2 mRNA
CTD PMID:9726391 PMID:12853844 PMID:15236176 PMID:15309881 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pth parathyroid hormone decreases secretion ISO PTH protein results in decreased secretion of Hydrochloric Acid CTD PMID:20380354 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Rassf1 Ras association domain family member 1 decreases expression ISO Hydrochloric Acid results in decreased expression of RASSF1 mRNA CTD PMID:15046208 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
JBrowse link
G Rhbg Rh family B glycoprotein multiple interactions
increases expression
ISO Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein]; RHBG protein affects the reaction [Hydrochloric Acid results in increased export of Ammonia]
Hydrochloric Acid results in increased expression of RHBG protein
CTD PMID:20719974 NCBI chr 2:173,704,852...173,717,380
Ensembl chr 2:173,704,562...173,717,321
JBrowse link
G Rhcg Rh family, C glycoprotein increases expression
multiple interactions
affects response to substance
ISO
EXP
Hydrochloric Acid results in increased expression of RHCG protein
[Hydrochloric Acid results in increased expression of RHCG protein] which results in increased secretion of Ammonia
RHCG protein affects the susceptibility to Hydrochloric Acid
RHCG protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]
CTD PMID:16144966 PMID:19321595 PMID:20462967 NCBI chr 1:133,531,704...133,555,902
Ensembl chr 1:133,531,716...133,555,876
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO Hydrochloric Acid results in increased expression of RRAD mRNA CTD PMID:15046208 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Rreb1 ras responsive element binding protein 1 decreases expression ISO Hydrochloric Acid results in decreased expression of RREB1 mRNA CTD PMID:15046208 NCBI chr17:26,876,686...27,002,615
Ensembl chr17:26,876,697...27,002,615
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Hydrochloric Acid results in increased expression of RUNX2 mRNA; Hydrochloric Acid results in increased expression of RUNX2 protein CTD PMID:17183249 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of SCGB1A1 protein
Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of SCGB1A1 protein]
CTD PMID:24122261 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
JBrowse link
G Serpine1 serpin family E member 1 affects response to substance ISO SERPINE1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:19060228 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sftpd surfactant protein D decreases expression
multiple interactions
increases expression
EXP Hydrochloric Acid results in decreased expression of SFTPD protein
S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in decreased expression of SFTPD protein]
Hydrochloric Acid results in increased expression of SFTPD protein
CTD PMID:11880309 PMID:18573544 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Slc38a1 solute carrier family 38, member 1 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA CTD PMID:29618784 NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA] CTD PMID:29618784 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
JBrowse link
G Slc38a4 solute carrier family 38, member 4 decreases expression
multiple interactions
ISO Hydrochloric Acid results in decreased expression of SLC38A4 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]
CTD PMID:29618784 NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
JBrowse link
G Slc38a7 solute carrier family 38, member 7 decreases expression ISO Hydrochloric Acid results in decreased expression of SLC38A7 mRNA CTD PMID:29618784 NCBI chr19:9,209,203...9,225,472
Ensembl chr19:9,209,257...9,225,454
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
decreases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA] CTD PMID:29618784 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc6a19 solute carrier family 6 member 19 decreases expression ISO Hydrochloric Acid results in decreased expression of SLC6A19 mRNA CTD PMID:29618784 NCBI chr 1:29,586,205...29,604,960
Ensembl chr 1:29,586,195...29,604,962
JBrowse link
G Slc7a7 solute carrier family 7 member 7 decreases expression ISO Hydrochloric Acid results in decreased expression of SLC7A7 mRNA CTD PMID:29618784 NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648
JBrowse link
G Slc7a9 solute carrier family 7 member 9 decreases expression
multiple interactions
ISO Hydrochloric Acid results in decreased expression of SLC7A9 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA]
CTD PMID:29618784 NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641
JBrowse link
G Slc9a4 solute carrier family 9 member A4 increases expression
increases activity
multiple interactions
ISO
EXP
Hydrochloric Acid results in increased expression of SLC9A4 mRNA
Hydrochloric Acid results in increased activity of SLC9A4 protein
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; SLC9A4 protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]
CTD PMID:20484819 PMID:29618784 NCBI chr 9:42,824,468...42,879,767
Ensembl chr 9:42,825,064...42,879,422
JBrowse link
G Sp7 Sp7 transcription factor decreases expression ISO Hydrochloric Acid results in decreased expression of SP7 mRNA; Hydrochloric Acid results in decreased expression of SP7 protein CTD PMID:17183249 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Sst somatostatin increases expression EXP Hydrochloric Acid results in increased expression of SST protein CTD PMID:9530148 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Sstr2 somatostatin receptor 2 affects response to substance ISO SSTR2 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17363388 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases secretion
EXP Botulinum Toxins, Type A inhibits the reaction [Hydrochloric Acid results in increased secretion of TAC1 protein] CTD PMID:18184328 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 affects response to substance EXP TACR1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:11730984 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tacr3 tachykinin receptor 3 affects response to substance EXP TACR3 protein affects the susceptibility to Hydrochloric Acid CTD PMID:11730984 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791
JBrowse link
G Tff2 trefoil factor 2 multiple interactions EXP [Aspirin co-treated with Hydrochloric Acid] results in increased expression of TFF2 mRNA CTD PMID:9726391 NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases expression
EXP [Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:9726391 PMID:15309881 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]
Hydrochloric Acid results in increased expression of TNF mRNA; Hydrochloric Acid results in increased expression of TNF protein
CTD PMID:15044056 PMID:15607125 PMID:16129981 PMID:25478868 PMID:32531310 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity
ISO
EXP
TRPV1 protein affects the susceptibility to Hydrochloric Acid
Hydrochloric Acid results in increased activity of TRPV1 protein
CTD PMID:15125461 PMID:15331673 PMID:17627983 PMID:18331834 PMID:19483072 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Hydrochloric Acid results in increased expression of VEGFC mRNA CTD PMID:15046208 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO Hydrochloric Acid results in decreased expression of VGF mRNA CTD PMID:15046208 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19759
      chemical role 19333
        donor 18645
          Bronsted acid 18527
            inorganic acid 14337
              hydrogen halide 102
                fluoridohydrogen(.1+) 0
                hydrogen astatide 0
                hydrogen bromide + 0
                hydrogen chloride + 102
                hydrogen fluoride + 0
                hydrogen iodide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19809
      composite particle 19809
        hadron 19809
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19706
                    main group molecular entity 19706
                      s-block molecular entity 19490
                        hydrogen molecular entity 19485
                          hydracid 6757
                            hydrogen halide 102
                              fluoridohydrogen(.1+) 0
                              hydrogen astatide 0
                              hydrogen bromide + 0
                              hydrogen chloride + 102
                              hydrogen fluoride + 0
                              hydrogen iodide + 0
paths to the root