Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylamine
go back to main search page
Accession:CHEBI:18139 term browser browse the term
Definition:A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.
Synonyms:related_synonym: (CH3)3N;   Formula=C3H9N;   InChI=1S/C3H9N/c1-4(2)3/h1-3H3;   InChIKey=GETQZCLCWQTVFV-UHFFFAOYSA-N;   N(CH3)3;   N,N,N-trimethylamine;   N,N-Dimethylmethanamine;   NMe3;   SMILES=CN(C)C;   TMA;   Trimethylamin;   tridimethylaminomethane
 alt_id: CHEBI:15261;   CHEBI:27125;   CHEBI:27127;   CHEBI:9732
 xref: CAS:75-50-3;   Gmelin:1309;   HMDB:HMDB0000906;   KEGG:C00565;   KNApSAcK:C00001433
 xref_mesh: MESH:C023336
 xref: MetaCyc:TRIMETHYLAMINE;   PDBeChem:KEN;   PMID:14047118;   PMID:15304308;   PMID:15752091;   PMID:17190852;   PMID:1801314;   PMID:24591617;   PMID:2501587;   PMID:5161463;   Reaxys:956566;   Wikipedia:Trimethylamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58389


show annotations for term's descendants           Sort by:
trimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing monooxygenase 3 affects metabolic processing
increases oxidation
multiple interactions
increases metabolic processing		 ISO FMO3 gene polymorphism affects the metabolism of trimethylamine
FMO3 protein results in increased oxidation of trimethylamine; FMO3 results in increased oxidation of trimethylamine
trimethylamine inhibits the reaction [FMO3 protein results in increased oxidation of Methimazole]
FMO3 protein results in increased metabolism of trimethylamine		 CTD PMID:11414682 PMID:12214664 PMID:16601883 PMID:17050781 PMID:17142560 NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 increases chemical synthesis
multiple interactions		 ISO MTARC1 protein results in increased chemical synthesis of trimethylamine
[MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine		 CTD PMID:29856598 NCBI chr 1:184,518,964...184,543,622
Ensembl chr 1:184,518,964...184,543,394 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects abundance EXP SLCO1A1 protein affects the abundance of trimethylamine CTD PMID:21561886 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance EXP SLCO1A4 protein affects the abundance of trimethylamine CTD PMID:21561886 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Taar5 trace amine-associated receptor 5 increases activity ISO trimethylamine results in increased activity of TAAR5 protein CTD PMID:23393561 NCBI chr10:23,846,604...23,847,617
Ensembl chr10:23,846,604...23,847,617 		JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction		 ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr 1:184,518,964...184,543,622
Ensembl chr 1:184,518,964...184,543,394 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance EXP SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions ISO trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22307
    role 22293
      biological role 22292
        biochemical role 21521
          metabolite 21470
            xenobiotic metabolite 17078
              human xenobiotic metabolite 16599
                trimethylamine 10
                  trimethylamine N-oxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 22307
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22184
                    main group molecular entity 22184
                      s-block molecular entity 21804
                        hydrogen molecular entity 21721
                          hydrides 20775
                            inorganic hydride 18716
                              pnictogen hydride 18697
                                nitrogen hydride 18571
                                  azane 18478
                                    ammonia 18477
                                      organic amino compound 18477
                                        amine 8347
                                          alkylamines 191
                                            methylamines 18
                                              trimethylamine 10
                                                trimethylamine N-oxide 7
paths to the root