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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphocholine
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Accession:CHEBI:18132 term browser browse the term
Definition:The phosphate of choline; and the parent compound of the phosphocholine family.
Synonyms:exact_synonym: N,N,N-trimethyl-2-(phosphonooxy)ethanaminium
 related_synonym: ChoP;   Choline phosphate;   Formula=C5H15NO4P;   InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1;   InChIKey=YHHSONZFOIEMCP-UHFFFAOYSA-O;   N-Trimethyl-2-aminoethylphosphonate;   O-phosphocholine;   Phosphoryl-choline;   Phosphorylcholine;   SMILES=C[N+](C)(C)CCOP(O)(O)=O;   Trimethyl(2-(phosphonooxy)ethyl)ammonium
 alt_id: CHEBI:12720;   CHEBI:13986;   CHEBI:23214;   CHEBI:3667;   CHEBI:44707
 xref: Beilstein:1784889;   CAS:107-73-3;   DrugBank:DB03945;   Gmelin:2594827;   HMDB:HMDB0001565;   KEGG:C00588;   KNApSAcK:C00007299
 xref_mesh: MESH:D010767
 xref: PDBeChem:PC;   PMID:10456913;   PMID:10596404;   PMID:10811914;   PMID:11437497;   PMID:11908950;   PMID:15267227;   PMID:15583011;   PMID:18684852;   PMID:19369878;   PMID:19748321;   PMID:19758165;   PMID:23572077;   PMID:24012478;   PMID:6420466;   PMID:6790611;   PMID:7450902;   Reaxys:1784889
 cyclic_relationship: is_conjugate_acid_of CHEBI:295975


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phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]
CTD PMID:15878362 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
phosphorylcholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]
CTD PMID:15878362 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        epitope 6844
          phosphocholine 5
            phosphocholine group 0
            phosphorylcholine chloride 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            inorganic hydride 17483
                              pnictogen hydride 17456
                                nitrogen hydride 17300
                                  ammonium 8230
                                    ammonium ion derivative 8226
                                      quaternary ammonium ion 5094
                                        cholines 4791
                                          choline 3542
                                            choline ester 124
                                              phosphocholines 124
                                                phosphocholine 5
                                                  phosphocholine group 0
                                                  phosphorylcholine chloride 5
paths to the root