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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylamine
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Accession:CHEBI:18139 term browser browse the term
Definition:A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.
Synonyms:related_synonym: (CH3)3N;   Formula=C3H9N;   InChI=1S/C3H9N/c1-4(2)3/h1-3H3;   InChIKey=GETQZCLCWQTVFV-UHFFFAOYSA-N;   N(CH3)3;   N,N,N-trimethylamine;   N,N-Dimethylmethanamine;   NMe3;   SMILES=CN(C)C;   TMA;   Trimethylamin;   tridimethylaminomethane
 alt_id: CHEBI:15261;   CHEBI:27125;   CHEBI:27127;   CHEBI:9732
 xref: Beilstein:956566;   CAS:75-50-3;   Gmelin:1309;   HMDB:HMDB0000906;   KEGG:C00565;   KNApSAcK:C00001433
 xref_mesh: MESH:C023336
 xref: MetaCyc:TRIMETHYLAMINE;   PDBeChem:KEN;   PMID:14047118;   PMID:15304308;   PMID:15752091;   PMID:17190852;   PMID:1801314;   PMID:24591617;   PMID:2501587;   PMID:5161463;   Reaxys:956566;   Wikipedia:Trimethylamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58389


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trimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases oxidation
multiple interactions
increases metabolic processing		 ISO
EXP		 FMO3 gene polymorphism affects the metabolism of trimethylamine
FMO3 protein results in increased oxidation of trimethylamine; FMO3 results in increased oxidation of trimethylamine
trimethylamine inhibits the reaction [FMO3 protein results in increased oxidation of Methimazole]
FMO3 protein results in increased metabolism of trimethylamine		 CTD PMID:11414682 PMID:12214664 PMID:16601883 PMID:17050781 PMID:17142560 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases chemical synthesis		 ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine
MTARC1 protein results in increased chemical synthesis of trimethylamine		 CTD PMID:29856598 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethylamine CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Taar5 trace amine-associated receptor 5 increases activity ISO trimethylamine results in increased activity of TAAR5 protein CTD PMID:23393561 NCBI chr 1:21,469,923...21,470,936
Ensembl chr 1:21,469,923...21,470,936 		JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction		 ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            xenobiotic metabolite 15445
              human xenobiotic metabolite 14813
                trimethylamine 9
                  trimethylamine N-oxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            inorganic hydride 18114
                              pnictogen hydride 18103
                                nitrogen hydride 18010
                                  azane 17819
                                    ammonia 17818
                                      organic amino compound 17818
                                        amine 8280
                                          alkylamines 190
                                            methylamines 17
                                              trimethylamine 9
                                                trimethylamine N-oxide 7
paths to the root