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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphocholine
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Accession:CHEBI:18132 term browser browse the term
Definition:The phosphate of choline; and the parent compound of the phosphocholine family.
Synonyms:exact_synonym: N,N,N-trimethyl-2-(phosphonooxy)ethanaminium
 related_synonym: ChoP;   Choline phosphate;   Formula=C5H15NO4P;   InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1;   InChIKey=YHHSONZFOIEMCP-UHFFFAOYSA-O;   N-Trimethyl-2-aminoethylphosphonate;   O-phosphocholine;   Phosphoryl-choline;   Phosphorylcholine;   SMILES=C[N+](C)(C)CCOP(O)(O)=O;   Trimethyl(2-(phosphonooxy)ethyl)ammonium
 alt_id: CHEBI:12720;   CHEBI:13986;   CHEBI:23214;   CHEBI:3667;   CHEBI:44707
 xref: Beilstein:1784889;   CAS:107-73-3;   DrugBank:DB03945;   Gmelin:2594827;   HMDB:HMDB0001565;   KEGG:C00588;   KNApSAcK:C00007299
 xref_mesh: MESH:D010767
 xref: PDBeChem:PC;   PMID:10456913;   PMID:10596404;   PMID:10811914;   PMID:11437497;   PMID:11908950;   PMID:15267227;   PMID:15583011;   PMID:18684852;   PMID:19369878;   PMID:19748321;   PMID:19758165;   PMID:23572077;   PMID:24012478;   PMID:6420466;   PMID:6790611;   PMID:7450902;   Reaxys:1784889
 cyclic_relationship: is_conjugate_acid_of CHEBI:295975



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phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Phosphorylcholine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]
CTD PMID:15878362 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
phosphorylcholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Phosphorylcholine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]
CTD PMID:15878362 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      biological role 19989
        epitope 6995
          phosphocholine 6
            phosphocholine group 0
            phosphorylcholine chloride 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    main group molecular entity 19938
                      s-block molecular entity 19726
                        hydrogen molecular entity 19718
                          hydrides 19086
                            inorganic hydride 17892
                              pnictogen hydride 17875
                                nitrogen hydride 17766
                                  ammonium 8241
                                    ammonium ion derivative 8237
                                      quaternary ammonium ion 5117
                                        cholines 4808
                                          choline 3563
                                            choline ester 128
                                              phosphocholines 128
                                                phosphocholine 6
                                                  phosphocholine group 0
                                                  phosphorylcholine chloride 6
paths to the root